Details of the Target

General Information of Target

Target ID LDTP08157
Target Name Multiple epidermal growth factor-like domains protein 8 (MEGF8)
Gene Name MEGF8
Gene ID 1954
Synonyms
C19orf49; EGFL4; KIAA0817; Multiple epidermal growth factor-like domains protein 8; Multiple EGF-like domains protein 8; Epidermal growth factor-like protein 4; EGF-like protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALGKVLAMALVLALAVLGSLSPGARAGDCKGQRQVLREAPGFVTDGAGNYSVNGNCEWL
IEAPSPQHRILLDFLFLDTECTYDYLFVYDGDSPRGPLLASLSGSTRPPPIEASSGKMLL
HLFSDANYNLLGFNASFRFSLCPGGCQSHGQCQPPGVCACEPGWGGPDCGLQECSAYCGS
HGTCASPLGPCRCEPGFLGRACDLHLWENQGAGWWHNVSARDPAFSARIGAAGAFLSPPG
LLAVFGGQDLNNALGDLVLYNFSANTWESWDLSPAPAARHSHVAVAWAGSLVLMGGELAD
GSLTNDVWAFSPLGRGHWELLAPPASSSSGPPGLAGHAAALVDDVWLYVSGGRTPHDLFS
SGLFRFRLDSTSGGYWEQVIPAGGRPPAATGHSMVFHAPSRALLVHGGHRPSTARFSVRV
NSTELFHVDRHVWTTLKGRDGLQGPRERAFHTASVLGNYMVVYGGNVHTHYQEEKCYEDG
IFFYHLGCHQWVSGAELAPPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAGGYSGRPRGDL
MAYKVPPFVFQAPAPDYHLDYCSMYTDHSVCSRDPECSWCQGACQAAPPPGTPLGACPAA
SCLGLGRLLGDCQACLAFSSPTAPPRGPGTLGWCVHNESCLPRPEQARCRGEQISGTVGW
WGPAPVFVTSLEACVTQSFLPGLHLLTFQQPPNTSQPDKVSIVRSTTITLTPSAETDVSL
VYRGFIYPMLPGGPGGPGAEDVAVWTRAQRLHVLARMARGPDTENMEEVGRWVAHQEKET
RRLQRPGSARLFPLPGRDHKYAVEIQGQLNGSAGPGHSELTLLWDRTGVPGGSEISFFFL
EPYRSSSCTSYSSCLGCLADQGCGWCLTSATCHLRQGGAHCGDDGAGGSLLVLVPTLCPL
CEEHRDCHACTQDPFCEWHQSTSRKGDAACSRRGRGRGALKSPEECPPLCSQRLTCEDCL
ANSSQCAWCQSTHTCFLFAAYLARYPHGGCRGWDDSVHSEPRCRSCDGFLTCHECLQSHE
CGWCGNEDNPTLGRCLQGDFSGPLGGGNCSLWVGEGLGLPVALPARWAYARCPDVDECRL
GLARCHPRATCLNTPLSYECHCQRGYQGDGISHCNRTCLEDCGHGVCSGPPDFTCVCDLG
WTSDLPPPTPAPGPPAPRCSRDCGCSFHSHCRKRGPGFCDECQDWTWGEHCERCRPGSFG
NATGSRGCRPCQCNGHGDPRRGHCDNLSGLCFCQDHTEGAHCQLCSPGYYGDPRAGGSCF
RECGGRALLTNVSSVALGSRRVGGLLPPGGGAARAGPGLSYCVWVVSATEELQPCAPGTL
CPPLTLTFSPDSSTPCTLSYVLAFDGFPRFLDTGVVQSDRSLIAAFCGQRRDRPLTVQAL
SGLLVLHWEANGSSSWGFNASVGSARCGSGGPGSCPVPQECVPQDGAAGAGLCRCPQGWA
GPHCRMALCPENCNAHTGAGTCNQSLGVCICAEGFGGPDCATKLDGGQLVWETLMDSRLS
ADTASRFLHRLGHTMVDGPDATLWMFGGLGLPQGLLGNLYRYSVSERRWTQMLAGAEDGG
PGPSPRSFHAAAYVPAGRGAMYLLGGLTAGGVTRDFWVLNLTTLQWRQEKAPQTVELPAV
AGHTLTARRGLSLLLVGGYSPENGFNQQLLEYQLATGTWVSGAQSGTPPTGLYGHSAVYH
EATDSLYVFGGFRFHVELAAPSPELYSLHCPDRTWSLLAPSQGAKRDRMRNVRGSSRGLG
QVPGEQPGSWGFREVRKKMALWAALAGTGGFLEEISPHLKEPRPRLFHASALLGDTMVVL
GGRSDPDEFSSDVLLYQVNCNAWLLPDLTRSASVGPPMEESVAHAVAAVGSRLYISGGFG
GVALGRLLALTLPPDPCRLLSSPEACNQSGACTWCHGACLSGDQAHRLGCGGSPCSPMPR
SPEECRRLRTCSECLARHPRTLQPGDGEASTPRCKWCTNCPEGACIGRNGSCTSENDCRI
NQREVFWAGNCSEAACGAADCEQCTREGKCMWTRQFKRTGETRRILSVQPTYDWTCFSHS
LLNVSPMPVESSPPLPCPTPCHLLPNCTSCLDSKGADGGWQHCVWSSSLQQCLSPSYLPL
RCMAGGCGRLLRGPESCSLGCAQATQCALCLRRPHCGWCAWGGQDGGGRCMEGGLSGPRD
GLTCGRPGASWAFLSCPPEDECANGHHDCNETQNCHDQPHGYECSCKTGYTMDNMTGLCR
PVCAQGCVNGSCVEPDHCRCHFGFVGRNCSTECRCNRHSECAGVGARDHCLLCRNHTKGS
HCEQCLPLFVGSAVGGGTCRPCHAFCRGNSHICISRKELQMSKGEPKKYSLDPEEIENWV
TEGPSEDEAVCVNCQNNSYGEKCESCLQGYFLLDGKCTKCQCNGHADTCNEQDGTGCPCQ
NNTETGTCQGSSPSDRRDCYKYQCAKCRESFHGSPLGGQQCYRLISVEQECCLDPTSQTN
CFHEPKRRALGPGRTVLFGVQPKFTNVDIRLTLDVTFGAVDLYVSTSYDTFVVRVAPDTG
VHTVHIQPPPAPPPPPPPADGGPRGAGDPGGAGASSGPGAPAEPRVREVWPRGLITYVTV
TEPSAVLVVRGVRDRLVITYPHEHHALKSSRFYLLLLGVGDPSGPGANGSADSQGLLFFR
QDQAHIDLFVFFSVFFSCFFLFLSLCVLLWKAKQALDQRQEQRRHLQEMTKMASRPFAKV
TVCFPPDPTAPASAWKPAGLPPPAFRRSEPFLAPLLLTGAGGPWGPMGGGCCPPAIPATT
AGLRAGPITLEPTEDGMAGVATLLLQLPGGPHAPNGACLGSALVTLRHRLHEYCGGGGGA
GGSGHGTGAGRKGLLSQDNLTSMSL
Target Bioclass
Other
Subcellular location
Membrane
Function Acts as a negative regulator of hedgehog signaling.
Uniprot ID
Q7Z7M0
Ensemble ID
ENST00000251268.11
HGNC ID
HGNC:3233

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 SNV: p.S1329F .
CAOV3 SNV: p.R1079L DBIA    Probe Info 
CCK81 SNV: p.P1087S .
COLO792 SNV: p.S1707F .
COLO800 SNV: p.Q2682E .
DEL SNV: p.M2747R .
DU145 SNV: p.R1088L; p.Q2527Ter DBIA    Probe Info 
EFO27 Insertion: p.S400LfsTer25 .
HCT15 SNV: p.S370I .
HEC1 SNV: p.R2514C DBIA    Probe Info 
HEC1B SNV: p.G1045D; p.R2514C .
HSC3 SNV: p.L631V .
HT115 SNV: p.R1926Ter .
L428 SNV: p.F137L .
MCC26 SNV: p.G2008S DBIA    Probe Info 
MEWO SNV: p.L250F; p.I2756T .
NCIH1793 Insertion: p.W2141LfsTer20 .
NCIH358 SNV: p.H409R; p.S1143Ter DBIA    Probe Info 
NCIH446 SNV: p.G2297V .
OVK18 SNV: p.G501Ter DBIA    Probe Info 
OZ SNV: p.A1481S DBIA    Probe Info 
RKO SNV: p.R875H .
RL SNV: p.Y2210S .
RL952 Deletion: p.T1670QfsTer60 DBIA    Probe Info 
SJSA1 Substitution: p.S2823G .
SKMEL30 SNV: p.P1826L .
SUPT1 SNV: p.R1783S .
SW837 SNV: p.G1911W DBIA    Probe Info 
TE10 SNV: p.G2146W .
TOV21G SNV: p.E1238Ter; p.Q1722H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1072(1.01); C1078(1.01)  LDD0078  [1]
IA-alkyne
 Probe Info  		C930(0.00); C1925(0.00); C2261(0.00)  LDD0165  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C2261(0.99); C990(1.06); C2273(1.16); C2270(1.09)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C2261(1.05); C990(1.05); C1114(1.15); C2253(1.00)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C2261(1.02); C990(1.05); C930(1.06); C1435(0.81)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C2261(1.03); C2240(1.02); C2273(0.97); C1931(0.96)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C2261(1.04); C990(0.99); C1710(1.29); C2273(0.95)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C2261(1.09); C990(1.08); C1710(0.92); C193(0.94)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C2261(1.15); C990(1.03); C2273(1.24); C2270(0.95)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C2261(1.03); C990(1.01); C1114(1.10); C2253(1.29)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C2261(1.74); C990(1.76); C930(1.89); C1435(0.94)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C2261(1.00); C990(1.09); C1114(0.96); C2253(1.06)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C2261(0.96); C2240(1.04); C2273(0.97); C1931(0.96)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C2261(0.93); C990(0.94); C1925(0.86); C2270(0.96)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C2261(0.99); C990(0.98); C1710(1.27); C2273(1.14)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C2261(1.02); C990(1.03); C1710(0.98); C193(0.77)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C2261(1.02); C990(0.98); C1114(1.06); C193(0.83)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C1435(0.97); C1444(0.97)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C1435(0.98); C1444(0.98)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C1435(0.90); C1444(0.90)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C1435(0.96); C1444(0.96)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C1435(0.90); C1444(0.90)  LDD0887  [1]
 LDCM0290  AC3 HEK-293T C2261(0.90); C990(1.04); C930(1.04); C1435(1.10)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C1435(0.89); C1444(0.89)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C1435(1.15); C1444(1.15)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C1435(1.25); C1444(1.25)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C1435(1.01); C1444(1.01)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C1435(1.00); C1444(1.00)  LDD0893  [1]
 LDCM0296  AC35 HEK-293T C1435(0.96); C1444(0.96)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C1435(0.69); C1444(0.69)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C1435(1.00); C1444(1.00)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C1435(1.00); C1444(1.00)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C1435(0.90); C1444(0.90)  LDD0898  [1]
 LDCM0301  AC4 HEK-293T C2261(1.02); C2240(1.21); C2273(1.05); C1931(0.99)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C1435(1.03); C1444(1.03)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C1435(0.88); C1444(0.88)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C1435(0.83); C1444(0.83)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C1435(0.80); C1444(0.80)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C1435(0.88); C1444(0.88)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C1435(0.87); C1444(0.87)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C1435(0.75); C1444(0.75)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C1435(0.96); C1444(0.96)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C1435(0.91); C1444(0.91)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C1435(1.06); C1444(1.06)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C2261(0.94); C990(1.02); C1925(1.08); C2270(0.94)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C1435(0.92); C1444(0.92)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C1435(1.06); C1444(1.06)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C1435(0.91); C1444(0.91)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C1435(0.96); C1444(0.96)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C1435(1.01); C1444(1.01)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C1435(1.00); C1444(1.00)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C1435(0.93); C1444(0.93)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C1435(0.82); C1444(0.82)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C1435(0.85); C1444(0.85)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C1435(0.89); C1444(0.89)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C2261(1.16); C990(1.13); C1710(0.98); C2273(1.01)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C1435(0.70); C1444(0.70)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C1435(1.03); C1444(1.03)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C1435(0.80); C1444(0.80)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C1435(1.07); C1444(1.07)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C1435(0.79); C1444(0.79)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C1435(1.10); C1444(1.10)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C1435(1.12); C1444(1.12)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C1435(0.96); C1444(0.96)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C1435(0.92); C1444(0.92)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C1435(1.24); C1444(1.24)  LDD0931  [1]
 LDCM0334  AC7 HEK-293T C2261(0.96); C990(1.13); C1710(1.14); C193(0.88)  LDD1568  [4]
 LDCM0335  AC70 HEK-293T C1435(0.77); C1444(0.77)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C1435(0.86); C1444(0.86)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C1435(0.97); C1444(0.97)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C1435(0.76); C1444(0.76)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C1435(0.93); C1444(0.93)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C1435(0.74); C1444(0.74)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C1435(0.91); C1444(0.91)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C1435(1.11); C1444(1.11)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C1435(0.92); C1444(0.92)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C1435(0.94); C1444(0.94)  LDD0942  [1]
 LDCM0345  AC8 HEK-293T C2261(0.93); C990(1.04); C1114(1.32); C193(0.94)  LDD1569  [4]
 LDCM0346  AC80 HEK-293T C1435(0.92); C1444(0.92)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C1435(1.13); C1444(1.13)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C1435(1.03); C1444(1.03)  LDD0946  [1]
 LDCM0248  AKOS034007472 HEK-293T C2261(0.95); C990(0.99); C1925(1.04); C2270(1.00)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C2261(1.10); C990(1.07); C2273(1.01); C2270(1.01)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C2261(1.06); C990(1.02); C1114(1.33); C193(1.01)  LDD1514  [4]
 LDCM0020  ARS-1620 HCC44 C1072(1.01); C1078(1.01)  LDD0078  [1]
 LDCM0367  CL1 HEK-293T C2261(1.08); C990(1.01); C1114(1.00); C1915(1.36)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C2261(1.07); C990(1.14); C1710(0.92); C2273(0.90)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C2261(1.08); C990(1.02); C930(1.02); C2273(1.04)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C2261(1.04); C990(1.07); C1114(0.92); C1915(1.08)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C990(1.02); C1710(1.04); C2253(0.78); C2270(1.03)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C2261(1.05); C990(1.01); C1114(1.15); C2253(1.00)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C2261(1.02); C990(0.84); C930(0.96); C2273(0.98)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C2261(1.01); C990(1.00); C1114(0.87); C1915(1.21)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C990(0.90); C1710(0.85); C2253(0.92); C2270(1.06)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C2261(0.93); C990(1.02); C1114(1.12); C2253(0.90)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C2261(1.00); C990(1.02); C930(0.95); C2273(1.01)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C2261(0.98); C990(0.99); C1114(1.00); C1915(0.89)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C2261(1.14); C990(1.17); C1710(0.91); C193(0.59)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C990(0.86); C1710(1.58); C2253(0.92); C2270(0.96)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C2261(1.03); C990(0.99); C1114(0.85); C2253(0.94)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C1435(0.95); C1444(0.95)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C1435(1.09); C1444(1.09)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C1435(1.17); C1444(1.17)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C1435(1.09); C1444(1.09)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C1435(0.89); C1444(0.89)  LDD0984  [1]
 LDCM0387  CL117 HEK-293T C1435(0.93); C1444(0.93)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C1435(1.01); C1444(1.01)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C1435(0.75); C1444(0.75)  LDD0987  [1]
 LDCM0390  CL12 HEK-293T C2261(1.12); C990(1.03); C1114(0.96); C193(0.67)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C1435(0.91); C1444(0.91)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C1435(0.81); C1444(0.81)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C1435(0.96); C1444(0.96)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C1435(0.93); C1444(0.93)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C1435(0.75); C1444(0.75)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C1435(0.86); C1444(0.86)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C1435(1.02); C1444(1.02)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C1435(0.77); C1444(0.77)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C1435(1.07); C1444(1.07)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C2261(1.36); C990(1.29); C1114(1.29); C1915(1.11)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C990(0.90); C1710(1.47); C2253(0.90); C2270(1.14)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C2261(1.02); C990(1.01); C1114(1.16); C2253(1.62)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C2261(1.00); C990(0.95); C930(1.02); C2273(1.09)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C2261(1.08); C990(1.13); C2273(1.09); C2270(1.12)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C2261(1.25); C990(1.04); C1114(1.16); C2253(1.13)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C2261(1.17); C990(1.10); C930(1.06); C1435(0.75)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C990(1.05); C1710(0.98); C2253(1.10); C2270(0.99)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C2261(0.97); C2240(1.19); C2273(0.93); C1931(1.10)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C2261(1.33); C990(1.04); C1925(0.58); C2270(0.99)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C2261(1.10); C990(1.00); C1710(0.88); C2273(1.33)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C2261(1.14); C990(1.20); C1710(0.84); C193(0.69)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C2261(1.08); C990(0.97); C1114(1.15); C193(0.98)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C2261(0.90); C990(1.03); C1114(1.01); C1915(0.97)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C990(0.84); C1710(0.91); C2253(0.90); C2270(0.95)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C2261(0.95); C990(1.02); C1114(0.96); C2253(0.87)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C2261(1.04); C990(1.06); C930(0.95); C2273(1.08)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C2261(1.12); C990(1.01); C2273(1.08); C2270(1.01)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C2261(0.93); C990(1.06); C1114(1.05); C2253(1.10)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C2261(1.11); C990(1.00); C1114(1.10); C2253(1.16)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C1435(1.09); C1444(1.09)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C1435(1.24); C1444(1.24)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C1435(1.15); C1444(1.15)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C1435(0.93); C1444(0.93)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C1435(1.07); C1444(1.07)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C1435(1.08); C1444(1.08)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C1435(0.94); C1444(0.94)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C1435(1.00); C1444(1.00)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C2261(1.04); C990(0.91); C930(1.03); C2273(1.05)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C1435(1.14); C1444(1.14)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C1435(0.99); C1444(0.99)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C1435(0.91); C1444(0.91)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C1435(1.05); C1444(1.05)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C1435(0.82); C1444(0.82)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C1435(0.91); C1444(0.91)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C1435(1.40); C1444(1.40)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C1435(1.36); C1444(1.36)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C1435(1.17); C1444(1.17)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C1435(1.05); C1444(1.05)  LDD1037  [1]
 LDCM0440  CL5 HEK-293T C2261(1.05); C990(1.06); C2273(1.21); C2270(1.04)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C1435(1.31); C1444(1.31)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C1435(1.08); C1444(1.08)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C1435(1.28); C1444(1.28)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C1435(1.07); C1444(1.07)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C1435(1.09); C1444(1.09)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C1435(1.03); C1444(1.03)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C1435(1.38); C1444(1.38)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C1435(1.17); C1444(1.17)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C1435(1.21); C1444(1.21)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C1435(1.13); C1444(1.13)  LDD1048  [1]
 LDCM0451  CL6 HEK-293T C2261(1.13); C990(1.06); C1114(1.11); C2253(1.05)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C1435(1.39); C1444(1.39)  LDD1050  [1]
 LDCM0453  CL61 HEK-293T C2261(0.99); C990(1.03); C1114(1.04); C1915(1.13)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C990(0.98); C1710(1.33); C2253(0.87); C2270(1.02)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C2261(0.93); C990(1.03); C1114(1.25); C2253(1.09)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C2261(1.00); C990(0.93); C930(0.95); C2273(1.09)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C2261(1.12); C990(1.06); C2273(1.19); C2270(1.06)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C2261(1.11); C990(1.09); C1114(1.09); C2253(1.09)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C2261(1.01); C990(1.15); C930(1.08); C1435(0.87)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C2261(1.03); C2240(1.42); C2273(1.15); C1931(1.08)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C2261(1.31); C990(0.92); C1925(0.55); C2270(1.02)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C2261(1.25); C990(1.09); C930(1.10); C1435(0.71)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C2261(1.26); C990(1.00); C1710(0.83); C2273(1.01)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C2261(1.16); C990(1.13); C1710(0.90); C193(0.69)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C2261(1.10); C990(0.97); C1114(1.03); C193(0.79)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C2261(1.03); C990(1.07); C1114(0.97); C1915(1.17)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C990(0.94); C1710(0.81); C2253(0.87); C2270(1.05)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C2261(1.09); C990(0.91); C930(1.01); C2273(0.97)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C2261(0.99); C990(1.04); C2273(1.09); C2270(0.95)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C2261(1.09); C990(0.99); C1114(1.22); C2253(0.96)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C2261(1.11); C990(1.02); C930(1.00); C1435(0.73)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C2261(0.94); C2240(1.26); C2273(0.93); C1931(0.86)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C2261(1.00); C2240(1.21); C2273(0.99); C1931(1.04)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C2261(1.32); C990(1.03); C1925(0.51); C2270(1.11)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C2261(1.10); C990(0.97); C1710(0.94); C2273(1.11)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C2261(1.10); C990(1.09); C1710(0.86); C193(0.71)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C2261(1.08); C990(1.01); C1114(1.12); C193(1.01)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C2261(1.05); C990(1.03); C1114(1.05); C1915(0.88)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C990(1.10); C1710(0.98); C2253(0.97); C2270(1.00)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C2261(1.00); C990(1.23); C1114(0.94); C2253(0.96)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C2261(1.05); C990(0.82); C930(1.14); C2273(0.99)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C2261(0.95); C990(1.10); C2273(1.26); C2270(1.09)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C2261(1.37); C990(1.22); C1925(0.60); C2270(1.03)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C2261(1.01); C990(1.21); C1114(1.04); C2253(1.16)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C2261(0.94); C990(1.08); C930(1.10); C1435(1.00)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C2261(1.02); C2240(1.16); C2273(0.96); C1931(1.08)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C2261(1.02); C990(1.02); C1925(0.65); C2270(0.98)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C2261(1.18); C990(0.99); C1710(0.92); C2273(1.10)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C2261(1.12); C990(1.06); C1710(1.17); C193(0.78)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C2261(0.99); C990(0.99); C1114(1.14); C193(0.66)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C2261(1.05); C990(1.15); C1114(0.91); C1915(1.05)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C990(1.00); C1710(1.18); C2253(1.05); C2270(1.00)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C2261(0.95); C990(1.11); C1114(1.12); C2253(1.04)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C2261(0.94); C990(1.01); C1114(1.30); C2253(1.06)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C2261(0.97); C990(1.07); C1114(1.03); C2253(0.91)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C1435(0.83); C1444(0.83)  LDD1025  [1]
 LDCM0022  KB02 HEK-293T C990(1.01); C1114(0.95); C1710(1.08)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C990(1.01); C1114(1.00); C1710(1.05)  LDD1497  [4]
 LDCM0024  KB05 COLO792 C2261(1.34)  LDD3310  [5]
 LDCM0021  THZ1 HCT 116 C1259(0.94); C990(0.80)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A) Calcium channel alpha-1 subunit (TC 1.A.1.11) family O00555
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-7 (ATXN7) Ataxin-7 family O15265

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840