Details of the Target

General Information of Target

Target ID LDTP10132
Target Name Transcriptional adapter 1 (TADA1)
Gene Name TADA1
Gene ID 117143
Synonyms
TADA1L; Transcriptional adapter 1; SPT3-associated factor 42; STAF42; Transcriptional adapter 1-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIALFNKLLDWFKALFWKEEMELTLVGLQYSGKTTFVNVIASGQFNEDMIPTVGFNMRKI
TKGNVTIKLWDIGGQPRFRSMWERYCRGVSAIVYMVDAADQEKIEASKNELHNLLDKPQL
QGIPVLVLGNKRDLPGALDEKELIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQH
SKSRRS
Target Bioclass
Other
Family
TADA1 family
Subcellular location
Nucleus
Function Probably involved in transcriptional regulation.
Uniprot ID
Q96BN2
Ensemble ID
ENST00000367874.5
HGNC ID
HGNC:30631

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C139(1.32)  LDD0531  [1]
AOyne
 Probe Info  		15.00  LDD0443  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C139(1.32)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C139(1.00)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C139(1.03)  LDD0543  [1]
 LDCM0230  AC113 HCT 116 C139(0.98)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C139(0.92)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C139(0.99)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C139(0.99)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C139(0.88)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C139(0.97)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C139(0.94)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C139(0.91)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C139(0.95)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C139(1.11)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C139(0.89)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C139(1.15)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C139(0.98)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C139(0.88)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C139(1.12)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C139(0.98)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C139(0.78)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C139(1.05)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C139(1.09)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C139(1.24)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C139(1.08)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C139(1.05)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C139(1.07)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C139(0.91)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C139(0.90)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C139(0.92)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C139(0.99)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C139(1.01)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C139(1.00)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C139(1.00)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C139(1.03); C70(1.06)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C139(1.05); C70(0.96)  LDD1528  [3]
 LDCM0290  AC3 HCT 116 C139(1.03)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C139(0.98); C70(0.95)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C139(1.04)  LDD1531  [3]
 LDCM0294  AC33 HEK-293T C139(1.08)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C139(0.98)  LDD1534  [3]
 LDCM0296  AC35 HCT 116 C139(1.03)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C139(1.06)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C139(0.97)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C139(1.05)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C139(1.00)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C139(1.14)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C139(1.17)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C139(1.03)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C139(0.87)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C139(1.25)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C139(1.44)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C139(1.28)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C139(1.11); C70(0.92)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C139(1.00)  LDD1548  [3]
 LDCM0311  AC49 HEK-293T C139(1.07)  LDD1550  [3]
 LDCM0312  AC5 HCT 116 C139(1.24)  LDD0629  [1]
 LDCM0313  AC50 HEK-293T C139(1.01)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C139(1.01)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C139(1.05); C70(1.04)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C139(0.95); C70(0.95)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C139(0.97); C70(0.84)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C139(0.99)  LDD1557  [3]
 LDCM0320  AC57 HEK-293T C139(1.10)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C139(0.98)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C139(1.01)  LDD1561  [3]
 LDCM0323  AC6 HCT 116 C139(0.96)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C139(1.08); C70(1.02)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C139(1.00); C70(0.91)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C139(0.98); C70(0.98)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C139(1.12)  LDD1566  [3]
 LDCM0334  AC7 HCT 116 C139(1.00)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C139(0.96)  LDD0662  [1]
 LDCM0248  AKOS034007472 HCT 116 C139(0.78)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C139(0.94)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C139(1.09)  LDD0592  [1]
 LDCM0367  CL1 HEK-293T C139(0.93); C70(1.55)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C139(1.04); C70(1.07)  LDD1572  [3]
 LDCM0369  CL100 HCT 116 C139(1.12)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C139(0.60)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C139(0.73)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C139(0.75)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C139(0.74)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C139(1.00)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C139(1.19)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C139(1.05)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C139(0.99)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C139(1.14)  LDD0695  [1]
 LDCM0379  CL11 HEK-293T C139(0.74)  LDD1583  [3]
 LDCM0380  CL110 HCT 116 C139(1.14)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C139(0.86)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C139(1.09)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C139(0.98); C70(1.16)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C139(1.08); C70(1.22)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C139(0.99); C70(1.17)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C139(0.99)  LDD1590  [3]
 LDCM0387  CL117 HCT 116 C139(1.67)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C139(1.26)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C139(1.14)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C139(1.15)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C139(0.97); C70(1.30)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C139(1.01); C70(1.02)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C139(0.96); C70(0.90)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C139(1.03)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C139(1.11); C70(1.34)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C139(1.02); C70(0.95)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C139(1.13); C70(0.86)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C139(1.13)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C139(0.98); C70(1.09)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C139(0.90); C70(0.93)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C139(0.87); C70(0.90)  LDD1606  [3]
 LDCM0403  CL16 HCT 116 C139(0.94)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C139(0.87)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C139(0.91)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C139(0.96)  LDD0723  [1]
 LDCM0407  CL2 HEK-293T C139(0.89); C70(0.94)  LDD1611  [3]
 LDCM0408  CL20 HCT 116 C139(0.86)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C139(0.98)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C139(1.09)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C139(0.84)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C139(0.76)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C139(0.67)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C139(0.94)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C139(0.58)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C139(0.61)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C139(0.59)  LDD0734  [1]
 LDCM0418  CL3 HEK-293T C139(0.81); C70(0.97)  LDD1622  [3]
 LDCM0419  CL30 HCT 116 C139(0.65)  LDD0736  [1]
 LDCM0420  CL31 HEK-293T C139(0.72)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C139(0.73); C70(1.02)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C139(0.98); C70(1.00)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C139(0.82); C70(0.97)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C139(0.68)  LDD1628  [3]
 LDCM0426  CL37 HEK-293T C139(0.98); C70(1.00)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C139(0.80); C70(0.97)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C139(0.89)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C139(0.88)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C139(0.92)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C139(0.88)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C139(0.75)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C139(0.78); C70(1.02)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C139(1.10); C70(0.84)  LDD1639  [3]
 LDCM0436  CL46 HCT 116 C139(0.75)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C139(1.06)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C139(1.43)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C139(1.21)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C139(0.92)  LDD1644  [3]
 LDCM0441  CL50 HCT 116 C139(1.12)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C139(0.94)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C139(1.02)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C139(1.06)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C139(0.84)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C139(0.84)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C139(0.79)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C139(0.81)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C139(1.00)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C139(0.96)  LDD0767  [1]
 LDCM0451  CL6 HEK-293T C139(0.88)  LDD1654  [3]
 LDCM0452  CL60 HCT 116 C139(0.93)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C139(1.04); C70(1.16)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C139(0.93); C70(1.09)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C139(0.99); C70(1.05)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C139(0.90)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C139(0.92)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C139(0.87)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C139(0.79)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C139(0.77); C70(1.18)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C139(1.02); C70(1.03)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C139(0.76)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C139(0.81); C70(1.09)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C139(0.76)  LDD1667  [3]
 LDCM0466  CL73 HEK-293T C139(1.00); C70(1.15)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C139(1.01); C70(1.07)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C139(0.94)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C139(0.92)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C139(0.87)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C139(0.82)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C139(0.77); C70(1.03)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C139(0.76); C70(1.05)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C139(1.06); C70(0.92)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C139(0.88); C70(1.15)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C139(0.74)  LDD1680  [3]
 LDCM0479  CL85 HEK-293T C139(1.16); C70(1.25)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C139(1.09); C70(1.23)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C139(1.00); C70(0.98)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C139(1.04)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C139(1.02)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C139(1.03); C70(0.89)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C139(0.85)  LDD1688  [3]
 LDCM0486  CL91 HCT 116 C139(1.19)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C139(1.28)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C139(1.19)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C139(1.41)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C139(1.16)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C139(1.02)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C139(1.00)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C139(1.12)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C139(1.07)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C139(0.85); C70(0.90)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C139(0.99); C70(1.00)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C139(0.96); C70(1.46)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C70(1.00)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C70(1.02)  LDD1497  [3]
 LDCM0024  KB05 SKMEL24 C139(1.96)  LDD3323  [4]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840