Details of the Target

General Information of Target

Target ID LDTP10918
Target Name Krueppel-like factor 6 (KLF6)
Gene Name KLF6
Gene ID 1316
Synonyms
BCD1; COPEB; CPBP; ST12; Krueppel-like factor 6; B-cell-derived protein 1; Core promoter element-binding protein; GC-rich sites-binding factor GBF; Proto-oncogene BCD1; Suppressor of tumorigenicity 12 protein; Transcription factor Zf9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEASATGACGEAMAAAEGSSGPAGLTLGRSFSNYRPFEPQALGLSPSWRLTGFSGMKGU
GCKVPQEALLKLLAGLTRPDVRPPLGRGLVGGQEEASQEAGLPAGAGPSPTFPALGIGMD
SCVIPLRHGGLSLVQTTDFFYPLVEDPYMMGRIACANVLSDLYAMGITECDNMLMLLSVS
QSMSEEEREKVTPLMVKGFRDAAEEGGTAVTGGQTVVNPWIIIGGVATVVCQPNEFIMPD
SAVVGDVLVLTKPLGTQVAVNAHQWLDNPERWNKVKMVVSREEVELAYQEAMFNMATLNR
TAAGLMHTFNAHAATDITGFGILGHSQNLAKQQRNEVSFVIHNLPIIAKMAAVSKASGRF
GLLQGTSAETSGGLLICLPREQAARFCSEIKSSKYGEGHQAWIVGIVEKGNRTARIIDKP
RVIEVLPRGATAAVLAPDSSNASSEPSS
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development.
Uniprot ID
Q99612
Ensemble ID
ENST00000469435.1
HGNC ID
HGNC:2235

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL62 Deletion: p.W239Ter .
HDMYZ Substitution: p.R197W .
MCAS SNV: p.E246K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K73(5.36)  LDD0277  [1]
DBIA
 Probe Info  		C48(1.04)  LDD0533  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C48(1.04)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C48(1.28)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C48(1.11)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C48(1.26)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C48(1.04)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C48(1.09)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C48(1.07)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C48(1.03)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C48(1.15)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C48(1.07)  LDD0542  [2]
 LDCM0227  AC110 HCT 116 C48(1.12)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C48(1.23)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C48(1.31)  LDD0546  [2]
 LDCM0296  AC35 HCT 116 C48(0.89)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C48(1.06)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C48(0.95)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C48(1.45)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C48(1.24)  LDD0617  [2]
 LDCM0302  AC40 HCT 116 C48(1.21)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C48(0.95)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C48(1.00)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C48(1.24)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C48(0.81)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C48(0.77)  LDD0624  [2]
 LDCM0365  AC98 HCT 116 C48(1.21)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C48(1.06)  LDD0683  [2]
 LDCM0387  CL117 HCT 116 C48(1.24)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C48(1.03)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C48(0.98)  LDD0706  [2]
 LDCM0391  CL120 HCT 116 C48(1.03)  LDD0708  [2]
 LDCM0404  CL17 HCT 116 C48(1.05)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C48(1.00)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C48(1.13)  LDD0723  [2]
 LDCM0408  CL20 HCT 116 C48(1.54)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C48(0.86)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C48(0.79)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C48(1.15)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C48(1.01)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C48(0.90)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C48(1.11)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C48(1.01)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C48(0.88)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C48(1.21)  LDD0734  [2]
 LDCM0419  CL30 HCT 116 C48(1.30)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C48(0.99)  LDD0737  [2]
 LDCM0436  CL46 HCT 116 C48(0.89)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C48(0.83)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C48(1.11)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C48(1.04)  LDD0756  [2]
 LDCM0441  CL50 HCT 116 C48(0.73)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C48(0.75)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C48(1.30)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C48(0.93)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C48(0.79)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C48(1.09)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C48(0.79)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C48(0.55)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C48(0.87)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C48(0.92)  LDD0767  [2]
 LDCM0452  CL60 HCT 116 C48(0.84)  LDD0769  [2]
 LDCM0469  CL76 HCT 116 C48(1.06)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C48(0.60)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C48(0.88)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C48(0.84)  LDD0789  [2]
 LDCM0474  CL80 HCT 116 C48(0.99)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C48(0.93)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C48(0.87)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C48(0.86)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C48(0.84)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C48(0.81)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C48(0.90)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C48(0.82)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C48(0.94)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C48(0.79)  LDD0800  [2]
 LDCM0485  CL90 HCT 116 C48(0.53)  LDD0802  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.