Details of the Target

General Information of Target

Target ID LDTP08956
Target Name Zinc finger protein 655 (ZNF655)
Gene Name ZNF655
Gene ID 79027
Synonyms
VIK; Zinc finger protein 655; Vav-interacting Krueppel-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEIPAQEAAGSPRVQFQSLETQSECLSPEPQFVQDTDMEQGLTGDGETREENKLLIPKQ
KISEEVHSYKVRVGRLKHDITQVPETREVYKSEDRLERLQEILRKFLYLEREFRQITISK
ETFTSEKNNECHEPEKSFSLDSTIDADQRVLRIQNTDDNDKYDMSFNQNSASGKHEHLNL
TEDFQSSECKESLMDLSHLNKWESIPNTEKSYKCDVCGKIFHQSSALTRHQRIHTREKPY
KCKECEKSFSQSSSLSRHKRIHTREKPYKCEASDKSCEASDKSCSPSSGIIQHKKIHTRA
KSYKCSSCERVFSRSVHLTQHQKIHKEMPCKCTVCGSDFCHTSYLLEHQRVHHEEKAYEY
DEYGLAYIKQQGIHFREKPYTCSECGKDFRLNSHLIQHQRIHTGEKAHECNECGKAFSQT
SCLIQHHKMHRKEKSYECNEYEGSFSHSSDLILQQEVLTRQKAFDCDVWEKNSSQRAHLV
QHQSIHTKENS
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8N720
Ensemble ID
ENST00000252713.9
HGNC ID
HGNC:30899

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.F221V; p.E409Ter .
IGROV1 SNV: p.W202R .
MOLT4 SNV: p.I290V IA-alkyne    Probe Info 
NCIH2172 SNV: p.S204I .
SNU449 SNV: p.D147A .
SW480 SNV: p.K301Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C457(2.04)  LDD3312  [1]
IA-alkyne
 Probe Info  		C284(0.00); C189(0.00); C270, C277(0.00)  LDD0165  [2]
IPM
 Probe Info  		C284(0.00); C189(0.00); C131(0.00)  LDD2156  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C422(1.12); C466(0.99); C131(1.01); C410(1.03)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C422(1.23); C466(1.04); C131(1.09)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C466(1.03); C131(1.20); C410(0.94)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C422(0.98); C466(0.90); C284(0.94); C410(0.94)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C422(0.97); C189(0.98); C466(1.01); C131(1.18)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C422(0.94); C189(1.12); C466(1.03); C131(1.07)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C422(1.06); C466(0.96); C131(1.04); C410(1.05)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C422(1.06); C466(1.00); C131(1.02)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C466(1.20); C131(1.63); C410(1.10)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C422(1.18); C466(1.07); C131(1.02)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C422(0.97); C466(0.66); C284(1.02); C410(1.17)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C422(1.20); C466(0.88); C131(1.02); C284(1.00)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C422(1.22); C189(0.97); C466(0.89); C131(1.05)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C422(0.87); C189(0.99); C466(0.87); C131(1.00)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C422(0.94); C466(0.93); C131(0.97); C284(1.02)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C422(1.37); C466(0.90); C131(0.99); C410(1.03)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C422(1.06); C466(1.06); C131(1.07)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C466(1.01); C131(1.06); C410(0.85)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C422(1.07); C466(0.82); C284(0.85); C410(1.07)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C422(1.35); C466(1.01); C131(0.97); C284(1.14)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C466(0.97); C131(0.99); C410(0.93)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C422(1.15); C189(0.95); C466(0.98); C131(1.03)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C422(0.89); C189(1.05); C466(0.99); C131(1.03)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C422(1.05); C466(0.91); C131(0.97); C284(1.07)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C422(1.06); C466(1.08); C131(1.07); C410(1.04)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C422(1.16); C466(1.11); C131(1.11)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C466(1.05); C131(1.06); C410(0.88)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C422(1.06); C466(0.90); C284(1.03); C410(0.99)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C422(1.00); C466(1.01); C131(1.01); C284(1.11)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C422(0.89); C189(1.03); C466(0.97); C131(1.10)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C422(0.99); C189(1.08); C466(1.00); C131(1.10)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C422(1.14); C466(1.00); C284(0.90); C410(1.10)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C422(0.99); C466(0.96); C131(1.03); C284(1.08)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C422(1.23); C466(0.96); C131(1.17); C410(1.08)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C422(1.31); C466(1.10); C131(1.17)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C466(0.98); C131(1.05); C410(1.01)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C422(1.04); C466(0.83); C284(1.02); C410(0.94)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C422(1.23); C466(1.00); C131(0.93); C284(1.08)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C422(0.97); C189(1.00); C466(1.09); C131(1.12)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C422(1.01); C189(1.07); C466(0.99); C131(1.09)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C422(0.92); C466(1.01); C131(1.17); C284(1.08)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C422(1.12); C466(0.95); C131(1.07); C410(1.01)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C422(1.16); C466(1.01); C131(0.97); C284(1.12)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C422(1.16); C466(1.10); C131(1.16)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C466(0.96); C131(1.08); C410(1.03)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C422(1.05); C466(0.94); C284(0.95); C410(1.01)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C422(1.20); C466(1.02); C131(1.04); C284(1.07)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C422(1.00); C189(0.98); C466(0.94); C131(1.07)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C422(0.95); C189(0.97); C466(0.99); C131(1.17)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C422(1.01); C466(0.97); C131(1.15); C284(0.91)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C422(1.35); C466(1.03); C131(1.05); C410(1.17)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C422(1.15); C466(1.06); C131(1.01)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C466(1.00); C131(1.01); C410(1.00)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C422(1.03); C189(0.89); C466(1.07); C131(1.01)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C422(1.08); C466(0.94); C284(1.00); C410(1.05)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C422(1.00); C466(1.09); C131(0.95); C284(1.09)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C422(1.04); C189(0.97); C466(1.01); C131(1.11)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C422(0.97); C189(1.07); C466(0.93); C131(0.96)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C422(0.87); C466(0.95); C131(1.06); C284(1.02)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C422(0.89); C189(0.93); C466(0.99); C131(1.03)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C422(1.17); C466(0.97); C131(1.00); C284(1.06)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C422(1.07); C466(1.04); C131(1.05); C284(1.15)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C422(1.37); C466(0.99); C131(1.07); C410(1.05)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C422(0.98); C466(0.93); C131(1.15); C284(1.02)  LDD1514  [5]
 LDCM0367  CL1 HEK-293T C422(0.97); C189(1.03); C466(0.92); C410(0.93)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C422(1.11); C189(1.05); C466(1.09); C131(1.13)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C422(1.22); C189(1.03); C466(1.00); C131(1.07)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C422(0.97); C189(1.01); C466(0.98); C410(1.07)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C422(1.13); C189(0.92); C466(1.00); C131(1.15)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C422(1.02); C466(0.86); C131(1.07)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C422(1.26); C189(0.75); C466(0.95); C131(1.10)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C422(0.81); C189(0.94); C466(0.97); C410(1.00)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C422(1.33); C189(0.96); C466(1.01); C131(1.09)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C422(1.04); C466(0.86); C131(1.13)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C422(1.06); C189(0.85); C466(0.99); C131(1.04)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C422(0.80); C189(1.04); C466(0.95); C410(0.98)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C422(1.11); C189(1.20); C466(1.09); C131(0.98)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C422(1.16); C189(0.86); C466(0.97); C131(1.02)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C422(1.11); C466(0.91); C131(1.00)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C422(1.13); C189(0.73); C466(1.15); C131(1.03)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C422(0.99); C189(1.07); C466(0.98); C410(1.10)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C422(2.33); C189(1.02); C466(1.05); C131(1.03)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C422(1.06); C466(0.83); C131(1.05)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C422(1.13); C189(0.90); C466(0.99); C131(1.17)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C422(0.75); C189(1.04); C466(0.99); C410(0.92)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C422(1.08); C189(1.07); C466(1.04); C131(1.25)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C422(1.00); C466(0.82); C131(1.05)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C422(1.07); C466(1.17); C131(1.01); C284(1.21)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C422(1.29); C189(0.89); C466(1.00); C131(1.28)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C422(0.90); C189(1.00); C466(0.99); C410(1.03)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C422(1.10); C189(0.95); C466(1.02); C131(1.19)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C422(1.02); C466(0.85); C131(1.07)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C422(1.02); C189(0.76); C466(1.00); C131(1.14)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C422(0.96); C189(0.93); C466(1.02); C410(1.12)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C422(1.23); C189(0.91); C466(1.01); C131(1.02)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C422(1.11); C466(0.91); C131(1.07)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C422(1.08); C189(0.76); C466(1.00); C131(1.12)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C422(1.21); C189(1.04); C466(0.93); C410(0.89)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C422(1.33); C189(0.98); C466(0.99); C131(1.18)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C422(1.04); C466(0.93); C131(1.11)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C422(1.02); C189(0.98); C466(0.89); C131(1.08)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C422(1.33); C466(1.02); C131(1.08); C410(0.94)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C422(1.33); C466(1.04); C131(1.29)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C466(1.14); C131(1.14); C410(0.79)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C422(1.24); C189(1.04); C466(1.06); C131(1.10)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C422(1.10); C466(1.07); C284(1.01); C410(1.06)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C422(1.22); C466(1.09); C131(1.04); C284(1.17)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C422(0.96); C189(1.14); C466(1.05); C131(1.14)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C422(0.90); C189(1.31); C466(1.07); C131(1.04)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C422(1.02); C466(1.11); C131(1.10); C284(1.02)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C422(0.96); C189(0.96); C466(1.00); C410(0.87)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C422(1.68); C189(1.03); C466(0.94); C131(1.10)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C422(1.05); C466(0.86); C131(1.04)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C422(1.57); C189(0.95); C466(0.94); C131(1.06)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C422(1.22); C466(0.95); C131(1.10); C410(1.04)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C422(1.06); C466(0.98); C131(0.99)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C422(1.15); C466(1.05); C131(1.14)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C466(0.77); C131(1.21); C410(0.79)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C422(1.05); C466(0.57); C284(0.99); C410(1.04)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C422(1.14); C466(1.11); C131(1.08); C284(1.03)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C422(1.05); C189(1.04); C466(1.01); C131(1.12)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C422(0.87); C189(1.23); C466(0.84); C131(1.09)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C422(1.05); C466(0.96); C131(1.03); C284(1.10)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C422(0.77); C189(1.00); C466(1.08); C410(0.80)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C422(1.11); C466(0.94); C131(0.95)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C422(1.31); C189(0.94); C466(0.97); C131(1.12)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C422(1.14); C189(1.30); C466(0.91); C131(0.97)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C422(1.10); C466(1.00); C131(0.99); C410(0.99)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C422(1.10); C466(1.08); C131(1.03)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C466(0.93); C131(1.10); C410(0.72)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C422(0.99); C466(0.98); C284(1.02); C410(1.17)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C422(1.18); C466(0.89); C131(0.99); C284(1.07)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C422(1.33); C189(1.03); C466(1.03); C131(1.16)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C422(0.92); C189(1.08); C466(1.03); C131(1.03)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C422(1.04); C466(1.08); C131(1.02); C284(1.09)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C422(0.65); C189(1.05); C466(1.06); C410(1.03)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C422(1.09); C466(0.95); C131(1.02); C410(1.10)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C422(1.00); C189(1.04); C466(1.05); C131(1.12)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C422(1.17); C189(0.86); C466(0.91); C131(1.15)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C422(1.55); C466(1.00); C131(1.06); C410(1.06)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C422(1.04); C466(1.10); C131(1.16)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C466(0.87); C131(1.16); C410(1.17)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C422(1.08); C466(0.75); C284(1.11); C410(1.09)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C422(1.13); C466(1.16); C131(1.03); C284(1.26)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C422(0.92); C189(1.11); C466(1.12); C131(1.19)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C422(0.97); C189(1.24); C466(0.90); C131(1.11)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C422(1.25); C466(1.07); C131(1.03)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C422(1.11); C466(1.02); C131(1.10); C284(0.96)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C422(0.92); C189(1.00); C466(0.96); C410(1.05)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C422(1.24); C189(0.96); C466(0.93); C131(1.09)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C422(1.08); C466(0.80); C131(1.02)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C422(1.21); C189(0.68); C466(1.11); C131(0.99)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C422(1.18); C466(1.00); C131(1.08); C410(1.02)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C422(1.04); C466(1.20); C131(1.14)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C466(0.97); C131(1.06); C410(0.90)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C422(0.99); C466(0.75); C284(1.07); C410(1.02)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C422(1.06); C466(1.05); C131(1.05); C284(1.07)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C466(1.14); C131(1.01); C410(0.90)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C422(1.00); C189(1.19); C466(1.07); C131(1.08)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C422(0.99); C189(1.24); C466(0.84); C131(1.14)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C422(0.92); C466(0.99); C131(1.16); C284(1.18)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C422(1.33); C189(1.09); C466(0.92); C410(0.94)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C422(1.13); C189(0.95); C466(1.00); C131(1.12)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C422(1.13); C189(0.93); C466(1.01); C131(1.09)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C422(0.98); C466(1.00); C131(1.02); C410(1.05)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C422(1.17); C466(1.05); C131(1.14)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C466(0.79); C131(1.16); C410(0.90)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C422(1.22); C466(1.10); C284(1.04); C410(0.93)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C422(1.00); C466(0.57); C284(0.94); C410(0.93)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C422(1.32); C466(1.06); C131(1.08); C284(1.17)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C422(0.90); C189(1.02); C466(1.01); C131(1.19)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C422(0.91); C189(1.15); C466(0.82); C131(1.12)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C422(0.96); C466(0.88); C131(1.04); C284(1.18)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C422(1.11); C189(0.95); C466(0.92); C410(0.96)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C422(0.96); C189(0.96); C466(1.03); C131(1.06)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C422(1.01); C466(0.89); C131(1.06)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C422(1.02); C189(1.15); C466(0.85); C131(1.11)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C422(0.86); C466(1.01); C131(1.03); C410(1.09)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C422(1.17); C466(1.13); C131(1.08); C284(1.23)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C422(1.24); C466(1.28); C131(1.00)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C466(1.04); C131(1.03); C410(0.93)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C422(0.90); C466(0.99); C284(1.02); C410(1.11)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C422(0.91); C466(1.12); C131(0.97); C284(1.18)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C422(0.97); C189(1.01); C466(1.03); C131(1.01)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C422(1.11); C189(1.12); C466(1.07); C131(1.06)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C422(0.97); C466(1.05); C131(1.03); C284(0.94)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C422(0.84); C189(1.01); C466(1.06); C410(0.98)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C422(1.35); C189(1.08); C466(1.01); C131(1.06)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C422(1.17); C466(0.83); C131(0.95)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C422(1.61); C466(0.85); C131(1.13)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C422(1.06); C466(0.89); C131(1.03)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C422(0.94); C189(1.01); C466(1.01); C131(1.06)  LDD1631  [5]
 LDCM0022  KB02 HEK-293T C131(0.94); C284(0.92); C422(0.82); C189(1.21)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C131(0.95); C284(0.92); C422(1.00); C189(1.19)  LDD1497  [5]
 LDCM0024  KB05 HMCB C457(2.04)  LDD3312  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 30 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7) 3-beta-HSD family Q9H2F3
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Neuroglobin (NGB) Globin family Q9NPG2
Glutathione S-transferase P (GSTP1) Pi family P09211
Inositol hexakisphosphate kinase 3 (IP6K3) Inositol phosphokinase (IPK) family Q96PC2
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL) Maf family O95671
Mediator of RNA polymerase II transcription subunit 21 (MED21) Mediator complex subunit 21 family Q13503
Protein N-lysine methyltransferase METTL21A (METTL21A) METTL21 family Q8WXB1
Uridine diphosphate glucose pyrophosphatase NUDT22 (NUDT22) Nudix hydrolase family Q9BRQ3
Cleavage and polyadenylation specificity factor subunit 5 (NUDT21) Nudix hydrolase family O43809
Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM) Pectinacetylesterase family Q6P988
Calpain-7 (CAPN7) Peptidase C2 family Q9Y6W3
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (PFKFB1) Phosphoglycerate mutase family P16118
Cyclin-dependent kinase 4 (CDK4) CMGC Ser/Thr protein kinase family P11802
Serine/threonine-protein kinase tousled-like 1 (TLK1) Ser/Thr protein kinase family Q9UKI8
Dual specificity protein phosphatase 4 (DUSP4) Protein-tyrosine phosphatase family Q13115
Myotubularin-related protein 9 (MTMR9) Protein-tyrosine phosphatase family Q96QG7
Ribonucleoside-diphosphate reductase large subunit (RRM1) Ribonucleoside diphosphate reductase large chain family P23921
Exosome complex component RRP46 (EXOSC5) RNase PH family Q9NQT4
GTP-binding protein GEM (GEM) RGK family P55040
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Protein yippee-like 5 (YPEL5) Yippee family P62699
BRCA1-associated RING domain protein 1 (BARD1) . Q99728
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
OTU domain-containing protein 4 (OTUD4) . Q01804
Prolyl hydroxylase EGLN3 (EGLN3) . Q9H6Z9
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Huntingtin (HTT) Huntingtin family P42858
Macoilin (MACO1) Macoilin family Q8N5G2
P2X purinoceptor 7 (P2RX7) P2X receptor family Q99572
Solute carrier family 12 member 4 (SLC12A4) SLC12A transporter family Q9UP95
Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) Small Tim family P62072
Sperm protein associated with the nucleus on the X chromosome N2 (SPANXN2) SPAN-X family Q5MJ10
Tripartite motif-containing protein 72 (TRIM72) TRIM/RBCC family Q6ZMU5
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger protein 552 (ZNF552) Krueppel C2H2-type zinc-finger protein family Q9H707
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
THAP domain-containing protein 6 (THAP6) . Q8TBB0
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hyaluronan and proteoglycan link protein 2 (HAPLN2) HAPLN family Q9GZV7
Other
Click To Hide/Show 69 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and SOCS box protein 6 (ASB6) Ankyrin SOCS box (ASB) family Q9NWX5
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
Large ribosomal subunit protein bL28m (MRPL28) Bacterial ribosomal protein bL28 family Q13084
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
Bystin (BYSL) Bystin family Q13895
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Deuterosome assembly protein 1 (DEUP1) CEP63 family Q05D60
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Cyclin-H (CCNH) Cyclin family P51946
EF-hand calcium-binding domain-containing protein 4B (CRACR2A) EFCAB4 family Q9BSW2
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) EIF4E-binding protein family Q13541
Protein FAM81A (FAM81A) FAM81 family Q8TBF8
Protein FAM81B (FAM81B) FAM81 family Q96LP2
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6) FKBP6 family O75344
Protein HEXIM2 (HEXIM2) HEXIM family Q96MH2
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Protein Hook homolog 1 (HOOK1) Hook family Q9UJC3
Integrator complex subunit 10 (INTS10) Integrator subunit 10 family Q9NVR2
Integrin beta-5 (ITGB5) Integrin beta chain family P18084
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cuticular Hb5 (KRT85) Intermediate filament family P78386
Keratin, type II cuticular Hb6 (KRT86) Intermediate filament family O43790
Keratin, type II cytoskeletal 2 oral (KRT76) Intermediate filament family Q01546
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 9-8 (KRTAP9-8) KRTAP type 9 family Q9BYQ0
Late cornified envelope protein 3C (LCE3C) LCE family Q5T5A8
Late cornified envelope protein 4A (LCE4A) LCE family Q5TA78
Late cornified envelope protein 5A (LCE5A) LCE family Q5TCM9
MAGUK p55 subfamily member 3 (MPP3) MAGUK family Q13368
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Protein MEMO1 (MEMO1) MEMO1 family Q9Y316
Protein Mis18-alpha (MIS18A) Mis18 family Q9NYP9
Protein Mis18-beta (OIP5) Mis18 family O43482
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
Zinc finger protein 330 (ZNF330) NOA36 family Q9Y3S2
Testis-specific Y-encoded-like protein 4 (TSPYL4) Nucleosome assembly protein (NAP) family Q9UJ04
Hippocalcin-like protein 1 (HPCAL1) Recoverin family P37235
Zinc finger protein ubi-d4 (DPF2) Requiem/DPF family Q92785
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Nonsense-mediated mRNA decay factor SMG9 (SMG9) SMG9 family Q9H0W8
Protein sprouty homolog 3 (SPRY3) Sprouty family O43610
Tektin-4 (TEKT4) Tektin family Q8WW24
Testis-specific protein TEX28 (TEX28; TEX28P1; TEX28P2) TEX28 family O15482
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
Centrosomal protein CEP57L1 (CEP57L1) Translokin family Q8IYX8
U3 small nucleolar ribonucleoprotein protein IMP3 (IMP3) Universal ribosomal protein uS4 family Q9NV31
Vacuolar protein sorting-associated protein 26C (VPS26C) VPS26 family O14972
DNA repair protein complementing XP-A cells (XPA) XPA family P23025
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Coiled-coil domain-containing protein 116 (CCDC116) . Q8IYX3
Coiled-coil domain-containing protein 179 (CCDC179) . H3BU77
Coiled-coil domain-containing protein 74A (CCDC74A) . Q96AQ1
Four and a half LIM domains protein 2 (FHL2) . Q14192
MIT domain-containing protein 1 (MITD1) . Q8WV92
Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2) . Q9UI95
Placental protein 13-like (LGALS14) . Q8TCE9
Proline-rich protein 35 (PRR35) . P0CG20
Proto-oncogene vav (VAV1) . P15498
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Thioredoxin domain-containing protein 9 (TXNDC9) . O14530
Uncharacterized protein C8orf74 (C8orf74) . Q6P047
VPS9 domain-containing protein 1 (VPS9D1) . Q9Y2B5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402