Details of the Target

General Information of Target

Target ID LDTP08550
Target Name Serine/threonine-protein kinase BRSK2 (BRSK2)
Gene Name BRSK2
Gene ID 9024
Synonyms
C11orf7; PEN11B; SADA; STK29; Serine/threonine-protein kinase BRSK2; EC 2.7.11.1; Brain-selective kinase 2; EC 2.7.11.26; Brain-specific serine/threonine-protein kinase 2; BR serine/threonine-protein kinase 2; Serine/threonine-protein kinase 29; Serine/threonine-protein kinase SAD-A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSTGKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVL
MKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARK
FFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPH
YACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIP
PDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDP
DVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDP
PRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGL
STSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRARLN
SIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKD
KPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGE
AQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHDPPAAQHLSDTTNCMEMMTGRLS
KCGSPLSNFFDVIKQLFSDEKNGQAAQAPSTPAKRSAHGPLGDSAAAGPGPGGDAEYPTG
KDTAKMGPPTARREQP
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion, BRSK2 phosphorylated at Thr-260 can promote insulin secretion. Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.
TTD ID
T10375
Uniprot ID
Q8IWQ3
DrugMap ID
TTHZN4X
Ensemble ID
ENST00000308219.13
HGNC ID
HGNC:11405
ChEMBL ID
CHEMBL4574

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.L701V .
COLO792 Substitution: p.S635R .
HT29 SNV: p.P277L .
IM95 SNV: p.L318R .
MFE319 SNV: p.H97R .
NCIH2172 SNV: p.H139Q .
OE33 SNV: p.E734D .
SNGM SNV: p.K539Q .
SNU5 SNV: p.E22G; p.K23E .
SW948 SNV: p.Ter737QextTer3 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C311(1.01); C39(1.17); C42(1.17)  LDD1492  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
AOyne
 Probe Info  		13.10  LDD0443  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C243(1.07); C311(1.07); C183(0.88); C39(1.06)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C311(1.07); C39(0.86)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C243(1.08); C311(0.97); C39(0.92)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C243(1.07); C311(1.11); C39(0.97)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C243(0.96); C311(1.02); C39(1.03); C176(1.14)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C243(0.93); C311(1.05)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C243(1.12); C311(1.05); C183(1.05); C39(1.09)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C311(1.11); C39(0.89)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C243(1.27); C311(0.99); C39(0.89)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C311(0.87); C39(0.89)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C243(0.98); C311(1.01); C39(0.95)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C243(0.87); C311(1.06); C39(0.98); C176(0.88)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C243(0.98); C311(1.10); C39(0.91); C176(0.98)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C243(1.08); C311(0.96)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C311(1.07); C183(1.04); C39(0.92); C176(1.08)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C243(1.15); C311(1.02); C183(0.99); C39(1.16)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C311(0.90); C39(0.95)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C243(1.09); C311(0.99); C39(0.95)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C243(1.10); C311(1.06); C39(0.96)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C243(0.92); C311(0.99); C39(0.97); C176(0.82)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C243(1.06); C311(0.90); C39(0.99)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C243(0.93); C311(0.87); C39(0.89); C176(0.98)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C243(0.96); C311(0.91)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C311(1.14); C183(1.15); C39(0.97); C176(1.19)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C243(1.04); C311(0.97); C183(1.25); C39(1.04)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C311(1.04); C39(1.01)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C243(1.04); C311(1.07); C39(1.04)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C243(1.04); C311(1.06); C39(0.99)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C243(0.92); C311(1.03); C39(1.05); C176(0.77)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C243(0.84); C311(0.93); C39(1.01); C176(1.15)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C243(1.05); C311(1.06)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C243(1.07); C311(1.07); C39(0.98)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C311(1.07); C183(0.86); C39(1.02); C176(1.13)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C243(1.12); C311(1.08); C183(1.09); C39(1.09)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C311(1.29); C39(0.91)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C243(1.05); C311(1.00); C39(0.96)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C243(1.02); C311(1.00); C39(0.91)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C243(0.89); C311(1.07); C39(1.02); C176(0.89)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C243(0.94); C311(1.01); C39(1.11); C176(0.79)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C243(1.02); C311(0.98)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C311(1.15); C183(1.12); C39(0.94); C176(1.18)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C243(1.19); C311(1.05); C183(1.15); C39(0.96)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C243(0.81); C311(0.94); C39(0.92); C176(0.79)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C311(0.96); C39(0.87)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C243(1.14); C311(1.00); C39(0.90)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C243(1.10); C311(0.92); C39(0.95)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C243(0.91); C311(0.94); C39(1.01); C176(0.80)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C243(1.00); C311(0.92); C39(0.75); C176(0.79)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C243(0.91); C311(0.94)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C311(0.93); C183(0.97); C39(0.90); C176(1.09)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C243(1.17); C311(1.07); C183(1.16); C39(1.01)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C311(1.02); C39(0.98)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C243(1.10); C311(0.91); C39(1.03)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C243(0.93); C311(0.92); C39(0.98); C176(0.97)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C243(0.99); C311(1.07); C39(1.06)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C243(0.92); C311(1.00); C39(1.07); C176(1.00)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C243(0.90); C311(0.90); C39(0.95); C176(0.88)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C243(0.94); C311(1.00)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C311(1.04); C183(0.98); C39(1.00); C176(0.95)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C243(1.00); C311(1.09)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C311(1.08); C183(1.17); C39(0.92); C176(1.05)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C243(0.86); C311(1.00); C39(1.02); C176(0.82)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C243(1.17); C311(1.03); C183(1.13); C39(1.04)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C311(1.02); C183(0.93); C39(0.97); C176(0.90)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C243(1.07); C311(0.96); C176(0.86)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C243(0.98); C311(1.03); C39(1.40); C176(0.97)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C311(0.99); C39(1.01)  LDD1573  [1]
 LDCM0370  CL101 HEK-293T C243(1.17); C311(0.87); C176(1.72)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C311(1.00); C39(0.99); C176(1.06)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C243(0.96); C311(1.04); C39(0.92); C176(0.88)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C311(0.96); C39(0.93)  LDD1577  [1]
 LDCM0374  CL105 HEK-293T C243(0.94); C311(0.93); C176(1.12)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C311(0.93); C39(1.01); C176(1.17)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C243(1.01); C311(0.91); C39(0.99); C176(0.89)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C311(0.97); C39(1.00)  LDD1581  [1]
 LDCM0378  CL109 HEK-293T C243(1.10); C311(0.94); C176(1.16)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C243(1.01); C311(1.26)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C311(0.98); C39(0.97); C176(1.21)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C243(1.18); C311(1.05); C39(0.93); C176(1.01)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C311(1.05); C39(1.02)  LDD1586  [1]
 LDCM0383  CL113 HEK-293T C243(1.02); C311(0.99); C176(1.18)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C311(1.06); C39(1.03); C176(1.34)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C243(1.11); C311(1.03); C39(1.00); C176(1.09)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C311(0.92); C39(1.07)  LDD1590  [1]
 LDCM0387  CL117 HEK-293T C243(1.08); C311(0.95); C176(1.30)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C311(0.92); C39(1.06); C176(1.25)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C243(1.13); C311(1.08); C39(0.95); C176(0.76)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C311(1.07); C183(1.16); C39(1.06); C176(1.26)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C311(0.93); C39(1.03)  LDD1595  [1]
 LDCM0392  CL121 HEK-293T C243(0.98); C311(0.87); C176(1.14)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C311(0.91); C39(0.95); C176(0.84)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C243(1.21); C311(1.00); C39(0.93); C176(0.70)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C311(0.95); C39(0.87)  LDD1599  [1]
 LDCM0396  CL125 HEK-293T C243(1.09); C311(1.09); C176(1.22)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C311(0.88); C39(1.05); C176(0.97)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C243(1.18); C311(0.96); C39(1.01); C176(0.88)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C311(1.00); C39(1.00)  LDD1603  [1]
 LDCM0400  CL13 HEK-293T C243(0.99); C311(0.94); C176(0.94)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C311(0.97); C39(0.99); C176(0.66)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C243(0.92); C311(1.08); C39(0.97); C176(0.94)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C311(0.92); C39(1.16)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C243(1.16); C311(1.19); C183(1.41); C39(1.00)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C311(1.02); C39(0.95)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C243(0.96); C311(1.08); C39(1.21)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C311(0.99); C39(1.01); C176(1.23)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C243(1.09); C311(0.99); C39(1.10)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C243(0.92); C311(0.92); C39(1.15); C176(0.87)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C243(0.91); C311(1.07); C39(1.07); C176(1.08)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C243(1.00); C311(1.19)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C311(1.12); C183(1.03); C39(1.08); C176(1.10)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C243(1.12); C311(0.85); C176(1.07)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C311(0.93); C39(1.00); C176(1.03)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C243(1.17); C311(1.12); C39(1.00); C176(0.97)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C311(0.94); C39(1.01)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C243(1.02); C311(1.14); C183(1.03); C39(1.07)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C243(1.17); C311(1.04); C39(1.05); C176(0.89)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C311(0.97); C39(0.98)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C243(0.89); C311(0.90); C39(1.01)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C243(1.05); C311(1.02); C39(1.05)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C243(0.99); C311(1.03); C39(1.18); C176(0.73)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C243(0.79); C311(1.02); C39(1.14); C176(0.81)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C243(0.88); C311(1.04)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C311(0.96); C183(1.01); C39(1.16); C176(1.20)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C243(1.18); C311(0.89); C176(1.41)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C243(0.93); C311(1.00); C39(0.99); C176(0.82)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C311(0.93); C39(1.09)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C311(0.95); C39(0.99)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C243(1.08); C311(1.02); C183(0.67); C39(1.04)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C311(0.90); C39(0.96)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C243(0.98); C311(1.17); C39(1.05)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C243(1.11); C311(0.98); C39(1.10)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C243(0.87); C311(0.95); C39(1.23); C176(0.98)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C243(0.86); C311(0.81); C39(1.11); C176(0.95)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C243(0.93); C311(1.00)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C311(1.12); C183(1.21); C39(1.12); C176(0.93)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C243(1.16); C311(0.94); C176(1.10)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C243(1.08); C311(1.03); C183(0.97); C39(0.98)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C311(0.91); C39(1.05); C176(1.03)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C311(0.93); C39(1.17)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C243(1.05); C311(1.17); C183(0.83); C39(1.05)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C311(1.03); C39(0.96)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C243(1.07); C311(1.16); C39(1.15)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C243(0.98); C311(1.04); C39(1.10)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C243(0.89); C311(0.95); C39(1.18); C176(0.69)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C243(0.88); C311(0.92); C39(1.08); C176(0.76)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C243(0.96); C311(1.14)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C311(0.92); C39(0.94)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C311(1.01); C183(0.91); C39(1.18); C176(1.19)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C243(1.05); C311(1.00); C176(0.86)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C311(0.93); C39(0.90); C176(1.27)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C243(1.03); C311(0.97); C39(0.95); C176(0.93)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C311(1.03); C39(1.00)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C243(1.00); C311(1.08); C183(1.00); C39(1.08)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C311(0.93); C39(0.97)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C243(1.19); C311(1.07); C39(1.06)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C243(1.04); C311(1.02); C39(1.20)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C243(0.97); C311(0.89); C39(1.13); C176(0.79)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C243(1.04); C311(1.03); C39(1.20)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C243(0.90); C311(1.08); C39(1.02); C176(0.83)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C243(0.93); C311(1.09)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C311(1.11); C183(0.99); C39(1.11); C176(1.08)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C243(0.98); C311(1.08); C176(1.19)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C311(0.88); C39(0.96); C176(0.93)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C311(0.98); C39(1.00)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C243(1.06); C311(1.09); C183(0.82); C39(1.10)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C311(1.07); C39(0.97)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C243(1.16); C311(1.07); C39(1.04)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C243(1.16); C311(1.14); C39(1.34)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C243(1.00); C311(1.06); C39(1.13)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C243(0.84); C311(0.99); C39(1.09); C176(0.93)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C243(1.08); C311(1.06); C39(1.08); C176(0.99)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C243(0.91); C311(0.99)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C311(1.10); C183(0.98); C39(1.02); C176(0.91)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C243(1.10); C311(0.89); C176(1.17)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C311(0.93); C39(1.11); C176(1.09)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C243(1.13); C311(0.92); C39(1.09); C176(0.88)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C311(0.99); C39(1.14)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C243(1.09); C311(1.07); C183(0.93); C39(1.11)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C243(0.86); C311(1.00); C39(1.19); C176(0.93)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C311(1.09); C39(0.93)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C243(1.06); C311(1.09); C39(1.11)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C243(0.97); C311(1.02); C39(1.09)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C243(0.95); C311(0.88); C39(1.15); C176(0.80)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C243(1.05); C311(1.18); C39(1.18); C176(0.99)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C243(1.11); C311(1.19)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C311(1.02); C183(0.99); C39(1.07); C176(1.10)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C243(1.14); C311(0.94); C176(1.23)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C311(0.81); C39(0.98); C176(0.94)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C243(0.89); C311(1.01); C39(1.04); C176(0.73)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C243(0.86); C311(0.96); C39(1.02); C176(0.90)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C243(1.00); C311(0.97); C39(1.00); C176(0.79)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C311(0.89); C39(1.04); C176(1.08)  LDD1631  [1]
 LDCM0022  KB02 HEK-293T C311(1.01); C39(1.17); C42(1.17)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C311(0.93); C39(1.14); C42(1.14)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C311(1.00); C39(1.03); C42(1.03)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 5 (COPS5) Peptidase M67A family Q92905
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cct244747 Small molecular drug D0Z8PT

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.