Details of the Target

General Information of Target

Target ID LDTP09101
Target Name E3 ubiquitin-protein ligase RNF169 (RNF169)
Gene Name RNF169
Gene ID 254225
Synonyms
KIAA1991; E3 ubiquitin-protein ligase RNF169; EC 2.3.2.27; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAGPSTRASSAAAAAALSRRGRRGRCDETAAAKTGAPGPASGPSLLVLSPPLLQPPLP
PRPEESGCAGCLEPPGEAAALPCGHSLCRGCAQRAADAAGPGCPRCRARGPGWARRRARD
DGQADSEVLGECARRSQPERCRPRRDGGAAAAGPRPEQEPRAAPAEPDFIFRAPIKLSKP
GELREEYESLRKLREEKLQEEKPSEDQIHKLLPEDTETGKRKMDEQKKRDEPLVLKTNLE
RCPARLSDSENEEPSRGQMTQTHRSAFVSKNNSYSLAFLAGKLNSKVERSQSCSDTAQER
AKSRVRAVPGNKAKVTTMTPASNPIIGVLLSTQNNRCVSAPDLTIEKRLPFSSLSSLASL
HKPERSVSPESNDSISEELNHFKPIVCSPCTPPKRLPDGRVLSPLIIKSTPRNLNRSLQK
QTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEMGEELLGSEGIHSSKEKPLVAV
NTRLSGGQVLSEYTGPTSADLDHFPSVSQTKAEQDSDNKSSTEIPLETCCSSELKGGGSG
TSLEREQFEGLGSTPDAKLDKTCISRAMKITTVNSVLPQNSVLGGVLKTKQQLKTLNHFD
LTNGVLVESLSEEPLPSLRRGRKRHCKTKHLEQNGSLKKLRQTSGEVGLAPTDPVLREME
QKLQQEEEDRQLALQLQRMFDNERRTVSRRKGSVDQYLLRSSNMAGAK
Target Bioclass
Enzyme
Family
RNF169 family
Subcellular location
Chromosome
Function
Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization. Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
Uniprot ID
Q8NCN4
Ensemble ID
ENST00000299563.5
HGNC ID
HGNC:26961

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K347(8.33)  LDD0274  [1]
m-APA
 Probe Info  		11.06  LDD0403  [2]
BTD
 Probe Info  		C28(2.27)  LDD2125  [3]
DBIA
 Probe Info  		C293(0.90)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
NAIA_5
 Probe Info  		C28(0.00); C337(0.00); C132(0.00)  LDD2224  [7]
TFBX
 Probe Info  		C103(0.00); C337(0.00); C242(0.00); C132(0.00)  LDD0027  [6]
Compound 10
 Probe Info  		C293(0.00); C337(0.00)  LDD2216  [8]
Compound 11
 Probe Info  		C293(0.00); C337(0.00)  LDD2213  [8]
ENE
 Probe Info  		N.A.  LDD0006  [9]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		C337(0.00); C563(0.00); C132(0.00); C103(0.00)  LDD0018  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C28(0.92)  LDD2142  [3]
 LDCM0025  4SU-RNA HEK-293T C337(2.45)  LDD0371  [12]
 LDCM0214  AC1 HEK-293T C529(0.93); C530(0.93)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C28(0.99); C337(1.01); C293(1.02); C103(1.06)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C28(1.13); C337(0.93); C293(1.08); C103(1.09)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C28(1.12); C337(1.03); C293(0.98); C103(0.93)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C28(1.07); C337(1.03); C293(1.04); C103(1.02)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C28(1.06); C337(1.07); C103(1.20); C529(0.96)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C28(1.12); C337(1.09); C103(1.02); C529(1.01)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C28(1.26); C337(0.91); C293(0.84); C103(0.95)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C28(1.80); C337(1.36); C293(1.51); C103(1.89)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C529(1.31); C530(1.31)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C28(1.08); C337(0.99); C293(1.12); C103(0.93)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C28(1.30); C337(1.06); C293(1.06)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C28(0.99); C337(0.98); C293(1.35); C103(1.07)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C28(1.16); C337(0.98); C103(1.07); C529(0.84)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C28(1.08); C337(0.98); C103(1.04)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C529(1.05); C530(1.05)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C529(1.41); C530(1.41)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C529(1.12); C530(1.12)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C529(0.97); C530(0.97)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C529(1.14); C530(1.14)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C529(1.07); C530(1.07)  LDD0888  [4]
 LDCM0291  AC30 HEK-293T C529(1.18); C530(1.18)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C529(1.33); C530(1.33)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C529(1.21); C530(1.21)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C529(1.25); C530(1.25)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C529(1.10); C530(1.10)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C529(1.14); C530(1.14)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C529(0.83); C530(0.83)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C529(0.90); C530(0.90)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C529(1.07); C530(1.07)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C529(1.19); C530(1.19)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C529(1.12); C530(1.12)  LDD0899  [4]
 LDCM0302  AC40 HEK-293T C529(1.04); C530(1.04)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C529(0.77); C530(0.77)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C529(0.92); C530(0.92)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C529(1.14); C530(1.14)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C529(0.78); C530(0.78)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C529(1.04); C530(1.04)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C529(0.77); C530(0.77)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C529(0.89); C530(0.89)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C529(0.78); C530(0.78)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C529(0.99); C530(0.99)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C529(1.50); C530(1.50)  LDD0910  [4]
 LDCM0313  AC50 HEK-293T C529(0.93); C530(0.93)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C529(1.04); C530(1.04)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C529(1.09); C530(1.09)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C529(1.24); C530(1.24)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C529(1.01); C530(1.01)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C529(1.00); C530(1.00)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C529(0.79); C530(0.79)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C28(1.01); C337(1.07); C103(1.06); C529(0.86)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C28(1.21); C337(0.99); C293(0.95); C103(0.93)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C28(0.94); C337(0.94); C293(0.99); C103(1.04)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C28(1.03); C337(1.07); C293(1.03); C103(1.13)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C28(1.12); C337(1.07); C293(0.82); C103(1.05)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C28(0.98); C337(1.02); C293(0.89)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C28(0.90); C337(1.12); C293(0.85); C103(0.90)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C28(0.90); C337(1.00); C103(1.07); C529(0.80)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C28(0.96); C337(1.04); C103(1.05)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C28(1.02); C337(1.02); C103(1.06); C529(1.10)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C28(0.93); C337(1.00); C103(1.05)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C28(1.12); C337(1.10); C293(0.93)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C28(1.10); C337(1.05); C103(0.98); C529(0.88)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C28(1.11); C337(1.03); C103(1.06)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 11.06  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C293(0.90)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C293(20.00); C28(0.65)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C28(1.02); C337(0.94); C293(1.03); C103(0.96)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C28(1.07); C337(1.04); C293(0.97); C103(0.93)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C529(0.97); C530(0.97)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C28(1.23); C337(1.20); C293(1.08); C103(0.99)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C28(1.16); C337(0.95); C293(1.18); C103(0.96)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C28(1.14); C337(0.96); C293(1.01); C103(1.02)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C28(1.10); C103(1.16); C529(0.88)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C28(1.31); C337(1.12); C293(0.99); C103(1.08)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C28(1.10); C337(0.93); C293(1.06); C103(1.08)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C28(0.95); C337(0.95); C293(0.88); C103(1.12)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C28(1.01); C103(1.07); C529(0.78)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C28(1.24); C337(0.95); C293(0.91); C103(1.11)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C28(0.90); C337(1.00); C103(1.01); C529(1.08)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C28(1.03); C337(0.92); C293(0.78); C103(0.89)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C28(0.96); C337(1.09); C293(1.02); C103(1.00)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C529(1.07); C530(1.07)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C529(1.03); C530(1.03)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C529(1.17); C530(1.17)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C529(0.98); C530(0.98)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C529(1.07); C530(1.07)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C529(1.24); C530(1.24)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C529(0.57); C530(0.57)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C529(0.72); C530(0.72)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C28(0.97); C337(1.06); C103(0.92)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C529(0.93); C530(0.93)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C529(0.76); C530(0.76)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C529(0.84); C530(0.84)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C529(1.27); C530(1.27)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C529(1.27); C530(1.27)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C28(1.01); C337(0.92); C293(0.95); C103(1.10)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C28(0.97); C337(1.04); C293(1.10); C103(0.99)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C28(0.98); C337(1.05); C293(1.00); C103(1.05)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C28(1.16); C103(0.94); C529(1.01)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C28(1.07); C337(0.90); C293(1.26); C103(1.05)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C28(1.05); C337(1.06); C293(1.00); C103(1.02)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C28(0.94); C337(1.12); C293(1.12); C103(1.13)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C28(0.94); C103(1.13); C529(0.94)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C28(1.03); C337(1.10); C103(1.03); C529(1.09)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C28(1.23); C337(0.97); C293(1.09); C103(1.03)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C28(1.20); C337(1.00); C293(1.11); C103(1.10)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C28(0.94); C337(1.03); C293(1.38); C103(0.97)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C28(1.18); C337(1.08); C293(0.85); C103(1.24)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C28(0.97); C337(1.09); C293(0.82)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C28(1.26); C337(1.07); C293(0.99); C103(0.98)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C28(1.07); C337(0.95); C103(1.04); C529(0.91)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C28(1.24); C337(1.00); C103(0.96)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C28(1.17); C337(1.23); C293(0.95); C103(0.87)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C28(1.13); C337(0.89); C293(0.93); C103(0.90)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C28(1.09); C337(0.97); C293(0.98); C103(1.13)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C28(1.03); C103(1.18); C529(1.01)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C28(1.22); C337(1.07); C103(1.00); C529(0.91)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C28(0.86); C337(1.17); C293(0.83); C103(1.13)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C28(1.36); C337(0.98); C293(1.07); C103(1.03)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C28(1.19); C337(0.96); C293(1.16); C103(1.00)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C28(1.32); C337(0.99); C293(1.72); C103(1.09)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C28(0.94); C337(1.03); C293(0.87)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C28(1.18); C337(1.06); C293(1.08); C103(0.95)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C28(1.25); C337(0.95); C103(1.06); C529(1.17)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C28(1.21); C337(0.99); C103(1.00)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C28(1.14); C337(1.05); C293(1.07); C103(1.01)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C28(1.15); C337(1.05); C293(0.99); C103(1.01)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C28(0.83); C103(1.08); C529(1.18)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C28(1.04); C103(1.35); C529(1.53)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C28(1.05); C337(1.08); C103(0.94); C529(0.97)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C28(0.94); C337(0.95); C293(0.89); C103(1.02)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C28(1.09); C337(0.98); C293(1.09); C103(1.00)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C28(1.14); C337(0.99); C293(0.96); C103(1.04)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C28(1.23); C337(1.13); C293(0.98)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C28(1.17); C337(1.14); C293(1.14); C103(1.08)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C28(1.02); C337(0.98); C103(1.10); C529(0.90)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C28(1.17); C337(1.06); C103(0.98)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C28(0.67); C337(1.01); C293(1.33); C103(0.96)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C28(1.13); C337(1.27); C103(1.07); C529(1.08)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C28(1.11); C337(0.98); C293(1.19); C103(1.13)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C28(1.07); C103(1.11); C529(0.96)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C28(1.09); C337(1.11); C103(1.04); C529(0.93)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C28(1.08); C337(0.92); C293(0.89); C103(0.96)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C28(1.09); C337(0.99); C293(1.08); C103(1.12)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C28(1.36); C337(1.03); C293(1.12); C103(0.88)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C28(1.23); C337(1.17); C293(1.08)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C28(1.20); C337(1.06); C293(1.56); C103(0.94)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C28(1.15); C337(1.00); C103(1.16); C529(0.95)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C28(0.92); C337(0.95); C293(1.05); C103(0.92)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C28(1.14); C337(1.03); C103(1.06)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C28(1.03); C337(1.02); C293(1.26); C103(0.96)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C28(1.10); C337(1.00); C293(1.00); C103(1.09)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C28(0.87); C337(1.08); C293(1.06); C103(1.15)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C28(1.03); C103(0.91); C529(0.94)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C28(1.13); C337(1.07); C103(1.00); C529(0.93)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C28(1.27); C337(0.98); C293(1.29); C103(0.80)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C28(1.09); C337(0.94); C293(1.04); C103(1.15)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C28(1.09); C337(1.03); C293(0.99); C103(1.02)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C28(1.30); C337(1.04); C293(1.45)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C28(0.94); C337(0.97); C293(1.09); C103(0.99)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C28(0.99); C337(1.03); C293(0.91); C103(1.08)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C28(1.20); C337(1.01); C103(1.16); C529(1.02)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C28(1.17); C337(1.06); C103(1.15)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C28(1.31); C337(0.97); C293(0.87); C103(0.94)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C28(1.14); C337(0.95); C293(1.12); C103(1.13)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C28(0.87); C103(1.03); C529(1.08)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C28(1.08); C337(1.12); C103(0.85); C529(0.75)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C28(1.39); C337(0.97); C293(1.09); C103(1.04)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C28(1.15); C337(0.97); C293(1.16); C103(1.02)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C28(1.00); C337(0.98); C293(0.84); C103(1.06)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C28(1.19); C337(0.98); C293(0.86); C103(1.05)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C28(1.28); C337(1.07); C293(0.94)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C28(1.08); C337(1.11); C293(0.93); C103(1.03)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C28(1.00); C337(1.00); C103(1.04); C529(1.07)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C28(1.32); C337(1.02); C103(0.98)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C28(0.97); C337(1.06); C293(1.32); C103(0.94)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C28(1.00); C337(1.00); C293(1.08); C103(0.88)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C28(1.03); C337(1.09); C293(1.07); C103(1.11)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C28(0.94); C103(1.11); C529(0.97)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C28(1.05); C337(1.08); C103(1.16); C529(0.87)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C28(1.14); C337(1.08); C293(1.40)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C28(0.71); C337(0.94); C293(0.89); C103(0.86)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C529(0.78); C530(0.78)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C529(1.54); C530(1.54)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C529(1.59); C530(1.59)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C529(1.34); C530(1.34)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C529(1.67); C530(1.67)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C529(1.76); C530(1.76)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C529(1.38); C530(1.38)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C529(1.52); C530(1.52)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C529(1.62); C530(1.62)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C28(1.08); C337(1.01); C293(1.08); C103(0.68)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C28(1.17); C337(1.04); C293(0.99); C103(1.14)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C28(1.12); C337(0.95); C293(1.27); C103(0.99)  LDD1631  [13]
 LDCM0022  KB02 HCT 116 C293(2.25); C103(1.16)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C293(1.56); C103(1.09)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C293(1.98); C103(1.02)  LDD0082  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C28(2.27)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C28(0.74)  LDD2127  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C28(0.84)  LDD2141  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C28(0.91)  LDD2146  [3]
 LDCM0021  THZ1 HCT 116 C103(1.31)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402