Details of the Target

General Information of Target

Target ID LDTP10086
Target Name DNA dC->dU-editing enzyme APOBEC-3D (APOBEC3D)
Gene Name APOBEC3D
Synonyms
APOBEC3DE; DNA dC->dU-editing enzyme APOBEC-3D; A3D; A3DE; EC 3.5.4.38
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVR
EIPPQSRGMYSNRMRSYKQEMGKLETDFKRSRIAYSDEVRNELLGDDGNSSENQRAHLLD
NTERLERSSRRLEAGYQIAVETEQIGQEMLENLSHDREKIQRARERLRETDANLGKSSRI
LTGMLRRIIQNRILLVILGIIVVITILMAITFSVRRH
Target Bioclass
Enzyme
Family
Cytidine and deoxycytidylate deaminase family
Subcellular location
Cytoplasm
Function
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Inhibits also the mobility of LTR and non-LTR retrotransposons.; (Microbial infection) Enhances hepatitis B virus/HBV replication by excluding restriction factors APOBEC3F and APOBEC3G from HBV capsids.
Uniprot ID
Q96AK3
Ensemble ID
ENST00000216099.13
HGNC ID
HGNC:17354

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C261(1.38)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C261(1.38)  LDD0531  [1]
 LDCM0279  AC2 HCT 116 C261(1.48)  LDD0596  [1]
 LDCM0290  AC3 HCT 116 C261(1.34)  LDD0607  [1]
 LDCM0301  AC4 HCT 116 C261(1.52)  LDD0618  [1]
 LDCM0312  AC5 HCT 116 C261(1.43)  LDD0629  [1]
 LDCM0020  ARS-1620 HCC44 C261(1.03)  LDD2171  [1]
 LDCM0369  CL100 HCT 116 C261(1.20)  LDD0686  [1]
 LDCM0420  CL31 HCT 116 C261(0.83)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C261(0.96)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C261(0.81)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C261(1.19)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C261(1.20)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C261(1.46)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C261(1.52)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C261(1.18)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C261(1.25)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C261(1.23)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C261(1.25)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C261(1.20)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C261(1.16)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C261(1.01)  LDD0752  [1]
 LDCM0453  CL61 HCT 116 C261(1.34)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C261(1.53)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C261(1.22)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C261(1.11)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C261(1.28)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C261(1.45)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C261(1.17)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C261(1.40)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C261(1.31)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C261(1.24)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C261(1.02)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C261(1.32)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C261(1.37)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C261(1.29)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C261(1.36)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C261(1.06)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C261(1.11)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C261(1.48)  LDD0789  [1]
 LDCM0474  CL80 HCT 116 C261(1.15)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C261(1.24)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C261(1.75)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C261(1.78)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C261(1.70)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C261(1.14)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C261(1.10)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C261(1.23)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C261(1.46)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C261(1.79)  LDD0800  [1]
 LDCM0485  CL90 HCT 116 C261(0.89)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C261(1.22)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C261(1.09)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C261(1.09)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C261(1.11)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C261(1.25)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C261(1.18)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C261(1.30)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C261(1.68)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C261(1.35)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C261(1.61)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C261(1.54)  LDD0744  [1]
 LDCM0022  KB02 769-P C36(1.58)  LDD2246  [3]
 LDCM0023  KB03 769-P C36(2.07)  LDD2663  [3]
 LDCM0024  KB05 COLO792 C36(0.91)  LDD3310  [3]
 LDCM0131  RA190 MM1.R C320(1.61)  LDD0304  [4]
 LDCM0021  THZ1 HCT 116 C261(1.03)  LDD2173  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.