Details of the Target

General Information of Target

Target ID LDTP07424
Target Name Pleckstrin homology domain-containing family A member 7 (PLEKHA7)
Gene Name PLEKHA7
Gene ID 144100
Synonyms
Pleckstrin homology domain-containing family A member 7; PH domain-containing family A member 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGW
EEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMV
SETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMR
LWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRA
LIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQA
VPQANHTESCHECGRVGPGHTRDCPHRGHDDIVNFERQEQEGEQYRSQRDPLEGKRDRSK
ARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRT
NPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTLPRQGPGQSLSFPENYQTLPKSTRHP
SGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAP
ICLGSPEFTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPD
QRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLK
KDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKENKD
QLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLK
LENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPE
RKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRK
VTSPLQSPTKAKPKVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQS
DERKRDRELGQCVNGDSRVELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLS
GSTSRLQQSSTIAPYVTLRRGLNAESSKATFPRPKSALERLYSGDHQRGKMSAEEQLERM
KRHQKALVRERKRTLGQGERTGLPSSRYLSRPLPGDLGSVC
Target Bioclass
Other
Subcellular location
Cell junction, adherens junction
Function
Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site. Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33.
Uniprot ID
Q6IQ23
Ensemble ID
ENST00000355661.7
HGNC ID
HGNC:27049
ChEMBL ID
CHEMBL4296241

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K424(1.92); K622(9.80); K805(7.69)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
Probe 1
 Probe Info  		Y243(12.61)  LDD3495  [3]
DBIA
 Probe Info  		C699(1.57)  LDD3319  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [6]
Compound 11
 Probe Info  		N.A.  LDD2213  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C699(0.91); C34(0.95); C972(0.79)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C699(0.91); C34(0.95); C972(1.06)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C699(0.90); C34(0.96); C972(0.85)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C699(1.01); C34(1.05)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C699(0.91); C972(0.67)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C699(0.96); C34(0.91); C542(1.05)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C699(0.92); C34(1.08); C972(0.83)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C699(0.84); C34(1.00); C972(1.04)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C699(0.88); C34(0.98); C972(1.04)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C699(1.02); C34(1.05); C972(0.84)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C699(1.08); C34(0.98)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C699(1.02); C34(0.98); C542(1.09)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C699(0.99); C972(0.87)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C699(1.12); C34(0.96); C542(1.12)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C699(1.10); C34(1.08); C542(1.01); C972(1.00)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C699(0.87); C34(1.09); C972(1.00)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C699(0.94); C34(0.99); C972(1.16)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C699(0.91); C34(1.07); C972(0.80)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C699(1.10); C34(1.06)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C699(1.01); C34(1.11); C542(1.14)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C699(0.87); C34(0.99); C972(0.85)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C699(1.03); C972(0.82)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C699(0.97); C34(0.89); C542(0.95)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C699(0.88); C34(1.10); C542(0.93); C972(1.16)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C699(0.93); C34(1.07); C972(0.90)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C699(0.87); C34(1.02); C972(0.98)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C699(0.93); C34(1.05); C972(0.78)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C699(1.10); C34(1.09)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C699(1.09); C34(1.16); C542(0.99)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C699(0.99); C972(0.74)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C699(0.98); C34(0.91); C542(0.93)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C699(0.97); C34(0.99)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C699(0.93); C34(1.20); C542(0.92); C972(0.98)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C699(0.89); C34(1.15); C972(1.01)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C699(0.83); C34(0.94); C972(0.95)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C699(0.94); C34(1.14); C972(0.80)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C699(1.03); C34(1.06)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C699(1.15); C34(1.10); C542(1.45)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C699(0.90); C972(0.77)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C699(0.97); C34(0.93); C542(1.01)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C699(0.99); C34(1.17); C542(0.92); C972(1.14)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C699(0.95); C34(1.14); C972(0.99)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C699(1.06); C34(1.00); C542(0.94)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C699(0.96); C34(1.03); C972(1.06)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C699(1.01); C34(1.02); C972(0.96)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C699(1.00); C34(1.12)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C699(1.06); C34(1.06); C542(1.16)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C699(1.03); C972(0.74)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C699(0.96); C34(0.93); C542(1.02)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C699(0.95); C34(1.02); C542(1.00); C972(1.02)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C699(0.92); C34(1.09); C972(1.09)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C699(0.83); C34(1.07); C972(1.19)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C699(0.89); C34(1.04); C972(0.81)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C699(0.89); C972(0.90)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C699(0.96); C34(0.94)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C699(1.04); C34(1.02); C542(1.07)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C699(1.01); C972(0.78)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C699(1.01); C34(0.95); C542(0.87)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C699(0.86); C34(1.16); C542(0.98); C972(0.98)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C699(0.94); C34(0.88); C542(1.02)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C699(0.93); C34(1.11); C542(1.04); C972(1.02)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C699(1.18); C34(1.18); C542(1.24)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C699(1.00); C34(1.03); C972(0.90)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C699(0.95); C34(1.18); C542(1.18); C972(1.12)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C699(0.93); C34(1.02); C542(0.99)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C699(0.96); C972(1.09)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C699(1.05); C34(0.97)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C699(1.04); C34(1.03); C542(0.85)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C699(0.95); C34(1.23); C542(0.95); C972(0.83)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C699(0.98); C34(1.02); C972(1.01)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C699(1.03); C34(0.95)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C699(1.05); C34(1.05); C542(0.88)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C699(0.97); C34(1.00); C542(0.90); C972(0.87)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C699(0.97); C34(1.10); C972(1.04)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C699(1.01); C34(0.98)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C699(0.91); C34(0.99); C542(0.85)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C699(0.95); C34(0.82); C542(0.89)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C699(0.94); C34(0.97); C542(1.11); C972(0.90)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C699(0.96); C34(1.04); C972(1.04)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C699(1.06); C34(0.87)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C699(1.00); C34(1.04); C542(0.88)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C699(0.60); C34(1.01); C542(1.20); C972(1.00)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C699(0.97); C34(1.01); C972(1.02)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C699(1.08); C34(1.05)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C699(1.02); C34(1.04); C542(1.00)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C699(1.05); C34(0.99); C542(1.14); C972(0.94)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C699(0.95); C34(1.05); C972(1.17)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C699(0.90); C34(1.13); C542(1.05); C972(1.29)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C699(1.07); C34(1.12)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C699(1.06); C34(1.00); C542(0.93)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C699(0.97); C34(0.96); C542(1.06); C972(0.92)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C699(0.96); C34(0.94); C972(1.04)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C699(0.99); C34(1.03)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C699(0.94); C34(0.95); C542(0.86)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C699(1.00); C34(0.97); C542(0.92); C972(0.75)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C699(1.03); C34(1.19); C972(0.99)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C699(1.02); C34(0.98)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C699(0.93); C34(1.09); C542(0.90)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C699(0.99); C34(1.01); C542(0.91); C972(0.88)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C699(0.87); C34(0.91); C972(1.00)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C699(1.05); C34(0.98)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C699(0.90); C34(1.07); C972(0.79)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C699(1.02); C34(1.06); C972(1.08)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C699(0.95); C34(0.99); C972(0.84)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C699(1.03); C34(1.06); C542(1.04); C972(0.82)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C699(1.04); C34(1.10)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C699(1.08); C34(1.37); C542(1.20)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C699(0.94); C972(1.41)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C699(1.02); C34(0.95); C542(1.00)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C699(0.90); C34(1.08); C542(0.92); C972(1.54)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C699(0.94); C34(0.92); C542(0.83)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C699(1.02); C34(1.04); C542(1.22); C972(0.79)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C699(1.06); C34(1.07); C972(1.00)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C699(0.97); C34(0.98)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C699(0.97); C34(1.16); C972(0.78)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C699(1.03); C34(1.08); C972(1.00)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C699(0.88); C34(1.06); C972(0.92)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C699(1.00); C34(1.10); C972(1.02)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C699(1.01); C34(1.01)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C699(1.02); C34(0.96); C542(1.03)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C699(1.14); C972(1.42)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C699(1.06); C34(0.94); C542(0.89)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C699(0.99); C34(1.04); C542(0.97); C972(1.71)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C699(1.05); C34(1.05); C542(0.95)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C699(1.07); C34(1.18); C972(0.97)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C699(1.08); C34(0.97)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C699(1.11); C34(1.06)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C699(0.90); C34(1.14); C972(0.93)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C699(0.91); C34(1.03); C972(1.18)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C699(0.95); C34(0.98); C972(0.93)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C699(1.01); C34(0.99)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C699(1.05); C34(1.12); C542(1.05)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C699(0.99); C972(0.98)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C699(1.08); C34(0.90); C542(0.93)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C699(0.99); C34(1.16); C542(0.94); C972(1.53)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C699(0.99); C34(1.09); C542(0.95)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C699(0.91); C34(1.04); C972(1.02)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C699(1.01); C34(0.91); C542(1.09); C972(1.01)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C699(1.07); C34(1.14)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C699(0.84); C34(1.10); C972(0.96)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C699(0.85); C34(1.00); C972(1.06)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C699(0.96); C34(1.00); C972(0.99)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C699(0.99); C34(1.01)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C699(1.07); C34(1.08); C542(0.90)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C699(0.91); C972(1.13)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C699(1.05); C34(0.91); C542(1.18)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C699(0.89); C34(0.91); C972(1.10)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C699(1.04); C34(1.07); C542(1.05); C972(1.31)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C699(1.00); C34(0.94); C542(0.87)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C699(1.07); C34(0.90); C542(1.09); C972(1.00)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C699(1.05); C34(1.03); C972(1.01)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C699(1.14); C34(1.01)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C699(0.87); C34(1.13); C972(0.85)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C699(0.91); C34(0.97); C972(1.14)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C699(1.00); C34(1.01); C972(0.97)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C699(1.08); C34(1.21)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C699(1.10); C34(1.10); C542(1.09)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C699(0.91); C34(1.07); C972(0.88)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C699(0.99); C972(1.19)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C699(0.94); C34(0.95); C542(1.00)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C699(1.15); C34(1.12); C542(1.14); C972(1.56)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C699(0.94); C34(0.96); C542(0.85)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C699(0.99); C34(1.12); C542(1.13); C972(0.82)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C699(1.03); C34(1.03)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C699(0.90); C34(1.03); C972(0.90)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C699(0.97); C34(1.15); C972(1.00)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C699(1.02); C34(1.08); C972(0.97)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C699(0.78); C34(0.84)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C699(1.10); C34(1.10)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C699(1.10); C34(1.14); C542(0.91)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C699(0.92); C972(1.15)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C699(0.99); C34(0.87); C542(0.90)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C699(1.04); C34(0.96); C542(0.93); C972(1.70)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C699(0.89); C34(0.95); C542(0.81)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C699(0.95); C34(0.91); C542(0.93); C972(0.86)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C699(1.07); C34(0.86); C972(1.07)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C699(1.27); C34(1.06)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C699(0.96); C34(1.14); C972(1.08)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C699(1.05); C34(1.06); C542(1.12)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C699(0.78); C34(0.85); C972(1.07)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C699(0.93); C34(1.00); C972(0.95)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C699(0.93); C34(0.96)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C699(1.16); C34(0.99); C542(1.00)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C699(0.94); C972(1.55)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C699(0.80); C34(0.85); C542(0.99)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C699(0.89); C34(0.91); C542(0.79); C972(1.12)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C699(0.95); C34(0.89); C542(0.85)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C699(1.00); C34(0.95); C542(0.93); C972(0.83)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C699(0.90); C34(0.93); C972(0.84)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C699(1.12); C34(0.98); C972(1.15)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C699(1.02); C34(1.10); C972(1.00)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C699(1.01); C34(1.15); C542(1.00); C972(0.81)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C972(0.98); C34(0.92); C542(0.98); C699(1.08)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C972(0.88); C34(1.01); C542(1.27); C699(0.90)  LDD1497  [8]
 LDCM0024  KB05 MEWO C699(1.57)  LDD3319  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein argonaute-2 (AGO2) Argonaute family Q9UKV8
Retinol dehydrogenase 12 (RDH12) Short-chain dehydrogenases/reductases (SDR) family Q96NR8
Rho-related GTP-binding protein RhoH (RHOH) Rho family Q15669
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit beta-1 (KPNB1) Importin beta family Q14974
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B9 domain-containing protein 2 (B9D2) B9D family Q9BPU9
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Protein FAM228A (FAM228A) FAM228 family Q86W67
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Periplakin (PPL) Plakin or cytolinker family O60437
Stathmin-3 (STMN3) Stathmin family Q9NZ72
Heat shock factor 2-binding protein (HSF2BP) . O75031
Insulin-like growth factor-binding protein 6 (IGFBP6) . P24592
PRKCA-binding protein (PICK1) . Q9NRD5
Zinc finger matrin-type protein 5 (ZMAT5) . Q9UDW3

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402