Details of the Target

General Information of Target

Target ID LDTP10363
Target Name Macrophage immunometabolism regulator (MACIR)
Gene Name MACIR
Gene ID 90355
Synonyms
C5orf30; Macrophage immunometabolism regulator
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNGLSLSELCCLFCCPPCPGRIAAKLAFLPPEATYSLVPEPEPGPGGAGAAPLGTLRASS
GAPGRWKLHLTERADFQYSQRELDTIEVFPTKSARGNRVSCMYVRCVPGARYTVLFSHGN
AVDLGQMSSFYIGLGSRLHCNIFSYDYSGYGASSGRPSERNLYADIDAAWQALRTRYGIS
PDSIILYGQSIGTVPTVDLASRYECAAVVLHSPLTSGMRVAFPDTKKTYCFDAFPNIEKV
SKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHNDIELYSQYLERLRRF
ISQELPSQRA
Target Bioclass
Other
Family
UNC119-binding protein family
Subcellular location
Cytoplasm
Function
Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages. The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis. May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B. May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells.
Uniprot ID
Q96GV9
Ensemble ID
ENST00000319933.7
HGNC ID
HGNC:25052

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C156(6.09)  LDD1704  [1]
DBIA
 Probe Info  		C36(1.05); C41(1.05)  LDD0078  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		N.A.  LDD0147  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C77(1.15)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C156(1.00); C77(1.20)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C156(0.98)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C156(1.00); C77(1.07)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C156(0.83); C36(1.11)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C156(0.92); C36(0.97)  LDD1513  [7]
 LDCM0276  AC17 HCT 116 C77(0.97)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C77(1.07)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C77(0.81)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C77(1.34)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C77(0.72)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C77(0.72)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C77(0.83)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C77(0.73)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C77(0.69)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C156(1.08); C77(1.19)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C156(0.97); C77(1.04)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C156(0.91)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C156(0.93); C77(1.05)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C156(0.89); C77(0.96)  LDD1528  [7]
 LDCM0290  AC3 HCT 116 C77(1.37)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C156(0.89); C36(1.25)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C156(0.88); C36(0.98)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C156(0.94); C77(1.01)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C156(1.03); C77(1.30)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C156(1.07); C77(1.11)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C156(1.07)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C156(0.91); C77(1.06)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C156(0.93); C77(1.04)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C156(0.83); C36(1.02)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C156(0.93); C36(1.06)  LDD1539  [7]
 LDCM0301  AC4 HCT 116 C77(1.43)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C156(0.95); C77(0.96)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C156(1.12); C77(1.08)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C156(1.09); C77(1.23)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C156(0.96)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C156(0.95); C77(1.05)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C156(0.99); C77(0.99)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C156(0.95); C36(0.98)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C156(0.96); C36(1.14)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C156(1.09); C77(0.97)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C156(1.01); C77(1.19)  LDD1550  [7]
 LDCM0312  AC5 HCT 116 C77(1.11)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C156(1.08); C77(1.09)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C156(0.98)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C156(1.10); C77(1.06)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C156(0.92); C77(1.07)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C156(0.94); C36(0.99)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C156(0.90); C36(1.03)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C156(0.98); C77(0.96)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C156(1.05); C77(1.09)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C156(1.05); C77(1.13)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C156(0.97)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C156(0.98); C36(1.20)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C156(1.07); C77(1.06)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C156(1.02); C77(1.04)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C156(1.01); C36(1.13)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C156(0.84); C36(0.94)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C156(1.04); C77(1.07)  LDD1567  [7]
 LDCM0332  AC68 HCT 116 C77(0.99)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C77(0.80)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C156(0.88); C36(0.92)  LDD1568  [7]
 LDCM0335  AC70 HCT 116 C77(1.27)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C77(0.91)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C77(1.28)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C77(0.96)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C77(0.86)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C77(0.79)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C77(0.63)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C77(0.63)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C77(0.55)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C77(0.76)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C156(1.00); C77(0.97)  LDD1569  [7]
 LDCM0346  AC80 HCT 116 C77(0.48)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C77(0.68)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C77(0.72)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C77(0.99)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C77(0.59)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C77(0.62)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C77(0.83)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C77(0.71)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C77(1.02)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C77(0.67)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C77(0.79)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C77(0.83)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C77(0.76)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C77(0.67)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C77(0.51)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C77(0.94)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C77(1.11)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C77(1.10)  LDD0681  [2]
 LDCM0248  AKOS034007472 HEK-293T C156(0.95); C77(1.04)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C156(1.10); C77(1.11)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C156(1.10); C77(1.06)  LDD1514  [7]
 LDCM0020  ARS-1620 HCC44 C36(1.05); C41(1.05)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C77(1.15); C77(1.12)  LDD2227  [3]
 LDCM0367  CL1 HEK-293T C156(0.99); C77(0.85)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C156(0.94); C36(1.18)  LDD1572  [7]
 LDCM0369  CL100 HCT 116 C77(1.13)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C156(1.12); C77(0.97)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C156(1.03); C77(1.36)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C156(0.96); C77(1.20)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C77(0.93)  LDD1577  [7]
 LDCM0374  CL105 HCT 116 C77(0.80)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C77(0.90)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C77(0.93)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C77(0.93)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C77(1.34)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C156(0.71); C36(1.16)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C77(0.92)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C77(0.75)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C77(1.05)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C156(1.05); C77(0.96)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C156(1.13); C77(1.29)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C156(0.96); C77(0.97)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C77(1.10)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C156(1.00); C77(1.11)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C156(1.07); C77(1.25)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C156(1.06); C77(1.28)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C156(0.85); C77(0.85)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C77(1.01)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C156(1.07); C77(1.09)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C156(0.95); C77(1.31)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C156(1.04); C77(1.79)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C77(1.15)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C156(1.16); C77(0.95)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C156(1.30); C77(1.24)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C156(1.11); C77(0.71)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C77(0.96)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C156(1.05); C77(1.04)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C156(0.91); C77(1.24)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C156(1.02); C77(0.69)  LDD1606  [7]
 LDCM0403  CL16 HCT 116 C77(1.34)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C77(1.09)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C77(1.15)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C77(1.36)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C156(0.90); C77(1.47)  LDD1611  [7]
 LDCM0408  CL20 HCT 116 C77(1.23)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C77(1.54)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C77(1.43)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C77(1.32)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C77(1.39)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C77(1.70)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C77(0.96)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C77(1.27)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C77(1.57)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C77(1.62)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C156(0.88); C77(0.90)  LDD1622  [7]
 LDCM0419  CL30 HCT 116 C77(1.20)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C156(0.92)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C156(0.74); C77(1.08)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C156(0.84); C77(1.06)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C156(0.78); C36(1.33)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C156(0.76); C36(1.07)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C156(0.88); C77(1.04)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C156(1.10); C77(0.95)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C156(0.92); C77(1.20)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C77(0.96)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C77(0.94)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C156(1.12); C77(0.96)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C156(0.93); C77(1.09)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C156(0.82)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C156(0.81); C77(1.12)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C156(0.82); C77(1.13)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C156(0.72); C36(1.24)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C156(0.71); C36(1.20)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C156(0.86); C77(1.07)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C156(1.09); C77(0.97)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C156(1.13); C77(1.14)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C156(1.18); C77(1.56)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C77(1.05)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C156(1.02); C77(1.17)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C156(1.04); C77(1.22)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C156(0.89)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C156(0.78); C77(1.07)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C156(0.93); C77(1.18)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C156(0.78); C36(1.52)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C156(0.77); C36(1.34)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C156(0.85); C77(0.90)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C156(0.89); C77(0.98)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C156(1.02); C77(1.05)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C156(1.18); C77(1.09)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C156(1.05); C77(0.83)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C77(0.98)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C156(1.08); C77(1.27)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C156(0.73); C77(1.15)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C156(0.90)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C156(0.82); C77(1.06)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C156(0.80); C77(1.14)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C156(0.94)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C156(0.79); C36(1.04)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C156(0.85); C36(1.23)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C156(0.92); C77(1.17)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C156(1.02); C77(1.21)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C156(1.10); C77(1.42)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C77(1.04)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C156(1.03); C77(1.16)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C156(0.93); C77(0.99)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C156(0.88)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C156(1.15); C77(1.15)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C156(0.83); C77(1.10)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C156(0.76); C77(1.14)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C156(0.74); C36(1.38)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C156(0.91); C36(1.16)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C156(0.91); C77(0.98)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C156(1.12); C77(0.86)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C156(1.12); C77(1.21)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C156(1.06); C77(1.00)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C77(1.00)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C156(1.11); C77(1.13)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C156(0.81); C77(0.93)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C156(1.00); C77(1.13)  LDD1688  [7]
 LDCM0486  CL91 HCT 116 C77(1.00)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C77(1.49)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C77(0.94)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C77(1.65)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C77(1.48)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C77(1.46)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C77(1.25)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C77(1.00)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C77(1.83)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C156(1.04); C77(0.85)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C156(1.05); C77(0.89)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C156(1.01); C77(1.03)  LDD1631  [7]
 LDCM0022  KB02 HCT 116 C36(4.00); C41(4.00)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C36(2.01); C41(2.01)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C36(5.06); C41(5.06)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Exosome complex component RRP43 (EXOSC8) RNase PH family Q96B26
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402