Details of the Target

General Information of Target

Target ID LDTP11251
Target Name Dehydrogenase/reductase SDR family member 6 (BDH2)
Gene Name BDH2
Gene ID 56898
Synonyms
DHRS6; SDR15C1; Dehydrogenase/reductase SDR family member 6; EC 1.1.1.-; (R)-beta-hydroxybutyrate dehydrogenase; 3-hydroxybutyrate dehydrogenase type 2; EC 1.1.1.30; 4-oxo-L-proline reductase; EC 1.1.1.104; Oxidoreductase UCPA; Short chain dehydrogenase/reductase family 15C member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQL
EESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAPPGFFPRLGVIGFA
GLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDL
WKENFQKPGNVKNSPGTK
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family
Subcellular location
Cytoplasm
Function
NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates. Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines. Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis. May act as a 3-hydroxybutyrate dehydrogenase.
Uniprot ID
Q9BUT1
Ensemble ID
ENST00000296424.9
HGNC ID
HGNC:32389
ChEMBL ID
CHEMBL5169190

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH1666 SNV: p.Q53Ter .
NCIH661 Insertion: p.D5Ter .
RL SNV: p.Y110C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y49(6.34)  LDD0260  [1]
DBIA
 Probe Info  		C44(1.06)  LDD3313  [2]
HHS-475
 Probe Info  		Y49(5.71)  LDD0264  [3]
HHS-465
 Probe Info  		Y49(8.98)  LDD2237  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
TFBX
 Probe Info  		C176(0.00); C172(0.00); C145(0.00)  LDD0027  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C145(1.09); C176(0.92)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C145(0.84); C176(0.91)  LDD0813  [10]
 LDCM0226  AC11 HEK-293T C145(0.86); C176(0.92)  LDD0824  [10]
 LDCM0237  AC12 HEK-293T C145(0.96); C176(0.90)  LDD0835  [10]
 LDCM0259  AC14 HEK-293T C145(0.90); C176(0.86)  LDD0857  [10]
 LDCM0270  AC15 HEK-293T C145(0.78); C176(1.02)  LDD0868  [10]
 LDCM0276  AC17 HEK-293T C176(1.76)  LDD0874  [10]
 LDCM0277  AC18 HEK-293T C176(0.96)  LDD0875  [10]
 LDCM0278  AC19 HEK-293T C176(1.22)  LDD0876  [10]
 LDCM0279  AC2 HEK-293T C93(0.92); C176(1.09)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C176(1.34)  LDD0878  [10]
 LDCM0281  AC21 HEK-293T C176(1.06)  LDD0879  [10]
 LDCM0282  AC22 HEK-293T C176(1.00)  LDD0880  [10]
 LDCM0283  AC23 HEK-293T C176(1.09)  LDD0881  [10]
 LDCM0284  AC24 HEK-293T C176(1.07)  LDD0882  [10]
 LDCM0285  AC25 HEK-293T C145(1.00); C176(1.09)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C93(1.06); C176(1.13)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C176(1.11)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C145(1.15); C176(1.25)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C145(0.96); C172(2.60)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C176(1.08)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C145(1.04); C93(0.98); C176(1.16)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C93(1.00); C176(0.97)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C145(1.06); C176(1.10)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C145(1.09); C176(0.95)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C93(1.02); C176(0.97)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C176(1.15)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C145(1.15); C176(1.17)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C145(0.83); C172(1.08)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C145(0.96); C93(0.93); C176(0.96)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C93(1.00); C176(1.08)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C145(1.14); C176(1.12)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C145(0.96); C176(1.01)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C145(0.94); C176(1.26)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C93(1.03); C176(0.92)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C176(1.17)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C145(1.13); C176(1.04)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C145(0.97); C172(1.01)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C176(1.84)  LDD0906  [10]
 LDCM0309  AC47 HEK-293T C176(0.86)  LDD0907  [10]
 LDCM0310  AC48 HEK-293T C176(1.53)  LDD0908  [10]
 LDCM0311  AC49 HEK-293T C176(1.50)  LDD0909  [10]
 LDCM0312  AC5 HEK-293T C145(0.94); C172(1.16)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C176(1.28)  LDD0911  [10]
 LDCM0314  AC51 HEK-293T C176(1.88)  LDD0912  [10]
 LDCM0315  AC52 HEK-293T C176(2.35)  LDD0913  [10]
 LDCM0316  AC53 HEK-293T C176(1.25)  LDD0914  [10]
 LDCM0317  AC54 HEK-293T C176(1.87)  LDD0915  [10]
 LDCM0318  AC55 HEK-293T C176(2.18)  LDD0916  [10]
 LDCM0319  AC56 HEK-293T C176(1.62)  LDD0917  [10]
 LDCM0320  AC57 HEK-293T C145(1.00); C176(0.88)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C93(0.95); C176(1.00)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C176(1.07)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C145(0.95); C176(0.86)  LDD0921  [10]
 LDCM0324  AC60 HEK-293T C145(1.14); C176(0.97)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C145(0.96); C172(0.85)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C145(0.91); C93(0.84); C176(1.02)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C93(1.00); C176(0.93)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C145(0.98); C176(1.11)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C145(0.93); C176(1.15)  LDD0932  [10]
 LDCM0345  AC8 HEK-293T C145(0.84); C176(1.12)  LDD0943  [10]
 LDCM0248  AKOS034007472 HEK-293T C145(0.88); C176(0.82)  LDD0846  [10]
 LDCM0356  AKOS034007680 HEK-293T C145(1.01); C176(0.81)  LDD0954  [10]
 LDCM0275  AKOS034007705 HEK-293T C145(0.87); C176(0.93)  LDD0873  [10]
 LDCM0367  CL1 HEK-293T C145(1.01)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C145(1.02); C93(0.30); C176(0.90)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C176(1.03)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C145(0.83); C176(0.77)  LDD0968  [10]
 LDCM0371  CL102 HEK-293T C145(0.87); C176(0.95)  LDD0969  [10]
 LDCM0372  CL103 HEK-293T C145(1.04); C176(0.76)  LDD0970  [10]
 LDCM0373  CL104 HEK-293T C145(0.98); C176(1.00)  LDD0971  [10]
 LDCM0374  CL105 HEK-293T C176(0.87)  LDD0972  [10]
 LDCM0375  CL106 HEK-293T C176(0.84)  LDD0973  [10]
 LDCM0376  CL107 HEK-293T C176(1.23)  LDD0974  [10]
 LDCM0377  CL108 HEK-293T C176(0.95)  LDD0975  [10]
 LDCM0378  CL109 HEK-293T C176(0.97)  LDD0976  [10]
 LDCM0379  CL11 HEK-293T C93(1.24); C176(0.83)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C176(1.27)  LDD0978  [10]
 LDCM0381  CL111 HEK-293T C176(1.03)  LDD0979  [10]
 LDCM0382  CL112 HEK-293T C176(1.20)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C145(0.95)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C145(1.21); C93(0.99); C172(0.76)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C176(1.04)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C176(1.02)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C145(0.98)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C145(1.07); C93(0.90); C172(0.71)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C176(1.07)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C145(1.12); C176(0.93)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C176(1.19)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C176(2.20)  LDD0990  [10]
 LDCM0393  CL122 HEK-293T C176(1.73)  LDD0991  [10]
 LDCM0394  CL123 HEK-293T C176(1.23)  LDD0992  [10]
 LDCM0395  CL124 HEK-293T C176(1.37)  LDD0993  [10]
 LDCM0396  CL125 HEK-293T C145(1.02)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C145(1.00); C93(0.94); C172(1.13)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C176(1.01)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C176(1.01)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C145(0.87)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C145(0.95); C93(1.11); C172(0.98)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C176(0.93)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C145(1.39)  LDD1001  [10]
 LDCM0404  CL17 HEK-293T C145(0.82)  LDD1002  [10]
 LDCM0405  CL18 HEK-293T C145(0.78)  LDD1003  [10]
 LDCM0406  CL19 HEK-293T C145(0.98)  LDD1004  [10]
 LDCM0407  CL2 HEK-293T C145(0.95); C93(0.98); C172(0.98)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C145(0.89)  LDD1006  [10]
 LDCM0409  CL21 HEK-293T C145(0.94)  LDD1007  [10]
 LDCM0410  CL22 HEK-293T C145(0.81)  LDD1008  [10]
 LDCM0411  CL23 HEK-293T C145(0.95)  LDD1009  [10]
 LDCM0412  CL24 HEK-293T C145(1.20)  LDD1010  [10]
 LDCM0413  CL25 HEK-293T C145(1.02)  LDD1011  [10]
 LDCM0414  CL26 HEK-293T C145(0.81)  LDD1012  [10]
 LDCM0415  CL27 HEK-293T C145(1.23)  LDD1013  [10]
 LDCM0416  CL28 HEK-293T C145(0.98)  LDD1014  [10]
 LDCM0417  CL29 HEK-293T C145(0.92)  LDD1015  [10]
 LDCM0418  CL3 HEK-293T C176(1.01)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C145(1.08)  LDD1017  [10]
 LDCM0420  CL31 HEK-293T C145(1.30)  LDD1018  [10]
 LDCM0421  CL32 HEK-293T C145(1.19)  LDD1019  [10]
 LDCM0422  CL33 HEK-293T C145(0.83)  LDD1020  [10]
 LDCM0423  CL34 HEK-293T C145(1.24)  LDD1021  [10]
 LDCM0424  CL35 HEK-293T C145(0.95)  LDD1022  [10]
 LDCM0425  CL36 HEK-293T C145(0.99)  LDD1023  [10]
 LDCM0426  CL37 HEK-293T C145(0.98)  LDD1024  [10]
 LDCM0428  CL39 HEK-293T C145(0.84)  LDD1026  [10]
 LDCM0429  CL4 HEK-293T C176(0.98)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C145(0.82)  LDD1028  [10]
 LDCM0431  CL41 HEK-293T C145(0.72)  LDD1029  [10]
 LDCM0432  CL42 HEK-293T C145(0.85)  LDD1030  [10]
 LDCM0433  CL43 HEK-293T C145(0.76)  LDD1031  [10]
 LDCM0434  CL44 HEK-293T C145(1.08)  LDD1032  [10]
 LDCM0435  CL45 HEK-293T C145(1.09)  LDD1033  [10]
 LDCM0436  CL46 HEK-293T C145(0.68)  LDD1034  [10]
 LDCM0437  CL47 HEK-293T C145(0.80)  LDD1035  [10]
 LDCM0438  CL48 HEK-293T C145(1.07)  LDD1036  [10]
 LDCM0439  CL49 HEK-293T C145(1.08)  LDD1037  [10]
 LDCM0440  CL5 HEK-293T C145(0.99); C176(1.43)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C145(0.75)  LDD1039  [10]
 LDCM0442  CL51 HEK-293T C145(0.79)  LDD1040  [10]
 LDCM0443  CL52 HEK-293T C145(1.10)  LDD1041  [10]
 LDCM0444  CL53 HEK-293T C145(0.98)  LDD1042  [10]
 LDCM0445  CL54 HEK-293T C145(0.72)  LDD1043  [10]
 LDCM0446  CL55 HEK-293T C145(0.67)  LDD1044  [10]
 LDCM0447  CL56 HEK-293T C145(0.82)  LDD1045  [10]
 LDCM0448  CL57 HEK-293T C145(0.84)  LDD1046  [10]
 LDCM0449  CL58 HEK-293T C145(0.78)  LDD1047  [10]
 LDCM0450  CL59 HEK-293T C145(1.04)  LDD1048  [10]
 LDCM0451  CL6 HEK-293T C93(0.95); C176(0.94)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C145(1.07)  LDD1050  [10]
 LDCM0453  CL61 HEK-293T C176(0.88)  LDD1051  [10]
 LDCM0454  CL62 HEK-293T C176(0.76)  LDD1052  [10]
 LDCM0455  CL63 HEK-293T C176(0.71)  LDD1053  [10]
 LDCM0456  CL64 HEK-293T C176(0.88)  LDD1054  [10]
 LDCM0457  CL65 HEK-293T C176(0.82)  LDD1055  [10]
 LDCM0458  CL66 HEK-293T C176(0.95)  LDD1056  [10]
 LDCM0459  CL67 HEK-293T C176(0.85)  LDD1057  [10]
 LDCM0460  CL68 HEK-293T C176(0.83)  LDD1058  [10]
 LDCM0461  CL69 HEK-293T C176(0.86)  LDD1059  [10]
 LDCM0462  CL7 HEK-293T C176(1.01)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C176(0.85)  LDD1061  [10]
 LDCM0464  CL71 HEK-293T C176(1.16)  LDD1062  [10]
 LDCM0465  CL72 HEK-293T C176(1.17)  LDD1063  [10]
 LDCM0466  CL73 HEK-293T C176(0.73)  LDD1064  [10]
 LDCM0467  CL74 HEK-293T C176(0.85)  LDD1065  [10]
 LDCM0469  CL76 HEK-293T C176(1.13)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C145(1.06); C176(1.03)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C93(1.06); C176(1.21)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C176(1.14)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C145(1.24); C176(0.78)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C145(1.16); C176(1.09)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C145(0.98); C172(1.08)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C145(1.05); C93(1.00); C176(1.28)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C93(1.09); C176(0.92)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C145(1.11); C176(0.95)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C145(0.98)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C145(1.01); C93(1.09); C172(0.81)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C176(0.89)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C176(1.00)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C145(0.95); C176(1.15)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C145(1.10); C172(0.79)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C93(0.84); C176(1.00)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C176(1.23)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C145(0.96); C176(0.93)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C145(1.01); C172(0.81)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C145(1.17); C93(0.98); C176(0.90)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C93(0.96); C176(1.11)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C145(1.02); C176(1.00)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C145(1.00)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C145(0.99); C93(0.93); C172(0.80)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C176(0.97)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C176(1.13)  LDD1698  [9]
 LDCM0625  F8 Ramos C145(0.54)  LDD2187  [11]
 LDCM0573  Fragment11 Ramos C145(0.46)  LDD2190  [11]
 LDCM0576  Fragment14 Ramos C145(1.11)  LDD2193  [11]
 LDCM0468  Fragment33 HEK-293T C176(0.51)  LDD1066  [10]
 LDCM0566  Fragment4 Ramos C145(0.45)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C145(1.35)  LDD1025  [10]
 LDCM0569  Fragment7 Ramos C145(0.48)  LDD2186  [11]
 LDCM0116  HHS-0101 DM93 Y49(5.71)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y49(3.99)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y49(3.96)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y49(2.11)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y49(1.98)  LDD0268  [3]
 LDCM0022  KB02 HEK-293T C145(0.95); C93(1.01); C176(1.13)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C145(1.02); C93(1.00); C176(0.91)  LDD1497  [9]
 LDCM0024  KB05 Hs 936.T C44(1.06)  LDD3313  [2]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578