Details of the Target

General Information of Target

Target ID LDTP10246
Target Name Transcription termination factor 3, mitochondrial (MTERF3)
Gene Name MTERF3
Gene ID 51001
Synonyms
MTERFD1; Transcription termination factor 3, mitochondrial; Mitochondrial transcription termination factor 3; mTERF3; mTERF domain-containing protein 1, mitochondrial
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTGLYELVWRVLHALLCLHRTLTSWLRVRFGTWNWIWRRCCRAASAAVLAPLGFTLRKPP
AVGRNRRHHRHPRGGSCLAAAHHRMRWRADGRSLEKLPVHMGLVITEVEQEPSFSDIASL
VVWCMAVGISYISVYDHQGIFKRNNSRLMDEILKQQQELLGLDCSKYSPEFANSNDKDDQ
VLNCHLAVKVLSPEDGKADIVRAAQDFCQLVAQKQKRPTDLDVDTLASLLSSNGCPDPDL
VLKFGPVDSTLGFLPWHIRLTEIVSLPSHLNISYEDFFSALRQYAACEQRLGK
Target Bioclass
Other
Family
MTERF family
Subcellular location
Mitochondrion
Function
Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function. Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit.
Uniprot ID
Q96E29
Ensemble ID
ENST00000287025.4
HGNC ID
HGNC:24258

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 SNV: p.D105N .
HSC4 SNV: p.N81T .
HUH7 SNV: p.N81T .
KYM1 Deletion: p.E400QfsTer8 .
KYSE180 SNV: p.E311D .
SUPT1 SNV: p.T63A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K246(1.12)  LDD0277  [1]
IA-alkyne
 Probe Info  		C399(2.02)  LDD2157  [2]
DBIA
 Probe Info  		C399(2.41)  LDD3337  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C399(0.97)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C399(0.99)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C399(1.12)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C399(1.03)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C399(0.92)  LDD1513  [7]
 LDCM0277  AC18 HEK-293T C399(0.90)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C399(1.01)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C399(1.02)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C399(0.97)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C399(1.00)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C399(1.01)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C399(0.93)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C399(0.99)  LDD1523  [7]
 LDCM0286  AC26 HEK-293T C399(1.05)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C399(1.07)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C399(0.99)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C399(1.03)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C399(1.06)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C399(1.06)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C399(0.90)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C399(1.07)  LDD1532  [7]
 LDCM0295  AC34 HEK-293T C399(1.01)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C399(1.09)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C399(1.10)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C399(0.94)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C399(0.89)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C399(1.05)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C399(1.02)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C399(0.97)  LDD1541  [7]
 LDCM0304  AC42 HEK-293T C399(0.94)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C399(1.04)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C399(0.96)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C399(0.99)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C399(1.02)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C399(1.00)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C399(0.97)  LDD1549  [7]
 LDCM0312  AC5 HEK-293T C399(0.94)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C399(0.94)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C399(1.09)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C399(1.09)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C399(0.89)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C399(0.97)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C399(0.96)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C399(1.08)  LDD1558  [7]
 LDCM0321  AC58 HEK-293T C399(1.03)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C399(1.21)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C399(0.98)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C399(1.07)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C399(1.04)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C399(1.01)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C399(1.03)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C399(1.06)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C399(1.05)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C399(0.99)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C399(0.89)  LDD1511  [7]
 LDCM0275  AKOS034007705 HEK-293T C399(1.03)  LDD1514  [7]
 LDCM0368  CL10 HEK-293T C399(0.90)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C399(0.94)  LDD1573  [7]
 LDCM0371  CL102 HEK-293T C399(1.12)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C399(0.96)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C399(0.97)  LDD1577  [7]
 LDCM0375  CL106 HEK-293T C399(0.95)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C399(0.93)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C399(1.01)  LDD1581  [7]
 LDCM0379  CL11 HEK-293T C399(1.00)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C399(0.98)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C399(0.85)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C399(1.04)  LDD1586  [7]
 LDCM0384  CL114 HEK-293T C399(1.07)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C399(0.94)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C399(1.01)  LDD1590  [7]
 LDCM0388  CL118 HEK-293T C399(0.97)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C399(1.01)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C399(0.97)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C399(1.10)  LDD1595  [7]
 LDCM0393  CL122 HEK-293T C399(0.98)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C399(0.94)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C399(1.08)  LDD1599  [7]
 LDCM0397  CL126 HEK-293T C399(1.15)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C399(0.95)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C399(1.05)  LDD1603  [7]
 LDCM0401  CL14 HEK-293T C399(1.25)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C399(0.92)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C399(1.20)  LDD1607  [7]
 LDCM0405  CL18 HEK-293T C399(1.02)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C399(1.25)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C399(1.10)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C399(1.02)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C399(1.03)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C399(1.05)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C399(0.90)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C399(0.98)  LDD1616  [7]
 LDCM0414  CL26 HEK-293T C399(1.15)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C399(0.91)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C399(0.98)  LDD1620  [7]
 LDCM0418  CL3 HEK-293T C399(0.91)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C399(1.01)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C399(1.09)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C399(1.03)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C399(1.05)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C399(0.97)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C399(1.10)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C399(1.05)  LDD1629  [7]
 LDCM0428  CL39 HEK-293T C399(0.95)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C399(0.95)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C399(1.07)  LDD1634  [7]
 LDCM0432  CL42 HEK-293T C399(1.02)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C399(1.24)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C399(1.12)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C399(0.82)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C399(1.03)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C399(1.16)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C399(0.98)  LDD1642  [7]
 LDCM0441  CL50 HEK-293T C399(1.03)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C399(0.95)  LDD1646  [7]
 LDCM0445  CL54 HEK-293T C399(0.92)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C399(1.06)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C399(1.07)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C399(0.95)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C399(0.93)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C399(0.85)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C399(0.94)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C399(0.97)  LDD1655  [7]
 LDCM0454  CL62 HEK-293T C399(1.08)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C399(1.05)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C399(0.97)  LDD1659  [7]
 LDCM0458  CL66 HEK-293T C399(0.95)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C399(1.05)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C399(1.04)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C399(0.95)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C399(1.08)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C399(1.02)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C399(1.00)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C399(1.02)  LDD1668  [7]
 LDCM0467  CL74 HEK-293T C399(1.12)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C399(0.97)  LDD1672  [7]
 LDCM0471  CL78 HEK-293T C399(1.07)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C399(1.20)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C399(0.62)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C399(1.05)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C399(0.90)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C399(1.06)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C399(1.02)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C399(1.01)  LDD1681  [7]
 LDCM0480  CL86 HEK-293T C399(1.04)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C399(0.99)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C399(1.10)  LDD1685  [7]
 LDCM0484  CL9 HEK-293T C399(1.12)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C399(0.99)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C399(1.11)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C399(1.08)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C399(1.00)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C399(0.96)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C399(0.77)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C399(0.97)  LDD1694  [7]
 LDCM0493  CL98 HEK-293T C399(0.95)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C399(0.88)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C399(0.90)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C399(0.97)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C399(1.15)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C399(0.99)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C399(0.97)  LDD1497  [7]
 LDCM0024  KB05 MSTO-211H C399(2.41)  LDD3337  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC21 (ZDHHC21) DHHC palmitoyltransferase family Q8IVQ6
Fatty acid desaturase 6 (FADS6) Fatty acid desaturase type 1 family Q8N9I5
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium channel flower homolog (CACFD1) Calcium channel flower family Q9UGQ2
Protein GPR108 (GPR108) LU7TM family Q9NPR9
Voltage-gated purine nucleotide uniporter SLC17A9 (SLC17A9) Sodium/anion cotransporter family Q9BYT1
Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5) Sugar transporter (TC 2.A.1.1) family P22732
Secretory carrier-associated membrane protein 1 (SCAMP1) SCAMP family O15126
Sugar transporter SWEET1 (SLC50A1) SWEET sugar transporter family Q9BRV3
Synaptophysin (SYP) Synaptophysin/synaptobrevin family P08247
Transmembrane protein 14C (TMEM14C) TMEM14 family Q9P0S9
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adhesion G protein-coupled receptor E2 (ADGRE2) G-protein coupled receptor 2 family Q9UHX3
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) Chemokine-like factor family Q96DZ9
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein C-I (APOC1) Apolipoprotein C1 family P02654
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
FUN14 domain-containing protein 1 (FUNDC1) FUN14 family Q8IVP5
Protein MAL2 (MAL2) MAL family Q969L2
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Protein YIF1A (YIF1A) YIF1 family O95070
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
HIG1 domain family member 1C (HIGD1C) . A8MV81
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402