Details of the Target

General Information of Target

Target ID LDTP09743
Target Name Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial (CHCHD10)
Gene Name CHCHD10
Gene ID 400916
Synonyms
C22orf16; Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; Protein N27C7-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRGSRSAASRPASRPAAPSAHPPAHPPPSAAAPAPAPSGQPGLMAQMATTAAGVAVGSA
VGHVMGSALTGAFSGGSSEPSQPAVQQAPTPAAPQPLQMGPCAYEIRQFLDCSTTQSDLS
LCEGFSEALKQCKYYHGLSSLP
Target Bioclass
Other
Subcellular location
Mitochondrion intermembrane space
Function May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure.
Uniprot ID
Q8WYQ3
Ensemble ID
ENST00000484558.3
HGNC ID
HGNC:15559

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C122(5.55)  LDD1706  [1]
Acrolein
 Probe Info  		N.A.  LDD0227  [2]
DBIA
 Probe Info  		C112(7.59); C122(7.59)  LDD0080  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C112(1.15); C122(1.15)  LDD0531  [3]
 LDCM0216  AC100 PaTu 8988t C112(1.04); C122(1.04)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C112(0.99); C122(0.99)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C112(0.94); C122(0.94)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C112(1.03); C122(1.03)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C112(0.93); C122(0.93)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C112(1.04); C122(1.04)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C112(1.06); C122(1.06)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C112(0.94); C122(0.94)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C112(1.46); C122(1.46)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C112(1.24); C122(1.24)  LDD1104  [3]
 LDCM0227  AC110 PaTu 8988t C112(1.40); C122(1.40)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C112(1.90); C122(1.90)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C112(1.03); C122(1.03)  LDD1108  [3]
 LDCM0230  AC113 HEK-293T C122(0.83)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C122(1.57)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C122(1.48)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C122(2.04)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C122(1.86)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C122(1.84)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C122(1.89)  LDD0834  [3]
 LDCM0238  AC120 HEK-293T C122(1.24)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C122(1.49)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C122(1.90)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C122(1.14)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C122(1.34)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C122(2.48)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C122(1.28)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C122(1.32)  LDD0843  [3]
 LDCM0279  AC2 HCT 116 C112(1.51); C122(1.51)  LDD0596  [3]
 LDCM0285  AC25 HEK-293T C122(0.81)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C122(0.80)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C122(0.98)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C122(0.78)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C122(0.64)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C112(0.98); C122(0.98)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C122(0.96)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C122(1.11)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C122(0.71)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C122(0.85)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C122(1.58)  LDD0893  [3]
 LDCM0301  AC4 HCT 116 C112(0.90); C122(0.90)  LDD0618  [3]
 LDCM0312  AC5 HCT 116 C112(1.01); C122(1.01)  LDD0629  [3]
 LDCM0365  AC98 PaTu 8988t C112(1.04); C122(1.04)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C112(1.17); C122(1.17)  LDD1245  [3]
 LDCM0367  CL1 HCT 116 C112(1.32); C122(1.32)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C112(1.43); C122(1.43)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C112(1.36); C122(1.36)  LDD0686  [3]
 LDCM0379  CL11 HCT 116 C112(1.10); C122(1.10)  LDD0696  [3]
 LDCM0382  CL112 HEK-293T C122(0.79)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C122(0.98)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C122(0.62)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C122(0.81)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C122(0.78)  LDD0984  [3]
 LDCM0390  CL12 HCT 116 C112(1.73); C122(1.73)  LDD0707  [3]
 LDCM0400  CL13 HCT 116 C112(0.65); C122(0.65)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C112(0.95); C122(0.95)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C112(1.23); C122(1.23)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C112(1.45); C122(1.45)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C112(1.76); C122(1.76)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C112(1.29); C122(1.29)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C112(1.92); C122(1.92)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C112(1.02); C122(1.02)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C112(2.03); C122(2.03)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C112(1.91); C122(1.91)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C112(2.63); C122(2.63)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C112(2.03); C122(2.03)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C112(2.29); C122(2.29)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C112(1.19); C122(1.19)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C112(1.25); C122(1.25)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C112(2.56); C122(2.56)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C112(1.67); C122(1.67)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C112(1.65); C122(1.65)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C112(1.24); C122(1.24)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C112(2.31); C122(2.31)  LDD0736  [3]
 LDCM0420  CL31 PaTu 8988t C112(1.08); C122(1.08)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C112(1.05); C122(1.05)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C112(0.95); C122(0.95)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C112(1.95); C122(1.95)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C112(1.64); C122(1.64)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C112(0.52); C122(0.52)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C112(1.28); C122(1.28)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C112(0.97); C122(0.97)  LDD1307  [3]
 LDCM0429  CL4 HCT 116 C112(1.06); C122(1.06)  LDD0746  [3]
 LDCM0430  CL40 PaTu 8988t C112(1.18); C122(1.18)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C112(1.00); C122(1.00)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C112(3.38); C122(3.38)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C112(2.02); C122(2.02)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C112(1.19); C122(1.19)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C112(1.13); C122(1.13)  LDD1314  [3]
 LDCM0436  CL46 HEK-293T C122(1.33)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C122(1.03)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C122(1.24)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C122(1.10)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C112(1.21); C122(1.21)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C122(0.89)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C122(0.89)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C122(1.24)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C122(1.15)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C122(0.94)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C122(1.08)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C122(0.87)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C122(1.23)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C122(1.08)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C122(1.11)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C112(1.34); C122(1.34)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C122(1.02)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C112(1.17); C122(1.17)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C112(0.81); C122(0.81)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C112(1.19); C122(1.19)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C112(1.03); C122(1.03)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C112(0.76); C122(0.76)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C112(1.11); C122(1.11)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C112(1.15); C122(1.15)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C112(0.81); C122(0.81)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C112(0.64); C122(0.64)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C112(1.91); C122(1.91)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C112(1.17); C122(1.17)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C112(1.12); C122(1.12)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C112(0.71); C122(0.71)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C112(0.69); C122(0.69)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C112(1.18); C122(1.18)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C112(0.91); C122(0.91)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C112(0.58); C122(0.58)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C112(0.62); C122(0.62)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C112(1.66); C122(1.66)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C112(1.18); C122(1.18)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C112(1.00); C122(1.00)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C112(1.06); C122(1.06)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C112(1.23); C122(1.23)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C112(0.90); C122(0.90)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C112(1.14); C122(1.14)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C112(0.74); C122(0.74)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C112(0.67); C122(0.67)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C112(0.50); C122(0.50)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C112(1.03); C122(1.03)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C112(1.04); C122(1.04)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C112(1.25); C122(1.25)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C112(0.36); C122(0.36)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C112(0.75); C122(0.75)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C112(0.93); C122(0.93)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C112(0.71); C122(0.71)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C112(1.64); C122(1.64)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C112(1.13); C122(1.13)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C112(1.20); C122(1.20)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C112(1.33); C122(1.33)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C112(1.78); C122(1.78)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C112(0.97); C122(0.97)  LDD0811  [3]
 LDCM0468  Fragment33 HCT 116 C112(0.82); C122(0.82)  LDD0785  [3]
 LDCM0427  Fragment51 PaTu 8988t C112(1.14); C122(1.14)  LDD1306  [3]
 LDCM0022  KB02 HCT 116 C112(7.59); C122(7.59)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C112(4.85); C122(4.85)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C112(6.36); C122(6.36)  LDD0082  [3]
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MICOS complex subunit MIC60 (IMMT) MICOS complex subunit Mic60 family Q16891
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (CHCHD2) . Q9Y6H1

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019