Details of the Target

General Information of Target

Target ID LDTP08901
Target Name Ubiquitin carboxyl-terminal hydrolase MINDY-1 (MINDY1)
Gene Name MINDY1
Gene ID 55793
Synonyms
FAM63A; KIAA1390; Ubiquitin carboxyl-terminal hydrolase MINDY-1; EC 3.4.19.12; Deubiquitinating enzyme MINDY-1; Protein FAM63A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEYHQPEDPAPGKAGTAEAVIPENHEVLAGPDEHPQDTDARDADGEAREREPADQALLPS
QCGDNLESPLPEASSAPPGPTLGTLPEVETIRACSMPQELPQSPRTRQPEPDFYCVKWIP
WKGEQTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELMAHLGNCLLSIKPQ
EKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGW
LVDPQSPEAVRAVGKLSYNQLVERIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLC
ELTAAAKEGELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFC
DSDFHLSHSLGKGPGAEGGSGSPETQLQVDQDYLIALSLQQQQPRGPLGLTDLELAQQLQ
QEEYQQQQAAQPVRMRTRVLSLQGRGATSGRPAGERRQRPKHESDCILL
Target Bioclass
Enzyme
Family
MINDY deubiquitinase family, FAM63 subfamily
Function
Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.
Uniprot ID
Q8N5J2
Ensemble ID
ENST00000312210.9
HGNC ID
HGNC:25648

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.P69L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y258(22.13)  LDD3495  [1]
DBIA
 Probe Info  		C20(1.12)  LDD3323  [2]
NAIA_4
 Probe Info  		C62(0.00); C226(0.00)  LDD2226  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
AOyne
 Probe Info  		13.40  LDD0443  [5]
NAIA_5
 Probe Info  		C300(0.00); C115(0.00)  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C94(1.00)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C94(1.06)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C94(0.97)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C94(0.98)  LDD1513  [6]
 LDCM0278  AC19 HEK-293T C94(1.13)  LDD1517  [6]
 LDCM0280  AC20 HEK-293T C94(1.19)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C94(0.97)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C94(0.99)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C94(1.34)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C94(1.01)  LDD1523  [6]
 LDCM0287  AC27 HEK-293T C94(0.96)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C94(0.87)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C94(1.36)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C94(1.10)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C94(0.94)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C94(1.18)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C94(1.05)  LDD1532  [6]
 LDCM0296  AC35 HEK-293T C94(1.07)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C94(0.96)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C94(1.39)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C94(0.93)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C94(0.93)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C94(0.88)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C94(0.93)  LDD1541  [6]
 LDCM0305  AC43 HEK-293T C94(1.13)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C94(1.02)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C94(1.44)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C94(1.03)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C94(0.99)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C94(0.98)  LDD1549  [6]
 LDCM0312  AC5 HEK-293T C94(1.37)  LDD1551  [6]
 LDCM0314  AC51 HEK-293T C94(0.98)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C94(1.12)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C94(1.17)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C94(0.99)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C94(1.07)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C94(0.79)  LDD1558  [6]
 LDCM0322  AC59 HEK-293T C94(1.16)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C94(1.01)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C94(1.06)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C94(1.09)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C94(1.05)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C94(1.06)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C94(1.05)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C94(0.91)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C94(0.94)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C94(1.24)  LDD1511  [6]
 LDCM0275  AKOS034007705 HEK-293T C94(1.02)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C94(1.03)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C94(0.88)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C94(1.03)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C94(1.16)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C94(1.01)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C94(0.99)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C94(1.03)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C94(0.98)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C94(0.97)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C94(1.03)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C94(0.96)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C94(0.93)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C94(1.15)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C94(1.21)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C94(0.93)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C94(1.02)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C94(0.94)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C94(1.11)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C94(0.99)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C94(1.02)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C94(1.14)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C94(1.17)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C94(1.01)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C94(0.89)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C94(0.99)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C94(1.00)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C94(0.94)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C94(0.86)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C94(0.99)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C94(0.74)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C94(1.23)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C94(1.12)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C94(0.96)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C94(1.00)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C94(0.63)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C94(0.52)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C94(1.06)  LDD1607  [6]
 LDCM0406  CL19 HEK-293T C94(1.08)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C94(1.01)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C94(0.91)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C94(0.85)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C94(0.79)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C94(1.01)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C94(0.73)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C94(1.03)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C94(1.05)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C94(0.94)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C94(0.98)  LDD1620  [6]
 LDCM0418  CL3 HEK-293T C94(0.90)  LDD1622  [6]
 LDCM0420  CL31 HEK-293T C94(1.04)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C94(0.96)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C94(1.18)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C94(1.04)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C94(1.38)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C94(1.19)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C94(1.29)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C94(0.78)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C94(0.95)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C94(0.91)  LDD1634  [6]
 LDCM0433  CL43 HEK-293T C94(0.95)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C94(1.08)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C94(0.92)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C94(0.80)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C94(1.03)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C94(0.88)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C94(1.21)  LDD1643  [6]
 LDCM0441  CL50 HEK-293T C94(1.08)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C94(0.96)  LDD1646  [6]
 LDCM0446  CL55 HEK-293T C94(0.97)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C94(1.02)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C94(1.12)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C94(0.90)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C94(1.12)  LDD1653  [6]
 LDCM0452  CL60 HEK-293T C94(1.03)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C94(1.01)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C94(1.24)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C94(1.08)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C94(1.00)  LDD1659  [6]
 LDCM0459  CL67 HEK-293T C94(1.05)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C94(1.11)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C94(1.09)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C94(1.00)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C94(0.99)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C94(1.15)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C94(1.04)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C94(1.14)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C94(1.19)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C94(0.99)  LDD1672  [6]
 LDCM0472  CL79 HEK-293T C94(1.06)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C94(0.93)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C94(1.09)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C94(1.12)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C94(1.04)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C94(1.18)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C94(1.02)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C94(0.95)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C94(0.87)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C94(0.77)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C94(1.06)  LDD1685  [6]
 LDCM0484  CL9 HEK-293T C94(1.03)  LDD1687  [6]
 LDCM0486  CL91 HEK-293T C94(0.96)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C94(0.41)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C94(0.91)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C94(0.79)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C94(1.13)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C94(0.88)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C94(0.94)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C94(1.19)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C94(0.90)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C94(1.02)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C94(1.06)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C94(0.92)  LDD1631  [6]
 LDCM0022  KB02 A2058 C94(2.15)  LDD2253  [2]
 LDCM0023  KB03 A2058 C94(2.16)  LDD2670  [2]
 LDCM0024  KB05 SKMEL24 C20(1.12)  LDD3323  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7) Ligand-gated ion channel family P36544
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DAZ-associated protein 2 (DAZAP2) . Q15038

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402