Details of the Target

General Information of Target

Target ID LDTP08526
Target Name ATP-dependent (S)-NAD(P)H-hydrate dehydratase (NAXD)
Gene Name NAXD
Gene ID 55739
Synonyms
CARKD; ATP-dependent; S)-NAD(P)H-hydrate dehydratase; EC 4.2.1.93; ATP-dependent NAD(P)HX dehydratase; Carbohydrate kinase domain-containing protein; NAD(P)HX dehydratase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVTRAGAGTAVAGAVVVALLSAALALYGPPLDAVLERAFSLRKAHSIKDMENTLQLVRNI
IPPLSSTKHKGQDGRIGVVGGCQEYTGAPYFAAISALKVGADLSHVFCASAAAPVIKAYS
PELIVHPVLDSPNAVHEVEKWLPRLHALVVGPGLGRDDALLRNVQGILEVSKARDIPVVI
DADGLWLVAQQPALIHGYRKAVLTPNHVEFSRLYDAVLRGPMDSDDSHGSVLRLSQALGN
VTVVQKGERDILSNGQQVLVCSQEGSSRRCGGQGDLLSGSLGVLVHWALLAGPQKTNGSS
PLLVAAFGACSLTRQCNHQAFQKHGRSTTTSDMIAEVGAAFSKLFET
Target Bioclass
Enzyme
Family
NnrD/CARKD family
Subcellular location
Mitochondrion
Function
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. {|HAMAP-Rule:MF_03157}.
Uniprot ID
Q8IW45
Ensemble ID
ENST00000309957.3
HGNC ID
HGNC:25576

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C95(1.55)  LDD3311  [1]
BTD
 Probe Info  		C108(0.46)  LDD2143  [2]
Acrolein
 Probe Info  		N.A.  LDD0223  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C82(0.00); C270(0.00); C108(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C82(0.00); C270(0.00); C108(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C82(0.00); C270(0.00)  LDD0037  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C316(1.18); C82(1.06); C270(0.86)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C316(0.96); C82(1.06); C270(1.23)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C316(1.05); C82(1.01); C270(0.93)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C316(1.15); C82(0.97)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C316(0.99); C82(0.90)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C316(1.04); C82(0.96)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C316(1.07); C82(1.01); C270(1.07)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C316(0.79); C82(1.08); C270(1.10)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C316(0.97); C82(0.74); C270(0.89)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C316(0.95); C82(0.97); C270(1.00)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C316(1.15); C82(0.99)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C316(1.02); C82(0.97)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C316(0.95); C82(1.00)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C316(0.98); C82(0.88)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C316(0.97); C82(1.04)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C316(1.25); C82(0.94); C270(0.89)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C316(0.97); C82(1.03); C270(1.06)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C316(0.88); C82(1.01); C270(1.09)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C316(1.05); C82(0.94)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C316(1.07); C82(0.94)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C316(0.95); C82(0.97); C270(0.95)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C316(1.06); C82(0.87)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C316(1.11); C82(0.88)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C316(0.99); C82(1.04)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C316(0.94); C82(1.07); C270(0.91)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C316(0.96); C82(1.03); C270(1.02)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C316(1.12); C82(0.85); C270(0.92)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C316(1.00); C82(0.94)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C316(0.97); C82(1.03)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C316(0.94); C82(1.00)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C316(1.12); C82(0.92)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C316(1.27); C82(0.94)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C316(1.07); C82(0.96)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C316(1.13); C82(1.02); C270(1.05)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C316(0.98); C82(0.96); C270(1.14)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C316(0.87); C82(0.82); C270(1.07)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C316(1.27); C82(0.91)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C316(0.92); C82(1.00)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C316(0.95); C82(0.98)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C316(1.00); C82(0.93)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C316(0.90); C82(1.03)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C316(0.78); C82(1.01); C270(1.09)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C316(0.89); C82(0.95)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C316(0.92); C82(1.08); C270(1.09)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C316(1.05); C82(0.87); C270(0.88)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C316(1.12); C82(0.96)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C316(1.00); C82(0.92)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C316(1.02); C82(0.88)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C316(0.97); C82(0.90)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C316(1.03); C82(1.04)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C316(0.98); C82(1.02); C270(0.94)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C316(0.95); C82(1.01); C270(0.97)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C316(0.98); C82(0.96); C270(1.07)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C316(1.13); C82(0.95)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C316(1.02); C82(0.89)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C316(1.21); C82(1.01)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C316(1.02); C82(1.06)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C316(0.98); C82(1.01)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C316(1.05); C82(1.06)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C316(1.07); C82(0.93)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C316(1.17); C82(1.14)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C316(0.97); C82(0.97)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C316(0.84); C82(1.04); C270(1.17)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C316(1.05); C82(0.96)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C316(1.35); C82(1.09); C270(0.90)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C316(0.92); C82(0.79)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C316(0.85); C82(1.02)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C316(1.27); C82(1.00); C270(1.08)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C316(0.95); C82(0.96); C270(0.85)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C316(1.06); C82(0.85); C270(1.01)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C316(1.08); C82(0.99)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C316(0.91); C82(0.96); C270(0.98)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C316(1.00); C82(0.93); C270(1.01)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C316(1.10); C82(0.93); C270(1.24)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C316(0.94); C82(0.92)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C316(1.10); C82(1.06); C270(0.94)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C316(0.87); C82(0.91)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C316(0.98); C82(0.81); C270(1.02)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C316(1.06); C82(0.82); C270(0.73)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C316(0.96); C82(0.90)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C316(1.24); C82(1.10); C270(0.98)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C316(0.85); C82(1.00); C270(0.92)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C316(1.17); C82(0.89); C270(0.68)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C316(1.01); C82(0.97)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C316(1.13); C82(0.94); C270(1.07)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C316(1.01); C82(1.06); C270(1.07)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C316(1.39); C82(0.93); C270(1.12)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C316(1.00); C82(1.07)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C316(0.86); C82(1.02)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C316(1.24); C82(1.09); C270(0.94)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C316(0.94); C82(1.11); C270(1.04)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C316(1.10); C82(0.78); C270(1.09)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C316(1.08); C82(0.86)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C316(1.48); C82(1.10); C270(0.93)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C316(1.06); C82(0.96); C270(1.05)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C316(1.17); C82(0.94); C270(0.87)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C316(1.15); C82(0.92)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C316(0.99); C82(1.04); C270(1.08)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C316(1.21); C82(1.05); C270(1.16)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C316(1.22); C82(0.80); C270(0.92)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C316(0.93); C82(0.95)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C316(0.81); C82(0.96); C270(1.07)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C316(1.08); C82(0.96); C270(1.10)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C316(0.95); C82(1.02); C270(1.05)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C316(0.93); C82(1.02); C270(1.07)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C316(1.20); C82(0.98)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C316(0.85); C82(0.92)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C316(0.92); C82(0.89)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C316(0.84); C82(0.94)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C316(0.95); C82(1.10)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C316(0.95); C82(0.97); C270(0.88)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C316(0.89); C82(1.03); C270(1.09)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C316(1.14); C82(0.93); C270(0.90)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C316(0.90); C82(1.01)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C316(1.11); C82(1.01); C270(0.88)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C316(1.23); C82(0.89); C270(0.98)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C316(0.85); C82(1.07); C270(1.15)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C316(0.90); C82(0.90); C270(1.01)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C316(1.09); C82(0.93)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C316(0.81); C82(0.85)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C316(0.94); C82(0.86)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C316(0.99); C82(0.85)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C316(0.90); C82(0.92)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C316(1.33); C82(1.05); C270(0.85)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C316(0.97); C82(0.85); C270(1.01)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C316(0.99); C82(0.96)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C316(0.87); C82(1.06)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C316(1.01); C82(1.05); C270(0.93)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C316(0.91); C82(0.96); C270(1.03)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C316(0.92); C82(0.84); C270(0.94)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C316(1.06); C82(0.91)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C316(0.86); C82(0.84)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C316(0.93); C82(0.90)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C316(0.91); C82(0.92)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C316(0.95); C82(1.01)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C316(1.31); C82(1.03); C270(0.95)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C316(1.40); C82(1.08); C270(1.01)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C316(1.00); C82(0.99); C270(1.07)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C316(1.24); C82(1.01)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C316(1.05); C82(0.94); C270(0.87)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C316(0.80); C82(0.85); C270(1.05)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C316(0.85); C82(1.07); C270(1.05)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C316(1.28); C82(0.91)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C316(0.90); C82(0.90)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C316(0.93); C82(1.02)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C316(0.97); C82(0.82)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C316(0.91); C82(0.95); C270(0.97)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C316(0.92); C82(0.95)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C316(1.24); C82(1.29); C270(0.86)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C316(0.94); C82(0.99); C270(1.00)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C316(1.31); C82(0.97); C270(0.92)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C316(0.99); C82(0.86)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C316(0.71); C82(1.03); C270(1.07)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C316(0.90); C82(0.98); C270(0.96)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C316(0.95); C82(1.00); C270(1.10)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C316(1.12); C82(0.92)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C316(1.07); C82(0.65)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C316(1.00); C82(0.87); C270(1.02)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C316(0.88); C82(0.95)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C316(0.88); C82(0.84)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C316(0.81); C82(0.94)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C316(1.30); C82(0.98); C270(0.97)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C316(1.07); C82(1.12); C270(0.98)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C316(1.04); C82(0.97)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C316(0.72); C82(0.94); C270(0.97)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C316(0.99); C82(1.04); C270(1.12)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C316(0.92); C82(0.92); C270(0.81)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C316(1.00); C82(0.80)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C316(1.27); C82(0.91)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C316(0.90); C82(1.01)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C316(1.03); C82(0.89)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C316(1.04); C82(0.93)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C316(1.01); C82(1.01)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C316(1.30); C82(1.14); C270(1.00)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C316(0.99); C82(1.12); C270(1.04)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C316(1.30); C82(0.96); C270(1.09)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C316(0.90); C82(1.05)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C316(0.82); C82(1.17); C270(0.83)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C316(1.20); C82(0.99)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C316(0.82); C82(0.82); C270(0.86)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C316(0.95); C82(0.99); C270(0.80)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C316(1.09); C82(0.95)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C316(0.93); C82(1.00)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C316(0.94); C82(0.99)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C316(0.90); C82(0.86)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C316(1.07); C82(0.96)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C316(1.17); C82(0.84); C270(0.89)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C316(1.15); C82(0.99); C270(0.92)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C316(1.10); C82(0.95); C270(0.81)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C316(1.08); C82(0.90); C270(0.86)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C316(1.19); C82(1.00); C270(0.99)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C316(1.01); C82(1.07); C270(1.17)  LDD1631  [7]
 LDCM0022  KB02 22RV1 C82(1.07)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C82(1.08)  LDD2660  [1]
 LDCM0024  KB05 G361 C95(1.55)  LDD3311  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C108(0.46)  LDD2143  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-6 (KRTAP10-6) KRTAP type 10 family P60371
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402