Details of the Target

General Information of Target

Target ID LDTP08118
Target Name Ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B)
Gene Name ANKS1B
Gene ID 56899
Synonyms
Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Amyloid-beta protein intracellular domain-associated protein 1; AIDA-1; E2A-PBX1-associated protein; EB-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGY
TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR
VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI
ISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVD
VVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQE
DATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNL
SKISEEELGKNGSQSVRTSSTINLSPGEVEEEDDDENTCGPSGLWEALTPCNGCRNLGFP
MLAQESYPKKRNYTMEIVPSASLDTFPSENENFLCDLMDTAVTKKPCSLEIARAPSPRTD
NASEVAVTTPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFHR
MNHNQEYFEINTSTGCTSFTASPPASPPTSSVGTTEVKNEGTNHTDDLSRQDDNDPPKEY
DPGQFAGLLHGSSPACESPENPFHLYGKREQCEKGQDEVSLANSPLPFKQSPIENNSEPL
VKKIKPKVVSRTIFHKKSNQLENHTIVGTRSTRSGSRNGDQWVMNAGGFVERACTLGRIR
SLPKALIDMHLSKSVSKSDSDLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSEW
EEIDKIMSSIDVGINNELKEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQ
FMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGD
YTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSIT
LREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQM
AQTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTES
TQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDP
EDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSST
LPESFENKPSKPIPKPRVSIRKSVDLLHASHTGQEPSERHTEEALRKF
Target Bioclass
Other
Subcellular location
Cytoplasm; Nucleus; Postsynaptic density
Function
Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Uniprot ID
Q7Z6G8
Ensemble ID
ENST00000341752.11
HGNC ID
HGNC:24600

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C965(3.20)  LDD3314  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C1085(1.08)  LDD1094  [5]
 LDCM0216  AC100 PaTu 8988t C1085(0.84)  LDD1095  [5]
 LDCM0217  AC101 PaTu 8988t C1085(0.81)  LDD1096  [5]
 LDCM0218  AC102 PaTu 8988t C1085(0.88)  LDD1097  [5]
 LDCM0219  AC103 PaTu 8988t C1085(0.83)  LDD1098  [5]
 LDCM0220  AC104 PaTu 8988t C1085(0.85)  LDD1099  [5]
 LDCM0221  AC105 PaTu 8988t C1085(1.06)  LDD1100  [5]
 LDCM0222  AC106 PaTu 8988t C1085(0.90)  LDD1101  [5]
 LDCM0223  AC107 PaTu 8988t C1085(0.89)  LDD1102  [5]
 LDCM0224  AC108 PaTu 8988t C1085(0.93)  LDD1103  [5]
 LDCM0225  AC109 PaTu 8988t C1085(0.92)  LDD1104  [5]
 LDCM0226  AC11 PaTu 8988t C1085(1.19)  LDD1105  [5]
 LDCM0227  AC110 PaTu 8988t C1085(0.88)  LDD1106  [5]
 LDCM0228  AC111 PaTu 8988t C1085(1.04)  LDD1107  [5]
 LDCM0229  AC112 PaTu 8988t C1085(1.02)  LDD1108  [5]
 LDCM0230  AC113 PaTu 8988t C1085(1.12)  LDD1109  [5]
 LDCM0231  AC114 PaTu 8988t C1085(1.02)  LDD1110  [5]
 LDCM0232  AC115 PaTu 8988t C1085(1.14)  LDD1111  [5]
 LDCM0233  AC116 PaTu 8988t C1085(1.03)  LDD1112  [5]
 LDCM0234  AC117 PaTu 8988t C1085(1.09)  LDD1113  [5]
 LDCM0235  AC118 PaTu 8988t C1085(0.97)  LDD1114  [5]
 LDCM0236  AC119 PaTu 8988t C1085(1.00)  LDD1115  [5]
 LDCM0237  AC12 PaTu 8988t C1085(1.36)  LDD1116  [5]
 LDCM0238  AC120 PaTu 8988t C1085(0.98)  LDD1117  [5]
 LDCM0239  AC121 PaTu 8988t C1085(1.14)  LDD1118  [5]
 LDCM0240  AC122 PaTu 8988t C1085(0.94)  LDD1119  [5]
 LDCM0241  AC123 PaTu 8988t C1085(1.01)  LDD1120  [5]
 LDCM0242  AC124 PaTu 8988t C1085(1.14)  LDD1121  [5]
 LDCM0243  AC125 PaTu 8988t C1085(0.86)  LDD1122  [5]
 LDCM0244  AC126 PaTu 8988t C1085(0.99)  LDD1123  [5]
 LDCM0245  AC127 PaTu 8988t C1085(1.12)  LDD1124  [5]
 LDCM0246  AC128 PaTu 8988t C1085(0.97)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C1085(0.97)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C1085(1.00)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C1085(0.99)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C1085(1.13)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C1085(1.24)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C1085(1.10)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C1085(1.26)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C1085(1.03)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C1085(1.17)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C1085(0.93)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C1085(1.02)  LDD1137  [5]
 LDCM0259  AC14 PaTu 8988t C1085(1.07)  LDD1138  [5]
 LDCM0260  AC140 PaTu 8988t C1085(0.96)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C1085(0.91)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C1085(0.99)  LDD1141  [5]
 LDCM0270  AC15 PaTu 8988t C1085(1.09)  LDD1149  [5]
 LDCM0276  AC17 PaTu 8988t C1085(0.91)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C1085(0.96)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C1085(0.88)  LDD1157  [5]
 LDCM0280  AC20 PaTu 8988t C1085(0.91)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C1085(1.03)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C1085(1.00)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C1085(0.92)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C1085(0.85)  LDD1163  [5]
 LDCM0285  AC25 PaTu 8988t C1085(1.17)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C1085(0.83)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C1085(0.62)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C1085(0.71)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C1085(0.66)  LDD1168  [5]
 LDCM0291  AC30 PaTu 8988t C1085(0.84)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C1085(0.75)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C1085(0.68)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C1085(0.74)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C1085(0.86)  LDD1174  [5]
 LDCM0296  AC35 PaTu 8988t C1085(0.95)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C1085(0.77)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C1085(0.74)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C1085(0.78)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C1085(0.76)  LDD1179  [5]
 LDCM0302  AC40 PaTu 8988t C1085(0.81)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C1085(0.78)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C1085(0.75)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C1085(0.73)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C1085(0.84)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C1085(0.78)  LDD1186  [5]
 LDCM0320  AC57 PaTu 8988t C1085(1.02)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C1085(1.00)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C1085(1.29)  LDD1201  [5]
 LDCM0323  AC6 PaTu 8988t C1085(1.06)  LDD1202  [5]
 LDCM0324  AC60 PaTu 8988t C1085(1.32)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C1085(1.22)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C1085(0.97)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C1085(1.28)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C1085(1.08)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C1085(1.11)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C1085(1.06)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C1085(1.25)  LDD1210  [5]
 LDCM0334  AC7 PaTu 8988t C1085(0.95)  LDD1213  [5]
 LDCM0345  AC8 PaTu 8988t C1085(1.31)  LDD1224  [5]
 LDCM0365  AC98 PaTu 8988t C1085(0.85)  LDD1244  [5]
 LDCM0366  AC99 PaTu 8988t C1085(0.84)  LDD1245  [5]
 LDCM0248  AKOS034007472 PaTu 8988t C1085(1.20)  LDD1127  [5]
 LDCM0356  AKOS034007680 PaTu 8988t C1085(1.19)  LDD1235  [5]
 LDCM0275  AKOS034007705 PaTu 8988t C1085(1.16)  LDD1154  [5]
 LDCM0370  CL101 PaTu 8988t C1085(1.01)  LDD1249  [5]
 LDCM0371  CL102 PaTu 8988t C1085(1.04)  LDD1250  [5]
 LDCM0372  CL103 PaTu 8988t C1085(1.12)  LDD1251  [5]
 LDCM0373  CL104 PaTu 8988t C1085(1.13)  LDD1252  [5]
 LDCM0374  CL105 PaTu 8988t C1085(0.91)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C1085(0.82)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C1085(0.96)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C1085(0.91)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C1085(0.90)  LDD1257  [5]
 LDCM0380  CL110 PaTu 8988t C1085(0.85)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C1085(0.97)  LDD1260  [5]
 LDCM0382  CL112 PaTu 8988t C1085(0.88)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C1085(0.79)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C1085(0.68)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C1085(0.68)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C1085(0.75)  LDD1265  [5]
 LDCM0387  CL117 PaTu 8988t C1085(0.76)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C1085(0.68)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C1085(0.71)  LDD1268  [5]
 LDCM0391  CL120 PaTu 8988t C1085(0.78)  LDD1270  [5]
 LDCM0396  CL125 PaTu 8988t C1085(1.17)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C1085(1.30)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C1085(1.24)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C1085(0.98)  LDD1278  [5]
 LDCM0403  CL16 PaTu 8988t C1085(0.92)  LDD1282  [5]
 LDCM0404  CL17 PaTu 8988t C1085(1.00)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C1085(1.15)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C1085(1.02)  LDD1285  [5]
 LDCM0408  CL20 PaTu 8988t C1085(1.23)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C1085(1.26)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C1085(1.21)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C1085(1.15)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C1085(0.98)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C1085(0.99)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C1085(1.16)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C1085(1.04)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C1085(1.35)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C1085(1.45)  LDD1296  [5]
 LDCM0419  CL30 PaTu 8988t C1085(1.08)  LDD1298  [5]
 LDCM0420  CL31 PaTu 8988t C1085(0.94)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C1085(1.06)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C1085(0.86)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C1085(1.11)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C1085(1.07)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C1085(0.96)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C1085(1.21)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C1085(0.89)  LDD1307  [5]
 LDCM0430  CL40 PaTu 8988t C1085(0.92)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C1085(1.02)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C1085(1.30)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C1085(1.67)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C1085(1.22)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C1085(0.89)  LDD1314  [5]
 LDCM0453  CL61 PaTu 8988t C1085(0.99)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C1085(0.82)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C1085(0.89)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C1085(0.94)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C1085(0.90)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C1085(0.87)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C1085(0.94)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C1085(1.00)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C1085(0.94)  LDD1340  [5]
 LDCM0463  CL70 PaTu 8988t C1085(1.02)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C1085(0.92)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C1085(0.93)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C1085(0.89)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C1085(0.87)  LDD1346  [5]
 LDCM0469  CL76 PaTu 8988t C1085(0.84)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C1085(0.68)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C1085(0.66)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C1085(0.70)  LDD1351  [5]
 LDCM0474  CL80 PaTu 8988t C1085(0.73)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C1085(0.75)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C1085(0.79)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C1085(0.69)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C1085(0.71)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C1085(0.64)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C1085(0.62)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C1085(0.64)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C1085(0.73)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C1085(0.66)  LDD1362  [5]
 LDCM0485  CL90 PaTu 8988t C1085(0.60)  LDD1364  [5]
 LDCM0468  Fragment33 PaTu 8988t C1085(0.84)  LDD1347  [5]
 LDCM0427  Fragment51 PaTu 8988t C1085(1.17)  LDD1306  [5]
 LDCM0022  KB02 22RV1 C965(3.49)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C965(5.01)  LDD2660  [1]
 LDCM0024  KB05 IGR37 C965(3.20)  LDD3314  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transforming protein RhoA (RHOA) Rho family P61586
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coilin (COIL) Coilin family P38432
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
Cytoplasmic protein NCK2 (NCK2) . O43639
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.