Details of the Target

General Information of Target

Target ID LDTP10576
Target Name Kelch-like protein 15 (KLHL15)
Gene Name KLHL15
Gene ID 80311
Synonyms
KIAA1677; Kelch-like protein 15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERD
RLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKK
ETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEER
KAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITS
IKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ
QEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEF
DRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQK
HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAAN
KMCLDKVQEVLSTHQVLPQNIHPMRKACPSKLPP
Target Bioclass
Other
Subcellular location
Nucleus
Function
Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).
Uniprot ID
Q96M94
Ensemble ID
ENST00000328046.8
HGNC ID
HGNC:29347

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C444(1.59)  LDD3331  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C444(1.24)  LDD1507  [3]
 LDCM0215  AC10 PaTu 8988t C467(1.00)  LDD1094  [4]
 LDCM0226  AC11 PaTu 8988t C467(0.86)  LDD1105  [4]
 LDCM0230  AC113 HEK-293T C467(1.08)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C467(0.61)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C467(0.76)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C467(1.02)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C467(1.03)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C467(1.08)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C467(0.74)  LDD0834  [4]
 LDCM0237  AC12 PaTu 8988t C467(0.65)  LDD1116  [4]
 LDCM0238  AC120 HEK-293T C467(0.80)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C467(0.58)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C467(0.99)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C467(0.66)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C467(0.66)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C467(0.68)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C467(1.18)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C467(1.58)  LDD0843  [4]
 LDCM0259  AC14 PaTu 8988t C467(0.89)  LDD1138  [4]
 LDCM0270  AC15 PaTu 8988t C467(1.02)  LDD1149  [4]
 LDCM0276  AC17 HEK-293T C467(0.62)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C467(0.66)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C467(0.72)  LDD0876  [4]
 LDCM0280  AC20 HEK-293T C467(0.67)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C467(0.69)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C467(0.80)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C467(0.58)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C467(0.67)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C444(0.89)  LDD1524  [3]
 LDCM0287  AC27 HEK-293T C444(0.91)  LDD1526  [3]
 LDCM0289  AC29 HEK-293T C444(1.12)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C444(1.16)  LDD1529  [3]
 LDCM0293  AC32 HEK-293T C588(1.18)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C444(0.87)  LDD1533  [3]
 LDCM0296  AC35 HEK-293T C444(0.91)  LDD1535  [3]
 LDCM0298  AC37 HEK-293T C444(1.01)  LDD1537  [3]
 LDCM0302  AC40 HEK-293T C588(1.36)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C444(0.90)  LDD1542  [3]
 LDCM0305  AC43 HEK-293T C444(0.99)  LDD1544  [3]
 LDCM0307  AC45 HEK-293T C444(1.00)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C467(0.82)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C467(0.66)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C467(0.77)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C467(0.72)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C444(0.89)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C467(0.68)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C467(0.68)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C467(0.71)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C467(0.63)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C467(0.71)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C467(0.67)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C467(0.73)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C467(0.89)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C467(1.19)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C467(0.93)  LDD0920  [4]
 LDCM0323  AC6 PaTu 8988t C467(0.96)  LDD1202  [4]
 LDCM0324  AC60 HEK-293T C467(1.07)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C467(1.12)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C467(1.22)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C467(1.09)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C467(1.24)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C467(1.18)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C467(1.23)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C467(1.08)  LDD0929  [4]
 LDCM0334  AC7 PaTu 8988t C467(0.86)  LDD1213  [4]
 LDCM0345  AC8 PaTu 8988t C467(0.93)  LDD1224  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C467(0.88)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C467(1.09)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C467(0.91)  LDD1154  [4]
 LDCM0367  CL1 HEK-293T C444(0.92)  LDD1571  [3]
 LDCM0369  CL100 HEK-293T C444(1.00)  LDD1573  [3]
 LDCM0370  CL101 PaTu 8988t C467(1.02)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C467(0.79)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C467(1.06)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C467(0.90)  LDD1252  [4]
 LDCM0374  CL105 HEK-293T C467(0.96)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C467(0.74)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C467(0.69)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C467(0.75)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C467(0.89)  LDD0976  [4]
 LDCM0380  CL110 HEK-293T C467(0.72)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C467(0.87)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C444(1.05)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C444(1.05)  LDD1587  [3]
 LDCM0386  CL116 HEK-293T C444(1.16)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C444(0.91)  LDD1591  [3]
 LDCM0390  CL12 HEK-293T C588(1.01)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C444(1.10)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C467(0.68)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C467(0.76)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C467(0.87)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C467(0.76)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C467(0.93)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C467(0.75)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C467(1.17)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C467(0.99)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C444(0.99)  LDD1604  [3]
 LDCM0403  CL16 HEK-293T C467(1.39)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C467(1.35)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C467(1.08)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C467(1.39)  LDD1004  [4]
 LDCM0408  CL20 HEK-293T C467(0.92)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C467(1.12)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C467(1.03)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C467(1.22)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C467(1.14)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C467(1.21)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C467(1.10)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C467(1.38)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C467(1.32)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C467(1.28)  LDD1015  [4]
 LDCM0419  CL30 HEK-293T C467(1.25)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C467(1.31)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C467(0.86)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C467(0.97)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C467(1.00)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C467(0.87)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C467(0.93)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C467(0.75)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C467(1.08)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C444(1.07)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C467(0.64)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C467(0.67)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C467(0.96)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C467(0.84)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C467(0.88)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C467(0.85)  LDD1033  [4]
 LDCM0436  CL46 PaTu 8988t C467(0.99)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C467(1.10)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C467(1.02)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C467(1.04)  LDD1318  [4]
 LDCM0440  CL5 HEK-293T C444(1.29)  LDD1644  [3]
 LDCM0441  CL50 PaTu 8988t C467(0.96)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C467(0.91)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C467(1.01)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C467(1.20)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C467(1.14)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C467(1.10)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C467(1.19)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C467(0.88)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C467(1.04)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C467(1.03)  LDD1329  [4]
 LDCM0452  CL60 PaTu 8988t C467(1.04)  LDD1331  [4]
 LDCM0453  CL61 PaTu 8988t C467(1.09)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C467(1.06)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C467(1.05)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C467(0.98)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C467(1.05)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C467(0.88)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C467(1.00)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C467(1.19)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C467(1.00)  LDD1340  [4]
 LDCM0462  CL7 HEK-293T C444(1.06)  LDD1665  [3]
 LDCM0463  CL70 PaTu 8988t C467(1.11)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C467(0.94)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C467(1.01)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C467(1.12)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C467(1.13)  LDD1346  [4]
 LDCM0469  CL76 HEK-293T C444(1.04)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C444(0.85)  LDD1673  [3]
 LDCM0472  CL79 HEK-293T C444(1.02)  LDD1675  [3]
 LDCM0475  CL81 HEK-293T C444(1.07)  LDD1678  [3]
 LDCM0478  CL84 HEK-293T C588(1.19)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C444(1.08)  LDD1682  [3]
 LDCM0482  CL88 HEK-293T C444(0.92)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C444(0.80)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C444(1.20)  LDD1687  [3]
 LDCM0486  CL91 HEK-293T C444(0.96)  LDD1689  [3]
 LDCM0488  CL93 HEK-293T C444(1.24)  LDD1691  [3]
 LDCM0491  CL96 HEK-293T C588(0.66)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C444(1.00)  LDD1695  [3]
 LDCM0468  Fragment33 PaTu 8988t C467(0.97)  LDD1347  [4]
 LDCM0427  Fragment51 HEK-293T C467(0.84)  LDD1025  [4]
 LDCM0022  KB02 786-O C444(1.72)  LDD2247  [1]
 LDCM0023  KB03 786-O C444(2.04)  LDD2664  [1]
 LDCM0024  KB05 MKN-1 C444(1.59)  LDD3331  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase DCLK1 (DCLK1) CAMK Ser/Thr protein kinase family O15075
Serine/threonine-protein kinase DCLK2 (DCLK2) CAMK Ser/Thr protein kinase family Q8N568

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.