Details of the Target

General Information of Target

Target ID LDTP11735
Target Name VIP36-like protein (LMAN2L)
Gene Name LMAN2L
Gene ID 81562
Synonyms
VIPL; VIP36-like protein; Lectin mannose-binding 2-like; LMAN2-like protein
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MALRSRFWGLFSVCRNPGCRFAALSTSSEPAAKPEVDPVENEAVAPEFTNRNPRNLELLS
VARKERGWRTVFPSREFWHRLRVIRTQHHVEALVEHQNGKVVVSASTREWAIKKHLYSTR
NVVACESIGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQSAMTEGGVVLREPQRIYE
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53.
Uniprot ID
Q9H0V9
Ensemble ID
ENST00000264963.9
HGNC ID
HGNC:19263

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.G155Ter .
HCT116 SNV: p.L291F .
MCC26 SNV: p.Y161H .
NCIH1793 SNV: p.G36W .
NCIH196 SNV: p.W234Ter DBIA    Probe Info 
SNU1 SNV: p.R170W DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K52(0.80)  LDD0277  [1]
DBIA
 Probe Info  		C66(1.89)  LDD3310  [2]
BTD
 Probe Info  		C200(1.37)  LDD2121  [3]
IPM
 Probe Info  		C104(4.62); C200(3.16)  LDD1701  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C200(0.00); C237(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
NAIA_5
 Probe Info  		C237(0.00); C200(0.00)  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C200(1.00)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C200(1.08); C237(1.01)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C200(1.06)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C200(0.97)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C200(0.96)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C200(0.97)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C200(1.02)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C200(1.05); C237(0.99)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C200(1.07)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C200(1.10); C237(0.89)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C200(1.03)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C200(0.98)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C200(0.96)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C200(0.75)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C200(0.90)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C200(0.97)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C200(1.07); C237(1.10)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C200(1.04)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C200(0.93)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C200(1.04)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C200(1.09)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C200(0.96)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C200(0.91)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C200(1.02)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C200(1.08)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C200(1.10); C237(1.19)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C200(1.05)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C200(1.05)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C200(0.89)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C200(0.92)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C200(1.11)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C200(0.98)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C200(1.01)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C200(1.00)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C200(1.13); C237(1.18)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C200(1.00)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C200(0.99)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C200(1.01)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C200(1.12)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C200(1.07)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C200(0.97)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C200(0.98)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C200(0.98)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C200(1.06); C237(1.08)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C200(1.02)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C200(0.98)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C200(0.96)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C200(1.09)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C200(0.92)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C200(0.85)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C200(1.00)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C200(1.15); C237(0.97)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C200(1.04)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C200(1.02)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C200(1.01)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C200(0.99)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C200(0.92)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C200(0.80)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C200(0.95)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C200(0.93)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C200(1.06)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C200(1.00)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C200(1.03)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C200(0.97)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C200(0.88)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C200(1.10)  LDD1572  [8]
 LDCM0370  CL101 HEK-293T C200(1.02)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C200(1.07)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C200(1.04)  LDD1576  [8]
 LDCM0374  CL105 HEK-293T C200(0.91)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C200(0.97)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C200(1.00)  LDD1580  [8]
 LDCM0378  CL109 HEK-293T C200(0.85)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C200(1.09)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C200(1.08)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C200(0.92)  LDD1585  [8]
 LDCM0383  CL113 HEK-293T C200(0.91)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C200(1.14)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C200(0.93)  LDD1589  [8]
 LDCM0387  CL117 HEK-293T C200(0.90)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C200(1.24)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C200(0.94)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C200(1.01)  LDD1594  [8]
 LDCM0392  CL121 HEK-293T C200(0.94)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C200(1.01)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C200(0.99)  LDD1598  [8]
 LDCM0396  CL125 HEK-293T C200(1.13)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C200(0.94)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C200(1.06)  LDD1602  [8]
 LDCM0400  CL13 HEK-293T C200(0.94)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C200(1.00)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C200(1.09)  LDD1606  [8]
 LDCM0404  CL17 HEK-293T C200(0.92)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C200(1.23); C237(1.02)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C200(1.12)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C200(1.01)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C200(1.01)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C200(0.94)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C200(1.09)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C200(1.19)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C200(1.08)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C200(0.98)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C200(0.96)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C200(1.00)  LDD1619  [8]
 LDCM0417  CL29 HEK-293T C200(0.93)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C200(1.03)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C200(1.05); C237(0.99)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C200(1.03)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C200(0.99)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C200(0.90)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C200(1.11)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C200(1.03)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C200(1.01)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C200(0.88)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C200(1.02)  LDD1632  [8]
 LDCM0431  CL41 HEK-293T C200(0.92)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C200(0.96); C237(0.99)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C200(1.03)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C200(1.05)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C200(1.04)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C200(0.96)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C200(0.89)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C200(1.05)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C200(1.10)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C200(1.05)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C200(1.00)  LDD1645  [8]
 LDCM0444  CL53 HEK-293T C200(0.95)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C200(1.01); C237(1.10)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C200(1.02)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C200(1.11)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C200(1.07)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C200(0.99)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C200(1.31)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C200(1.10); C237(1.09)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C200(0.83)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C200(0.85)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C200(1.12)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C200(0.94)  LDD1658  [8]
 LDCM0457  CL65 HEK-293T C200(1.00)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C200(0.93); C237(1.01)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C200(0.94)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C200(1.02)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C200(1.03)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C200(0.92)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C200(0.97)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C200(0.93)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C200(0.99)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C200(0.91)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C200(1.00)  LDD1670  [8]
 LDCM0470  CL77 HEK-293T C200(1.04)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C200(1.07); C237(1.07)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C200(1.04)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C200(1.12)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C200(1.03)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C200(1.02)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C200(1.07)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C200(0.99)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C200(1.15)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C200(0.95)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C200(0.86)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C200(1.09)  LDD1684  [8]
 LDCM0483  CL89 HEK-293T C200(1.05)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C200(1.02)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C200(1.17); C237(1.13)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C200(1.18)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C200(1.06)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C200(0.93)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C200(0.95)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C200(1.22)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C200(0.96)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C200(0.92)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C200(0.99)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C200(1.00)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C200(1.05)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C200(0.98)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C200(0.98)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C200(0.94)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C200(0.93)  LDD1497  [8]
 LDCM0024  KB05 COLO792 C66(1.89)  LDD3310  [2]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C200(1.37)  LDD2121  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Myelin and lymphocyte protein (MAL) MAL family P21145

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402