Details of the Target

General Information of Target

Target ID LDTP11471
Target Name Serine/threonine-protein kinase WNK3 (WNK3)
Gene Name WNK3
Gene ID 65267
Synonyms
KIAA1566; PRKWNK3; Serine/threonine-protein kinase WNK3; EC 2.7.11.1; Protein kinase lysine-deficient 3; Protein kinase with no lysine 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQAIFEALEGMDNQTVLAVQSLLDGQGAVPDPTGQSVNAPPAIQPLDDEDVFLCGKCKK
QFNSLPAFMTHKREQCQGNAPALATVSLATNSIYPPSAAPTAVQQAPTPANRQISTYITV
PPSPLIQTLVQGNILVSDDVLMSAMSAFTSLDQPMPQGPPPVQSSLNMHSVPSYLTQPPP
PPPPPPPLPPPPPPQPPPPPPQSLGPPGRPNPGGNGVVEVYSAAAPLAGSGTVEIQALGM
QPYPPLEVPNQCVEPPVYPTPTVYSPGKQGFKPKGPNPAAPMTSATGGTVATFDSPATLK
TRRAKGARGLPEAAGKPKAQKLKCSYCDKSFTKNFDLQQHIRSHTGEKPFQCIACGRAFA
QKSNVKKHMQTHKVWPPGHSGGTVSRNSVTVQVMALNPSRQEDEESTGLGQPLPGAPQPQ
ALSTAGEEEGDKPESKQVVLIDSSYLCQFCPSKFSTYFQLKSHMTQHKNEQVYKCVVKSC
AQTFPKLDTFLEHIKSHQEELSYRCHLCGKDFPSLYDLGVHQYSHSLLPQHSPKKDNAVY
KCVKCVNKYSTPEALEHHLQTATHNFPCPHCQKVFPCERYLRRHLPTHGSGGRFKCQVCK
KFFRREHYLKLHAHIHSGEKPYKCSVCESAFNRKDKLKRHMLIHEPFKKYKCPFSTHTGC
SKEFNRPDKLKAHILSHSGMKLHKCALCSKSFSRRAHLAEHQRAHTGNYKFRCAGCAKGF
SRHKYLKDHRCRLGPQKDKDLQTRRPPQRRAAPRSCGSGGRKVLTPLPDPLGLEELKDTG
AGLVPEAVPGKPPFAEPDAVLSIVVGGAVGAETELVVPGHAEGLGSNLALAELQAGAEGP
CAMLAVPVYIQASE
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family, WNK subfamily
Subcellular location
Cytoplasm
Function
Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress. WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation. The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK. Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity. Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux. Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC. May also phosphorylate NEDD4L. Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway.
TTD ID
T53468
Uniprot ID
Q9BYP7
DrugMap ID
TTI7FDX
Ensemble ID
ENST00000354646.6
HGNC ID
HGNC:14543
ChEMBL ID
CHEMBL6055

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.T1761I .
COLO800 Substitution: p.N1791T DBIA    Probe Info 
HCT15 SNV: p.P1730T .
HEC1 SNV: p.R872Q .
HEC1B SNV: p.R872Q .
HT115 SNV: p.G364D .
ICC3 SNV: p.N793K DBIA    Probe Info 
MCC26 SNV: p.E79K;p.E1356K
Substitution: p.T1284I		 .
MEWO SNV: p.R1588Ter DBIA    Probe Info 
NCIH1155 SNV: p.A1376T DBIA    Probe Info 
NCIH146 SNV: p.T1392S DBIA    Probe Info 
NCIH2170 SNV: p.H1679R DBIA    Probe Info 
ONS76 SNV: p.K218N .
OVK18 SNV: p.S75F DBIA    Probe Info 
PANC1 SNV: p.T995I .
RL952 SNV: p.Y615C .
SH4 SNV: p.W871Ter DBIA    Probe Info 
SHP77 SNV: p.R967K DBIA    Probe Info 
SW620 SNV: p.S905N DBIA    Probe Info 
TE4 SNV: p.R737L .
YSCCC SNV: p.W1276Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.16  LDD0402  [1]
ONAyne
 Probe Info  		K482(5.77)  LDD0274  [2]
DBIA
 Probe Info  		C52(4.09)  LDD3332  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		C278(0.00); C385(0.00)  LDD0036  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
TFBX
 Probe Info  		C385(0.00); C278(0.00)  LDD0148  [6]
VSF
 Probe Info  		C278(0.00); C949(0.00)  LDD0007  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C874(0.64); C1406(1.11); C502(1.01); C949(0.99)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C991(1.13); C874(0.77); C1406(1.01); C176(0.94)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C874(1.18); C176(1.05); C502(1.02); C949(1.10)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C991(0.88); C874(0.97); C1406(1.10); C176(1.00)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C874(0.91); C176(1.14); C502(1.02); C949(1.09)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C991(0.56); C874(1.06); C502(0.97); C949(1.05)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C874(0.95); C1406(0.99); C502(0.99); C949(0.97)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C991(0.94); C874(0.95); C1406(1.07); C176(1.00)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C874(1.22); C176(0.96); C502(1.39); C949(1.60)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C991(0.94); C874(0.59); C1406(0.94); C176(0.99)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C991(0.82); C874(0.88); C1406(1.02); C176(1.22)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C874(0.98); C1406(1.06); C176(0.96); C502(1.03)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C874(0.95); C176(1.05); C502(0.99); C949(0.89)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C991(0.76); C874(1.03); C502(1.00); C949(0.94)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C874(0.92); C1406(1.06); C176(0.94); C502(0.99)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C874(0.97); C1406(0.95); C502(0.95); C949(0.92)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C991(0.95); C874(0.70); C1406(1.00); C176(1.08)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C874(0.95); C176(1.12); C502(1.06); C949(1.03)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C991(0.78); C874(0.98); C1406(1.06); C176(1.19)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C874(0.99); C1406(1.02); C176(0.92); C502(1.03)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C874(0.88); C176(1.01); C502(1.01); C949(1.00)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C874(0.94); C176(0.99); C502(1.03); C949(1.00)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C991(0.68); C874(0.99); C502(0.92); C949(1.16)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C874(1.07); C1406(0.93); C176(0.90); C502(0.98)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C874(1.01); C1406(1.00); C502(1.06); C949(1.03)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C991(1.03); C874(0.82); C1406(1.11); C176(1.05)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C874(0.95); C176(1.33); C502(1.02); C949(0.96)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C991(0.86); C874(1.09); C1406(0.99); C176(1.01)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C874(0.94); C1406(0.95); C176(1.06); C502(0.91)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C874(0.92); C176(1.10); C502(0.98); C949(1.04)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C991(0.64); C874(1.02); C502(0.96); C949(0.99)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C991(0.94); C874(0.87); C1406(1.11); C176(0.97)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C874(1.35); C1406(1.20); C176(0.78); C502(0.99)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C874(1.01); C1406(1.02); C502(1.02); C949(0.96)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C991(0.89); C874(0.96); C1406(1.07); C176(0.90)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C874(0.95); C176(1.05); C502(1.02); C949(1.13)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C991(0.79); C874(0.98); C1406(1.12); C176(1.01)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C874(0.83); C1406(1.06); C176(1.14); C502(0.93)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C874(1.00); C176(0.97); C502(0.99); C949(1.03)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C991(0.65); C874(1.05); C502(1.04); C949(0.92)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C874(0.90); C1406(1.20); C176(0.88); C502(1.00)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C874(0.93); C1406(1.03); C502(0.99); C949(0.97)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C874(0.91); C1406(1.03); C176(1.06); C502(1.08)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C991(1.44); C874(0.85); C1406(1.09); C176(1.01)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C874(1.01); C176(0.94); C502(1.03); C949(1.02)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C991(0.95); C874(0.95); C1406(0.99); C176(0.99)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C874(1.16); C1406(1.06); C176(1.10); C502(0.92)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C874(1.06); C176(1.17); C502(1.02); C949(0.99)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C991(0.73); C874(1.08); C502(0.93); C949(0.95)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C874(0.83); C1406(1.13); C176(0.69); C502(1.05)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C874(0.90); C1406(0.85); C502(0.99); C949(1.02)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C991(0.89); C874(0.87); C1406(0.99); C176(0.98)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C874(0.93); C176(1.05); C502(1.02); C949(0.99)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C874(0.99); C176(0.84); C502(1.10); C949(1.03)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C991(0.90); C874(0.94); C1406(1.08); C176(1.17)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C874(1.03); C1406(1.02); C176(0.95); C502(0.97)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C874(0.89); C176(0.72); C502(1.05); C949(0.99)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C991(0.86); C874(1.07); C502(0.91); C949(1.08)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C874(0.79); C1406(1.07); C176(0.97); C502(1.02)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C991(0.61); C874(0.88); C502(0.97); C949(0.96)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C874(0.78); C1406(1.11); C176(0.95); C502(1.15)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C874(0.88); C1406(1.02); C176(0.95); C502(0.92)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C874(0.94); C1406(0.93); C502(1.00); C949(0.98)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C874(1.13); C1406(1.08); C176(0.80); C502(1.06)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C991(1.03); C874(0.85); C1406(1.02); C176(1.09)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C874(0.96); C176(0.74); C502(0.86); C949(0.92)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C991(1.14); C874(0.63); C1406(1.16); C502(1.07)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C991(1.09); C874(0.88); C1406(1.06); C176(0.97)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C991(0.76); C874(0.96); C176(1.23); C502(1.02)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C991(1.05); C874(1.21); C502(1.00); C949(0.97)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C991(0.91); C874(0.75); C1406(0.94); C502(1.06)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C991(1.07); C874(0.93); C1406(1.04); C176(0.76)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C991(0.74); C874(0.91); C176(1.22); C502(1.07)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C991(0.81); C874(1.06); C502(0.93); C949(1.09)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C991(0.84); C874(0.96); C1406(1.05); C502(1.00)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C991(1.06); C874(0.88); C1406(0.95); C176(1.08)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C991(0.61); C874(1.13); C502(0.93); C949(0.93)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C991(1.39); C874(0.94); C176(0.95); C502(1.04)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C991(0.91); C874(0.85); C502(0.88); C949(0.89)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C991(1.01); C874(0.88); C1406(1.01); C502(1.04)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C991(1.13); C874(0.97); C1406(1.04); C176(0.91)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C991(0.81); C874(1.01); C176(0.99); C502(1.09)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C991(0.93); C874(1.04); C502(1.04); C949(0.88)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C991(1.12); C874(0.87); C1406(1.00); C502(1.04)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C991(1.16); C874(0.94); C1406(1.05); C176(0.90)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C991(0.84); C874(1.07); C176(1.12); C502(1.22)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C991(0.89); C874(0.94); C502(0.99); C949(1.11)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C874(1.09); C1406(1.13); C176(0.71); C502(1.12)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C991(0.93); C874(0.97); C1406(0.97); C502(1.10)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C991(1.05); C874(1.01); C1406(1.05); C176(0.87)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C991(0.69); C874(0.93); C176(1.05); C502(1.00)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C991(0.95); C874(1.23); C502(1.00); C949(0.85)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C991(0.93); C874(0.85); C1406(1.02); C502(1.04)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C991(0.91); C874(1.04); C1406(1.11); C176(0.87)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C991(0.89); C874(0.93); C176(0.82); C502(1.06)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C991(0.97); C874(0.98); C502(1.08); C949(0.90)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C991(0.83); C874(0.98); C1406(1.07); C502(1.08)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C991(1.18); C874(1.25); C1406(1.27); C176(0.72)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C991(0.86); C874(0.92); C176(1.37); C502(1.10)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C991(0.89); C874(0.95); C502(1.00); C949(1.00)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C991(1.07); C874(1.09); C1406(1.07); C502(1.18)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C874(0.92); C1406(1.11); C502(0.95); C949(1.01)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C991(0.72); C874(0.89); C1406(1.00); C176(0.92)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C874(1.06); C176(1.09); C502(0.94); C949(1.00)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C991(0.81); C874(0.90); C176(1.24); C502(1.07)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C991(0.96); C874(0.98); C1406(1.00); C176(0.98)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C874(0.85); C1406(1.04); C176(0.98); C502(0.93)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C874(0.97); C176(0.72); C502(0.95); C949(1.11)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C991(0.89); C874(1.03); C502(0.94); C949(1.04)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C874(1.20); C1406(1.03); C176(0.80); C502(1.00)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C991(1.15); C874(0.84); C1406(1.08); C176(0.72)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C991(0.79); C874(0.97); C176(0.98); C502(0.96)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C991(0.91); C874(1.10); C502(1.02); C949(0.93)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C991(0.87); C874(1.04); C1406(1.06); C502(1.02)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C874(0.92); C1406(1.06); C502(1.00); C949(0.90)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C991(0.89); C874(0.97); C502(1.02); C949(1.02)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C991(1.00); C874(0.66); C1406(1.00); C176(0.95)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C874(1.04); C176(0.96); C502(1.00); C949(1.08)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C991(0.98); C874(0.91); C1406(0.93); C176(0.96)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C874(0.80); C1406(0.95); C176(0.80); C502(0.81)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C874(0.95); C176(0.72); C502(0.96); C949(0.99)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C991(0.81); C874(1.09); C502(0.96); C949(1.17)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C874(1.18); C1406(1.01); C176(0.51); C502(0.91)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C991(1.08); C874(0.81); C1406(1.02); C176(0.78)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C991(1.00); C874(0.97); C502(0.99); C949(0.91)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C991(0.88); C874(0.71); C1406(1.09); C502(1.06)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C991(1.03); C874(0.86); C1406(0.96); C502(1.08)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C874(0.91); C1406(1.17); C502(0.94); C949(0.84)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C991(0.99); C874(0.84); C1406(0.96); C176(1.38)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C874(1.08); C176(0.94); C502(1.00); C949(0.99)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C991(1.12); C874(1.02); C1406(1.04); C176(0.91)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C874(1.09); C1406(1.04); C176(1.12); C502(0.88)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C874(0.93); C176(0.82); C502(0.94); C949(1.00)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C991(0.91); C874(1.28); C502(0.95); C949(1.03)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C874(1.21); C1406(1.02); C176(0.67); C502(0.99)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C991(1.07); C874(1.05); C1406(0.93); C176(0.83)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C874(1.05); C1406(0.99); C502(1.02); C949(1.03)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C991(0.69); C874(0.83); C176(1.01); C502(1.06)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C991(0.87); C874(0.96); C1406(1.28); C502(1.05)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C874(0.96); C1406(0.98); C502(0.92); C949(1.01)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C991(0.91); C874(0.79); C1406(0.97); C176(0.95)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C874(0.90); C176(1.08); C502(0.95); C949(1.09)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C991(0.99); C874(1.17); C1406(1.19); C176(1.01)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C874(1.24); C1406(1.16); C176(0.94); C502(1.10)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C874(1.02); C176(0.98); C502(0.95); C949(0.95)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C991(0.73); C874(1.05); C502(0.92); C949(0.91)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C991(0.77); C874(0.89); C1406(0.95); C176(0.99)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C874(0.88); C1406(1.15); C176(0.66); C502(1.04)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C991(0.95); C874(0.85); C1406(1.00); C176(0.84)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C991(0.97); C874(0.85); C176(1.17); C502(1.05)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C991(0.94); C874(0.87); C502(0.98); C949(1.02)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C991(0.98); C874(0.81); C1406(1.03); C502(1.09)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C874(0.93); C1406(1.02); C502(0.94); C949(1.06)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C991(0.85); C874(0.78); C1406(0.98); C176(1.00)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C874(0.89); C176(1.29); C502(0.95); C949(1.13)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C991(1.01); C874(1.01); C1406(0.91); C176(0.88)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C874(1.09); C1406(1.00); C176(0.89); C502(0.90)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C874(0.98); C176(1.02); C502(0.97); C949(0.93)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C874(0.85); C176(0.78); C502(0.88); C949(1.07)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C991(0.78); C874(1.06); C502(0.93); C949(1.02)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C874(0.96); C1406(1.09); C176(0.73); C502(0.99)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C991(0.87); C874(0.79); C1406(0.93); C176(0.97)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C991(0.87); C874(0.81); C176(0.96); C502(1.08)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C991(1.03); C874(0.94); C1406(0.90); C502(1.04)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C874(0.89); C1406(1.17); C502(0.97); C949(0.88)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C991(0.82); C874(0.82); C1406(0.92); C176(1.08)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C874(1.01); C176(1.06); C502(1.06); C949(1.06)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C991(0.65); C874(0.93); C1406(0.98); C176(0.66)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C991(1.13); C874(1.03); C1406(1.06); C176(0.97)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C874(1.02); C1406(1.05); C176(1.19); C502(0.97)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C874(1.00); C176(1.12); C502(1.01); C949(1.06)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C991(0.64); C874(1.11); C502(0.93); C949(0.94)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C874(0.99); C1406(1.02); C176(0.65); C502(1.02)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C991(0.97); C874(0.77); C1406(0.94); C176(0.99)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C991(1.01); C874(0.83); C176(0.94); C502(1.06)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C991(0.93); C874(1.01); C502(1.07); C949(0.89)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C991(0.94); C874(0.91); C1406(1.03); C502(1.05)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C874(0.86); C1406(1.10); C502(1.06); C949(0.91)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C874(1.06); C1406(1.04); C176(1.07); C502(1.01)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C991(0.83); C874(0.69); C1406(1.02); C176(0.84)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C874(0.97); C176(1.04); C502(1.03); C949(1.04)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C991(0.90); C874(0.94); C1406(0.97); C176(0.96)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C874(0.95); C1406(1.04); C176(0.86); C502(0.93)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C874(1.03); C176(1.20); C502(0.91); C949(0.97)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C991(0.82); C874(1.02); C502(1.05); C949(1.01)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C874(0.87); C1406(1.04); C176(0.78); C502(0.93)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C991(1.13); C874(0.65); C1406(0.98); C176(0.90)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C991(1.06); C874(0.75); C176(1.19); C502(1.03)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C991(0.89); C874(0.75); C502(0.99); C949(0.79)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C991(0.94); C874(1.04); C502(0.98); C949(0.84)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C735(1.72)  LDD1702  [8]
 LDCM0468  Fragment33 HEK-293T C991(1.13); C874(1.12); C502(1.04); C949(0.95)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C991(0.73); C874(1.15); C176(1.24); C502(1.07)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C1406(0.78)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C1406(1.01)  LDD1497  [7]
 LDCM0024  KB05 MKN45 C52(4.09)  LDD3332  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-3 (CASP3) Peptidase C14A family P42574
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor LBX1 (LBX1) . P52954

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid24900538c2c Small molecular drug D0E7VO

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761