Details of the Target

General Information of Target

Target ID LDTP09869
Target Name Zinc finger protein neuro-d4 (DPF1)
Gene Name DPF1
Gene ID 8193
Synonyms
BAF45B; NEUD4; Zinc finger protein neuro-d4; BRG1-associated factor 45B; BAF45B; D4, zinc and double PHD fingers family 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWLPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCL
TPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGP
TPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKF
GLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGGA
FLTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPAS
LVDAVLTWVLPKPAQAVY
Target Bioclass
Other
Family
Requiem/DPF family
Subcellular location
Cytoplasm
Function
May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Uniprot ID
Q92782
Ensemble ID
ENST00000355526.10
HGNC ID
HGNC:20225

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C122(138.31)  LDD0209  [1]
NAIA_4
 Probe Info  		C122(0.00); C141(0.00)  LDD2226  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]
Phosphinate-6
 Probe Info  		C95(0.00); C122(0.00); C322(0.00)  LDD0018  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C50(0.96); C128(1.00); C122(1.07); C149(1.07)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C50(0.98); C128(1.26); C122(1.02); C149(1.07)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C50(1.14); C149(0.94); C79(1.10); C269(0.88)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C50(0.98); C128(1.02); C122(1.03); C269(1.04)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C50(1.02); C128(1.10); C122(1.11); C149(1.16)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C50(0.84); C128(1.12); C122(1.03); C149(1.05)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C50(0.94); C128(1.07); C122(0.97); C149(0.96)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C50(0.99); C128(1.07); C122(1.03); C149(0.98)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C50(1.53); C149(0.98); C79(1.35); C269(1.24)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C50(1.02); C128(0.88); C122(1.02); C149(0.96)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C50(1.05); C128(1.08); C122(1.05); C269(1.01)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C128(1.02); C122(1.05); C149(1.10); C79(1.03)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C50(1.09); C128(1.11); C122(1.15); C149(1.11)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C50(0.94); C128(1.09); C122(1.00); C149(0.91)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C50(1.11); C79(0.86)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C50(0.89); C128(1.00); C122(1.00); C149(0.96)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C50(0.92); C128(1.12); C122(1.05); C149(0.94)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C50(1.03); C149(0.88); C79(0.98); C269(0.94)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C50(1.06); C128(1.10); C122(1.09); C269(0.91)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C128(1.06); C122(1.07); C149(1.12); C79(1.17)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C50(1.25); C149(0.89); C79(1.21); C269(1.00)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C50(0.95); C128(1.12); C122(1.12); C149(1.11)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C50(1.12); C128(1.08); C122(1.00); C149(1.02)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C50(0.86); C79(1.03)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C50(1.05); C128(0.98); C122(1.04); C149(1.08)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C50(1.05); C128(1.32); C122(1.04); C149(1.06)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C50(1.07); C149(1.02); C79(1.06); C269(1.04)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C50(1.07); C128(1.14); C122(0.99); C269(0.76)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C128(1.07); C122(1.06); C149(1.07); C79(1.16)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C50(1.08); C128(1.16); C122(1.03); C149(1.18)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C50(0.86); C128(1.08); C122(1.01); C149(1.00)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C50(0.95); C128(1.03); C122(1.05); C269(0.82)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C50(0.98); C79(0.96)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C50(1.01); C128(1.14); C122(1.00); C149(1.01)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C50(0.76); C128(1.33); C122(1.05); C149(0.88)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C50(1.11); C149(0.92); C79(1.03); C269(1.04)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C50(1.09); C128(1.09); C122(0.98); C269(1.03)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C128(1.16); C122(1.10); C149(1.13); C79(1.10)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C50(1.15); C128(1.06); C122(1.09); C149(1.32)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C50(0.87); C128(1.06); C122(1.00); C149(1.13)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C50(0.98); C79(0.90)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C50(0.95); C128(0.99); C122(0.95); C149(1.00)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C128(0.95); C122(1.08); C149(1.20); C79(0.92)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C50(1.23); C128(1.12); C122(1.05); C149(0.95)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C50(1.18); C149(1.02); C79(1.25); C269(1.08)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C50(1.05); C128(1.12); C122(1.03); C269(0.93)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C128(1.03); C122(1.03); C149(1.08); C79(1.04)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C50(1.04); C128(1.12); C122(1.03); C149(1.31)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C50(1.04); C128(1.03); C122(0.99); C149(0.98)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C50(0.93); C79(0.96)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C50(1.08); C128(1.03); C122(1.08); C149(0.98)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C50(0.86); C128(1.15); C122(1.05); C149(0.92)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C50(1.34); C149(0.93); C79(1.10); C269(0.97)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C50(1.10); C128(0.94); C122(1.16); C149(1.16)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C50(0.96); C128(1.13); C122(1.03); C269(1.06)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C128(1.15); C122(1.16); C149(1.08); C79(1.56)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C50(0.97); C128(1.25); C122(1.07); C149(1.06)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C50(1.05); C128(1.19); C122(1.05); C149(0.97)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C50(0.92); C79(0.85)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C50(1.18); C128(0.97); C122(0.96); C149(0.92)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C50(0.95); C79(0.94)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C128(1.07); C122(1.12); C149(0.86); C79(1.14)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C50(1.03); C128(0.94); C122(1.00); C149(1.02)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C50(0.97); C79(0.81)  LDD1514  [5]
 LDCM0367  CL1 HEK-293T C50(0.96); C128(1.08); C122(0.89); C149(1.02)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C50(0.87); C128(0.73); C122(1.23); C149(1.15)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C128(1.13); C79(0.96)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C50(0.74); C128(1.09); C122(0.98); C149(0.97)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C50(0.88); C128(1.10); C122(1.04); C79(0.93)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C50(1.03); C128(1.14); C122(1.02); C269(0.95)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C128(1.17); C79(1.07)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C50(0.80); C128(1.00); C122(0.95); C149(1.06)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C50(0.91); C128(1.05); C122(1.03); C79(0.97)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C50(0.93); C128(1.08); C122(0.99); C269(0.73)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C128(1.27); C79(0.93)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C50(0.89); C128(0.98); C122(0.89); C149(1.07)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C50(1.15); C128(0.74); C122(0.99); C149(1.20)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C50(1.13); C128(1.12); C122(0.99); C79(0.87)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C50(0.94); C128(1.08); C122(1.03); C269(0.87)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C128(1.19); C79(0.99)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C50(1.19); C128(1.07); C122(0.91); C149(1.00)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C50(1.00); C128(1.21); C122(1.01); C79(0.84)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C50(0.94); C128(1.11); C122(0.99); C269(0.97)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C128(1.16); C79(1.02)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C50(1.23); C128(1.04); C122(1.00); C149(1.05)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C50(1.07); C128(1.01); C122(1.08); C79(1.15)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C50(0.93); C128(1.07); C122(0.99); C269(1.09)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C50(0.96); C79(0.92)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C128(1.20); C79(1.10)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C50(1.03); C128(1.03); C122(0.97); C149(0.91)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C50(1.05); C128(1.05); C122(1.02); C79(0.98)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C50(0.87); C128(1.07); C122(0.96); C269(0.97)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C128(1.23); C79(0.97)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C50(1.01); C128(1.11); C122(0.92); C149(0.98)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C50(0.94); C128(0.97); C122(1.08); C79(0.97)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C50(0.97); C128(1.11); C122(1.01); C269(0.79)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C128(1.36); C79(1.14)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C50(1.20); C128(1.17); C122(0.92); C149(1.02)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C50(1.04); C128(1.00); C122(1.02); C79(1.10)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C50(1.04); C128(1.29); C122(1.07); C269(1.15)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C128(1.12); C79(0.98)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C50(0.86); C128(1.05); C122(1.04); C149(1.18)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C50(0.77); C128(1.03); C122(1.05); C149(1.09)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C50(1.05); C149(1.01); C79(1.18); C269(0.93)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C50(0.88); C128(0.97); C122(0.99); C79(0.98)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C50(1.01); C128(0.95); C122(1.05); C269(0.95)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C128(0.72); C122(1.13); C149(1.17); C79(1.06)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C50(1.07); C128(0.73); C122(1.08); C149(1.24)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C50(1.18); C128(0.81); C122(1.02); C149(1.19)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C50(0.88); C79(0.95)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C50(0.82); C128(1.02); C122(0.90); C149(1.00)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C50(1.03); C128(1.02); C122(1.05); C79(0.89)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C50(0.94); C128(1.09); C122(1.01); C269(1.22)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C128(1.15); C79(0.91)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C50(0.94); C128(1.03); C122(0.98); C149(0.99)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C50(1.00); C128(1.18); C122(0.97); C269(1.30)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C50(1.00); C128(0.98); C122(1.04); C149(1.01)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C50(1.03); C149(0.87); C79(0.98); C269(0.91)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C50(1.03); C128(1.01); C122(1.00); C269(0.98)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C128(0.74); C122(1.09); C149(1.07); C79(0.87)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C50(1.08); C128(0.75); C122(1.09); C149(1.28)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C50(1.15); C128(0.80); C122(1.09); C149(1.06)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C50(0.93); C79(0.89)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C50(0.89); C128(1.05); C122(0.90); C149(1.02)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C50(0.94); C128(0.98); C122(1.08); C269(0.93)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C128(1.25); C79(1.02)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C128(1.00); C79(0.99)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C50(1.00); C128(1.09); C122(0.96); C149(1.04)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C50(1.06); C128(0.90); C122(1.09); C149(1.05)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C50(1.29); C149(0.88); C79(0.95); C269(0.83)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C50(1.02); C128(1.00); C122(1.13); C269(1.04)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C128(0.73); C122(1.23); C149(0.92); C79(1.37)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C50(1.07); C128(0.77); C122(1.10); C149(1.33)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C50(1.02); C128(0.74); C122(1.07); C149(1.15)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C50(0.98); C79(0.98)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C50(0.96); C128(1.04); C122(0.89); C149(0.98)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C50(0.85); C128(1.09); C122(0.95); C149(0.96)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C50(1.39); C128(1.07); C122(1.02); C79(1.11)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C128(1.12); C79(0.97)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C50(0.92); C128(1.14); C122(1.08); C149(0.95)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C50(0.85); C128(1.04); C122(0.99); C149(1.10)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C50(1.14); C149(1.10); C79(1.12); C269(0.94)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C50(1.02); C128(1.05); C122(1.11); C269(1.02)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C128(0.86); C122(1.33); C149(1.23); C79(1.04)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C50(0.99); C128(0.78); C122(1.04); C149(1.27)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C50(0.96); C128(0.83); C122(1.11); C149(1.25)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C50(0.75); C128(1.05); C122(1.02); C149(1.04)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C50(1.18); C79(0.97)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C50(0.89); C128(1.09); C122(0.89); C149(1.01)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C50(1.11); C128(0.96); C122(1.02); C79(1.01)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C50(1.06); C128(1.12); C122(0.93); C269(0.73)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C128(1.12); C79(1.11)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C50(1.02); C128(1.07); C122(1.01); C149(1.06)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C50(1.03); C128(1.00); C122(1.08); C149(1.07)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C50(1.07); C149(1.00); C79(1.26); C269(1.13)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C50(0.99); C128(1.00); C122(1.10); C269(1.07)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C128(0.78); C122(1.10); C149(0.96); C79(1.01)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C50(0.89); C149(1.15); C79(1.16); C269(1.21)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C50(1.00); C128(0.76); C122(1.09); C149(1.12)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C50(0.97); C128(0.75); C122(1.01); C149(1.19)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C50(0.96); C79(0.89)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C50(0.84); C128(1.07); C122(0.94); C149(1.12)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C50(0.85); C128(0.98); C122(1.02); C79(0.92)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C128(1.09); C79(0.98)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C50(0.93); C128(1.00); C122(0.97); C149(0.99)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C50(0.87); C128(1.08); C122(1.04); C149(1.00)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C50(1.07); C149(0.90); C79(0.93); C269(1.07)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C50(0.95); C128(1.11); C122(1.14); C269(0.91)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C50(0.98); C128(1.01); C122(1.11); C269(1.02)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C128(0.79); C122(1.06); C149(1.08); C79(1.20)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C50(1.12); C128(0.78); C122(1.02); C149(1.18)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C50(1.07); C128(0.83); C122(1.05); C149(1.06)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C50(0.88); C79(0.93)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C50(0.99); C128(1.14); C122(0.88); C149(0.91)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C50(0.88); C128(0.88); C122(1.05); C79(1.07)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C50(0.99); C128(1.14); C122(0.98); C269(0.98)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C128(1.29); C79(1.11)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C50(0.98); C128(0.92); C122(0.99); C149(1.00)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C128(0.81); C122(1.17); C149(1.11); C79(1.08)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C50(0.73); C128(1.21); C122(1.10); C149(0.87)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C50(0.98); C149(0.89); C79(0.98); C269(0.92)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C50(0.97); C128(1.14); C122(1.00); C269(0.87)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C128(0.90); C122(1.14); C149(1.13); C79(0.94)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C50(0.97); C128(0.86); C122(1.09); C149(1.30)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C50(1.06); C128(0.89); C122(1.19); C149(0.99)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C50(0.91); C79(0.92)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C50(1.03); C128(1.01); C122(0.87); C149(1.00)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C50(1.04); C128(0.98); C122(1.03); C79(1.12)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C50(0.92); C128(1.04); C122(0.97); C269(0.82)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C50(1.04); C128(1.09); C122(1.05); C269(0.71)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C50(1.02); C128(1.06); C122(0.96); C269(1.05)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C50(1.05); C128(0.96); C122(1.09); C79(1.02)  LDD1631  [5]
 LDCM0022  KB02 HEK-293T C50(0.99); C122(0.94); C128(1.04); C269(0.95)  LDD1492  [5]
 LDCM0023  KB03 Jurkat C122(138.31)  LDD0209  [1]
 LDCM0024  KB05 HEK-293T C50(1.26); C122(0.94); C128(1.11); C269(0.93)  LDD1502  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase subunit NDUFA4 (NDUFA4) Complex IV NDUFA4 subunit family O00483
Caspase-6 (CASP6) Peptidase C14A family P55212
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) Classic translation factor GTPase family P41091
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1) WD repeat G protein beta family P62873
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PHD finger protein 1 (PHF1) Polycomblike family O43189
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
Gelsolin (GSN) Villin/gelsolin family P06396
General transcription factor 3C polypeptide 3 (GTF3C3) . Q9Y5Q9
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402