Details of the Target

General Information of Target

Target ID LDTP07978
Target Name SH3 domain-binding protein 5-like (SH3BP5L)
Gene Name SH3BP5L
Gene ID 80851
Synonyms
KIAA1720; SH3 domain-binding protein 5-like; SH3BP-5-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAELRQVPGGRETPQGELRPEVVEDEVPRSPVAEEPGGGGSSSSEAKLSPREEEELDPRI
QEELEHLNQASEEINQVELQLDEARTTYRRILQESARKLNTQGSHLGSCIEKARPYYEAR
RLAKEAQQETQKAALRYERAVSMHNAAREMVFVAEQGVMADKNRLDPTWQEMLNHATCKV
NEAEEERLRGEREHQRVTRLCQQAEARVQALQKTLRRAIGKSRPYFELKAQFSQILEEHK
AKVTELEQQVAQAKTRYSVALRNLEQISEQIHARRRGGLPPHPLGPRRSSPVGAEAGPED
MEDGDSGIEGAEGAGLEEGSSLGPGPAPDTDTLSLLSLRTVASDLQKCDSVEHLRGLSDH
VSLDGQELGTRSGGRRGSDGGARGGRHQRSVSL
Target Bioclass
Other
Family
SH3BP5 family
Function Functions as a guanine nucleotide exchange factor (GEF) for RAB11A.
Uniprot ID
Q7L8J4
Ensemble ID
ENST00000366472.6
HGNC ID
HGNC:29360

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.A210T DBIA    Probe Info 
DU145 Deletion: p.E17SfsTer7 DBIA    Probe Info 
HT115 SNV: p.R189Ter .
IGROV1 SNV: p.V158I DBIA    Probe Info 
KURAMOCHI SNV: p.E78G DBIA    Probe Info 
MCC26 SNV: p.G304E DBIA    Probe Info 
REH SNV: p.G365S DBIA    Probe Info 
RKO SNV: p.R288H DBIA    Probe Info 
SUPT1 SNV: p.P281H DBIA    Probe Info 
SW620 SNV: p.R376P; p.S378C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C201(1.03)  LDD2099  [1]
IPM
 Probe Info  		C201(1.66)  LDD1701  [1]
DBIA
 Probe Info  		C201(0.84)  LDD0531  [2]
m-APA
 Probe Info  		N.A.  LDD2232  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C201(0.84)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C201(1.45)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C201(1.35)  LDD0543  [2]
 LDCM0230  AC113 PaTu 8988t C201(0.90)  LDD1109  [2]
 LDCM0231  AC114 PaTu 8988t C201(1.00)  LDD1110  [2]
 LDCM0232  AC115 PaTu 8988t C201(1.22)  LDD1111  [2]
 LDCM0233  AC116 PaTu 8988t C201(1.43)  LDD1112  [2]
 LDCM0234  AC117 PaTu 8988t C201(1.06)  LDD1113  [2]
 LDCM0235  AC118 PaTu 8988t C201(1.10)  LDD1114  [2]
 LDCM0236  AC119 PaTu 8988t C201(3.09)  LDD1115  [2]
 LDCM0237  AC12 HCT 116 C201(1.27)  LDD0554  [2]
 LDCM0238  AC120 PaTu 8988t C201(1.33)  LDD1117  [2]
 LDCM0239  AC121 PaTu 8988t C201(1.77)  LDD1118  [2]
 LDCM0240  AC122 PaTu 8988t C201(1.15)  LDD1119  [2]
 LDCM0241  AC123 PaTu 8988t C201(1.02)  LDD1120  [2]
 LDCM0242  AC124 PaTu 8988t C201(1.91)  LDD1121  [2]
 LDCM0243  AC125 PaTu 8988t C201(1.45)  LDD1122  [2]
 LDCM0244  AC126 PaTu 8988t C201(0.93)  LDD1123  [2]
 LDCM0245  AC127 PaTu 8988t C201(1.62)  LDD1124  [2]
 LDCM0246  AC128 HCT 116 C201(0.55)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C201(0.58)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C201(1.11)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C201(0.84)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C201(0.75)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C201(0.77)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C201(0.77)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C201(1.06)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C201(1.00)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C201(0.59)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C201(0.73)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C201(1.03)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C201(1.64)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C201(0.95)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C201(1.07)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C201(0.91)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C201(1.09)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C201(1.65)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C201(1.53)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C201(1.17)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C201(1.34)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C201(1.29)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C201(0.98)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C201(1.83)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C201(1.03)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C201(1.29)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C201(0.98)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C201(1.59)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C201(1.35)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C201(1.32)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C201(1.20)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C201(1.63)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C201(0.60)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C201(0.53)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C201(0.67)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C201(0.82)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C201(0.70)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C201(0.78)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C201(0.53)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C201(0.53)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C201(0.65)  LDD0601  [2]
 LDCM0286  AC26 HEK-293T C109(0.96)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C109(1.09)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C109(0.98)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C201(0.93)  LDD1528  [7]
 LDCM0290  AC3 HCT 116 C201(0.77)  LDD0607  [2]
 LDCM0295  AC34 HEK-293T C109(0.92)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C109(1.01)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C109(0.98)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C201(0.90)  LDD1537  [7]
 LDCM0301  AC4 HCT 116 C201(0.77)  LDD0618  [2]
 LDCM0304  AC42 HEK-293T C109(0.95)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C109(1.08)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C109(0.95)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C201(0.93)  LDD1546  [7]
 LDCM0308  AC46 PaTu 8988t C201(1.14)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C201(1.15)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C201(1.28)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C201(2.25)  LDD1190  [2]
 LDCM0312  AC5 HCT 116 C201(0.82)  LDD0629  [2]
 LDCM0313  AC50 PaTu 8988t C201(1.79)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C201(0.56)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C201(1.41)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C201(1.96)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C201(2.24)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C201(1.84)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C201(1.85)  LDD1198  [2]
 LDCM0321  AC58 HEK-293T C109(1.01)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C109(1.00)  LDD1561  [7]
 LDCM0323  AC6 HCT 116 C201(1.51)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C109(0.95)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C201(0.82)  LDD1564  [7]
 LDCM0332  AC68 HCT 116 C201(0.98)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C201(0.92)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C201(1.25)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C201(0.96)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C201(0.79)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C201(0.81)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C201(1.05)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C201(1.11)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C201(0.96)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C201(0.86)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C201(1.05)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C201(0.96)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C201(0.87)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C201(1.19)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C201(1.11)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C201(0.90)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C201(1.03)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C201(1.04)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C201(0.93)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C201(0.94)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C201(1.14)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C201(0.94)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C201(0.85)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C201(0.97)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C201(0.84)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C201(1.04)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C201(0.92)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C201(1.00)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C201(1.19)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C201(0.91)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C201(0.92)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C201(1.09)  LDD0681  [2]
 LDCM0248  AKOS034007472 HCT 116 C201(1.40)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C201(1.40)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C201(2.21)  LDD0592  [2]
 LDCM0369  CL100 HCT 116 C201(0.78)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C201(1.37)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C201(1.43)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C201(1.29)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C201(1.15)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C201(0.80)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C201(0.87)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C201(0.73)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C201(0.79)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C201(0.85)  LDD0695  [2]
 LDCM0380  CL110 HCT 116 C201(0.64)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C201(0.66)  LDD0698  [2]
 LDCM0384  CL114 HEK-293T C201(0.83)  LDD1588  [7]
 LDCM0388  CL118 HEK-293T C201(0.87)  LDD1592  [7]
 LDCM0392  CL121 PaTu 8988t C201(1.62)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C201(1.58)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C201(1.47)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C201(2.49)  LDD1274  [2]
 LDCM0397  CL126 HEK-293T C201(0.92)  LDD1601  [7]
 LDCM0401  CL14 HEK-293T C201(0.81)  LDD1605  [7]
 LDCM0403  CL16 HCT 116 C201(0.71)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C201(0.61)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C201(0.93)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C201(1.02)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C201(0.73)  LDD1611  [7]
 LDCM0408  CL20 HCT 116 C201(1.20)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C201(1.44)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C201(2.63)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C201(0.88)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C201(1.72)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C201(2.01)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C201(0.92)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C201(1.24)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C201(1.53)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C201(1.62)  LDD0734  [2]
 LDCM0419  CL30 HCT 116 C201(1.05)  LDD0736  [2]
 LDCM0420  CL31 PaTu 8988t C201(0.51)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C201(0.71)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C201(0.89)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C201(1.74)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C201(1.18)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C201(0.39)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C201(1.17)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C201(1.90)  LDD1307  [2]
 LDCM0430  CL40 PaTu 8988t C201(0.71)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C201(1.01)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C201(0.99)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C201(1.06)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C201(1.16)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C201(1.26)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C201(0.85)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C201(0.77)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C201(1.04)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C201(0.85)  LDD1318  [2]
 LDCM0441  CL50 PaTu 8988t C201(1.28)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C201(0.95)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C201(0.97)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C201(1.19)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C201(1.09)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C201(0.92)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C201(0.95)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C201(1.01)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C201(0.98)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C201(1.20)  LDD1329  [2]
 LDCM0451  CL6 HEK-293T C109(0.89)  LDD1654  [7]
 LDCM0452  CL60 PaTu 8988t C201(1.07)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C201(1.11)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C201(0.94)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C201(1.01)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C201(0.86)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C201(1.08)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C201(1.08)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C201(1.78)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C201(1.04)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C201(2.40)  LDD1340  [2]
 LDCM0462  CL7 HEK-293T C109(1.07)  LDD1665  [7]
 LDCM0463  CL70 PaTu 8988t C201(1.38)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C201(1.02)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C201(1.07)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C201(2.01)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C201(1.01)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C201(1.35)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C201(1.35)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C201(2.26)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C201(1.34)  LDD1351  [2]
 LDCM0473  CL8 HEK-293T C109(1.06)  LDD1676  [7]
 LDCM0474  CL80 PaTu 8988t C201(2.70)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C201(1.60)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C201(2.12)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C201(2.09)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C201(1.53)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C201(1.76)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C201(2.73)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C201(2.36)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C201(2.64)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C201(1.54)  LDD1362  [2]
 LDCM0484  CL9 HEK-293T C201(0.82)  LDD1687  [7]
 LDCM0485  CL90 PaTu 8988t C201(2.96)  LDD1364  [2]
 LDCM0486  CL91 HCT 116 C201(0.97)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C201(0.84)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C201(0.75)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C201(0.80)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C201(0.89)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C201(0.82)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C201(0.89)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C201(0.88)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C201(0.67)  LDD0811  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C109(1.65); C201(1.16)  LDD1702  [1]
 LDCM0468  Fragment33 PaTu 8988t C201(1.32)  LDD1347  [2]
 LDCM0427  Fragment51 PaTu 8988t C201(1.38)  LDD1306  [2]
 LDCM0022  KB02 22RV1 C201(1.44)  LDD2243  [8]
 LDCM0023  KB03 MDA-MB-231 C201(1.66)  LDD1701  [1]
 LDCM0024  KB05 COLO792 C201(1.00)  LDD3310  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C201(1.03)  LDD2099  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C201(0.95)  LDD2107  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C201(0.46)  LDD2115  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C201(0.83)  LDD2125  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-11B (RAB11B) Rab family Q15907
Ras-related protein Rab-14 (RAB14) Rab family P61106
Ras-related protein Rab-25 (RAB25) Rab family P57735
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
ER membrane protein complex subunit 2 (EMC2) EMC2 family Q15006
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Cholecystokinin (CCK) Gastrin/cholecystokinin family P06307

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840