Details of the Target

General Information of Target

Target ID LDTP10125
Target Name E3 ubiquitin-protein ligase RNF25 (RNF25)
Gene Name RNF25
Gene ID 64320
Synonyms
E3 ubiquitin-protein ligase RNF25; EC 2.3.2.27; RING finger protein 25; RING finger protein AO7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFS
GNSKSAFELPGSVPPACFQQILSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLM
FKVSSPHCDSQTAVIEDAGSEPQSPCNQLQPAAAAAAPYVVSPSVPIPLLTRVKHEAMEL
PPAGPGLAPKRPLETGPRDGVAVAAGAAVAAGTAPLKLPRVSYYGVPSLATLIPGIQQMP
YPQGERTSPGASSLPTTDSPTSYHNEEDEEDDEAYDTMVEEQYGQMYIKASGSYAVQEKP
EPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELVAGSGVYITRGQ
LMNCHLCAGVKHKVLLRRLLATFFDRNTLANSCGTGIRSSTSDPSRKPLDSRVLNAVKLY
CQNFAPSFKESEMNVIAADMCTNARRVRKRWLPKIKSMLPEGVEMYRTVMGSAAASVPLD
PEFPPAAAQVFEQRIYAERRGDAATIVALRTDAVNVDLSAAANPAFDAGEEVDGAGSVIQ
EVAAPEPLPADGQSPPQPFEQGGGGPSRPQTPAAAARRPEGTYAGTL
Target Bioclass
Enzyme
Function
E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes. Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14. RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17. Also involved in ubiquitination and degradation of stalled ETF1/eRF1. Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2. May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65.
Uniprot ID
Q96BH1
Ensemble ID
ENST00000295704.7
HGNC ID
HGNC:14662

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IPM
 Probe Info  		C360(1.33)  LDD1702  [2]
DBIA
 Probe Info  		C198(1.53); C201(1.53)  LDD0080  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C360(1.06); C316(1.01); C159(1.04)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C198(1.02); C201(1.02)  LDD0813  [3]
 LDCM0226  AC11 HEK-293T C198(1.05); C201(1.05)  LDD0824  [3]
 LDCM0237  AC12 HEK-293T C198(1.10); C201(1.10)  LDD0835  [3]
 LDCM0259  AC14 HEK-293T C198(1.00); C201(1.00)  LDD0857  [3]
 LDCM0270  AC15 HEK-293T C198(1.03); C201(1.03)  LDD0868  [3]
 LDCM0276  AC17 HEK-293T C360(1.09); C316(0.99); C159(0.93)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C360(1.05); C316(0.89); C159(1.11)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C360(1.41); C316(1.28); C159(1.22); C201(0.69)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C360(1.00); C316(0.98); C159(0.99)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C360(0.96); C316(1.12)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C360(0.98); C316(0.96); C159(0.91)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C360(1.02); C316(1.06); C159(0.97)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C360(0.91); C316(0.95); C159(0.90)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C360(0.97); C316(0.96)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C198(1.25); C201(1.25)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C198(1.06); C201(1.06)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C198(1.14); C201(1.14)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C198(1.12); C201(1.12)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C198(1.14); C201(1.14)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C360(1.03); C316(1.02); C159(1.09); C201(1.07)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C198(1.24); C201(1.24)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C198(1.53); C201(1.53)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C198(0.98); C201(0.98)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C198(1.19); C201(1.19)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C198(1.09); C201(1.09)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C198(0.93); C201(0.93)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C198(1.35); C201(1.35)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C198(1.11); C201(1.11)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C198(1.10); C201(1.10)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C198(0.97); C201(0.97)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C360(1.01); C316(0.99)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C198(1.15); C201(1.15)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C198(0.92); C201(0.92)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C198(1.23); C201(1.23)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C198(0.94); C201(0.94)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C198(0.90); C201(0.90)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C198(0.95); C201(0.95)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C198(1.12); C201(1.12)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C198(0.97); C201(0.97)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C198(0.91); C201(0.91)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C198(0.99); C201(0.99)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C360(1.01); C316(1.02); C159(0.88)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C198(0.95); C201(0.95)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C198(0.97); C201(0.97)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C198(0.97); C201(0.97)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C198(0.95); C201(0.95)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C198(1.02); C201(1.02)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C198(0.87); C201(0.87)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C198(1.20); C201(1.20)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C360(1.03); C316(0.99); C159(1.04)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C360(1.02); C316(0.96); C159(1.08)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C360(0.99); C316(1.01); C159(1.20); C201(0.87)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C198(0.94); C201(0.94)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C360(0.96); C316(1.08)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C360(1.05); C316(0.97); C159(0.96)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C360(0.95); C316(0.97); C159(1.06)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C360(1.05); C316(1.10); C159(1.05)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C360(0.94); C316(1.09)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C198(1.00); C201(1.00)  LDD0932  [3]
 LDCM0345  AC8 HEK-293T C198(0.84); C201(0.84)  LDD0943  [3]
 LDCM0248  AKOS034007472 HEK-293T C198(1.03); C201(1.03)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C198(1.05); C201(1.05)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C198(0.90); C201(0.90)  LDD0873  [3]
 LDCM0156  Aniline NCI-H1299 11.56  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C360(0.81); C316(0.92)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C360(0.83); C316(0.96); C159(0.50)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C360(1.05); C316(1.05); C138(0.94); C198(0.80)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C198(0.83); C201(0.83)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C198(0.84); C201(0.84)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C198(1.07); C201(1.07)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C198(0.86); C201(0.86)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C360(1.06); C316(1.04)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C360(1.01); C316(0.95); C159(1.08)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C360(1.01); C316(0.98)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C360(1.00); C316(1.10); C138(0.85); C198(0.96)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C360(0.79); C316(0.99)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C360(0.96); C316(1.21); C159(0.63)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C360(1.02); C316(1.00); C159(1.02)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C360(1.01); C316(0.92)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C198(1.05); C201(1.05)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C198(1.01); C201(1.01)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C198(1.01); C201(1.01)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C198(0.96); C201(0.96)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C198(1.16); C201(1.16)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C198(1.03); C201(1.03)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C198(1.06); C201(1.06)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C198(1.08); C201(1.08)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C360(0.89); C316(1.12)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C198(0.94); C201(0.94)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C198(1.00); C201(1.00)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C198(0.98); C201(0.98)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C198(0.90); C201(0.90)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C198(0.95); C201(0.95)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C360(0.86); C316(0.92)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C360(1.02); C316(1.05); C159(1.15)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C360(1.01); C316(0.98)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C360(0.97); C316(0.94); C138(1.09); C198(0.79)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C360(1.02); C316(1.09)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C360(0.96); C316(1.14); C159(1.01)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C360(0.96); C316(0.89)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C360(0.95); C316(1.14); C138(0.86); C198(1.28)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C360(0.98); C316(0.95); C159(0.73)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C360(1.06); C316(1.08); C159(0.59)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C360(0.94); C316(1.13); C159(0.65); C201(0.98)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C360(0.97); C316(1.20); C159(0.92)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C360(0.97); C316(1.13)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C360(0.96); C316(1.14); C159(0.54)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C360(0.92); C316(1.00); C159(0.52)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C360(0.99); C316(1.28); C159(0.58)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C360(0.91); C316(1.10)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C360(0.97); C316(0.95)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C360(0.99); C316(1.05); C159(1.18)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C360(1.03); C316(0.95)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C360(0.90); C316(0.98); C138(1.17); C198(1.20)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C360(1.13); C316(1.00); C159(0.77)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C360(0.93); C316(0.94)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C360(0.97); C316(0.96); C159(0.74)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C360(0.98); C316(1.10); C159(0.52); C201(1.24)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C360(1.00); C316(1.07)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C360(0.99); C316(1.03); C159(0.53)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C360(1.04); C316(1.03); C159(0.50)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C360(1.01); C316(1.15); C159(0.50)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C360(0.94); C316(1.02)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C360(0.85); C316(1.07)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C360(0.95); C316(0.98)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C360(0.91); C316(1.10); C138(0.99); C198(1.06)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C360(0.96); C316(1.15); C138(0.94); C198(1.15)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C360(0.99); C316(1.02); C159(0.80)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C360(0.97); C316(0.99); C159(0.66)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C360(1.00); C316(1.10); C159(0.49); C201(1.20)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C360(1.02); C316(1.16)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C360(1.11); C316(1.14); C159(0.51)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C198(1.13); C201(1.13)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C198(1.12); C201(1.12)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C198(1.13); C201(1.13)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C198(1.13); C201(1.13)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C360(0.99); C316(1.14); C159(0.79)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C198(1.16); C201(1.16)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C198(0.99); C201(0.99)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C198(1.05); C201(1.05)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C198(1.02); C201(1.02)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C198(0.94); C201(0.94)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C198(0.99); C201(0.99)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C198(1.05); C201(1.05)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C198(0.95); C201(0.95)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C198(1.28); C201(1.28)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C198(1.05); C201(1.05)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C360(0.99); C316(1.00); C159(0.65)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C198(1.04); C201(1.04)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C360(0.91); C316(0.98)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C360(0.97); C316(1.00); C159(1.13)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C360(0.99); C316(0.93)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C360(0.96); C316(1.47); C138(1.04); C198(1.23)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C360(1.02); C316(1.09); C159(0.86)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C360(1.15); C316(1.03); C159(0.65)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C360(0.94); C316(1.15); C159(0.63); C201(0.87)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C360(0.91); C316(1.02)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C360(0.95); C316(1.00); C159(0.56)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C360(0.88); C316(1.18); C159(0.60); C201(0.98)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C360(0.93); C316(1.03); C159(0.56)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C360(1.03); C316(1.10); C159(0.55)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C360(0.94); C316(0.97)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C360(0.86); C316(0.99)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C360(1.05); C316(1.00); C159(1.34)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C360(1.04); C316(1.11); C138(0.92); C198(1.07)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C360(1.03); C316(0.97); C159(0.85)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C360(1.03); C316(1.03); C159(0.71)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C360(0.95); C316(1.13); C159(0.62); C201(1.19)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C360(0.85); C316(0.91)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C360(0.97); C316(0.98)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C360(1.04); C316(1.05); C159(0.60)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C360(0.96); C316(1.00); C159(0.54)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C360(1.06); C316(0.96); C159(0.59)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C360(0.94); C316(0.91)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C360(0.79); C316(0.91)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C360(1.02); C316(1.13); C159(1.17)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C360(0.98); C316(0.97)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C360(1.06); C316(1.10); C138(1.08); C198(0.78)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C360(1.03); C316(0.95); C159(0.94)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C360(0.98); C316(1.08); C159(0.50)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C360(1.06); C316(0.92); C159(0.78)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C360(0.95); C316(1.08); C159(0.75); C201(0.89)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C360(0.93); C316(1.08)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C360(1.00); C316(1.04); C159(0.55)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C360(1.07); C316(1.06); C159(0.54)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C360(1.15); C316(1.08); C159(0.60)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C360(0.93); C316(1.02)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C360(0.82); C316(0.95)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C360(1.09); C316(1.14); C159(1.10)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C360(1.03); C316(0.96)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C360(1.05); C316(1.00)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C360(1.33)  LDD1702  [2]
 LDCM0468  Fragment33 HEK-293T C360(0.95); C316(0.92)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C360(1.01); C316(1.16); C159(1.06)  LDD1631  [8]
 LDCM0022  KB02 HCT 116 C198(1.53); C201(1.53)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C198(1.29); C201(1.29)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C198(1.21); C201(1.21)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) Ubiquitin-conjugating enzyme family P51668
Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Ubiquitin-conjugating enzyme family P62837
Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) Ubiquitin-conjugating enzyme family P61077
Ubiquitin-conjugating enzyme E2 D4 (UBE2D4) Ubiquitin-conjugating enzyme family Q9Y2X8
Ubiquitin-conjugating enzyme E2 E1 (UBE2E1) Ubiquitin-conjugating enzyme family P51965
Ubiquitin-conjugating enzyme E2 E3 (UBE2E3) Ubiquitin-conjugating enzyme family Q969T4
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein naked cuticle homolog 2 (NKD2) NKD family Q969F2
BTB/POZ domain-containing protein KCTD21 (KCTD21) . Q4G0X4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402