Details of the Target

General Information of Target

Target ID LDTP10445
Target Name Kin of IRRE-like protein 1 (KIRREL1)
Gene Name KIRREL1
Gene ID 55243
Synonyms
KIRREL; NEPH1; Kin of IRRE-like protein 1; Kin of irregular chiasm-like protein 1; Nephrin-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP
WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL
SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG
PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS
FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG
YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP
FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM
LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT
LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML
GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK
ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP
LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM
QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE
EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS
RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF
NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP
YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED
FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA
VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE
IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL
IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI
SKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTI
REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS
LR
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily
Subcellular location
Cell membrane
Function
Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Uniprot ID
Q96J84
Ensemble ID
ENST00000359209.11
HGNC ID
HGNC:15734

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL72 Substitution: p.R632C .
DU145 Deletion: p.L337SfsTer14 .
ECC2 Substitution: p.S645I .
HCT116 Deletion: p.P120QfsTer11
SNV: p.R256M		 .
HCT15 SNV: p.V443M .
JHH4 SNV: p.M1? DBIA    Probe Info 
JURKAT SNV: p.A631T .
KMS12BM SNV: p.A627T .
MCC13 SNV: p.G81E .
REH SNV: p.L536M .
RKO SNV: p.P222T .
RL952 SNV: p.A623T .
SNGM SNV: p.Y521H .
TOV21G Deletion: p.L337SfsTer14 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K67(0.92); K113(2.15); K410(2.51)  LDD3494  [1]
DBIA
 Probe Info  		C387(3.44)  LDD3310  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C310
 Probe Info  		11.55  LDD1977  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C42(1.09)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C42(0.93)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C42(1.00)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C42(0.91)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C42(1.03)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C42(1.12)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C42(1.13)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C42(1.06)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C42(0.97)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C42(1.00)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C42(0.99)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C42(1.04)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C42(1.10)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C42(1.05)  LDD1522  [6]
 LDCM0285  AC25 HEK-293T C42(1.81)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C42(1.05)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C42(0.90)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C42(0.92)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C42(0.77)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C42(1.09)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C42(0.95)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C42(0.78)  LDD1531  [6]
 LDCM0294  AC33 HEK-293T C42(0.94)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C42(1.14)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C42(1.14)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C42(1.07)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C42(0.98)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C42(0.96)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C42(1.10)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C42(1.22)  LDD1540  [6]
 LDCM0303  AC41 HEK-293T C42(0.98)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C42(0.92)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C42(1.04)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C42(0.92)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C42(1.09)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C42(1.17)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C42(0.87)  LDD1548  [6]
 LDCM0311  AC49 HEK-293T C42(0.89)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C42(1.25)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C42(0.97)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C42(0.96)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C42(1.00)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C42(1.28)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C42(0.98)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C42(0.90)  LDD1557  [6]
 LDCM0320  AC57 HEK-293T C42(1.13)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C42(1.09)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C42(1.13)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C42(1.01)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C42(0.96)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C42(1.30)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C42(1.06)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C42(1.29)  LDD1566  [6]
 LDCM0334  AC7 HEK-293T C42(0.95)  LDD1568  [6]
 LDCM0248  AKOS034007472 HEK-293T C42(1.17)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C42(0.79)  LDD1570  [6]
 LDCM0367  CL1 HEK-293T C42(1.32)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C42(1.28)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C42(0.88)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C42(1.01)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C42(1.02); C413(0.96)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C42(0.89)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C42(1.13)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C42(1.22)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C42(0.85); C413(0.93)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C42(1.06)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C42(0.89)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C42(1.27)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C42(1.14)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C42(1.21); C413(0.91)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C42(0.95)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C42(0.84)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C42(0.92)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C42(1.00); C413(0.84)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C42(0.97)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C42(1.10)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C42(1.15)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C42(1.07); C413(0.89)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C42(0.99)  LDD1593  [6]
 LDCM0391  CL120 HEK-293T C42(1.38)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C42(1.10)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C42(0.99); C413(0.97)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C42(1.14)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C42(1.67)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C42(1.00)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C42(1.01); C413(1.00)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C42(1.20)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C42(1.28)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C42(1.37)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C42(0.96); C413(0.88)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C42(1.88)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C42(1.21)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C42(1.06)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C42(1.07)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C42(1.01)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C42(0.99); C413(0.95)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C42(0.84)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C42(1.53)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C42(1.05)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C42(0.82)  LDD1615  [6]
 LDCM0413  CL25 HEK-293T C42(1.16)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C42(1.06); C413(0.86)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C42(1.18)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C42(1.16)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C42(1.03)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C42(1.03)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C42(0.77)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C42(0.98)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C42(0.84)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C42(1.05)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C42(0.88)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C42(0.96)  LDD1628  [6]
 LDCM0426  CL37 HEK-293T C42(0.98)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C42(1.12)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C42(1.45)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C42(0.79)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C42(1.23)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C42(1.03)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C42(1.01)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C42(1.13)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C42(0.63)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C42(0.93)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C42(1.17)  LDD1641  [6]
 LDCM0439  CL49 HEK-293T C42(0.84)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C42(1.43)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C42(0.99); C413(0.83)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C42(0.81)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C42(1.71)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C42(0.93)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C42(1.01)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C42(0.99)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C42(1.09)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C42(0.99)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C42(0.93)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C42(1.13)  LDD1654  [6]
 LDCM0453  CL61 HEK-293T C42(1.18)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C42(0.96); C413(0.87)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C42(0.94)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C42(1.05)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C42(1.28)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C42(0.97)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C42(1.04)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C42(0.89)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C42(1.04)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C42(0.93)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C42(0.99)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C42(1.01)  LDD1667  [6]
 LDCM0466  CL73 HEK-293T C42(1.32)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C42(1.02); C413(0.86)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C42(1.00)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C42(1.20)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C42(0.92)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C42(1.02)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C42(1.46)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C42(0.92)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C42(0.79)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C42(0.97)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C42(1.14)  LDD1680  [6]
 LDCM0479  CL85 HEK-293T C42(1.25)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C42(0.91); C413(0.88)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C42(1.07)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C42(1.10)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C42(1.47)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C42(1.02)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C42(1.16)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C42(1.03)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C42(1.07)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C42(1.17)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C42(0.95)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C42(0.95)  LDD1693  [6]
 LDCM0492  CL97 HEK-293T C42(1.34)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C42(1.08); C413(0.84)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C42(1.27)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C42(1.02)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C42(1.12)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C42(1.00); C413(0.89)  LDD1631  [6]
 LDCM0022  KB02 786-O C603(1.92)  LDD2247  [2]
 LDCM0023  KB03 786-O C603(2.90)  LDD2664  [2]
 LDCM0024  KB05 COLO792 C387(3.44)  LDD3310  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tight junction protein ZO-1 (TJP1) MAGUK family Q07157

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402