Details of the Target

General Information of Target

Target ID LDTP09233
Target Name F-box DNA helicase 1 (FBH1)
Gene Name FBH1
Gene ID 84893
Synonyms
FBX18; FBXO18; F-box DNA helicase 1; hFBH1; EC 5.6.2.4; DNA 3'-5' helicase 1; F-box only protein 18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRRFKRKHLTAIDCQHLARSHLAVTQPFGQRWTNRDPNHGLYPKPRTKRGSRGQGSQRCI
PEFFLAGKQPCTNDMAKSNSVGQDSCQDSEGDMIFPAESSCALPQEGSAGPGSPGSAPPS
RKRSWSSEEESNQATGTSRWDGVSKKAPRHHLSVPCTRPREARQEAEDSTSRLSAESGET
DQDAGDVGPDPIPDSYYGLLGTLPCQEALSHICSLPSEVLRHVFAFLPVEDLYWNLSLVC
HLWREIISDPLFIPWKKLYHRYLMNEEQAVSKVDGILSNCGIEKESDLCVLNLIRYTATT
KCSPSVDPERVLWSLRDHPLLPEAEACVRQHLPDLYAAAGGVNIWALVAAVVLLSSSVND
IQRLLFCLRRPSSTVTMPDVTETLYCIAVLLYAMREKGINISNRIHYNIFYCLYLQENSC
TQATKVKEEPSVWPGKKTIQLTHEQQLILNHKMEPLQVVKIMAFAGTGKTSTLVKYAEKW
SQSRFLYVTFNKSIAKQAERVFPSNVICKTFHSMAYGHIGRKYQSKKKLNLFKLTPFMVN
SVLAEGKGGFIRAKLVCKTLENFFASADEELTIDHVPIWCKNSQGQRVMVEQSEKLNGVL
EASRLWDNMRKLGECTEEAHQMTHDGYLKLWQLSKPSLASFDAIFVDEAQDCTPAIMNIV
LSQPCGKIFVGDPHQQIYTFRGAVNALFTVPHTHVFYLTQSFRFGVEIAYVGATILDVCK
RVRKKTLVGGNHQSGIRGDAKGQVALLSRTNANVFDEAVRVTEGEFPSRIHLIGGIKSFG
LDRIIDIWILLQPEEERRKQNLVIKDKFIRRWVHKEGFSGFKRYVTAAEDKELEAKIAVV
EKYNIRIPELVQRIEKCHIEDLDFAEYILGTVHKAKGLEFDTVHVLDDFVKVPCARHNLP
QLPHFRVESFSEDEWNLLYVAVTRAKKRLIMTKSLENILTLAGEYFLQAELTSNVLKTGV
VRCCVGQCNNAIPVDTVLTMKKLPITYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQV
RAMERTVENIVLPRHEALLFLVF
Target Bioclass
Enzyme
Family
Helicase family, UvrD subfamily
Subcellular location
Nucleus
Function
3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location.
Uniprot ID
Q8NFZ0
Ensemble ID
ENST00000362091.9
HGNC ID
HGNC:13620

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.H16Y; p.H151R .
COLO792 Substitution: p.H692Y .
HCC15 SNV: p.D194G DBIA    Probe Info 
HCT116 SNV: p.A1011V .
MDAMB468 SNV: p.G142A .
MFE319 SNV: p.L473P .
OVCAR4 SNV: p.N359Y .
RKO SNV: p.C289R .
RL952 SNV: p.V1031I DBIA    Probe Info 
SKMEL28 SNV: p.E569K DBIA    Probe Info 
SUPT1 SNV: p.P228L; p.R896Q .
SW756 SNV: p.S909Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C302(4.72)  LDD0209  [1]
N1
 Probe Info  		N.A.  LDD0245  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
NAIA_5
 Probe Info  		C302(0.00); C156(0.00); C508(0.00)  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C857(1.14); C580(1.06)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C508(1.01); C280(1.03)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C580(0.84)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C857(1.09); C280(1.18)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C857(1.17); C580(1.15)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C508(0.94); C289(1.00)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C857(0.86); C580(1.01)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C508(1.08); C280(1.02)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C580(0.76)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C508(0.94); C280(1.02)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C857(1.00); C280(1.21)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C857(0.90); C580(0.86); C289(1.01)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C857(1.06); C580(1.12)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C508(0.99); C289(0.89)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C857(1.07); C580(1.00); C508(0.90)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C857(0.97); C580(1.00)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C508(1.12); C280(1.00)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C580(1.00)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C857(1.03); C280(0.95)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C857(0.96); C580(1.03); C289(1.18)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C580(0.89)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C857(1.16); C580(1.10)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C508(0.87); C289(0.90)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C857(0.94); C580(0.96); C508(0.94)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C857(0.99); C580(1.08)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C508(1.07); C280(0.95)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C580(0.91)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C857(0.97); C280(1.04)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C857(0.96); C580(0.98); C289(0.95)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C857(1.17); C580(1.08)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C508(0.98); C289(1.04)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C857(0.99); C280(1.01)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C857(0.99); C580(0.97); C508(0.96)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C857(0.97); C580(1.01)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C508(1.07); C280(0.99)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C580(0.94)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C857(1.01); C280(0.99)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C857(1.15); C580(1.01); C289(1.31)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C857(1.24); C580(1.02)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C508(0.93); C289(1.08)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C857(1.10); C580(1.00); C508(1.08)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C857(1.02); C580(1.07)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C857(1.07); C580(0.96); C289(1.29)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C508(1.04); C280(1.01)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C580(0.89)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C857(1.10); C280(0.99)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C857(0.96); C580(0.98); C289(1.08)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C857(1.05); C580(1.17)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C508(0.88); C289(1.12)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C857(1.01); C580(1.06); C508(0.98)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C857(1.01); C580(1.10)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C508(1.00); C280(1.05)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C580(1.02)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C857(1.09); C580(1.00)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C857(1.56); C280(1.12)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C857(1.04); C580(0.99); C289(0.98)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C857(1.05); C580(1.08)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C508(0.97); C289(1.07)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C857(0.84); C580(1.06); C508(0.99)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C508(0.89); C289(0.87)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C857(1.09); C580(0.88); C508(1.13)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C857(0.90); C580(1.03); C289(1.32)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C857(1.06); C580(1.06)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C857(1.05); C580(0.88); C508(0.96)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C857(1.13)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C857(0.87); C580(0.91)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C857(0.72)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C857(1.30)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C857(0.95); C580(1.09)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C508(1.04)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C857(0.77)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C857(1.10)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C857(0.98); C580(0.97)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C508(1.00)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C857(0.91)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C857(1.52)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C508(0.83); C289(0.64)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C857(1.02); C580(1.13)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C508(1.01)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C857(0.95)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C857(1.42)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C857(0.93); C580(0.96)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C508(1.00)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C857(0.84)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C857(0.99)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C857(0.93); C580(1.09)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C508(1.10)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C857(1.25); C580(0.58); C508(1.04)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C857(0.84)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C857(1.30)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C857(0.99); C580(0.95)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C508(1.11)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C857(1.14)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C857(1.22)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C857(0.99); C580(1.08)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C508(1.10)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C857(0.63)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C857(0.97)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C857(1.12); C580(1.18)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C508(1.10)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C857(0.77)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C857(1.61); C580(0.82)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C508(1.07); C280(1.06)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C580(0.99)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C857(1.06); C580(1.09)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C857(1.15); C280(1.04)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C857(1.05); C580(0.61); C289(1.33)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C857(1.10); C580(0.92)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C508(0.84); C289(0.96)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C857(1.18); C580(1.34); C508(1.09)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C857(0.95)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C857(1.30); C580(1.08)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C508(1.08)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C857(0.96)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C857(0.86); C580(0.92)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C508(1.17)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C508(0.99); C280(1.02)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C580(0.80)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C857(0.96); C280(1.15)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C857(1.02); C580(0.79); C289(1.18)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C857(1.06); C580(0.92)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C508(0.72); C289(1.14)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C857(1.00); C580(0.78); C508(0.92)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C857(1.20)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C508(1.00)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C857(0.82)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C857(0.83)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C857(1.22); C580(1.16)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C508(1.01); C280(1.01)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C580(0.89)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C857(1.31); C280(0.99)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C857(0.87); C580(0.95); C289(0.63)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C857(1.11); C580(1.00)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C508(0.79); C289(0.93)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C857(0.94); C580(0.99); C508(0.95)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C857(1.28)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C857(1.02); C580(1.25)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C857(1.08); C580(1.16)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C857(1.39)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C857(0.98); C580(0.91)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C508(1.14); C280(1.26)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C580(0.88)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C857(1.22); C280(1.02)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C857(1.03); C580(0.78); C289(1.23)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C857(1.47); C580(0.98)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C508(0.81); C289(0.78)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C508(1.17); C280(1.03)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C857(1.00); C580(1.07); C508(0.93)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C857(1.12)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C857(1.10); C580(0.96)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C508(1.01)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C857(1.02)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C857(1.12); C580(1.15)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C508(1.01); C280(1.04)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C580(0.93)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C857(0.79); C280(1.08)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C857(1.02); C580(0.93); C289(1.16)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C580(0.86)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C857(1.11); C580(0.95)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C508(0.83); C289(0.91)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C857(1.27); C580(1.08); C508(1.01)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C857(1.12)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C857(1.05); C580(1.05)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C857(0.98)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C857(1.06); C580(0.97)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C508(0.98); C280(1.00)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C580(0.82)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C857(1.33); C280(1.11)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C857(0.92); C280(1.03)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C857(0.97); C580(1.06); C289(1.12)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C857(1.04); C580(1.08)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C508(0.88); C289(1.10)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C857(0.98); C580(1.07); C508(1.04)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C857(0.99)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C857(0.88); C580(0.98)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C508(1.01)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C857(0.87)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C857(0.93); C580(0.96)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C857(0.96); C580(0.91); C289(1.17)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C508(1.04); C280(1.20)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C580(0.88)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C857(1.07); C280(1.06)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C857(0.99); C580(0.80); C289(1.21)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C857(1.24); C580(0.98)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C508(0.90); C289(1.16)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C857(0.82); C580(1.07); C508(0.86)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C857(1.08)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C857(0.77); C580(0.99)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C508(0.98)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C508(0.98)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C508(0.92)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C857(0.81); C580(0.88)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C857(1.13)  LDD1492  [4]
 LDCM0023  KB03 Jurkat C302(4.72)  LDD0209  [1]
 LDCM0024  KB05 MEL167 C353(1.26)  LDD3316  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840