Details of the Target

General Information of Target

Target ID LDTP07887
Target Name MOB kinase activator 3C (MOB3C)
Gene Name MOB3C
Gene ID 148932
Synonyms
MOBKL2C; MOB kinase activator 3C; Mob1 homolog 2C; Mps one binder kinase activator-like 2C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALCLKQVFAKDKTFRPRKRFEPGTQRFELYKKAQASLKSGLDLRSVVRLPPGENIDDWI
AVHVVDFFNRINLIYGTMAERCSETSCPVMAGGPRYEYRWQDERQYRRPAKLSAPRYMAL
LMDWIEGLINDEEVFPTRVGVPFPKNFQQVCTKILTRLFRVFVHVYIHHFDSILSMGAEA
HVNTCYKHFYYFIREFSLVDQRELEPLREMTERICH
Target Bioclass
Other
Family
MOB1/phocein family
Function May regulate the activity of kinases.
Uniprot ID
Q70IA8
Ensemble ID
ENST00000271139.13
HGNC ID
HGNC:29800

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C82(0.85); C87(0.85)  LDD0547  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C82(0.73); C87(0.73)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C82(1.25); C87(1.25)  LDD1105  [1]
 LDCM0230  AC113 HCT 116 C82(0.85); C87(0.85)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C82(0.84); C87(0.84)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C82(0.97); C87(0.97)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C82(0.94); C87(0.94)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C82(0.91); C87(0.91)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C82(0.86); C87(0.86)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C82(0.75); C87(0.75)  LDD0553  [1]
 LDCM0237  AC12 PaTu 8988t C82(0.70); C87(0.70)  LDD1116  [1]
 LDCM0238  AC120 HCT 116 C82(0.61); C87(0.61)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C82(0.75); C87(0.75)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C82(0.79); C87(0.79)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C82(0.58); C87(0.58)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C82(0.70); C87(0.70)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C82(0.69); C87(0.69)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C82(0.78); C87(0.78)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C82(0.63); C87(0.63)  LDD0562  [1]
 LDCM0259  AC14 PaTu 8988t C82(1.17); C87(1.17)  LDD1138  [1]
 LDCM0263  AC143 HCT 116 C82(1.14); C87(1.14)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C82(0.90); C87(0.90)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C82(0.93); C87(0.93)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C82(0.94); C87(0.94)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C82(0.96); C87(0.96)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C82(0.92); C87(0.92)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C82(0.86); C87(0.86)  LDD0586  [1]
 LDCM0270  AC15 PaTu 8988t C82(0.98); C87(0.98)  LDD1149  [1]
 LDCM0271  AC150 HCT 116 C82(1.01); C87(1.01)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C82(1.13); C87(1.13)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C82(1.27); C87(1.27)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C82(1.13); C87(1.13)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C82(1.23); C87(1.23)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C82(1.50); C87(1.50)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C82(0.97); C87(0.97)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C82(1.70); C87(1.70)  LDD2161  [1]
 LDCM0296  AC35 HCT 116 C82(0.51); C87(0.51)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C82(0.84); C87(0.84)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C82(0.97); C87(0.97)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C82(0.88); C87(0.88)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C82(0.71); C87(0.71)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C82(1.03); C87(1.03)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C82(0.87); C87(0.87)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C82(0.89); C87(0.89)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C82(0.95); C87(0.95)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C82(1.03); C87(1.03)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C82(0.94); C87(0.94)  LDD0624  [1]
 LDCM0323  AC6 PaTu 8988t C82(0.65); C87(0.65)  LDD1202  [1]
 LDCM0332  AC68 HCT 116 C82(1.34); C87(1.34)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C82(1.25); C87(1.25)  LDD0650  [1]
 LDCM0334  AC7 PaTu 8988t C82(1.51); C87(1.51)  LDD1213  [1]
 LDCM0335  AC70 HCT 116 C82(1.66); C87(1.66)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C82(1.48); C87(1.48)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C82(1.13); C87(1.13)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C82(2.53); C87(2.53)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C82(1.75); C87(1.75)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C82(1.76); C87(1.76)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C82(1.82); C87(1.82)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C82(1.87); C87(1.87)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C82(1.56); C87(1.56)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C82(1.20); C87(1.20)  LDD0661  [1]
 LDCM0345  AC8 PaTu 8988t C82(0.72); C87(0.72)  LDD1224  [1]
 LDCM0346  AC80 HCT 116 C82(1.15); C87(1.15)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C82(0.86); C87(0.86)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C82(2.37); C87(2.37)  LDD0665  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C82(1.40); C87(1.40)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C82(1.19); C87(1.19)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C82(0.89); C87(0.89)  LDD1154  [1]
 LDCM0367  CL1 HCT 116 C82(0.94); C87(0.94)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C82(0.81); C87(0.81)  LDD0685  [1]
 LDCM0370  CL101 PaTu 8988t C82(1.52); C87(1.52)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C82(1.53); C87(1.53)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C82(1.20); C87(1.20)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C82(0.79); C87(0.79)  LDD1252  [1]
 LDCM0379  CL11 HCT 116 C82(1.21); C87(1.21)  LDD0696  [1]
 LDCM0387  CL117 HCT 116 C82(0.83); C87(0.83)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C82(0.76); C87(0.76)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C82(0.69); C87(0.69)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C82(1.70); C87(1.70)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C82(0.88); C87(0.88)  LDD0708  [1]
 LDCM0400  CL13 HCT 116 C82(1.05); C87(1.05)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C82(1.17); C87(1.17)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C82(0.97); C87(0.97)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C82(1.19); C87(1.19)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C82(1.59); C87(1.59)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C82(0.84); C87(0.84)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C82(1.40); C87(1.40)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C82(1.16); C87(1.16)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C82(1.03); C87(1.03)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C82(1.26); C87(1.26)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C82(1.33); C87(1.33)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C82(1.02); C87(1.02)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C82(1.04); C87(1.04)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C82(1.47); C87(1.47)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C82(0.82); C87(0.82)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C82(1.01); C87(1.01)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C82(0.70); C87(0.70)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C82(1.37); C87(1.37)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C82(1.12); C87(1.12)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C82(1.19); C87(1.19)  LDD0736  [1]
 LDCM0429  CL4 HCT 116 C82(0.94); C87(0.94)  LDD0746  [1]
 LDCM0440  CL5 HCT 116 C82(1.05); C87(1.05)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C82(0.99); C87(0.99)  LDD0768  [1]
 LDCM0453  CL61 HCT 116 C82(1.14); C87(1.14)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C82(1.02); C87(1.02)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C82(0.98); C87(0.98)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C82(1.18); C87(1.18)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C82(1.13); C87(1.13)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C82(1.11); C87(1.11)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C82(1.23); C87(1.23)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C82(1.18); C87(1.18)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C82(0.96); C87(0.96)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C82(1.02); C87(1.02)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C82(1.01); C87(1.01)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C82(0.96); C87(0.96)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C82(0.97); C87(0.97)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C82(0.99); C87(0.99)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C82(1.27); C87(1.27)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C82(1.02); C87(1.02)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C82(0.76); C87(0.76)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C82(1.05); C87(1.05)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C82(1.14); C87(1.14)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C82(1.67); C87(1.67)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C82(0.86); C87(0.86)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C82(1.07); C87(1.07)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C82(1.19); C87(1.19)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C82(1.15); C87(1.15)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C82(1.64); C87(1.64)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C82(1.14); C87(1.14)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C82(0.80); C87(0.80)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C82(1.00); C87(1.00)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C82(1.39); C87(1.39)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C82(1.40); C87(1.40)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C82(1.03); C87(1.03)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C82(1.03); C87(1.03)  LDD0802  [1]
 LDCM0468  Fragment33 HCT 116 C82(1.10); C87(1.10)  LDD0785  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytosolic purine 5'-nucleotidase (NT5C2) 5'(3')-deoxyribonucleotidase family P49902
Choline-phosphate cytidylyltransferase A (PCYT1A) Cytidylyltransferase family P49585
Tyrosine-protein phosphatase non-receptor type 21 (PTPN21) Protein-tyrosine phosphatase family Q16825
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
Tryptophan 2,3-dioxygenase (TDO2) Tryptophan 2,3-dioxygenase family P48775
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-globin transcription factor CP2 (TFCP2) Grh/CP2 family Q12800
Zinc finger protein Eos (IKZF4) Ikaros C2H2-type zinc-finger protein family Q9H2S9
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 3 (CMTM3) Chemokine-like factor family Q96MX0
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM118A (FAM118A) FAM118 family Q9NWS6
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
PRKCA-binding protein (PICK1) . Q9NRD5
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
Zinc finger and BTB domain-containing protein 10 (ZBTB10) . Q96DT7

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255