Details of the Target

General Information of Target

Target ID LDTP08818
Target Name Large neutral amino acids transporter small subunit 4 (SLC43A2)
Gene Name SLC43A2
Gene ID 124935
Synonyms
LAT4; Large neutral amino acids transporter small subunit 4; L-type amino acid transporter 4; Solute carrier family 43 member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPTLATAHRRRWWMACTAVLENLLFSAVLLGWGSLLIMLKSEGFYSYLCTEPENVTNGT
VGGTAEPGHEEVSWMNGWLSCQAQDEMLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRL
LGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLPNMFGDLRSTFI
ALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLEPFPGPEDM
DYSVKIKFSWLGFDHKITGKQFYKQVTTVGRRLSVGSSMRSAKEQVALQEGHKLCLSTVD
LEVKCQPDAAVAPSFMHSVFSPILLLSLVTMCVTQLRLIFYMGAMNNILKFLVSGDQKTV
GLYTSIFGVLQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDRQIQK
ITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVYPSTQ
FGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRR
QLERQLQQRQEDDKLFLKINGSSNQEAFV
Target Bioclass
Transporter and channel
Family
SLC43A transporter (TC 2.A.1.44) family
Subcellular location
Cell membrane
Function
Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine. The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent.
Uniprot ID
Q8N370
Ensemble ID
ENST00000301335.10
HGNC ID
HGNC:23087

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.A215T .
OVK18 SNV: p.K283N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C392(3.91)  LDD2184  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]
DBIA
 Probe Info  		C295(1.04)  LDD1507  [3]
IPM
 Probe Info  		C392(0.00); C295(0.00)  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C295(1.04)  LDD1507  [3]
 LDCM0226  AC11 HEK-293T C392(1.18)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C295(0.90)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C295(1.30)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C295(1.06)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C295(0.98)  LDD1515  [3]
 LDCM0278  AC19 HEK-293T C392(1.17)  LDD1517  [3]
 LDCM0280  AC20 HEK-293T C295(0.90)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C295(1.06)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C295(0.97)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C295(0.98)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C295(1.03)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C295(0.95)  LDD1524  [3]
 LDCM0287  AC27 HEK-293T C392(1.05)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C295(1.12)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C295(0.99)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C392(0.96)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C295(0.92)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C295(0.91)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C295(0.84)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C295(0.98)  LDD1533  [3]
 LDCM0296  AC35 HEK-293T C392(1.06)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C295(1.01)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C295(0.99)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C295(1.03)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C295(0.94)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C295(1.00)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C295(1.01)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C295(1.02)  LDD1542  [3]
 LDCM0305  AC43 HEK-293T C392(1.25)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C295(0.90)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C295(0.83)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C295(0.91)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C295(0.95)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C295(0.85)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C295(0.99)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C295(1.01)  LDD1551  [3]
 LDCM0314  AC51 HEK-293T C392(1.05)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C295(0.81)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C295(1.08)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C295(0.92)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C295(0.93)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C295(0.76)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C295(0.97)  LDD1559  [3]
 LDCM0322  AC59 HEK-293T C392(0.93)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C295(1.15)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C295(0.96)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C295(0.96)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C295(1.08)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C295(0.95)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C295(0.85)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C295(0.94)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C295(1.04)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C295(0.93)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C295(0.97)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C295(0.90)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C295(1.24)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C295(1.47)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C295(0.99)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C295(1.03)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C295(1.00)  LDD1575  [3]
 LDCM0373  CL104 HEK-293T C295(0.92)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C295(1.05)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C295(1.02)  LDD1579  [3]
 LDCM0377  CL108 HEK-293T C295(0.91)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C295(0.95)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C295(1.54)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C295(1.04)  LDD1584  [3]
 LDCM0382  CL112 HEK-293T C295(0.61)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C295(1.17)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C295(0.97)  LDD1588  [3]
 LDCM0386  CL116 HEK-293T C295(0.91)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C295(1.03)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C295(0.98)  LDD1592  [3]
 LDCM0390  CL12 HEK-293T C295(1.19)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C295(0.98)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C295(1.05)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C295(1.03)  LDD1597  [3]
 LDCM0395  CL124 HEK-293T C295(0.94)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C295(1.35)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C295(0.97)  LDD1601  [3]
 LDCM0399  CL128 HEK-293T C295(0.94)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C295(1.17)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C295(0.97)  LDD1605  [3]
 LDCM0403  CL16 HEK-293T C295(1.05)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C295(1.32)  LDD1608  [3]
 LDCM0406  CL19 HEK-293T C392(1.30)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C295(0.91)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C295(1.17)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C295(1.23)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C295(1.43)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C295(1.75)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C295(1.63)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C295(1.11)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C295(0.96)  LDD1618  [3]
 LDCM0416  CL28 HEK-293T C295(1.03)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C295(1.12)  LDD1621  [3]
 LDCM0420  CL31 HEK-293T C392(1.33)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C295(1.12)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C295(1.32)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C295(1.11)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C295(1.88)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C295(1.77)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C295(1.01)  LDD1630  [3]
 LDCM0429  CL4 HEK-293T C295(1.01)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C295(0.96)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C295(1.20)  LDD1635  [3]
 LDCM0433  CL43 HEK-293T C392(1.16)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C295(1.13)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C295(1.24)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C295(1.34)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C295(1.42)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C295(1.42)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C295(1.27)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C295(1.03)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C295(1.03)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C295(1.14)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C295(1.26)  LDD1647  [3]
 LDCM0446  CL55 HEK-293T C392(1.11)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C295(1.19)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C295(1.23)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C295(1.59)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C295(1.76)  LDD1653  [3]
 LDCM0452  CL60 HEK-293T C295(1.80)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C295(1.19)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C295(0.96)  LDD1657  [3]
 LDCM0456  CL64 HEK-293T C295(1.00)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C295(1.11)  LDD1660  [3]
 LDCM0459  CL67 HEK-293T C392(1.24)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C295(0.88)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C295(1.23)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C392(1.23)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C295(1.38)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C295(1.38)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C295(1.64)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C295(1.12)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C295(0.85)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C295(0.95)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C295(1.20)  LDD1673  [3]
 LDCM0472  CL79 HEK-293T C392(1.21)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C295(2.57)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C295(0.90)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C295(1.03)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C295(1.08)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C295(1.59)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C295(1.58)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C295(1.17)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C295(0.75)  LDD1683  [3]
 LDCM0482  CL88 HEK-293T C295(0.88)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C295(1.02)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C295(1.30)  LDD1687  [3]
 LDCM0486  CL91 HEK-293T C392(1.02)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C295(1.22)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C295(1.14)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C295(1.08)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C295(1.16)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C295(0.97)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C295(1.02)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C295(0.93)  LDD1696  [3]
 LDCM0625  F8 Ramos C392(1.91)  LDD2187  [1]
 LDCM0575  Fragment13 Ramos C392(1.21)  LDD2192  [1]
 LDCM0580  Fragment21 Ramos C392(0.80)  LDD2195  [1]
 LDCM0582  Fragment23 Ramos C392(0.93)  LDD2196  [1]
 LDCM0578  Fragment27 Ramos C392(0.87)  LDD2197  [1]
 LDCM0586  Fragment28 Ramos C392(0.37)  LDD2198  [1]
 LDCM0588  Fragment30 Ramos C392(0.94)  LDD2199  [1]
 LDCM0589  Fragment31 Ramos C392(0.85)  LDD2200  [1]
 LDCM0468  Fragment33 Ramos C392(1.08)  LDD2202  [1]
 LDCM0566  Fragment4 Ramos C392(3.91)  LDD2184  [1]
 LDCM0427  Fragment51 HEK-293T C295(0.87)  LDD1631  [3]
 LDCM0610  Fragment52 Ramos C392(1.19)  LDD2204  [1]
 LDCM0614  Fragment56 Ramos C392(0.83)  LDD2205  [1]
 LDCM0569  Fragment7 Ramos C392(2.53)  LDD2186  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019