Details of the Target

General Information of Target

Target ID LDTP08396
Target Name Prostate tumor-overexpressed gene 1 protein (PTOV1)
Gene Name PTOV1
Gene ID 53635
Synonyms
ACID2; Prostate tumor-overexpressed gene 1 protein; PTOV-1; Activator interaction domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVRPRRAPYRSGAGGPLGGRGRPPRPLVVRAVRSRSWPASPRGPQPPRIRARSAPPMEGA
RVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLP
CQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCR
IMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTRKQAV
GPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPR
KLYMQLIPQQLLTTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFAGCVHFSYKASCE
IRVLMLLYSSEKKIFIGLIPHDQGNFVNGIRRVIANQQQVLQRNLEQEQQQRGMGG
Target Bioclass
Other
Family
Mediator complex subunit 25 family, PTOV1 subfamily
Subcellular location
Cytoplasm
Function May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
Uniprot ID
Q86YD1
Ensemble ID
ENST00000391842.6
HGNC ID
HGNC:9632

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HUH28 SNV: p.Q147Ter .
SNU1 SNV: p.P155L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C121(6.49); C359(191.70)  LDD0209  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C172(2.36)  LDD0372  [5]
 LDCM0215  AC10 HEK-293T C121(1.03)  LDD1508  [6]
 LDCM0237  AC12 HEK-293T C121(1.01)  LDD1510  [6]
 LDCM0270  AC15 HEK-293T C121(1.06)  LDD1513  [6]
 LDCM0277  AC18 HEK-293T C121(1.06)  LDD1516  [6]
 LDCM0279  AC2 HEK-293T C121(1.07)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C121(0.95)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C121(0.95)  LDD1520  [6]
 LDCM0283  AC23 HEK-293T C121(1.01)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C121(1.00)  LDD1523  [6]
 LDCM0286  AC26 HEK-293T C121(0.97)  LDD1525  [6]
 LDCM0288  AC28 HEK-293T C121(1.02)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C121(0.89)  LDD1528  [6]
 LDCM0292  AC31 HEK-293T C121(0.88)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C121(1.05)  LDD1532  [6]
 LDCM0295  AC34 HEK-293T C121(1.11)  LDD1534  [6]
 LDCM0297  AC36 HEK-293T C121(1.05)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C121(1.11)  LDD1537  [6]
 LDCM0300  AC39 HEK-293T C121(0.96)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C121(0.92)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C121(1.08)  LDD1541  [6]
 LDCM0304  AC42 HEK-293T C121(1.03)  LDD1543  [6]
 LDCM0306  AC44 HEK-293T C121(1.08)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C121(1.34)  LDD1546  [6]
 LDCM0309  AC47 HEK-293T C121(0.99)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C121(1.11)  LDD1549  [6]
 LDCM0312  AC5 HEK-293T C121(1.07)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C121(1.07)  LDD1552  [6]
 LDCM0315  AC52 HEK-293T C121(1.08)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C121(1.06)  LDD1555  [6]
 LDCM0318  AC55 HEK-293T C121(0.95)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C121(1.09)  LDD1558  [6]
 LDCM0321  AC58 HEK-293T C121(0.96)  LDD1560  [6]
 LDCM0324  AC60 HEK-293T C121(1.04)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C121(1.07)  LDD1564  [6]
 LDCM0327  AC63 HEK-293T C121(0.96)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C121(1.18)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C121(0.88)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C121(1.17)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C121(1.18)  LDD1511  [6]
 LDCM0275  AKOS034007705 HEK-293T C121(1.11)  LDD1514  [6]
 LDCM0369  CL100 HEK-293T C121(0.96)  LDD1573  [6]
 LDCM0371  CL102 HEK-293T C121(1.12)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C121(1.01)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C121(0.91)  LDD1577  [6]
 LDCM0375  CL106 HEK-293T C121(1.00)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C121(0.86)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C121(0.94)  LDD1581  [6]
 LDCM0379  CL11 HEK-293T C121(1.12)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C121(1.06)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C121(1.07)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C121(0.94)  LDD1586  [6]
 LDCM0384  CL114 HEK-293T C121(1.13)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C121(1.10)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C121(1.03)  LDD1590  [6]
 LDCM0388  CL118 HEK-293T C121(1.08)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C121(0.72)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C121(1.11)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C121(0.99)  LDD1595  [6]
 LDCM0393  CL122 HEK-293T C121(1.01)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C121(1.00)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C121(0.94)  LDD1599  [6]
 LDCM0397  CL126 HEK-293T C121(1.09)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C121(0.99)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C121(0.93)  LDD1603  [6]
 LDCM0401  CL14 HEK-293T C121(0.93)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C121(0.99)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C121(1.09)  LDD1607  [6]
 LDCM0405  CL18 HEK-293T C121(1.29)  LDD1609  [6]
 LDCM0407  CL2 HEK-293T C121(1.00)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C121(1.06)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C121(1.45)  LDD1613  [6]
 LDCM0411  CL23 HEK-293T C121(1.11)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C121(1.12)  LDD1616  [6]
 LDCM0414  CL26 HEK-293T C121(1.08)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C121(1.02)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C121(0.96)  LDD1620  [6]
 LDCM0418  CL3 HEK-293T C121(1.19)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C121(1.06)  LDD1623  [6]
 LDCM0421  CL32 HEK-293T C121(1.00)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C121(1.18)  LDD1626  [6]
 LDCM0424  CL35 HEK-293T C121(0.92)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C121(0.96)  LDD1629  [6]
 LDCM0428  CL39 HEK-293T C121(1.12)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C121(1.10)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C121(1.02)  LDD1634  [6]
 LDCM0432  CL42 HEK-293T C121(0.96)  LDD1636  [6]
 LDCM0434  CL44 HEK-293T C121(0.97)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C121(0.99)  LDD1639  [6]
 LDCM0437  CL47 HEK-293T C121(1.02)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C121(1.08)  LDD1642  [6]
 LDCM0441  CL50 HEK-293T C121(1.11)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C121(1.11)  LDD1646  [6]
 LDCM0445  CL54 HEK-293T C121(1.11)  LDD1648  [6]
 LDCM0447  CL56 HEK-293T C121(0.86)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C121(1.13)  LDD1651  [6]
 LDCM0450  CL59 HEK-293T C121(0.96)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C121(1.21)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C121(1.07)  LDD1655  [6]
 LDCM0454  CL62 HEK-293T C121(1.02)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C121(0.85)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C121(1.13)  LDD1659  [6]
 LDCM0458  CL66 HEK-293T C121(1.02)  LDD1661  [6]
 LDCM0460  CL68 HEK-293T C121(1.16)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C121(1.15)  LDD1664  [6]
 LDCM0464  CL71 HEK-293T C121(1.04)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C121(1.20)  LDD1668  [6]
 LDCM0467  CL74 HEK-293T C121(1.13)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C121(0.98)  LDD1672  [6]
 LDCM0471  CL78 HEK-293T C121(0.99)  LDD1674  [6]
 LDCM0473  CL8 HEK-293T C121(1.30)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C121(1.04)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C121(1.07)  LDD1678  [6]
 LDCM0477  CL83 HEK-293T C121(1.08)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C121(1.20)  LDD1681  [6]
 LDCM0480  CL86 HEK-293T C121(1.11)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C121(1.05)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C121(0.88)  LDD1685  [6]
 LDCM0484  CL9 HEK-293T C121(1.31)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C121(1.52)  LDD1688  [6]
 LDCM0487  CL92 HEK-293T C121(1.07)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C121(1.10)  LDD1691  [6]
 LDCM0490  CL95 HEK-293T C121(1.16)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C121(1.30)  LDD1694  [6]
 LDCM0493  CL98 HEK-293T C121(1.02)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C121(1.06)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C121(1.39)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C121(0.79)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C121(0.98)  LDD1631  [6]
 LDCM0023  KB03 Jurkat C121(6.49); C359(191.70)  LDD0209  [1]

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402