Details of the Target

General Information of Target

Target ID LDTP10048
Target Name tRNA modification GTPase GTPBP3, mitochondrial (GTPBP3)
Gene Name GTPBP3
Gene ID 84705
Synonyms
MTGP1; tRNA modification GTPase GTPBP3, mitochondrial; GTP-binding protein 3; Mitochondrial GTP-binding protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHES
RATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGC
EDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVH
KMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQ
SIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTAL
ISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRL
GSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNY
EHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQ
SGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNN
LVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHD
AYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRRTAHAFKISKIYKPLLFMDLLDERT
LVAVERPLDDIIAQLPPPIKKKKFGT
Target Bioclass
Enzyme
Family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, TrmE GTPase family
Subcellular location
Mitochondrion
Function GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
Uniprot ID
Q969Y2
Ensemble ID
ENST00000324894.13
HGNC ID
HGNC:14880

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.R136Ter .
CAOV3 SNV: p.E309G DBIA    Probe Info 
COLO320 Substitution: p.H60P .
JURKAT SNV: p.R320W .
MDAMB453 SNV: p.D181G .
MV411 SNV: p.P68S DBIA    Probe Info 
NCIH358 SNV: p.S451Ter DBIA    Probe Info 
OCIAML2 SNV: p.T53P DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C210(3.93)  LDD3314  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C398(0.00); C489(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C489(0.00); C398(0.00)  LDD0036  [3]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [4]
Lodoacetamide azide
 Probe Info  		C489(0.00); C398(0.00); C419(0.00)  LDD0037  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Phosphinate-6
 Probe Info  		C46(0.00); C188(0.00)  LDD0018  [7]
AOyne
 Probe Info  		11.20  LDD0443  [8]
NAIA_5
 Probe Info  		C20(0.00); C489(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C188(1.02); C441(0.97); C489(0.84)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C188(1.11); C441(1.03)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C188(0.98); C46(1.13)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C188(1.02); C46(1.01)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C188(1.01); C441(0.97); C46(1.21)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C188(0.93); C441(0.95); C46(1.10)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C188(1.00); C441(0.91); C489(0.93)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C188(0.95); C441(1.05)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C188(1.11); C46(1.15)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C188(0.97); C441(1.01)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C188(0.98); C46(1.00)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C188(1.01); C441(0.99); C46(1.06)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C188(1.00); C441(0.91); C46(1.09)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C188(0.94); C441(0.94); C46(0.99)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C188(0.97); C46(1.10)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C188(1.00); C441(1.06); C489(0.84)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C188(0.95); C441(0.94)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C188(1.00); C46(1.03)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C188(0.99); C46(0.96)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C188(0.98); C441(1.09); C46(1.05)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C188(0.97); C46(0.94)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C188(0.98); C441(1.03); C46(1.02)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C188(0.93); C441(0.88); C46(1.03)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C188(1.03); C46(1.07)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C188(1.01); C441(1.10); C489(1.08)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C188(0.93); C441(1.10)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C188(0.98); C46(1.09)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C188(1.02); C46(0.99)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C188(0.98); C441(1.19); C46(1.06)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C188(0.99); C441(0.96); C46(1.13)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C188(0.97); C441(1.00); C46(1.06)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C188(1.00); C46(0.96)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C188(0.93); C46(1.02)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C188(1.00); C441(1.06); C489(0.75)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C188(1.11); C441(1.09)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C188(1.02); C46(1.09)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C188(1.11); C46(1.00)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C188(0.98); C441(1.04); C46(1.01)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C188(1.03); C441(0.96); C46(1.04)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C188(1.04); C441(1.15); C46(1.03)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C188(1.05); C46(1.06)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C188(1.03); C441(0.94); C489(0.89)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C188(0.95); C441(1.08); C46(0.86)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C188(1.13); C441(1.07)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C188(1.04); C46(1.08)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C188(1.10); C46(1.02)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C188(1.01); C441(1.08); C46(1.06)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C188(1.04); C441(0.96); C46(1.06)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C188(0.96); C441(1.04); C46(0.95)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C188(1.00); C46(1.04)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C188(1.03); C441(0.90); C489(0.89)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C188(1.05); C441(0.98)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C188(1.02); C46(0.97)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C188(0.99); C441(1.08); C46(0.95)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C188(1.10); C46(0.95)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C188(1.07); C441(1.10); C46(0.91)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C188(1.02); C441(1.07); C46(0.88)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C188(1.02); C441(0.97); C46(1.06)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C188(1.02); C46(0.95)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C188(0.88); C441(0.96); C46(1.06)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C188(0.97); C46(0.91)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C188(0.98); C441(1.10); C46(1.07)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C188(1.02); C441(1.01); C489(0.85)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C188(1.00); C46(1.06)  LDD1514  [10]
 LDCM0367  CL1 HEK-293T C188(1.23)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C188(0.98); C441(0.97); C46(1.21)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C188(1.01); C441(0.88)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C188(1.08)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C188(1.06); C441(1.03)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C188(0.97); C441(1.16); C46(1.06)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C188(1.02); C441(0.98)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C188(1.08)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C188(1.04); C441(0.92)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C188(1.02); C441(1.28); C46(1.10)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C188(1.00); C441(0.94)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C188(1.08)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C188(1.05); C441(0.92); C46(1.00)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C188(1.03); C441(1.05)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C188(0.96); C441(1.12); C46(0.99)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C188(0.96); C441(0.83)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C188(1.06)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C188(1.07); C441(1.06)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C188(1.00); C441(1.17); C46(1.01)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C188(1.00); C441(0.97)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C188(1.08)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C188(1.11); C441(0.91)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C188(1.04); C441(1.20); C46(1.08)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C188(1.14); C46(1.38)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C188(1.02); C441(0.94)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C188(1.12)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C188(1.02); C441(1.07)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C188(0.97); C441(1.08); C46(0.91)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C188(1.08); C441(0.86)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C188(1.21)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C188(1.07); C441(1.05)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C188(1.01); C441(1.13); C46(0.90)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C188(1.02); C441(0.94)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C188(1.18)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C188(1.05); C441(0.92)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C188(0.96); C441(1.00); C46(0.90)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C188(1.02); C441(1.08)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C188(1.06); C441(0.91); C489(0.96)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C188(0.93); C441(1.07)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C188(1.10); C46(1.21)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C188(1.03); C441(1.01)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C188(0.96); C46(1.16)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C188(1.19); C441(1.10); C46(1.51)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C188(0.99); C441(1.01); C46(1.74)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C188(1.02); C441(1.03); C46(1.13)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C188(0.94); C46(1.57)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C188(1.24)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C188(1.01); C441(0.93)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C188(0.99); C441(1.10); C46(1.11)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C188(1.00); C441(1.08)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C188(1.02); C441(0.93); C489(0.85)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C188(0.95); C441(0.99); C46(1.03)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C188(1.07); C441(1.10)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C188(0.99); C46(1.22)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C188(1.08); C46(1.16)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C188(1.14); C441(0.96); C46(1.42)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C188(1.02); C441(1.00); C46(1.60)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C188(0.91); C441(0.96); C46(1.08)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C188(0.98); C46(1.49)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C188(1.09)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C188(1.03); C441(1.06); C46(1.04)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C188(1.02); C441(0.98)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C188(1.02); C441(0.82)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C188(0.97); C441(0.96); C489(0.63)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C188(1.11); C441(1.05)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C188(1.04); C46(1.23)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C188(1.01); C46(1.16)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C188(1.04); C441(0.98); C46(1.49)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C188(1.03); C441(0.94); C46(1.68)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C188(0.98); C441(0.92); C46(1.18)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C188(0.98); C46(1.46)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C188(1.21)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C188(0.99); C441(1.03); C489(0.92)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C188(1.00); C441(0.98)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C188(1.02); C441(0.82)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C188(1.04); C441(1.04); C489(0.95)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C188(1.14); C441(1.05)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C188(1.02); C46(1.23)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C188(1.08); C46(1.17)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C188(1.12); C441(1.41); C46(1.50)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C188(1.11); C441(0.91); C46(1.71)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C188(1.03); C441(1.10); C46(1.13)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C188(1.10); C441(1.09)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C188(1.11); C46(1.41)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C188(1.18)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C188(1.07); C441(0.98)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C188(1.01); C441(0.98); C46(1.05)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C188(1.09); C441(0.85)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C188(1.06); C441(0.96); C489(0.89)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C188(0.98); C441(1.03)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C188(1.00); C46(1.17)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C188(1.07); C46(1.17)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C188(0.99); C441(1.13); C46(1.40)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C188(1.20); C46(1.05)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C188(0.99); C441(1.00); C46(1.44)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C188(1.00); C441(1.04); C46(1.04)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C188(1.00); C46(1.55)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C188(1.19)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C188(1.05); C441(1.01)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C188(1.06); C441(0.84)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C188(1.05); C441(1.03); C489(0.74)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C188(1.06); C441(1.01)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C188(0.98); C46(1.16)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C188(1.45); C46(0.92)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C188(1.11); C46(1.18)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C188(0.98); C441(1.18); C46(1.65)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C188(1.02); C441(1.10); C46(1.43)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C188(0.96); C441(1.04); C46(1.05)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C188(1.04); C46(1.26)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C188(1.21)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C188(1.11); C441(0.96)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C188(1.04); C441(1.10); C46(0.88)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C188(1.04); C441(0.92)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C188(1.09); C441(1.08); C489(0.85)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C188(1.08); C441(1.13); C46(1.37)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C188(1.28); C441(0.98)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C188(1.11); C46(1.12)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C188(1.08); C46(1.06)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C188(1.15); C441(1.06); C46(1.26)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C188(1.04); C441(0.98); C46(1.21)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C188(1.03); C441(1.17); C46(1.22)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C188(1.08); C46(1.05)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C188(1.10)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C188(1.00); C441(1.10)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C188(0.92); C441(1.10); C46(0.86)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C188(1.05); C441(1.04); C46(1.08)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C188(2.17)  LDD1702  [11]
 LDCM0468  Fragment33 HEK-293T C188(1.03); C441(1.10); C46(0.97)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C188(1.02); C441(1.00)  LDD1631  [10]
 LDCM0022  KB02 HEK-293T C441(1.04); C188(0.97)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C441(0.99); C188(1.06)  LDD1497  [10]
 LDCM0024  KB05 IGR37 C210(3.93)  LDD3314  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
COP9 signalosome complex subunit 5 (COPS5) Peptidase M67A family Q92905
ATP-dependent 6-phosphofructokinase, liver type (PFKL) Phosphofructokinase type A (PFKA) family P17858
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) UDP-N-acetylglucosamine 2-epimerase family; ROK (NagC/XylR) family Q9Y223
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein 90 homolog (ZFP90) Krueppel C2H2-type zinc-finger protein family Q8TF47
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Reticulocalbin-1 (RCN1) CREC family Q15293
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Protein INCA1 (INCA1) INCA family Q0VD86
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
LRP chaperone MESD (MESD) MESD family Q14696
Centromere protein R (ITGB3BP) . Q13352
Coiled-coil domain-containing protein 32 (CCDC32) . Q9BV29
Developmental pluripotency-associated protein 4 (DPPA4) . Q7L190
Phostensin (PPP1R18) . Q6NYC8
SERTA domain-containing protein 3 (SERTAD3) . Q9UJW9
TAR DNA-binding protein 43 (TARDBP) . Q13148
TBC1 domain family member 3G (TBC1D3G) . Q6DHY5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761