Details of the Target

General Information of Target

Target ID LDTP11296
Target Name AP-4 complex accessory subunit RUSC1 (RUSC1)
Gene Name RUSC1
Gene ID 23623
Synonyms
NESCA; AP-4 complex accessory subunit RUSC1; New molecule containing SH3 at the carboxy-terminus; Nesca; RUN and SH3 domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALVFVYGTLKRGQPNHRVLRDGAHGSAAFRARGRTLEPYPLVIAGEHNIPWLLHLPGSG
RLVEGEVYAVDERMLRFLDDFESCPALYQRTVLRVQLLEDRAPGAEEPPAPTAVQCFVYS
RATFPPEWAQLPHHDSYDSEGPHGLRYNPRENR
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Signaling adapter which plays a role in neuronal differentiation. Involved in regulation of NGF-dependent neurite outgrowth. May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.
Uniprot ID
Q9BVN2
Ensemble ID
ENST00000292254.8
HGNC ID
HGNC:17153

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.Q735L .
HCT15 SNV: p.S705R .
HUH7 SNV: p.E92V .
IM95 Deletion: p.S355RfsTer66 .
MOLT4 SNV: p.S558N .
RL952 SNV: p.R339C .
SKHEP1 SNV: p.H14N .
SNGM Deletion: p.P391QfsTer30 .
SNU1196 SNV: p.R124W .
SW1271 SNV: p.Y122Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.69  LDD0402  [1]
DBIA
 Probe Info  		C532(0.65)  LDD1492  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
AOyne
 Probe Info  		12.40  LDD0443  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C532(1.06)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C532(0.92)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C532(0.95)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C532(1.02); C853(1.28)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C532(1.07); C853(1.01)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C532(1.12)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C532(1.07)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C532(0.88)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C532(0.78)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C532(0.91)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C532(1.01); C853(1.13)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C532(0.98)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C532(1.03); C853(1.04)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C532(1.11)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C532(1.05); C853(1.05)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C532(1.06)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C532(0.96)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C532(0.86)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C532(0.97); C853(1.09)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C532(1.08)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C532(0.90)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C532(1.03); C853(0.96)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C532(1.18)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C532(1.01); C853(1.13)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C532(1.20)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C532(0.96)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C532(0.84)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C532(1.07); C853(0.94)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C532(1.06)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C532(0.96); C853(1.23)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C532(1.23)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C532(1.02); C853(1.13)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C532(1.15); C853(1.19)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C532(1.10)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C532(0.87)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C532(0.82)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C532(0.92); C853(1.25)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C532(1.08)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C532(1.04); C853(0.92)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C532(1.15)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C532(1.01); C853(1.21)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C532(1.06)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C532(0.97)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C532(0.90)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C532(0.85)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C532(0.91); C853(1.09)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C532(1.05)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C532(0.96); C853(1.12)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C532(1.07)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C532(0.99); C853(1.11)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C532(1.04)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C532(0.86)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C532(0.86)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C532(1.01); C853(1.12)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C532(1.07); C853(1.09)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C532(0.97)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C532(0.89); C853(0.98)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C532(1.13)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C532(0.96); C853(1.25)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C532(1.17)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C532(1.08); C853(1.30)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C532(1.00)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C532(1.16)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C532(1.07); C853(1.18)  LDD1514  [2]
 LDCM0632  CL-Sc Hep-G2 C853(2.07)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C532(1.42)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C532(2.42); C853(1.08)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C532(1.20); C853(0.97)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C532(1.01)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C532(1.25); C853(1.04)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C532(1.01)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C532(1.13); C853(1.02)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C532(1.14)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C532(1.15); C853(1.25)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C532(0.91)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C532(1.15); C853(0.98)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C532(1.49)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C532(1.83)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C532(1.37); C853(1.20)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C532(1.30)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C532(1.21); C853(0.99)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C532(1.06)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C532(1.37); C853(1.14)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C532(1.11)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C532(1.16); C853(1.09)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C532(1.07)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C532(0.94); C853(1.13)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C532(0.97)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C532(1.42); C853(1.22)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C532(1.11); C853(1.13)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C532(1.19)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C532(0.95); C853(1.11)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C532(2.43)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C532(1.47); C853(1.04)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C532(0.86)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C532(1.05); C853(1.12)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C532(0.95)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C532(0.97); C853(1.01)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C532(1.04)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C532(0.95); C853(1.06)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C532(2.03)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C532(1.08); C853(1.11)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C532(2.25)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C532(0.91)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C532(0.98)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C532(0.91); C853(0.93)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C532(1.05); C853(0.85)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C532(2.28)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C532(1.36); C853(1.09)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C532(1.29)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C532(1.35); C853(1.24)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C532(1.64)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C532(0.96); C853(1.07)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C532(0.99)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C532(1.05); C853(1.05)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C532(1.02)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C532(1.23)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C532(0.93)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C532(1.22)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C532(0.92); C853(0.82)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C532(2.51)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C532(1.47); C853(0.99)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C532(1.14)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C532(1.42); C853(1.07)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C532(1.13)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C532(1.15)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C532(1.24); C853(1.05)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C532(0.92); C853(0.97)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C532(1.11)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C532(0.82)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C532(0.99)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C532(0.91); C853(0.88)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C532(1.51)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C532(1.34); C853(0.94)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C532(1.21)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C532(1.12); C853(1.15)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C532(0.93)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C532(1.00)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C532(1.02); C853(1.66)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C532(1.09); C853(1.11)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C532(1.86)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C532(1.84)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C532(1.09)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C532(0.91); C853(0.80)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C532(1.63)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C532(1.31); C853(1.01)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C532(1.21)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C532(1.49)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C532(1.37); C853(1.09)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C532(0.89)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C532(0.93); C853(1.06)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C532(0.92)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C532(1.72); C853(0.99)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C532(1.07)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C532(0.93)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C532(0.93)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C532(1.02); C853(0.86)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C532(1.17)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C532(1.01)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C532(1.14); C853(1.07)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C532(1.27)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C532(1.19); C853(1.22)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C532(1.22)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C532(0.95); C853(1.05)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C532(1.08); C853(1.14)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C532(1.88)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C532(0.89)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C532(0.92)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C532(3.74); C853(1.02)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C532(0.86); C853(0.90)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C532(0.98)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C532(1.09); C853(1.17)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C532(1.21)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C532(1.61); C853(1.15)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C532(0.90)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C532(0.90); C853(1.31)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C532(0.98)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C532(0.96); C853(1.11)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C532(0.93)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C532(1.26)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C532(1.91)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C532(0.89)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C532(1.22); C853(1.09)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C532(1.60)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C532(1.09); C853(1.16)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C532(2.58)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C532(1.89); C853(1.42)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C532(1.48)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C532(1.10); C853(1.15)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C532(0.98)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C532(1.02)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C532(1.03)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C532(0.89); C853(1.23)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C532(0.65)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C532(0.82)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C532(0.64)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Histone-lysine N-methyltransferase SMYD1 (SMYD1) Class V-like SAM-binding methyltransferase superfamily Q8NB12
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Uridine diphosphate glucose pyrophosphatase NUDT22 (NUDT22) Nudix hydrolase family Q9BRQ3
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) P4HA family Q7Z4N8
Inactive Ufm1-specific protease 1 (UFSP1) Peptidase C78 family Q6NVU6
Xaa-Arg dipeptidase (PM20D2) Peptidase M20A family Q8IYS1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) Peptidase S33 family Q8WTS1
Testis-specific serine/threonine-protein kinase 3 (TSSK3) CAMK Ser/Thr protein kinase family Q96PN8
Exosome complex component RRP43 (EXOSC8) RNase PH family Q96B26
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
Transcription initiation factor IIB (GTF2B) TFIIB family Q00403
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
V-type proton ATPase subunit d 2 (ATP6V0D2) V-ATPase V0D/AC39 subunit family Q8N8Y2
85/88 kDa calcium-independent phospholipase A2 (PLA2G6) . O60733
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
Zinc finger protein ZIC 1 (ZIC1) GLI C2H2-type zinc-finger protein family Q15915
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger protein 77 (ZNF77) Krueppel C2H2-type zinc-finger protein family Q15935
Chorion-specific transcription factor GCMb (GCM2) . O75603
High mobility group protein 20A (HMG20A) . Q9NP66
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 (SOHLH1) . Q5JUK2
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) Chemokine-like factor family Q9NX76
Other
Click To Hide/Show 43 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Beta-crystallin A2 (CRYBA2) Beta/gamma-crystallin family P53672
BPI fold-containing family A member 1 (BPIFA1) Plunc family Q9NP55
Cyclin-dependent kinase 4 inhibitor B (CDKN2B) CDKN2 cyclin-dependent kinase inhibitor family P42772
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Cyclin-C (CCNC) Cyclin family P24863
Docking protein 6 (DOK6) DOK family, Type B subfamily Q6PKX4
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Mediator of RNA polymerase II transcription subunit 25 (MED25) Mediator complex subunit 25 family Q71SY5
Protein Mis18-beta (OIP5) Mis18 family O43482
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
NEDD4-binding protein 3 (N4BP3) N4BP3 family O15049
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
Modulator of apoptosis 1 (MOAP1) PNMA family Q96BY2
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Trichoplein keratin filament-binding protein (TCHP) TCHP family Q9BT92
Tektin-4 (TEKT4) Tektin family Q8WW24
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) TTC19 family Q6DKK2
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
General transcription factor 3C polypeptide 3 (GTF3C3) . Q9Y5Q9
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
LIM and senescent cell antigen-like-containing domain protein 4 (LIMS4) . P0CW20
Melanoma-associated antigen 3 (MAGEA3) . P43357
Melanoma-associated antigen 6 (MAGEA6) . P43360
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
MORN repeat-containing protein 3 (MORN3) . Q6PF18
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Nicolin-1 (NICN1) . Q9BSH3
Proline-rich protein 35 (PRR35) . P0CG20
Protein inscuteable homolog (INSC) . Q1MX18
RNA-binding protein with multiple splicing (RBPMS) . Q93062
TBC1 domain family member 25 (TBC1D25) . Q3MII6
Tetratricopeptide repeat protein 7B (TTC7B) . Q86TV6
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264