Details of the Target

General Information of Target

Target ID LDTP10331
Target Name Cilia- and flagella-associated protein 36 (CFAP36)
Gene Name CFAP36
Gene ID 112942
Synonyms
CCDC104; Cilia- and flagella-associated protein 36; Coiled-coil domain-containing protein 104
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLN
KVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQ
EKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPTDTNA
LVAAVAFGKGLSNWRPSGSSGPGQAGQPGAGTILAGTSGLQQVQMAGAPSQQQPMLSGVQ
MAQAGQPGKMPSGIKTNIKSASMHPYQR
Target Bioclass
Enzyme
Family
CFAP36 family
Subcellular location
Nucleus
Function May act as an effector for ARL3.
Uniprot ID
Q96G28
Ensemble ID
ENST00000339012.7
HGNC ID
HGNC:30540

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.D105Y; p.E273D .
OVCAR5 Insertion: p.K342Ter .
PATU8988T Insertion: p.N117KfsTer3 .
SKNAS SNV: p.R233S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C83(1.14)  LDD3345  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0175  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
Lodoacetamide azide
 Probe Info  		C83(0.00); C138(0.00)  LDD0037  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		C138(0.00); C83(0.00)  LDD2156  [5]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0472  [6]
FFF probe13
 Probe Info  		20.00  LDD0476  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C83(0.72)  LDD1507  [7]
 LDCM0226  AC11 HEK-293T C37(1.11)  LDD1509  [7]
 LDCM0259  AC14 HEK-293T C138(1.01)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C138(1.17)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C83(0.75)  LDD1515  [7]
 LDCM0278  AC19 HEK-293T C37(1.10)  LDD1517  [7]
 LDCM0282  AC22 HEK-293T C138(1.09)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C138(0.87)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C138(1.06); C83(1.18)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C83(0.70)  LDD1524  [7]
 LDCM0287  AC27 HEK-293T C37(1.00)  LDD1526  [7]
 LDCM0290  AC3 HEK-293T C37(0.97)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C138(0.97)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C138(1.07)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C138(0.95); C83(1.09)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C83(0.79)  LDD1533  [7]
 LDCM0296  AC35 HEK-293T C37(0.89)  LDD1535  [7]
 LDCM0299  AC38 HEK-293T C138(1.05)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C138(1.20)  LDD1539  [7]
 LDCM0302  AC40 HEK-293T C138(1.10); C83(1.22)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C83(0.77)  LDD1542  [7]
 LDCM0305  AC43 HEK-293T C37(1.05)  LDD1544  [7]
 LDCM0308  AC46 HEK-293T C138(1.12)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C138(1.01)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C138(1.17); C83(1.15)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C83(0.93)  LDD1550  [7]
 LDCM0314  AC51 HEK-293T C37(0.98)  LDD1553  [7]
 LDCM0317  AC54 HEK-293T C138(1.05)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C138(1.29)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C138(1.21); C83(1.04)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C83(0.71)  LDD1559  [7]
 LDCM0322  AC59 HEK-293T C37(1.10)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C138(1.01)  LDD1562  [7]
 LDCM0326  AC62 HEK-293T C138(1.10)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C138(0.95)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C138(1.06); C83(1.06)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C138(1.01)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C138(1.01); C83(0.94)  LDD1569  [7]
 LDCM0356  AKOS034007680 HEK-293T C83(0.93)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C138(1.21); C83(1.21)  LDD1514  [7]
 LDCM0368  CL10 HEK-293T C138(0.86)  LDD1572  [7]
 LDCM0379  CL11 HEK-293T C138(0.85)  LDD1583  [7]
 LDCM0390  CL12 HEK-293T C138(0.85); C83(1.06)  LDD1594  [7]
 LDCM0404  CL17 HEK-293T C83(0.79)  LDD1608  [7]
 LDCM0406  CL19 HEK-293T C37(1.36)  LDD1610  [7]
 LDCM0410  CL22 HEK-293T C138(0.99)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C138(0.93)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C138(0.96); C83(1.09)  LDD1616  [7]
 LDCM0417  CL29 HEK-293T C83(0.93)  LDD1621  [7]
 LDCM0420  CL31 HEK-293T C37(1.16)  LDD1624  [7]
 LDCM0423  CL34 HEK-293T C138(0.99)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C138(0.81)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C138(0.94); C83(0.96)  LDD1629  [7]
 LDCM0431  CL41 HEK-293T C83(0.71)  LDD1635  [7]
 LDCM0433  CL43 HEK-293T C37(1.21)  LDD1637  [7]
 LDCM0436  CL46 HEK-293T C138(1.01)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C138(0.76)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C138(0.93); C83(1.02)  LDD1642  [7]
 LDCM0440  CL5 HEK-293T C83(1.11)  LDD1644  [7]
 LDCM0444  CL53 HEK-293T C83(0.69)  LDD1647  [7]
 LDCM0446  CL55 HEK-293T C37(1.08)  LDD1649  [7]
 LDCM0449  CL58 HEK-293T C138(0.99)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C138(0.71)  LDD1653  [7]
 LDCM0452  CL60 HEK-293T C138(0.98); C83(1.09)  LDD1655  [7]
 LDCM0457  CL65 HEK-293T C83(0.78)  LDD1660  [7]
 LDCM0459  CL67 HEK-293T C37(1.04)  LDD1662  [7]
 LDCM0462  CL7 HEK-293T C37(1.06)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C138(1.11)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C138(1.06)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C138(0.96); C83(1.08)  LDD1668  [7]
 LDCM0470  CL77 HEK-293T C83(0.67)  LDD1673  [7]
 LDCM0472  CL79 HEK-293T C37(1.09)  LDD1675  [7]
 LDCM0476  CL82 HEK-293T C138(1.00)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C138(1.03)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C138(0.84); C83(1.12)  LDD1681  [7]
 LDCM0483  CL89 HEK-293T C83(0.68)  LDD1686  [7]
 LDCM0486  CL91 HEK-293T C37(1.12)  LDD1689  [7]
 LDCM0489  CL94 HEK-293T C138(1.03)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C138(0.78)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C138(1.12); C83(1.05)  LDD1694  [7]
 LDCM0022  KB02 A101D C83(1.23)  LDD2250  [1]
 LDCM0023  KB03 A204 C83(1.12)  LDD2669  [1]
 LDCM0024  KB05 NCI-H1650 C83(1.14)  LDD3345  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DAZ-associated protein 2 (DAZAP2) . Q15038

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402