Details of the Target

General Information of Target

Target ID LDTP11314
Target Name Cyclin-dependent kinase 2-interacting protein (CINP)
Gene Name CINP
Gene ID 51550
Synonyms
Cyclin-dependent kinase 2-interacting protein; CDK2-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELL
EEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREV
RPLRKEMAGVGARGPVGRAHPISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPK
FDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRP
WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYA
PTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNF
PWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADI
TNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKY
EKWMVEFGSA
Target Bioclass
Other
Family
CINP family
Subcellular location
Nucleus
Function
Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling in response to DNA damage. Also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. Promotes maturation of pre-60S ribosome together with AFG2A, AFG2B and AIRIM.
Uniprot ID
Q9BW66
Ensemble ID
ENST00000216756.11
HGNC ID
HGNC:23789

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC15 Substitution: p.I34_L35delinsMV .
MDAMB453 SNV: p.E169Q .
SISO SNV: p.W140Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C81(5.69)  LDD0209  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		C120(0.00); C92(0.00)  LDD2156  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C92(0.97); C120(0.92); C81(0.95)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C92(1.02); C120(1.05); C81(0.97)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C92(1.01); C81(0.98)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C92(1.02); C120(1.00); C81(0.99)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C92(0.98); C120(1.02)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C92(1.03); C120(0.88); C81(0.96)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C92(1.02); C120(0.99); C81(0.95)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C92(1.07); C120(0.96); C81(0.99)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C92(0.81); C81(0.95)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C92(1.10); C120(1.06); C81(0.91)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C92(1.06); C120(1.04); C81(0.97)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C92(0.98); C120(0.99); C81(0.90)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C92(1.07); C120(1.06)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C92(1.05); C120(0.92); C81(0.99)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C92(0.93); C120(0.98); C81(1.03)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C92(1.00); C120(0.97); C81(1.00)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C92(1.00); C120(0.95); C81(0.95)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C92(0.99); C81(0.97)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C92(1.04); C120(0.99); C81(0.99)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C92(0.85); C120(1.03); C81(1.00)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C92(0.95); C81(0.95)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C92(1.08); C120(1.00)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C92(1.06); C120(1.00); C81(1.02)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C92(0.92); C120(0.99); C81(1.01)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C92(1.02); C120(0.97); C81(0.96)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C92(1.06); C120(1.25); C81(0.87)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C92(1.01); C81(0.99)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C92(0.95); C120(0.98); C81(1.04)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C92(1.01); C120(0.91); C81(0.98)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C92(1.01); C120(1.01)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C92(0.98); C120(0.80); C81(1.00)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C92(1.03); C120(1.00); C81(1.02)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C92(0.95); C120(1.09); C81(1.02)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C92(0.99); C120(1.05); C81(1.15)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C92(0.99); C120(1.10); C81(0.93)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C92(1.02); C81(1.06)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C92(1.09); C120(0.94); C81(1.05)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C92(1.07); C120(1.09); C81(0.94)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C92(1.04); C120(0.99)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C92(0.97); C120(0.92); C81(0.98)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C92(0.96); C120(1.12); C81(1.12)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C92(0.99); C120(0.99); C81(1.09)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C92(1.04); C120(0.98); C81(1.03)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C92(0.97); C120(0.96); C81(0.95)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C92(1.02); C81(1.10)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C92(1.07); C120(0.95); C81(0.99)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C92(1.10); C120(0.98); C81(1.01)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C92(1.04); C120(0.99)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C92(1.08); C120(0.94); C81(0.99)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C92(0.84); C120(1.01); C81(1.13)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C92(1.02); C120(0.95); C81(0.99)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C92(1.09); C120(0.98); C81(0.97)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C92(1.02); C81(1.03)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C92(0.98); C120(1.08)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C92(0.93); C120(0.96); C81(1.01)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C92(0.98); C120(0.98); C81(1.00)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C92(0.96); C120(1.07)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C92(1.02); C120(1.02); C81(1.05)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C92(0.89); C120(0.99); C81(1.00)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C92(1.00); C120(0.86); C81(0.98)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C92(1.01); C120(1.10); C81(1.04)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C92(1.07); C120(0.99); C81(1.00)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C92(0.99); C120(0.97); C81(0.96)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C92(0.92); C120(1.07); C81(1.05)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C92(1.17); C120(1.08)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C92(0.93); C120(1.14)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C92(0.87); C120(1.00); C81(1.05)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C92(1.18); C120(0.94)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C92(0.95); C120(0.94); C81(1.03)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C92(1.00); C120(0.77); C81(1.10)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C92(0.87); C120(1.04); C81(1.07)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C92(1.09); C120(0.94)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C92(0.94); C120(0.98); C81(1.09)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C92(1.03); C120(0.96); C81(1.00)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C92(0.99); C120(0.95); C81(1.02)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C92(0.91); C120(1.06)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C92(1.06); C120(1.27); C81(0.94)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C92(0.95); C120(0.94); C81(0.95)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C92(0.92); C120(0.93); C81(0.98)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C92(0.94); C120(0.97); C81(1.00)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C92(1.22); C120(1.00)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C92(0.93); C120(0.97); C81(0.95)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C92(1.11); C120(0.87); C81(0.97)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C92(0.89); C120(0.99); C81(1.07)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C92(1.23); C120(1.01)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C92(1.14); C120(1.01); C81(1.06)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C92(0.96); C120(0.92); C81(1.05)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C92(0.94); C120(1.12); C81(1.10)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C92(0.93); C120(1.02); C81(1.09)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C92(1.24); C120(1.03)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C92(1.17); C120(0.93); C81(1.03)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C92(0.80); C120(0.90); C81(1.09)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C92(0.94); C120(1.09); C81(1.12)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C92(1.01); C120(0.93)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C92(0.90); C120(0.96); C81(1.09)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C92(1.07); C120(0.94); C81(1.03)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C92(0.93); C120(1.01); C81(1.19)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C92(1.08); C120(1.03)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C92(1.26); C120(0.98); C81(1.10)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C92(0.86); C120(0.99); C81(1.02)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C92(0.87); C120(1.00); C81(1.07)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C92(0.99); C120(1.04); C81(0.94)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C92(1.00); C120(1.12); C81(0.94)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C92(1.01); C81(1.01)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C92(1.09); C120(0.97); C81(1.11)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C92(1.08); C120(1.14); C81(1.07)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C92(1.01); C120(1.23); C81(0.87)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C92(1.14); C120(1.13)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C92(1.11); C120(1.15); C81(1.05)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C92(0.87); C120(1.07); C81(1.14)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C92(1.05); C120(1.04)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C92(0.96); C120(0.96); C81(1.12)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C92(1.04); C120(0.99); C81(1.07)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C92(1.03); C120(0.98); C81(1.13)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C92(1.00); C120(0.97); C81(1.02)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C92(1.03); C120(1.13); C81(0.99)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C92(1.21); C120(1.05); C81(0.96)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C92(1.03); C81(1.00)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C92(1.09); C120(1.25); C81(1.04)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C92(0.88); C120(1.13); C81(0.92)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C92(1.11); C120(1.12)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C92(1.13); C120(1.16); C81(1.07)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C92(0.99); C120(1.04); C81(1.08)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C92(1.23); C120(0.97)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C92(0.98); C120(0.97); C81(1.11)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C92(1.05); C120(1.04); C81(1.10)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C92(1.02); C120(1.04); C81(1.08)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C92(0.95); C120(1.22); C81(0.97)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C92(1.07); C120(1.05); C81(0.96)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C92(1.03); C81(0.91)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C92(1.01); C120(1.08); C81(1.02)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C92(1.02); C120(1.27); C81(1.07)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C92(1.11); C120(1.06)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C92(1.01); C120(1.26); C81(1.05)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C92(1.08); C120(1.04); C81(1.15)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C92(1.25); C120(1.06)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C92(1.23); C120(0.97); C81(1.06)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C92(1.05); C120(1.02); C81(0.47)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C92(0.96); C120(1.09); C81(1.04)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C92(0.95); C120(1.03); C81(0.96)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C92(0.79); C120(1.23); C81(0.91)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C92(1.07); C81(0.87)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C92(1.13); C120(1.12); C81(1.11)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C92(0.89); C120(1.15); C81(0.97)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C92(1.04); C120(1.12)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C92(1.12); C120(1.17); C81(1.01)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C92(1.00); C120(0.99); C81(0.86)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C92(0.90); C120(1.07); C81(1.16)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C92(1.25); C120(0.99)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C92(1.35); C120(0.97); C81(1.09)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C92(0.91); C120(0.95); C81(1.06)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C92(0.87); C120(1.20); C81(0.94)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C92(1.12); C120(0.99); C81(1.04)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C92(1.05); C120(1.03); C81(0.92)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C92(0.97); C81(0.97)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C92(1.20); C120(1.16); C81(1.09)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C92(0.98); C120(1.13); C81(0.99)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C92(1.03); C81(1.02)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C92(1.16); C120(1.10)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C92(1.07); C120(1.20); C81(1.00)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C92(0.94); C120(1.14); C81(1.17)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C92(1.08); C120(1.04)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C92(0.91); C120(1.02); C81(0.85)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C92(0.96); C120(1.14); C81(1.04)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C92(0.91); C120(1.11); C81(0.94)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C92(1.06); C120(1.15); C81(0.93)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C92(1.05); C81(0.95)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C92(0.88); C120(1.05); C81(0.99)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C92(1.07); C120(1.13); C81(1.04)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C92(1.04); C120(1.05); C81(0.94)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C92(1.13); C120(1.10)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C92(1.00); C120(1.17); C81(1.00)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C92(0.87); C120(1.06); C81(1.00)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C92(1.28); C120(0.97)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C92(1.16); C120(0.93); C81(1.00)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C92(1.18); C120(0.94); C81(1.06)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C92(0.99); C120(1.00); C81(1.15)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C92(1.05); C120(0.88); C81(1.11)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C92(1.08); C120(1.16); C81(0.95)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C92(0.91); C120(1.30); C81(0.90)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C92(1.06); C81(1.01)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C92(1.13); C120(1.10); C81(1.03)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C92(1.01); C120(1.15); C81(1.00)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C92(1.06); C120(1.10)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C92(0.88); C120(1.10); C81(1.04)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C92(0.94); C120(1.10); C81(1.10)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C92(1.07); C120(0.95)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C92(1.05); C120(0.93); C81(0.92)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C92(1.04); C120(0.79); C81(1.07)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C92(0.99); C120(0.93); C81(1.09)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C92(1.09); C120(1.01); C81(0.98)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C92(0.97); C120(0.97); C81(1.13)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C120(1.03); C81(1.05); C92(0.96)  LDD1492  [6]
 LDCM0023  KB03 Jurkat C81(5.69)  LDD0209  [1]
 LDCM0024  KB05 MSTO-211H C92(1.87)  LDD3337  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7) Complex I NDUFB7 subunit family P17568
Protein regulator of cytokinesis 1 (PRC1) MAP65/ASE1 family O43663
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Serine/threonine-protein kinase ATR (ATR) PI3/PI4-kinase family Q13535
BTB/POZ domain-containing protein 2 (BTBD2) . Q9BX70
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 19 (ZNF19) Krueppel C2H2-type zinc-finger protein family P17023
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger and BTB domain-containing protein 42 (ZBTB42) Krueppel C2H2-type zinc-finger protein family B2RXF5
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Paired mesoderm homeobox protein 1 (PRRX1) Paired homeobox family P54821
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Golgin-45 (BLZF1) . Q9H2G9
Proto-oncogene c-Rel (REL) . Q04864
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin-like protein 2 (AMOTL2) Angiomotin family Q9Y2J4
ATR-interacting protein (ATRIP) ATRIP family Q8WXE1
Clusterin-associated protein 1 (CLUAP1) CLUAP1 family Q96AJ1
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Protein INCA1 (INCA1) INCA family Q0VD86
Major intrinsically disordered Notch2-binding receptor 1 (MINAR1) MINAR family Q9UPX6
Mitotic-spindle organizing protein 1 (MZT1) MOZART1 family Q08AG7
Small nuclear ribonucleoprotein Sm D2 (SNRPD2) SnRNP core protein family P62316
Synaptonemal complex central element protein 1 (SYCE1) SYCE family Q8N0S2
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Cilia- and flagella-associated protein 161 (CFAP161) . Q6P656
Cobalamin trafficking protein CblD (MMADHC) . Q9H3L0
Fibronectin type III domain-containing protein 11 (FNDC11) . Q9BVV2
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Melanoma-associated antigen 3 (MAGEA3) . P43357
Putative uncharacterized protein TXNRD3NB (TXNRD3NB) . Q6F5E7
SERTA domain-containing protein 1 (SERTAD1) . Q9UHV2

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840