Details of the Target

General Information of Target

Target ID LDTP10765
Target Name Protein capicua homolog (CIC)
Gene Name CIC
Gene ID 23152
Synonyms
KIAA0306; Protein capicua homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAYPESCVDTTVLDFVADLSLASPRRPLLCDFAPGVSLGDPALALREGRPRRMARFEEG
DPEEEECEVDQGDGEEEEEEERGRGVSLLGRPKRKRVITYAQRQAANIRERKRMFNLNEA
FDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLESCEKKESG
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.
Uniprot ID
Q96RK0
Ensemble ID
ENST00000575354.6
HGNC ID
HGNC:14214

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C336(21.13); C1506(4.57)  LDD0209  [2]
HHS-475
 Probe Info  		Y239(0.76)  LDD0264  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
WYneO
 Probe Info  		N.A.  LDD0022  [5]
IPM
 Probe Info  		N.A.  LDD0005  [5]
Phosphinate-6
 Probe Info  		C1420(0.00); C1506(0.00); C270(0.00)  LDD0018  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C1432(0.88)  LDD0532  [7]
 LDCM0226  AC11 HCT 116 C1432(0.67)  LDD0543  [7]
 LDCM0237  AC12 HCT 116 C1432(0.76)  LDD0554  [7]
 LDCM0246  AC128 HCT 116 C1432(0.49)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C1432(0.56)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C1432(0.48)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C1432(0.57)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C1432(0.68)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C1432(0.60)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C1432(0.58)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C1432(0.56)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C1432(0.68)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C1432(0.59)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C1432(0.51)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C1432(0.61)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C1432(0.47)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C1432(0.60)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C1432(0.83)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C1432(0.59)  LDD0579  [7]
 LDCM0270  AC15 HCT 116 C1432(0.64)  LDD0587  [7]
 LDCM0323  AC6 HCT 116 C1432(0.98)  LDD0640  [7]
 LDCM0334  AC7 HCT 116 C1432(0.85)  LDD0651  [7]
 LDCM0345  AC8 HCT 116 C1432(0.70)  LDD0662  [7]
 LDCM0248  AKOS034007472 HCT 116 C1432(0.59)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C1432(0.76)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C1432(0.64)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 14.04  LDD0403  [1]
 LDCM0370  CL101 HCT 116 C1432(0.47)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C1432(0.48)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C1432(0.43)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C1432(0.36)  LDD0690  [7]
 LDCM0436  CL46 HCT 116 C1432(1.06)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C1432(1.35)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C1432(1.08)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C1432(0.84)  LDD0756  [7]
 LDCM0441  CL50 HCT 116 C1432(0.99)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C1432(1.27)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C1432(1.09)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C1432(1.47)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C1432(0.95)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C1432(1.00)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C1432(0.88)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C1432(1.05)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C1432(1.12)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C1432(0.87)  LDD0767  [7]
 LDCM0452  CL60 HCT 116 C1432(1.00)  LDD0769  [7]
 LDCM0469  CL76 HCT 116 C1432(0.77)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C1432(1.04)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C1432(1.02)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C1432(0.86)  LDD0789  [7]
 LDCM0474  CL80 HCT 116 C1432(0.69)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C1432(0.86)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C1432(0.72)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C1432(1.22)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C1432(0.99)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C1432(0.92)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C1432(1.11)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C1432(0.87)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C1432(0.93)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C1432(0.74)  LDD0800  [7]
 LDCM0485  CL90 HCT 116 C1432(0.85)  LDD0802  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C336(1.88)  LDD1702  [8]
 LDCM0116  HHS-0101 DM93 Y239(0.76)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y239(0.77)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y239(0.24)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y239(0.58)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y239(0.77)  LDD0268  [3]
 LDCM0022  KB02 22RV1 C336(2.11)  LDD2243  [9]
 LDCM0023  KB03 Jurkat C336(21.13); C1506(4.57)  LDD0209  [2]
 LDCM0024  KB05 G361 C336(1.80)  LDD3311  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Centromere protein J (CENPJ) TCP10 family Q9HC77

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840