Details of the Target

General Information of Target

Target ID LDTP10180
Target Name GRIP and coiled-coil domain-containing protein 1 (GCC1)
Gene Name GCC1
Gene ID 79571
Synonyms
GRIP and coiled-coil domain-containing protein 1; Golgi coiled-coil protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEFRRSYSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLC
TELVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLT
LEWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLR
WNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQAR
THVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINA
LKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLR
DLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKR
RCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSER
GQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQL
GLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAAL
ERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQA
SPVRTLSPPK
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Probably involved in maintaining Golgi structure.
Uniprot ID
Q96CN9
Ensemble ID
ENST00000321407.3
HGNC ID
HGNC:19095

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
Probe 1
 Probe Info  		Y31(11.88)  LDD3495  [2]
m-APA
 Probe Info  		11.97  LDD0403  [3]
DBIA
 Probe Info  		C570(2.22)  LDD3312  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C460(1.09)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C460(1.20)  LDD1508  [8]
 LDCM0237  AC12 HEK-293T C460(1.00)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C460(1.06)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C460(1.18)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C460(1.01)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C460(1.03)  LDD1516  [8]
 LDCM0279  AC2 HEK-293T C460(1.00)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C460(1.03)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C460(1.17)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C460(1.08)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C460(1.04)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C460(1.06)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C460(1.21)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C460(1.19)  LDD1525  [8]
 LDCM0288  AC28 HEK-293T C460(1.03)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C460(1.11)  LDD1528  [8]
 LDCM0291  AC30 HEK-293T C460(1.07)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C460(1.04)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C460(1.00)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C460(0.90)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C460(0.95)  LDD1534  [8]
 LDCM0297  AC36 HEK-293T C460(1.21)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C460(1.00)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C460(1.13)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C460(1.08)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C460(1.04)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C460(1.00)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C460(0.93)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C460(1.17)  LDD1543  [8]
 LDCM0306  AC44 HEK-293T C460(0.86)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C460(1.21)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C460(1.12)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C460(1.03)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C460(0.97)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C460(1.06)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C460(1.17)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C460(1.06)  LDD1552  [8]
 LDCM0315  AC52 HEK-293T C460(0.86)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C460(1.11)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C460(1.09)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C460(1.06)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C460(1.10)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C460(0.98)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C460(0.98)  LDD1560  [8]
 LDCM0323  AC6 HEK-293T C460(1.23)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C460(1.05)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C460(1.03)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C460(1.03)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C460(1.01)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C460(0.93)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C460(1.07)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C460(0.91)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C460(1.16)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C460(1.10)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C460(1.07)  LDD1514  [8]
 LDCM0156  Aniline NCI-H1299 11.97  LDD0403  [3]
 LDCM0367  CL1 HEK-293T C87(1.10); C460(0.89)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C460(0.93)  LDD1572  [8]
 LDCM0370  CL101 HEK-293T C87(0.98); C460(1.07)  LDD1574  [8]
 LDCM0372  CL103 HEK-293T C460(0.93)  LDD1576  [8]
 LDCM0374  CL105 HEK-293T C87(0.94); C460(1.02)  LDD1578  [8]
 LDCM0376  CL107 HEK-293T C460(0.99)  LDD1580  [8]
 LDCM0378  CL109 HEK-293T C87(0.91); C460(1.12)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C460(1.01)  LDD1583  [8]
 LDCM0381  CL111 HEK-293T C460(1.00)  LDD1585  [8]
 LDCM0383  CL113 HEK-293T C87(1.01); C460(0.98)  LDD1587  [8]
 LDCM0385  CL115 HEK-293T C460(0.89)  LDD1589  [8]
 LDCM0387  CL117 HEK-293T C87(1.07); C460(1.06)  LDD1591  [8]
 LDCM0389  CL119 HEK-293T C460(1.06)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C460(1.02)  LDD1594  [8]
 LDCM0392  CL121 HEK-293T C87(0.98); C460(0.99)  LDD1596  [8]
 LDCM0394  CL123 HEK-293T C460(1.03)  LDD1598  [8]
 LDCM0396  CL125 HEK-293T C87(0.78); C460(0.95)  LDD1600  [8]
 LDCM0398  CL127 HEK-293T C460(1.06)  LDD1602  [8]
 LDCM0400  CL13 HEK-293T C87(0.86); C460(1.03)  LDD1604  [8]
 LDCM0402  CL15 HEK-293T C460(1.05)  LDD1606  [8]
 LDCM0404  CL17 HEK-293T C460(1.00)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C460(1.08)  LDD1609  [8]
 LDCM0408  CL20 HEK-293T C460(1.04)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C460(1.12)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C460(1.09)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C460(1.16)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C460(1.16)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C87(0.81); C460(1.04)  LDD1617  [8]
 LDCM0415  CL27 HEK-293T C460(0.96)  LDD1619  [8]
 LDCM0417  CL29 HEK-293T C460(1.00)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C460(1.02)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C460(1.04)  LDD1623  [8]
 LDCM0421  CL32 HEK-293T C460(1.14)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C460(1.23)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C460(1.03)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C460(0.94)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C460(1.16)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C87(0.89); C460(0.91)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C460(1.02)  LDD1632  [8]
 LDCM0431  CL41 HEK-293T C460(1.01)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C460(1.07)  LDD1636  [8]
 LDCM0434  CL44 HEK-293T C460(0.95)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C460(1.04)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C460(1.05)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C460(1.39)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C460(1.05)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C87(0.87); C460(0.92)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C460(0.96)  LDD1644  [8]
 LDCM0444  CL53 HEK-293T C460(1.09)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C460(1.06)  LDD1648  [8]
 LDCM0447  CL56 HEK-293T C460(1.12)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C460(1.02)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C460(1.18)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C460(1.19)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C460(1.14)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C460(1.02)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C87(0.91); C460(1.00)  LDD1656  [8]
 LDCM0455  CL63 HEK-293T C460(0.91)  LDD1658  [8]
 LDCM0457  CL65 HEK-293T C460(1.17)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C460(1.06)  LDD1661  [8]
 LDCM0460  CL68 HEK-293T C460(1.09)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C460(1.06)  LDD1664  [8]
 LDCM0463  CL70 HEK-293T C460(1.08)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C460(1.19)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C460(1.09)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C87(1.02); C460(0.93)  LDD1669  [8]
 LDCM0470  CL77 HEK-293T C460(0.94)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C460(1.06)  LDD1674  [8]
 LDCM0473  CL8 HEK-293T C460(1.06)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C460(1.08)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C460(1.03)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C460(0.97)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C460(1.09)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C460(0.95)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C87(0.93); C460(0.90)  LDD1682  [8]
 LDCM0481  CL87 HEK-293T C460(0.97)  LDD1684  [8]
 LDCM0483  CL89 HEK-293T C460(0.96)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C460(1.09)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C460(0.95)  LDD1688  [8]
 LDCM0487  CL92 HEK-293T C460(0.92)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C460(0.71)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C460(1.07)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C460(1.01)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C460(0.91)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C87(0.91); C460(1.07)  LDD1695  [8]
 LDCM0494  CL99 HEK-293T C460(0.94)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C460(0.93)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C460(0.97)  LDD1671  [8]
 LDCM0022  KB02 HEK-293T C460(0.93)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C460(0.95)  LDD1497  [8]
 LDCM0024  KB05 HMCB C570(2.22)  LDD3312  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fidgetin-like protein 1 (FIGNL1) AAA ATPase family Q6PIW4
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) AAA ATPase family Q9BW62
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Baculoviral IAP repeat-containing protein 2 (BIRC2) IAP family Q13490
E3 ubiquitin-protein ligase XIAP (XIAP) IAP family P98170
Serine/threonine-protein kinase PAK 5 (PAK5) STE Ser/Thr protein kinase family Q9P286
E3 ubiquitin-protein ligase TRIM50 (TRIM50) TRIM/RBCC family Q86XT4
Tripartite motif-containing protein 29 (TRIM29) . Q14134
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kinesin-1 heavy chain (KIF5B) Kinesin family P33176
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
Fos-related antigen 1 (FOSL1) BZIP family P15407
Zinc finger protein GLI1 (GLI1) GLI C2H2-type zinc-finger protein family P08151
Zinc finger protein 90 homolog (ZFP90) Krueppel C2H2-type zinc-finger protein family Q8TF47
Highly divergent homeobox (HDX) . Q7Z353
Homeobox protein MOX-1 (MEOX1) . P50221
Other
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Abl interactor 2 (ABI2) ABI family Q9NYB9
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Protein FAM83A (FAM83A) FAM83 family Q86UY5
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Lebercilin (LCA5) LCA5 family Q86VQ0
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
Protein Mis18-beta (OIP5) Mis18 family O43482
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Centrosomal protein of 57 kDa (CEP57) Translokin family Q86XR8
U3 small nucleolar RNA-associated protein 14 homolog C (UTP14C) UTP14 family Q5TAP6
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
F-box only protein 28 (FBXO28) . Q9NVF7
Microspherule protein 1 (MCRS1) . Q96EZ8
Phostensin (PPP1R18) . Q6NYC8
Protein moonraker (KIAA0753) . Q2KHM9
Protein phosphatase 1 regulatory subunit 27 (PPP1R27) . Q86WC6
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5
Zinc finger C4H2 domain-containing protein (ZC4H2) . Q9NQZ6

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402