Details of the Target

General Information of Target

Target ID LDTP10261
Target Name Mitochondrial assembly of ribosomal large subunit protein 1 (MALSU1)
Gene Name MALSU1
Gene ID 115416
Synonyms
C7orf30; Mitochondrial assembly of ribosomal large subunit protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEAPAQKAGQGGLPKADAQGASGAREKRPEEPRPLEEDRAGSRPTQKGDLRGAAGGRTTP
PGGGSRGCSLGVSPGPGTRHSAGTRPLVREPCGPTSSQNPELVIPEGLQAREGPCRSPAR
GGDCSRNSCLAWHRGAPAGETPPVCDPCPERIQNHPRTQLCEVHTDCWPCQPGTGAPTCP
RTPKPTSRGRNPLVEQPRACACGEAFAWRALRIPQERLQATEEPRPCARCGKRFRPNQQQ
QAGKSPPVCPECGQTSRPRPIVPDPPAQRLYACDECGKAFTRTSSLLQHQRIHTGERPYE
CAECGKAFVRCSGLYRHQKTHSAERHRRGPVLARRAFRLGCPPCGDYSERSPRRGSGAGE
KPYECADCAKAFGLFSHLVEHRRVHTGEKPYACPECGKAFNQRSNLSRHQRTHSSAKPYA
CPLCEKAFKGRSGLVQHQRAHTGERPYGCSECGKTFRGCSELRQHERLHSGEKPYICRDC
GKAFVRNCSLVRHLRTHTGERPYACGDCGRAFSQRSNLNEHRKRHGGRAAP
Target Bioclass
Other
Family
Iojap/RsfS family
Subcellular location
Mitochondrion matrix
Function
Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor (Probable).
Uniprot ID
Q96EH3
Ensemble ID
ENST00000466681.2
HGNC ID
HGNC:21721

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C110(1.08)  LDD1507  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
1d-yne
 Probe Info  		N.A.  LDD0356  [7]
Acrolein
 Probe Info  		H87(0.00); C110(0.00)  LDD0217  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C110(1.08)  LDD1507  [2]
 LDCM0226  AC11 HEK-293T C110(0.94)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C110(1.07)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C110(0.91)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C110(0.94)  LDD1515  [2]
 LDCM0278  AC19 HEK-293T C110(1.01)  LDD1517  [2]
 LDCM0280  AC20 HEK-293T C110(1.01)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C110(0.82)  LDD1520  [2]
 LDCM0283  AC23 HEK-293T C110(0.84)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C110(1.14)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C110(0.98)  LDD1524  [2]
 LDCM0287  AC27 HEK-293T C110(0.97)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C110(1.14)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C110(1.00)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C110(1.00)  LDD1529  [2]
 LDCM0292  AC31 HEK-293T C110(1.02)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C110(1.11)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C110(1.38)  LDD1533  [2]
 LDCM0296  AC35 HEK-293T C110(1.04)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C110(1.10)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C110(0.98)  LDD1537  [2]
 LDCM0300  AC39 HEK-293T C110(0.91)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C110(1.07)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C110(1.29)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C110(1.08)  LDD1542  [2]
 LDCM0305  AC43 HEK-293T C110(0.89)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C110(1.05)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C110(0.93)  LDD1546  [2]
 LDCM0309  AC47 HEK-293T C110(0.93)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C110(0.80)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C110(0.77)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C110(1.29)  LDD1551  [2]
 LDCM0314  AC51 HEK-293T C110(1.05)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C110(1.20)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C110(0.82)  LDD1555  [2]
 LDCM0318  AC55 HEK-293T C110(0.74)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C110(0.89)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C110(1.31)  LDD1559  [2]
 LDCM0322  AC59 HEK-293T C110(0.83)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C110(1.17)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C110(0.99)  LDD1564  [2]
 LDCM0327  AC63 HEK-293T C110(0.94)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C110(0.99)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C110(1.09)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C110(1.37)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C110(0.85)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C110(1.10)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C110(1.17)  LDD1514  [2]
 LDCM0156  Aniline NCI-H1299 13.40  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C110(1.49)  LDD1571  [2]
 LDCM0369  CL100 HEK-293T C110(0.88)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C110(1.24)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C110(1.04)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C110(0.81)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C110(0.83)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C110(1.07)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C110(1.18)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C110(0.76)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C110(0.93)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C110(0.93)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C110(1.36)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C110(1.11)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C110(1.01)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C110(0.80)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C110(1.20)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C110(1.00)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C110(1.07)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C110(0.85)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C110(0.91)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C110(0.90)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C110(0.86)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C110(1.16)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C110(1.08)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C110(0.93)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C110(1.03)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C110(0.85)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C110(0.68)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C110(1.03)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C110(1.32)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C110(0.97)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C110(0.90)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C110(1.26)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C110(1.21)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C110(1.01)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C110(0.98)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C110(1.14)  LDD1608  [2]
 LDCM0406  CL19 HEK-293T C110(1.29)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C110(1.04)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C110(0.96)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C110(1.08)  LDD1613  [2]
 LDCM0411  CL23 HEK-293T C110(1.02)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C110(1.56)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C110(1.05)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C110(1.00)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C110(0.91)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C110(0.78)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C110(0.99)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C110(1.00)  LDD1622  [2]
 LDCM0420  CL31 HEK-293T C110(1.26)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C110(1.17)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C110(1.19)  LDD1626  [2]
 LDCM0424  CL35 HEK-293T C110(1.29)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C110(1.48)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C110(1.17)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C110(1.22)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C110(1.27)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C110(0.96)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C110(1.07)  LDD1635  [2]
 LDCM0433  CL43 HEK-293T C110(0.97)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C110(0.99)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C110(1.57)  LDD1639  [2]
 LDCM0437  CL47 HEK-293T C110(1.37)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C110(1.14)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C110(1.26)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C110(1.26)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C110(1.31)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C110(0.99)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C110(1.10)  LDD1647  [2]
 LDCM0446  CL55 HEK-293T C110(1.25)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C110(1.08)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C110(1.26)  LDD1651  [2]
 LDCM0450  CL59 HEK-293T C110(1.21)  LDD1653  [2]
 LDCM0452  CL60 HEK-293T C110(1.18)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C110(1.20)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C110(1.07)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C110(1.10)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C110(0.90)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C110(1.17)  LDD1660  [2]
 LDCM0459  CL67 HEK-293T C110(1.44)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C110(1.13)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C110(1.16)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C110(1.05)  LDD1665  [2]
 LDCM0464  CL71 HEK-293T C110(0.81)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C110(1.18)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C110(1.27)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C110(1.19)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C110(0.84)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C110(0.99)  LDD1673  [2]
 LDCM0472  CL79 HEK-293T C110(0.98)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C110(0.82)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C110(1.21)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C110(1.28)  LDD1678  [2]
 LDCM0477  CL83 HEK-293T C110(1.03)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C110(1.06)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C110(1.22)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C110(1.04)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C110(0.95)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C110(0.71)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C110(1.19)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C110(1.47)  LDD1687  [2]
 LDCM0486  CL91 HEK-293T C110(1.01)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C110(1.03)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C110(1.08)  LDD1691  [2]
 LDCM0490  CL95 HEK-293T C110(1.19)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C110(1.07)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C110(1.30)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C110(1.09)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C110(1.23)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C110(0.98)  LDD1698  [2]
 LDCM0625  F8 Ramos C110(0.11)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C110(0.32)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C151(2.18); C110(0.11)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C110(0.20)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C110(0.85)  LDD2192  [9]
 LDCM0576  Fragment14 Ramos C151(0.53); C110(3.09)  LDD2193  [9]
 LDCM0579  Fragment20 Ramos C110(0.74)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C110(0.65)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C110(1.12)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C110(0.68)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C151(1.37); C110(0.63)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C110(1.00)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C110(0.97)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C110(0.20)  LDD2201  [9]
 LDCM0468  Fragment33 HEK-293T C110(0.97)  LDD1671  [2]
 LDCM0596  Fragment38 Ramos C110(0.33)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C151(0.80); C110(0.08)  LDD2184  [9]
 LDCM0427  Fragment51 HEK-293T C110(1.07)  LDD1631  [2]
 LDCM0610  Fragment52 Ramos C110(0.09)  LDD2204  [9]
 LDCM0614  Fragment56 Ramos C110(0.13)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C151(0.81); C110(0.06)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C110(0.22)  LDD2188  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 Ramos C151(3.47); C110(0.06)  LDD2182  [9]
 LDCM0023  KB03 Ramos C151(0.93); C110(0.08)  LDD2183  [9]
 LDCM0024  KB05 Ramos C151(0.70)  LDD2185  [9]
 LDCM0109  NEM HeLa H87(0.00); C110(0.00)  LDD0224  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Deoxycytidylate deaminase (DCTD) Cytidine and deoxycytidylate deaminase family P32321
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 90 homolog (ZFP90) Krueppel C2H2-type zinc-finger protein family Q8TF47
Transcription factor Sp6 (SP6) Sp1 C2H2-type zinc-finger protein family Q3SY56
Zinc finger protein 426 (ZNF426) . Q9BUY5
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myosin-binding protein H-like (MYBPHL) MyBP family A2RUH7
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
Puratrophin-1 (PLEKHG4) . Q58EX7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578