Details of the Target

General Information of Target

Target ID LDTP08860
Target Name Sesquipedalian-1 (PHETA1)
Gene Name PHETA1
Gene ID 144717
Synonyms
FAM109A; Sesquipedalian-1; Ses1; 27 kDa inositol polyphosphate phosphatase-interacting protein A; IPIP27A; PH domain-containing endocytic trafficking adaptor 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGV
IILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRASFDYLRLVV
RELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSA
LPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARLHECYGQEIRALRG
QWLSSRVQP
Target Bioclass
Other
Family
Sesquipedalian family
Subcellular location
Early endosome
Function Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
Uniprot ID
Q8N4B1
Ensemble ID
ENST00000361483.4
HGNC ID
HGNC:26509

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.L162M .
MFE319 SNV: p.V40M .
SW403 SNV: p.Q142P .
SW480 Deletion: p.Q144VfsTer50 .
SW620 Deletion: p.Q144VfsTer50 .
TE10 SNV: p.A137P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
AHL-Pu-1
 Probe Info  		C230(2.85)  LDD0171  [2]
DBIA
 Probe Info  		C14(0.99)  LDD1508  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
W1
 Probe Info  		N.A.  LDD0236  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C230(2.85)  LDD0171  [2]
 LDCM0215  AC10 HEK-293T C14(0.99)  LDD1508  [3]
 LDCM0237  AC12 HEK-293T C230(0.91)  LDD1510  [3]
 LDCM0270  AC15 HEK-293T C230(0.91); C14(0.96); C188(1.01)  LDD1513  [3]
 LDCM0277  AC18 HEK-293T C14(0.98)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C14(1.05)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C230(0.87)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C230(0.95)  LDD1520  [3]
 LDCM0283  AC23 HEK-293T C230(0.98); C14(1.00); C188(1.10)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C230(0.91); C188(1.03)  LDD1523  [3]
 LDCM0286  AC26 HEK-293T C14(1.09)  LDD1525  [3]
 LDCM0288  AC28 HEK-293T C230(1.02)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C230(0.93)  LDD1528  [3]
 LDCM0292  AC31 HEK-293T C230(0.98); C14(0.89); C188(1.02)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C230(0.92); C188(0.84)  LDD1532  [3]
 LDCM0295  AC34 HEK-293T C14(1.02)  LDD1534  [3]
 LDCM0297  AC36 HEK-293T C230(1.01)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C230(1.01)  LDD1537  [3]
 LDCM0300  AC39 HEK-293T C230(0.95); C14(0.89); C188(0.93)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C230(1.09)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C230(0.92); C188(0.91)  LDD1541  [3]
 LDCM0304  AC42 HEK-293T C14(1.04)  LDD1543  [3]
 LDCM0306  AC44 HEK-293T C230(0.92)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C230(0.93)  LDD1546  [3]
 LDCM0309  AC47 HEK-293T C230(0.96); C14(1.13); C188(1.13)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C230(0.86); C188(0.86)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C230(0.93)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C14(0.97)  LDD1552  [3]
 LDCM0315  AC52 HEK-293T C230(1.01)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C230(0.96)  LDD1555  [3]
 LDCM0318  AC55 HEK-293T C230(0.97); C14(0.90); C188(1.02)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C230(0.94); C188(1.08)  LDD1558  [3]
 LDCM0321  AC58 HEK-293T C14(1.13)  LDD1560  [3]
 LDCM0324  AC60 HEK-293T C230(1.02)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C230(1.12)  LDD1564  [3]
 LDCM0327  AC63 HEK-293T C230(0.96); C14(1.02); C188(1.08)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C230(0.88); C188(0.95)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C230(0.97); C14(0.96); C188(1.10)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C230(0.96); C188(0.88)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C230(1.01)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C230(0.92); C188(0.98)  LDD1514  [3]
 LDCM0632  CL-Sc Hep-G2 C230(0.85)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C230(0.95)  LDD1571  [3]
 LDCM0369  CL100 HEK-293T C14(0.86)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C230(1.04)  LDD1574  [3]
 LDCM0372  CL103 HEK-293T C230(0.88)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C14(0.92)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C230(0.92)  LDD1578  [3]
 LDCM0376  CL107 HEK-293T C230(0.91)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C14(0.91)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C230(0.98)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C230(1.00); C14(1.12); C188(0.98)  LDD1583  [3]
 LDCM0381  CL111 HEK-293T C230(0.88)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C14(0.91)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C230(0.92)  LDD1587  [3]
 LDCM0385  CL115 HEK-293T C230(0.94)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C14(1.04)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C230(1.02)  LDD1591  [3]
 LDCM0389  CL119 HEK-293T C230(0.84)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C230(0.86); C188(0.95)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C14(0.87)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C230(1.01)  LDD1596  [3]
 LDCM0394  CL123 HEK-293T C230(0.89)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C14(1.07)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C230(0.96)  LDD1600  [3]
 LDCM0398  CL127 HEK-293T C230(1.04)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C14(1.01)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C230(1.08)  LDD1604  [3]
 LDCM0402  CL15 HEK-293T C230(0.90)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C14(1.16)  LDD1607  [3]
 LDCM0405  CL18 HEK-293T C14(1.07)  LDD1609  [3]
 LDCM0408  CL20 HEK-293T C230(1.04)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C230(1.01)  LDD1613  [3]
 LDCM0411  CL23 HEK-293T C230(0.99); C14(1.06); C188(1.20)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C230(0.85); C188(0.93)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C230(0.94)  LDD1617  [3]
 LDCM0415  CL27 HEK-293T C230(0.87)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C14(0.95)  LDD1620  [3]
 LDCM0418  CL3 HEK-293T C230(0.93)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C14(0.98)  LDD1623  [3]
 LDCM0421  CL32 HEK-293T C230(1.03)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C230(1.02)  LDD1626  [3]
 LDCM0424  CL35 HEK-293T C230(0.95); C14(0.88); C188(0.79)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C230(0.95); C188(0.97)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C230(0.94)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C230(0.83)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C14(0.97)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C14(0.83)  LDD1634  [3]
 LDCM0432  CL42 HEK-293T C14(0.93)  LDD1636  [3]
 LDCM0434  CL44 HEK-293T C230(0.91)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C230(1.05)  LDD1639  [3]
 LDCM0437  CL47 HEK-293T C230(0.95); C14(1.02); C188(1.05)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C230(0.93); C188(0.85)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C230(0.91)  LDD1643  [3]
 LDCM0443  CL52 HEK-293T C14(0.85)  LDD1646  [3]
 LDCM0445  CL54 HEK-293T C14(1.11)  LDD1648  [3]
 LDCM0447  CL56 HEK-293T C230(0.99)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C230(1.11)  LDD1651  [3]
 LDCM0450  CL59 HEK-293T C230(1.00); C14(0.86); C188(1.06)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C14(1.18)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C230(0.88); C188(0.82)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C230(0.93)  LDD1656  [3]
 LDCM0455  CL63 HEK-293T C230(0.88)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C14(1.04)  LDD1659  [3]
 LDCM0458  CL66 HEK-293T C14(1.11)  LDD1661  [3]
 LDCM0460  CL68 HEK-293T C230(0.97)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C230(0.99)  LDD1664  [3]
 LDCM0464  CL71 HEK-293T C230(0.88); C14(1.02); C188(1.02)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C230(0.88); C188(0.83)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C230(0.95)  LDD1669  [3]
 LDCM0469  CL76 HEK-293T C14(0.90)  LDD1672  [3]
 LDCM0471  CL78 HEK-293T C14(1.13)  LDD1674  [3]
 LDCM0473  CL8 HEK-293T C230(1.18)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C230(1.00)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C230(1.11)  LDD1678  [3]
 LDCM0477  CL83 HEK-293T C230(1.01); C14(0.96); C188(1.16)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C230(0.95); C188(1.18)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C230(0.91)  LDD1682  [3]
 LDCM0481  CL87 HEK-293T C230(1.01)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C14(0.94)  LDD1685  [3]
 LDCM0484  CL9 HEK-293T C230(1.00)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C14(1.03)  LDD1688  [3]
 LDCM0487  CL92 HEK-293T C230(1.07)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C230(1.03)  LDD1691  [3]
 LDCM0490  CL95 HEK-293T C230(1.01); C14(1.02); C188(1.18)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C230(0.88); C188(0.92)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C230(1.01)  LDD1695  [3]
 LDCM0494  CL99 HEK-293T C230(0.95)  LDD1697  [3]
 LDCM0634  CY-0357 Hep-G2 C230(0.78)  LDD2228  [4]
 LDCM0495  E2913 HEK-293T C230(0.91)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C230(0.90)  LDD1671  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Protein Mis18-beta (OIP5) Mis18 family O43482
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Sesquipedalian-2 (PHETA2) Sesquipedalian family Q6ICB4
Cytoplasmic protein NCK2 (NCK2) . O43639
Pleckstrin homology domain-containing family J member 1 (PLEKHJ1) . Q9NW61
Vinexin (SORBS3) . O60504

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264