Details of the Target

General Information of Target

Target ID LDTP09908
Target Name Amyloid beta precursor protein binding family B member 2 (APBB2)
Gene Name APBB2
Gene ID 323
Synonyms
FE65L; FE65L1; Amyloid beta precursor protein binding family B member 2; Amyloid-beta; A4) precursor protein-binding family B member 2; Protein Fe65-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
AGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKE
GIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPG
PAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLK
KYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPA
TQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPA
TDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSP
HAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFV
INAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIP
ANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKD
VTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQ
ELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGS
DYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRA
ACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPV
DNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDN
PHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTC
CTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALP
STPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDE
LTKEMAHLEGLMKDLNAITTA
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum
Function
Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength. Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning. Activates transcription of APP.
Uniprot ID
Q92870
Ensemble ID
ENST00000295974.12
HGNC ID
HGNC:582

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K738(5.42); K749(6.38)  LDD0277  [2]
DBIA
 Probe Info  		C561(3.96); C447(3.09)  LDD3311  [3]
BTD
 Probe Info  		C245(0.67)  LDD2121  [4]
IA-alkyne
 Probe Info  		C652(1.29)  LDD2184  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
IPM
 Probe Info  		C245(0.00); C560(0.00)  LDD0147  [7]
TFBX
 Probe Info  		C446(0.00); C545(0.00)  LDD0148  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C446(1.02); C709(0.88); C560(1.05); C245(0.94)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C446(1.16); C709(1.01); C560(0.95); C148(1.09)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C446(0.97); C709(1.02); C560(1.00); C245(1.02)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C709(1.01); C560(1.07); C245(1.06)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C446(0.82); C709(1.01); C560(1.07)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C446(0.98); C709(1.01); C560(0.99); C245(1.07)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C446(0.87); C709(1.08); C560(1.11); C245(1.04)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C446(1.03); C709(0.93); C560(0.99); C148(1.05)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C446(0.90); C709(1.32); C560(1.37); C245(1.00)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C446(1.03); C709(0.93); C560(1.06); C148(0.97)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C709(1.02); C560(0.98); C245(1.10)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C446(1.00); C709(1.03); C560(0.96); C148(0.95)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C446(0.88); C709(0.97); C560(1.06)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C446(0.96); C709(0.93); C560(1.00); C245(1.09)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C446(0.93); C709(0.90); C560(0.94); C245(1.02)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C446(0.98); C709(0.92); C560(0.99); C245(1.10)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C446(1.13); C709(0.93); C560(1.00); C148(1.06)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C446(0.93); C709(0.91); C560(1.03); C245(0.96)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C709(1.05); C560(0.99); C245(1.09)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C446(1.02); C709(0.97); C560(1.03); C148(0.95)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C446(1.00); C709(0.98); C560(1.17); C245(0.90)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C446(0.97); C709(0.96); C560(0.98)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C446(1.00); C709(0.95); C560(0.97); C245(1.04)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C446(0.94); C709(0.94); C560(1.08); C245(1.06)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C446(1.10); C709(0.87); C560(0.98); C245(1.20)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C446(1.03); C709(0.96); C560(1.01); C148(1.11)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C446(0.96); C709(0.96); C560(1.03); C245(0.96)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C709(1.03); C560(1.17); C245(1.11)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C446(1.04); C709(0.98); C560(1.03); C148(1.18)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C446(0.93); C709(1.06); C560(1.01)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C446(1.03); C709(0.94); C560(0.98); C245(1.04)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C709(0.98); C560(1.03); C245(1.07)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C446(1.01); C709(1.01); C560(1.09); C245(0.97)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C446(0.98); C709(0.95); C560(0.97); C245(1.06)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C446(0.95); C709(0.92); C560(1.28); C148(1.14)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C446(0.96); C709(0.95); C560(1.02); C245(0.96)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C709(1.13); C560(1.19); C245(1.06)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C446(1.06); C709(0.99); C560(1.08); C148(0.98)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C446(0.95); C709(0.95); C560(1.01)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C446(0.97); C709(1.00); C560(1.08); C245(1.03)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C446(1.00); C709(1.06); C560(1.04); C245(1.03)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C446(1.08); C709(0.98); C560(1.02); C245(0.97)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C446(1.01); C709(0.95); C560(1.02); C148(1.08)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C446(1.10); C709(0.95); C560(1.03); C148(1.13)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C446(0.97); C709(1.06); C560(0.97); C245(1.04)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C709(1.02); C560(1.06); C245(1.10)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C446(0.99); C709(1.04); C560(1.02); C148(0.89)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C446(0.97); C709(1.05); C560(0.96)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C446(0.99); C709(0.91); C560(0.97); C245(1.07)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C446(0.97); C709(1.05); C560(1.01); C245(0.97)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C446(1.15); C709(0.96); C560(1.07); C245(1.05)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C446(1.00); C709(0.92); C560(1.10); C148(1.09)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C446(0.97); C709(0.92); C560(1.03); C245(0.95)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C446(0.83); C709(1.20); C560(0.98)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C709(1.07); C560(1.11); C245(1.10)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C446(1.03); C709(1.01); C560(1.00); C148(0.87)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C446(0.85); C709(0.97); C560(1.09)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C446(1.18); C709(0.94); C560(0.98); C245(0.94)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C446(0.90); C709(1.02); C560(1.11); C245(0.89)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C446(0.92); C709(1.06); C560(0.98); C245(1.00)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C446(1.07); C709(1.07); C560(1.04); C245(0.99)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C446(0.95); C709(1.04); C560(0.96); C148(0.88)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C446(0.98); C709(1.00); C560(1.04); C245(1.10)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C446(0.96); C709(0.97); C560(1.04); C245(1.00)  LDD1514  [9]
 LDCM0156  Aniline NCI-H1299 11.75  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C446(1.16); C709(0.81); C560(1.11); C245(0.92)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C446(0.72); C709(1.00); C560(0.99)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C446(1.06); C709(0.94); C560(1.12); C148(1.06)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C446(1.14); C709(0.94); C560(1.08); C245(0.92)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C446(0.96); C709(1.07); C560(0.97); C148(0.95)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C446(1.16); C709(1.09); C560(0.99)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C446(0.99); C709(1.00); C560(1.11); C148(0.89)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C446(0.98); C709(0.91); C560(1.08); C245(0.99)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C446(1.01); C709(0.89); C560(0.89); C148(0.95)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C446(0.99); C709(0.92); C560(0.93)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C446(0.90); C709(0.94); C560(1.07); C148(0.95)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C446(1.01); C709(1.00); C560(1.05); C245(1.06)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C446(1.09); C709(1.00); C560(0.96); C245(0.99)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C446(0.93); C709(0.92); C560(0.93); C148(0.96)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C446(1.12); C709(0.82); C560(1.05)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C446(0.99); C709(0.99); C560(1.20); C148(0.91)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C446(1.18); C709(0.89); C560(1.00); C245(0.92)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C446(1.13); C709(0.94); C560(0.95); C148(0.94)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C446(1.13); C709(0.95); C560(1.02)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C446(0.99); C709(1.00); C560(1.06); C148(0.95)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C446(1.18); C709(0.96); C560(1.11); C245(1.04)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C446(1.17); C709(1.04); C560(1.02); C148(1.04)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C446(1.07); C709(0.86); C560(1.00)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C446(0.98); C709(1.03); C560(1.08); C245(1.04)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C446(0.98); C709(1.01); C560(1.09); C148(1.17)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C446(1.01); C709(0.87); C560(1.02); C245(1.06)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C446(1.06); C709(0.90); C560(1.07); C148(1.09)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C446(0.90); C709(0.80); C560(0.96)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C446(1.04); C709(1.04); C560(1.09); C148(0.98)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C446(1.18); C709(0.90); C560(1.11); C245(0.83)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C446(1.02); C709(1.01); C560(0.94); C148(0.99)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C446(1.04); C709(0.87); C560(1.08)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C446(1.02); C709(0.92); C560(1.14); C148(0.84)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C446(1.20); C709(0.92); C560(1.19); C245(0.96)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C446(1.10); C709(0.95); C560(0.96); C148(0.90)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C446(1.08); C709(1.04); C560(1.11)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C446(0.95); C709(1.20); C560(1.00); C148(1.08)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C446(0.99); C709(0.94); C560(1.02); C245(1.01)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C446(1.16); C709(1.03); C560(1.07); C148(1.33)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C446(0.97); C709(1.04); C560(0.98); C245(1.13)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C446(0.94); C709(0.91); C560(0.95); C148(1.10)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C709(1.10); C560(1.05); C245(1.17)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C446(0.95); C709(0.94); C560(0.97); C148(1.20)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C446(0.89); C709(1.02); C560(1.03)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C446(1.11); C709(1.10); C560(1.07); C245(1.13)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C446(0.99); C709(1.04); C560(1.11); C245(1.10)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C446(1.13); C709(0.94); C560(1.06); C245(0.90)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C446(1.03); C709(0.94); C560(0.93); C148(1.03)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C446(1.11); C709(0.91); C560(0.92)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C446(1.06); C709(0.91); C560(0.91); C148(1.14)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C446(1.03); C709(1.01); C560(0.96); C245(1.27)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C446(1.01); C709(1.02); C560(1.06)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C446(1.11); C709(0.93); C560(0.95); C148(1.25)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C446(0.98); C709(1.01); C560(0.99); C245(1.02)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C709(1.06); C560(0.99); C245(1.37)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C446(0.98); C709(0.96); C560(0.92); C148(1.08)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C446(1.14); C709(0.96); C560(0.87)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C446(0.94); C709(0.98); C560(0.97); C245(1.17)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C446(0.99); C709(1.08); C560(1.09); C245(1.17)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C446(1.05); C709(0.88); C560(1.05); C245(0.89)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C446(1.03); C709(0.83); C560(0.97)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C446(1.04); C709(1.01); C560(0.92); C148(1.08)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C446(1.18); C709(0.95); C560(1.08); C148(1.47)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C446(1.03); C709(1.05); C560(0.99); C245(1.32)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C446(1.14); C709(0.88); C560(1.00); C148(1.02)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C446(0.99); C709(0.99); C560(0.99); C245(0.97)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C709(1.07); C560(1.08); C245(1.39)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C446(1.08); C709(1.04); C560(0.89); C148(1.20)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C446(0.95); C709(1.03); C560(0.94)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C446(1.05); C709(1.02); C560(0.96); C245(1.05)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C446(1.04); C709(1.05); C560(1.02); C245(1.18)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C446(1.06); C709(0.78); C560(1.12); C245(0.83)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C446(0.99); C709(1.03); C560(1.06); C245(0.88)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C446(1.01); C709(0.94); C560(0.94); C148(1.01)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C446(1.06); C709(1.06); C560(1.04); C148(1.15)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C446(0.95); C709(0.93); C560(1.02); C245(1.22)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C446(0.90); C709(0.92); C560(1.02); C148(1.04)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C446(0.91); C709(1.04); C560(0.92); C245(1.15)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C709(1.20); C560(1.15); C245(1.18)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C446(0.93); C709(1.38); C560(1.00); C148(1.23)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C446(0.94); C709(1.06); C560(0.92)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C446(1.06); C709(1.18); C560(1.14); C245(1.09)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C446(1.02); C709(0.98); C560(1.06); C148(1.26)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C446(1.08); C709(1.09); C560(1.07); C245(1.12)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C446(1.30); C709(0.89); C560(1.16); C245(0.92)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C446(1.05); C709(0.97); C560(0.97); C148(1.13)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C446(0.94); C709(0.85); C560(1.06)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C446(0.99); C709(0.93); C560(1.02); C148(1.00)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C446(0.99); C709(0.90); C560(1.02); C245(1.20)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C446(1.07); C709(0.93); C560(1.02); C148(1.49)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C446(0.90); C709(0.92); C560(1.06); C245(1.13)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C709(1.05); C560(1.14); C245(1.09)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C446(0.93); C709(0.97); C560(1.03); C148(1.24)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C446(0.89); C709(1.04); C560(1.04); C245(0.90)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C446(1.13); C709(0.98); C560(1.15)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C446(1.21); C709(0.99); C560(1.02); C245(1.07)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C446(1.02); C709(1.11); C560(1.09); C245(1.09)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C446(1.05); C709(0.92); C560(1.08); C245(0.89)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C446(1.11); C709(0.93); C560(0.86); C148(1.01)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C446(1.06); C709(1.00); C560(1.02); C148(1.01)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C446(0.96); C709(0.99); C560(1.10); C245(1.11)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C446(1.16); C709(0.97); C560(0.93); C148(1.09)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C446(0.95); C709(1.07); C560(1.05); C245(1.15)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C709(1.09); C560(1.16); C245(0.96)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C709(1.09); C560(1.05); C245(1.03)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C446(1.05); C709(1.01); C560(1.06); C148(0.99)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C446(1.11); C709(0.95); C560(0.98)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C446(1.03); C709(1.02); C560(1.07); C245(0.98)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C446(1.08); C709(0.98); C560(1.00); C245(0.95)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C446(1.20); C709(0.85); C560(1.04); C245(0.83)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C446(1.04); C709(1.10); C560(0.97); C148(0.90)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C446(1.26); C709(0.89); C560(1.03)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C446(0.97); C709(0.96); C560(1.10); C148(0.94)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C446(1.13); C709(0.88); C560(1.09); C245(0.81)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C446(0.94); C709(1.03); C560(1.09); C148(1.63)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C446(0.90); C709(0.96); C560(0.92); C148(0.89)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C446(0.96); C709(0.96); C560(1.00); C245(0.89)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C709(1.13); C560(1.07); C245(1.01)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C446(0.95); C709(1.07); C560(0.97); C148(0.96)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C446(1.01); C709(1.07); C560(1.10)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C446(0.88); C709(1.19); C560(1.01); C245(1.10)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C446(0.95); C709(1.07); C560(1.07); C245(0.83)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C446(0.99); C709(0.96); C560(1.05); C245(1.01)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C446(1.03); C709(1.06); C560(0.98); C148(0.92)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C446(1.11); C709(0.95); C560(0.93)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C446(1.12); C709(1.01); C560(0.91)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C245(2.24); C560(1.58)  LDD1702  [4]
 LDCM0625  F8 Ramos C652(1.80)  LDD2187  [5]
 LDCM0573  Fragment11 Ramos C652(0.10)  LDD2190  [5]
 LDCM0576  Fragment14 Ramos C652(1.43)  LDD2193  [5]
 LDCM0468  Fragment33 HEK-293T C446(1.09); C709(0.80); C560(0.94)  LDD1671  [9]
 LDCM0566  Fragment4 Ramos C652(1.29)  LDD2184  [5]
 LDCM0427  Fragment51 HEK-293T C446(1.03); C709(1.03); C560(1.01); C148(1.12)  LDD1631  [9]
 LDCM0569  Fragment7 Ramos C652(4.81)  LDD2186  [5]
 LDCM0022  KB02 HEK-293T C245(0.93); C709(0.79); C560(0.99); C446(0.95)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C245(1.02); C709(0.89); C560(1.00); C446(0.97)  LDD1497  [9]
 LDCM0024  KB05 G361 C561(3.96); C447(3.09)  LDD3311  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C245(0.67)  LDD2121  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C245(0.65)  LDD2150  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha/beta hydrolase domain-containing protein 17C (ABHD17C) ABHD17 family Q6PCB6
Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) Aldo/keto reductase family O43488
Phosphatidate cytidylyltransferase 2 (CDS2) CDS family O95674
DNA-directed RNA polymerase III subunit RPC6 (POLR3F) Eukaryotic RPC34/RPC39 RNA polymerase subunit family Q9H1D9
Eyes absent homolog 3 (EYA3) EYA family Q99504
Hexokinase-3 (HK3) Hexokinase family P52790
Polyamine deacetylase HDAC10 (HDAC10) Histone deacetylase family Q969S8
Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2) MsrB Met sulfoxide reductase family Q9Y3D2
E3 SUMO-protein ligase PIAS1 (PIAS1) PIAS family O75925
Protein prune homolog 2 (PRUNE2) PPase class C family Q8WUY3
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) AGC Ser/Thr protein kinase family P17612
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
Zinc-regulated GTPase metalloprotein activator 1C (ZNG1C) SIMIBI class G3E GTPase family Q5JTY5
ADP-ribosylation factor-like protein 16 (ARL16) Arf family Q0P5N6
Ras-related protein Rab-6C (RAB6C) Rab family Q9H0N0
Inactive C-alpha-formylglycine-generating enzyme 2 (SUMF2) Sulfatase-modifying factor family Q8NBJ7
Ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) Ubiquitin-conjugating enzyme family Q13404
G/T mismatch-specific thymine DNA glycosylase (TDG) TDG/mug family Q13569
E3 ubiquitin-protein ligase MYLIP (MYLIP) . Q8WY64
E3 ubiquitin-protein ligase RNF183 (RNF183) . Q96D59
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Voltage-dependent anion-selective channel protein 2 (VDAC2) Eukaryotic mitochondrial porin family P45880
Transcription factor
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A5 (HOXA5) Antp homeobox family P20719
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) BZIP family P18847
Homeobox protein DLX-3 (DLX3) Distal-less homeobox family O60479
Transcription factor E2F8 (E2F8) E2F/DP family A0AVK6
Zinc finger and BTB domain-containing protein 17 (ZBTB17) Krueppel C2H2-type zinc-finger protein family Q13105
Visual system homeobox 2 (VSX2) Paired homeobox family P58304
Pituitary homeobox 1 (PITX1) Paired homeobox family P78337
Achaete-scute homolog 4 (ASCL4) . Q6XD76
Forkhead box protein R1 (FOXR1) . Q6PIV2
Homeobox protein MOX-1 (MEOX1) . P50221
Transcription factor SOX-7 (SOX7) . Q9BT81
Zinc finger protein 366 (ZNF366) . Q8N895
Zinc fingers and homeoboxes protein 1, isoform 2 (ZHX1-C8orf76) . Q96EF9
Other
Click To Hide/Show 33 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-modifying factor (BMF) Bcl-2 family Q96LC9
Cyclin-C (CCNC) Cyclin family P24863
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
RNA polymerase II elongation factor ELL2 (ELL2) ELL/occludin family O00472
Nck-associated protein 1 (NCKAP1) HEM-1/HEM-2 family Q9Y2A7
Baculoviral IAP repeat-containing protein 5 (BIRC5) IAP family O15392
Kinesin light chain 3 (KLC3) Kinesin light chain family Q6P597
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Protein Mis18-beta (OIP5) Mis18 family O43482
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
Phosphofurin acidic cluster sorting protein 1 (PACS1) PACS family Q6VY07
Histone deacetylase complex subunit SAP30 (SAP30) SAP30 family O75446
Spermatogenesis-associated protein 2-like protein (SPATA2L) SPATA2 family Q8IUW3
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
Tigger transposable element-derived protein 1 (TIGD1) Tigger transposable element derived protein family Q96MW7
Bublin coiled-coil protein (BBLN) UPF0184 (EST00098) family Q9BUW7
Zinc finger HIT domain-containing protein 1 (ZNHIT1) ZNHIT1 family O43257
Abscission/NoCut checkpoint regulator (ZFYVE19) . Q96K21
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Enkurin (ENKUR) . Q8TC29
Fanconi anemia group G protein (FANCG) . O15287
Period circadian protein homolog 1 (PER1) . O15534
Pleckstrin homology domain-containing family G member 7 (PLEKHG7) . Q6ZR37
Protein MGARP (MGARP) . Q8TDB4
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34
Putative uncharacterized protein encoded by LINC00518 (LINC00518) . Q8N0U6
Shieldin complex subunit 1 (SHLD1) . Q8IYI0
Sperm-associated microtubule inner protein 4 (SPMIP4) . Q8N865
Spermatogenesis-associated protein 12 (SPATA12) . Q7Z6I5
Spindle assembly abnormal protein 6 homolog (SASS6) . Q6UVJ0
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) . Q7Z698
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402