Details of the Target

General Information of Target

Target ID LDTP08258
Target Name NEDD4-binding protein 2 (N4BP2)
Gene Name N4BP2
Gene ID 55728
Synonyms
B3BP; KIAA1413; NEDD4-binding protein 2; N4BP2; EC 3.-.-.-; BCL-3-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRRRKNLGGNPFRKTANPKEVVVSSVASREEPTTTLPSMGETKVDQEELFTSISEIFSD
LDPDVVYLMLSECDFKVENAMDCLLELSATDTKIEESSSQSFVASENQVGAAESKIMEKR
PEEESEDSKMDSFLDMQLTEDLDSLIQNAFEKLNSSPDDQVYSFLPSQDVNSFNDSSEFI
NPDSSNMTPIFSTQNMNLNGENLENSGSTLSLNPLPSHSVLNESKCFIKDNTLALESNYP
EDSLLSSSLNVASDSIAGCSSLNQKQKELLESECVEAQFSEAPVDLDASEPQACLNLPGL
DLPGTGGDQKSTRVSDVFLPSEGFNFKPHKHPELPTKGKDVSYCPVLAPLPLLLPPPPPP
PMWNPMIPAFDLFQGNHGFVAPVVTTAAHWRSVNYTFPPSVISHTSPTKVWRNKDGTSAY
QVQETPVSQVVRKKTSYVGLVLVLLRGLPGSGKSFLARTLQEDNPSGVILSTDDYFYING
QYQFDVKYLGEAHEWNQNRAKEAFEKKISPIIIDNTNLQAWEMKPYVALSQKHKYKVLFR
EPDTWWKFKPKELARRNIHGVSKEKITRMLEHYQRFVSVPIIMSSSVPEKIERIELCAYS
CEDRSTSPRDDEDIISEKEENILSLSLKHLEFTEEKNLDVTKETMLPENVAYLSNADLNK
RRKEISDMNPSIQSALILETPHMYFSDSESKLQATDKSENEQIEMVAVKGYSKTDTDSSM
ERVSPSTCCSENNQEDCDLANSGPLQNEKSSPGEIVEERATVTKKAFGKQKSKSTLEKFP
RHELSNFVGDWPVDKTIGQRTKRNRKTEKTSSVQSDKKYNYPQSHKLVNSVSVNTDCVQQ
RGSPHESVEDGRKSQCDDASEPLNSYKYDAYKNIDKNSFNIMGDWPSSDSLAQREHRSRM
PKTGLSEPNLEIGTNDKMNEISLSTAHEACWGTSSQKLKTLGSSNLGSSEMLLSEMTCES
QTCLSKKSHGQHTSLPLTFTNSAPTVSGVVEPQTLAECQEQMPKRDPGKEVGMCTQTEPQ
DFALLWKIEKNKISISDSIKVLTGRLDGFKPKVFNINTKSDVQEAIPYRVMYDKSTFVEE
SELTSADESENLNILCKLFGSFSLEALKDLYERCNKDIIWATSLLLDSETKLCEDTEFEN
FQKSCDGSQIGPFSLGLNLKEIISQRGTLENSNSPVPEFSHGIGISNADSQSTCDAERGN
SEQAEMRAVTPENHESMTSIFPSAAVGLKNNNDILPNSQEELLYSSKQSFPGILKATTPK
DMSETEKNLVVTETGDNIHSPSHFSDIFNFVSSTSNLELNEEIYFTDSLEIKRNENFPKD
YVKFSDEEEFMNEDEKEMKEILMAGSSLSAGVSGEDKTEILNPTPAMAKSLTIDCLELAL
PPELAFQLNELFGPVGIDSGSLTVEDCVVHIDLNLAKVIHEKWKESVMERQRQEEVSCGK
FMQDPSLVGHTGLDNPEQKSSQRTGKKLLKTLTASEMLPLLDHWNTQTKKVSLREIMSEE
IALQEKHNLKRETLMFEKDCATKLKEKQLFKIFPAINQNFLVDIFKDHNYSLEHTVQFLN
CVLEGDPVKTVVAQEFVHQNENVTSHTGQKSKEKKPKKLKETEETPSELSFQDFEYPDYD
DYRAEAFLHQQKRMECYSKAKEAYRIGKKNVATFYAQQGTLHEQKMKEANHLAAIEIFEK
VNASLLPQNVLDLHGLHVDEALEHLMRVLEKKTEEFKQNGGKPYLSVITGRGNHSQGGVA
RIKPAVIKYLISHSFRFSEIKPGCLKVMLK
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.
Uniprot ID
Q86UW6
Ensemble ID
ENST00000261435.11
HGNC ID
HGNC:29851

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.L1725F .
CCK81 SNV: p.D82N; p.E118G .
HCT116 SNV: p.Q292H .
HCT15 SNV: p.N621K .
HS936T SNV: p.E541K .
HT115 SNV: p.E1302Ter .
JURKAT SNV: p.C259Y; p.N621S; p.T1522I Compound 10    Probe Info 
KYM1 SNV: p.I1397T .
KYSE180 SNV: p.S1103L .
MFE319 SNV: p.D158G .
MOLT4 SNV: p.P303S; p.A1474T IA-alkyne    Probe Info 
NCIH1993 Deletion: p.T52del .
PF382 SNV: p.P365T DBIA    Probe Info 
RKO Insertion: p.S192FfsTer10
SNV: p.V561A		 .
RL SNV: p.D687G .
SNU5 SNV: p.S114I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C597(1.00); C601(1.00)  LDD0078  [2]
IA-alkyne
 Probe Info  		C1764(0.00); C1438(0.00); C837(0.00)  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
IPM
 Probe Info  		C837(0.00); C1438(0.00); C1133(0.00)  LDD2156  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C837(0.93); C83(1.17); C1133(1.01); C1764(1.18)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C837(1.05); C1145(1.10); C83(0.92); C1133(1.10)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C837(0.70); C930(0.86); C1145(0.99); C83(1.10)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C837(1.05); C930(0.92); C1145(1.14); C83(1.01)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C837(1.16); C1145(0.84); C83(1.05); C1133(1.03)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C1145(1.05); C83(1.05); C1014(1.13); C1764(1.08)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C597(1.18); C601(1.18)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C597(1.27); C601(1.27)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C597(1.22); C601(1.22)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C837(0.88); C1145(1.11); C83(0.86); C1133(1.03)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C597(1.20); C601(1.20)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C597(1.19); C601(1.19)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C597(1.15); C601(1.15)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C597(1.15); C601(1.15)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C597(1.15); C601(1.15)  LDD0882  [2]
 LDCM0285  AC25 HEK-293T C597(0.70); C601(0.70)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C597(0.88); C601(0.88)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C597(0.77); C601(0.77)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C597(0.79); C601(0.79)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C597(0.80); C601(0.80)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C837(0.65); C930(0.95); C1145(1.22); C83(0.99)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C597(0.80); C601(0.80)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C597(0.77); C601(0.77)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C597(0.81); C601(0.81)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C597(0.86); C601(0.86)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C597(0.82); C601(0.82)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C837(0.73); C930(0.98); C1145(1.00); C83(1.13)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C837(0.79); C930(1.08); C1145(1.14); C83(1.02)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C930(0.92); C1145(0.90); C83(0.95); C1133(0.97)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C837(0.84); C1145(0.85); C83(1.07); C1133(1.02)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C1145(1.04); C83(1.23); C1014(1.18); C1764(1.17)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C837(0.82); C930(0.95); C1145(1.22); C83(1.07)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C837(0.84); C930(0.93); C1145(1.08); C83(1.24)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C837(1.02); C83(0.97); C1133(1.05); C1764(1.33)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C837(1.18); C1145(1.20); C83(0.86); C1133(1.10)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C837(0.90); C930(0.89); C1145(0.94); C83(1.00)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C837(0.70); C930(1.04); C1145(1.08); C83(1.04)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C930(0.88); C1145(1.05); C83(0.95); C1133(1.03)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C597(0.80); C601(0.80)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C597(0.87); C601(0.87)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C597(0.74); C601(0.74)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C597(0.82); C601(0.82)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C930(0.77); C1145(1.01); C83(0.94); C1133(1.01)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C597(0.90); C601(0.90)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C597(0.92); C601(0.92)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C597(0.81); C601(0.81)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C597(1.11); C601(1.11)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C597(1.00); C601(1.00)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C597(1.23); C601(1.23)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C597(0.83); C601(0.83)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C597(0.86); C601(0.86)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C597(0.77); C601(0.77)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C597(0.86); C601(0.86)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C837(1.02); C1145(1.02); C83(1.11); C1133(1.04)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C597(0.94); C601(0.94)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C597(0.82); C601(0.82)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C597(0.86); C601(0.86)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C597(0.85); C601(0.85)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C597(0.94); C601(0.94)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C597(1.07); C601(1.07)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C597(1.01); C601(1.01)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C597(1.06); C601(1.06)  LDD0929  [2]
 LDCM0334  AC7 HEK-293T C1145(0.98); C83(0.93); C1014(1.09); C1764(1.32)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C837(0.97); C930(0.91); C1145(1.15); C83(0.99)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C930(0.86); C1145(1.03); C83(0.90); C1133(1.05)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C837(0.88); C83(0.94); C1133(1.00); C1764(1.31)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C837(0.95); C930(0.98); C1145(1.21); C83(1.03)  LDD1514  [8]
 LDCM0156  Aniline NCI-H1299 13.39  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C597(1.00); C601(1.00)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C837(1.21); C930(0.91); C1145(1.09); C83(0.93)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C837(1.08); C1145(0.93); C83(1.33); C1133(1.17)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C837(1.05); C930(1.02); C83(1.02); C1133(1.10)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C837(1.04); C930(0.87); C1145(1.11); C83(1.00)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C837(1.19); C1145(1.14); C83(1.03); C1133(1.05)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C837(1.00); C83(1.01); C1014(1.03); C1096(1.27)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C837(0.94); C930(0.89); C83(1.14); C1133(0.99)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C597(1.25); C601(1.25)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C597(1.15); C601(1.15)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C597(1.02); C601(1.02)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C597(1.14); C601(1.14)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C597(1.19); C601(1.19)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C1145(0.74); C83(1.24); C1014(1.18); C1764(0.87)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C597(1.50); C601(1.50)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C597(1.34); C601(1.34)  LDD0979  [2]
 LDCM0382  CL112 HEK-293T C597(1.02); C601(1.02)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C597(0.90); C601(0.90)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C597(1.26); C601(1.26)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C597(1.01); C601(1.01)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C597(0.80); C601(0.80)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C837(1.14); C930(0.87); C1145(1.05); C83(1.06)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C837(1.04); C1145(1.11); C83(1.05); C1133(1.21)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C837(1.02); C83(1.27); C1014(0.97); C1096(1.15)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C837(0.92); C930(1.12); C1145(0.94); C83(1.29)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C837(1.05); C930(1.02); C83(1.00); C1133(1.07)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C597(0.93); C601(0.93)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C597(1.00); C601(1.00)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C597(1.32); C601(1.32)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C597(0.96); C601(0.96)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C597(0.84); C601(0.84)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C597(0.87); C601(0.87)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C597(0.74); C601(0.74)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C597(0.91); C601(0.91)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C837(1.28); C930(0.89); C1145(1.15); C83(1.12)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C837(1.55); C1145(0.99); C83(1.01); C1133(1.01)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C837(1.00); C83(0.99); C1014(1.16); C1096(1.59)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C837(0.92); C930(1.04); C83(1.04); C1133(0.99)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C837(0.96); C83(1.04); C1133(1.04); C1764(0.96)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C837(1.17); C1145(0.87); C83(1.12); C1133(1.01)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C837(0.68); C930(0.93); C1145(0.97); C83(1.09)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C837(1.06); C1145(1.00); C83(0.97); C1133(1.02)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C837(1.16); C930(0.90); C1145(0.88); C83(1.25)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C930(0.76); C1145(0.72); C83(1.08); C1133(1.13)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C837(0.96); C1145(0.74); C83(1.25); C1133(1.16)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C1145(0.83); C83(1.38); C1014(1.04); C1764(0.88)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C837(1.09); C930(0.99); C1145(0.85); C83(1.19)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C837(0.93); C930(0.79); C1145(1.07); C83(1.18)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C837(1.13); C1145(0.84); C83(0.90); C1133(0.90)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C837(0.85); C83(0.96); C1014(1.15); C1096(1.16)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C837(0.81); C930(1.18); C83(1.13); C1133(1.05)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C837(0.85); C83(1.01); C1133(0.99); C1764(1.19)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C837(0.98); C83(0.51); C1014(1.11); C1096(1.44)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C837(1.39); C1145(0.81); C83(0.90); C1133(1.05)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C837(1.13); C930(0.99); C1145(0.85); C83(1.25)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C837(0.87); C930(1.04); C1145(0.90); C83(1.14)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C930(0.81); C1145(0.89); C83(0.90); C1133(1.11)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C837(1.00); C1145(0.65); C83(1.29); C1133(1.12)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C1145(0.75); C83(1.33); C1014(1.16); C1764(0.85)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C837(1.15); C930(1.02); C1145(0.86); C83(1.37)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C837(0.95); C930(0.86); C1145(1.06); C83(1.06)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C837(0.97); C83(0.92); C1014(0.93); C1096(1.16)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C837(1.18); C930(1.03); C83(1.00); C1133(1.04)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C837(0.85); C930(1.18); C83(1.08); C1133(1.06)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C837(0.86); C83(1.04); C1133(0.93); C1764(1.11)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C837(1.43); C1145(0.79); C83(0.89); C1133(0.95)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C837(0.79); C930(0.84); C1145(0.82); C83(1.29)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C837(0.69); C930(1.16); C1145(0.89); C83(1.07)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C930(0.85); C1145(0.75); C83(0.89); C1133(1.02)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C597(1.01); C601(1.01)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C597(0.97); C601(0.97)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C597(1.04); C601(1.04)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C597(1.88); C601(1.88)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C837(0.96); C83(1.20); C1133(1.01); C1764(1.08)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C597(1.00); C601(1.00)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C597(1.69); C601(1.69)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C597(1.25); C601(1.25)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C597(1.21); C601(1.21)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C597(1.25); C601(1.25)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C597(0.96); C601(0.96)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C597(1.21); C601(1.21)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C597(2.31); C601(2.31)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C597(1.20); C601(1.20)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C597(1.19); C601(1.19)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C837(1.09); C1145(0.99); C83(0.84); C1133(1.11)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C597(1.23); C601(1.23)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C837(0.92); C930(1.03); C1145(1.17); C83(1.13)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C837(1.28); C1145(0.92); C83(1.06); C1133(0.92)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C837(0.98); C83(0.86); C1014(1.03); C1096(1.41)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C837(1.13); C930(1.02); C83(1.15); C1133(0.92)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C837(0.97); C83(1.14); C1133(0.99); C1764(1.19)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C837(1.14); C1145(0.98); C83(0.98); C1133(1.09)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C837(0.76); C930(0.95); C1145(0.89); C83(1.21)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C837(0.98); C930(0.92); C1145(0.92); C83(1.09)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C930(1.00); C1145(0.78); C83(0.98); C1133(1.04)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C837(0.84); C930(0.89); C1145(1.08); C83(1.05)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C837(1.10); C1145(0.78); C83(1.09); C1133(1.05)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C1145(0.73); C83(1.21); C1014(1.15); C1764(0.99)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C837(1.33); C930(0.98); C1145(0.79); C83(1.17)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C837(1.08); C930(0.95); C1145(1.37); C83(0.47)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C837(1.12); C1145(1.14); C83(1.11); C1133(1.10)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C837(1.09); C930(1.02); C83(0.99); C1133(1.01)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C837(1.15); C83(1.11); C1133(0.93); C1764(1.08)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C837(1.10); C1145(0.90); C83(0.95); C1133(1.06)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C837(0.89); C930(0.81); C1145(1.00); C83(1.08)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C837(0.93); C930(1.00); C1145(1.27); C83(1.36)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C837(1.14); C930(0.90); C1145(0.88); C83(0.92)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C930(0.91); C1145(0.79); C83(0.95); C1133(0.97)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C837(1.06); C1145(0.72); C83(1.15); C1133(1.12)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C1145(0.78); C83(1.11); C1014(1.10); C1764(1.03)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C837(1.34); C930(0.93); C1145(0.91); C83(1.07)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C837(0.99); C930(0.77); C1145(1.28); C83(1.02)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C837(1.01); C1145(1.18); C83(0.96); C1133(1.09)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C837(1.02); C83(0.90); C1014(1.09); C1096(0.99)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C837(0.97); C930(1.08); C83(1.17); C1133(0.96)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C837(0.99); C83(1.20); C1133(0.96); C1764(1.23)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C930(0.92); C1145(0.72); C83(1.20); C1133(1.03)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C837(1.41); C1145(1.18); C83(1.05); C1133(1.00)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C837(0.85); C930(0.89); C1145(1.01); C83(1.21)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C837(1.02); C930(0.86); C1145(1.05); C83(0.97)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C930(0.83); C1145(0.80); C83(1.08); C1133(1.04)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C837(0.90); C1145(0.74); C83(1.07); C1133(1.05)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C1145(1.06); C83(1.22); C1014(1.15); C1764(0.92)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C837(1.06); C930(0.84); C1145(1.06); C83(1.21)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C837(1.18); C930(1.15); C1145(1.09); C83(0.94)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C837(1.73); C1145(1.17); C83(1.08); C1133(1.04)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C837(1.01); C83(0.84); C1014(1.16); C1096(0.85)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C837(1.08); C83(1.03); C1014(1.03); C1096(0.96)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C837(1.09); C83(0.86); C1014(0.98); C1096(1.37)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C837(1.15); C1145(1.00); C83(1.00); C1133(1.09)  LDD1631  [8]
 LDCM0022  KB02 HCT 116 C1014(1.89); C1438(1.97)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C1014(1.69); C1438(1.54)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C1014(2.17); C1438(2.11)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C958(0.96); C963(0.96)  LDD2173  [2]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402