Details of the Target

General Information of Target

Target ID LDTP07179
Target Name Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (MAGI3)
Gene Name MAGI3
Gene ID 260425
Synonyms
KIAA1634; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; Membrane-associated guanylate kinase inverted 3; MAGI-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVV
SGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQ
FQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLES
GTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEE
EDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWE
MAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDH
LNQKTQFENPVEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGF
GFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLV
PVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQ
NGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQK
VKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSP
TKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPP
NTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIP
VKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEV
PARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG
DHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRP
MGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCY
PVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT
HTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDINNPSSSNVIYDEQSPLPPSSHFASIF
EESHVPVIEESLRVQICEKAEELKDIVPEKKSTLNENQPEIKHQSLLQKNVSKRDPPSSH
GHSNKKNLLKVENGVTRRGRSVSPKKPASQHSEEHLDKIPSPLKNNPKRRPRDQSLSPSK
GENKSCQVSTRAGSGQDQCRKSRGRSASPKKQQKIEGSKAPSNAEAKLLEGKSRRIAGYT
GSNAEQIPDGKEKSDVIRKDAKQNQLEKSRTRSPEKKIKRMVEKSLPSKMTNKTTSKEVS
ENEKGKKVTTGETSSSNDKIGENVQLSEKRLKQEPEEKVVSNKTEDHKGKELEAADKNKE
TGRFKPESSSPVKKTLITPGPWKVPSGNKVTGTIGMAEKRQ
Target Bioclass
Other
Family
MAGUK family
Subcellular location
Cell membrane
Function
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
Uniprot ID
Q5TCQ9
Ensemble ID
ENST00000307546.14
HGNC ID
HGNC:29647
ChEMBL ID
CHEMBL5212

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0225  [1]
DBIA
 Probe Info  		C1304(1.00)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
AOyne
 Probe Info  		13.60  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1291(1.23)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C1266(0.95); C525(0.87); C1019(1.04); C464(1.16)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C1266(0.90); C525(1.15); C336(0.86); C464(1.00)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C1266(1.10); C525(1.09); C1019(1.07); C464(0.72)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C1266(1.13); C1279(0.89); C464(0.99); C57(1.04)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C1266(0.91); C525(0.98); C57(1.04)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C1266(1.15); C464(1.10); C57(1.01)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C1266(1.13); C525(0.97); C1019(0.93); C464(1.01)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C1266(1.86); C525(0.97); C336(0.92); C464(0.78)  LDD1517  [7]
 LDCM0279  AC2 HCT 116 C1291(1.10)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C1266(0.99); C525(1.14); C1019(0.93); C464(0.70)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C1266(0.83); C336(0.69); C464(1.07); C57(1.02)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C1266(1.13); C1279(0.97); C464(1.08); C57(1.05)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C1266(0.98); C525(0.94); C57(0.93)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C1266(1.06); C525(0.99); C1019(1.15); C464(0.89)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C1266(1.12); C464(1.23); C57(1.09)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C1266(1.00); C525(0.88); C1019(1.01); C464(1.24)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C1266(0.95); C525(1.10); C336(0.93); C464(0.89)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C1266(1.14); C525(1.12); C1019(0.95); C464(0.61)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C1266(0.95); C336(0.87); C464(0.96); C57(1.00)  LDD1528  [7]
 LDCM0290  AC3 HCT 116 C1291(1.07)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C1266(0.99); C1279(0.90); C464(0.90); C57(1.03)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C1266(1.19); C525(0.90); C57(1.05)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C1266(0.96); C525(1.13); C1019(0.95); C464(1.08)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C1266(1.02); C464(1.62); C57(1.14)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C1266(1.21); C525(1.09); C1019(0.96); C464(1.16)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C1266(0.88); C525(1.14); C336(0.84); C464(0.91)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C1266(1.27); C525(1.12); C1019(1.12); C464(0.87)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C1266(0.86); C336(1.08); C464(0.93); C57(0.87)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C1266(1.16); C1279(0.74); C464(1.05); C57(0.95)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C1266(0.92); C525(1.01); C57(1.00)  LDD1539  [7]
 LDCM0301  AC4 HCT 116 C1291(1.15)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C1266(1.00); C525(1.17); C1019(1.12); C464(1.11)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C1266(1.06); C464(1.20); C57(1.16)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C1266(1.09); C525(1.03); C1019(0.98); C464(1.12)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C1266(0.91); C525(1.05); C336(0.84); C464(0.98)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C1266(1.12); C525(0.97); C1019(1.12); C464(1.03)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C1266(1.01); C336(0.89); C464(1.11); C57(1.03)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C1266(1.07); C1279(1.02); C464(1.11); C57(1.06)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C1266(0.95); C525(1.01); C57(0.98)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C1266(0.98); C525(1.17); C1019(1.15); C464(1.12)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C1266(1.05); C464(1.03); C57(0.99)  LDD1550  [7]
 LDCM0312  AC5 HCT 116 C1291(1.27)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C1266(0.91); C525(0.93); C1019(1.08); C464(1.14)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C1266(0.93); C525(1.00); C336(0.88); C464(1.01)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C1266(1.21); C525(1.10); C1019(1.01); C464(0.87)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C1266(1.10); C336(1.18); C464(0.91); C57(0.96)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C1266(1.27); C1279(0.94); C464(1.19); C57(1.05)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C1266(0.91); C525(1.06); C57(1.00)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C1266(1.17); C525(0.99); C1019(1.03); C464(0.86)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C1266(1.15); C464(1.21); C57(1.12)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C1266(1.05); C525(0.96); C1019(1.05); C464(1.06)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C1266(0.99); C525(1.22); C336(1.01); C464(1.14)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C1266(0.99); C1279(0.96); C464(1.07); C57(1.21)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C1266(1.12); C525(1.22); C1019(1.02); C464(0.71)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C1266(1.00); C336(1.07); C464(1.15); C57(1.04)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C1266(1.12); C1279(0.87); C464(1.07); C57(1.08)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C1266(0.83); C525(1.03); C57(1.23)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C1266(0.94); C525(1.02); C1019(0.84); C464(1.05)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C1266(0.78); C525(1.05); C57(1.00)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C1266(1.06); C525(0.99); C1019(1.05); C464(1.40)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C1266(0.94); C336(1.17); C464(0.99); C57(0.98)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C1266(1.02); C464(1.09); C57(1.06)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C1266(1.02); C525(0.99); C1019(1.05); C464(0.99)  LDD1514  [7]
 LDCM0020  ARS-1620 HCC44 C1304(1.00)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C1266(0.96); C525(1.12); C464(0.99); C57(1.12)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C1266(0.97); C1279(1.72); C464(1.04); C57(1.72)  LDD1572  [7]
 LDCM0369  CL100 HCT 116 C1291(1.15)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C1266(1.07); C525(1.07); C464(0.81); C57(1.06)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C525(0.93); C464(0.94); C57(1.17)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C1266(0.83); C525(1.08); C464(1.20); C57(1.05)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C1266(0.95); C525(1.11); C1019(1.01); C464(0.87)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C1266(1.04); C525(0.80); C464(0.88); C57(1.00)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C525(0.94); C464(0.79); C57(0.96)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C1266(0.97); C525(0.92); C464(0.89); C57(0.97)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C1266(0.92); C525(1.06); C1019(0.92); C464(1.05)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C1266(1.00); C525(0.85); C464(1.18); C57(1.15)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C1266(0.90); C525(1.01); C57(1.18)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C525(0.94); C464(0.67); C57(1.57)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C1266(0.78); C525(0.97); C464(1.06); C57(1.12)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C1266(1.08); C525(1.18); C1019(1.07); C464(0.94)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C1266(0.93); C525(1.11); C464(0.76); C57(1.07)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C525(1.03); C464(0.74); C57(1.03)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C1266(0.87); C525(0.97); C464(1.12); C57(0.91)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C1266(1.09); C525(1.05); C1019(0.92); C464(1.10)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C1266(0.90); C525(1.15); C464(1.26); C57(1.02)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C525(1.03); C464(0.86); C57(0.94)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C1266(0.79); C525(1.03); C464(1.06); C57(0.93)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C1266(1.21); C525(0.76); C1019(0.89); C464(0.86)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C1266(0.97); C525(1.22); C1019(0.98); C464(0.97)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C1266(1.16); C525(1.15); C464(0.92); C57(1.00)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C525(1.03); C464(0.75); C57(1.04)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C1266(0.79); C525(0.97); C464(1.00); C57(4.06)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C1266(1.00); C525(1.09); C1019(0.87); C464(1.03)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C1266(0.96); C525(1.10); C464(1.11); C57(1.12)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C525(1.04); C464(0.95); C57(1.03)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C1266(0.89); C525(1.07); C464(1.23); C57(0.98)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C1266(1.05); C525(1.17); C1019(0.97); C464(1.17)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C1266(1.00); C525(1.11); C464(0.98); C57(0.92)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C525(1.01); C464(0.70); C57(0.97)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C1266(0.82); C525(0.93); C464(1.02); C57(1.14)  LDD1606  [7]
 LDCM0403  CL16 HCT 116 C1291(1.86)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C1291(1.15)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C1291(1.10)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C1291(1.50)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C525(1.09); C464(0.86); C57(0.96)  LDD1611  [7]
 LDCM0408  CL20 HCT 116 C1291(1.22)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C1291(1.41)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C1291(1.27)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C1291(1.85)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C1291(1.62)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C1291(1.05)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C1291(1.35)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C1291(1.45)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C1291(1.69)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C1291(1.51)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C1266(0.82); C525(1.04); C464(0.97); C57(1.99)  LDD1622  [7]
 LDCM0419  CL30 HCT 116 C1291(1.38)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C1266(0.95); C525(0.98); C336(1.06); C464(0.99)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C1266(1.01); C525(0.97); C1019(1.13); C464(0.72)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C1266(0.85); C336(0.78); C464(0.67); C57(1.67)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C1266(1.21); C1279(0.91); C464(0.96); C57(1.27)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C1266(0.90); C525(0.94); C57(0.92)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C1266(1.00); C525(0.66); C1019(1.16); C464(0.82)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C1266(0.97); C525(0.97); C464(0.99); C57(1.08)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C1266(0.69); C525(0.98); C464(0.89); C57(1.40)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C1266(0.88); C525(1.09); C1019(1.12); C464(1.13)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C1266(0.84); C525(0.98); C1019(1.23); C464(1.01)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C1266(0.88); C464(1.09); C57(1.08)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C1266(0.98); C525(1.11); C1019(0.97); C464(1.07)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C1266(0.85); C525(0.95); C336(0.93); C464(0.95)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C1266(1.09); C525(1.11); C1019(1.09); C464(0.66)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C1266(0.76); C336(0.97); C464(0.89); C57(1.37)  LDD1639  [7]
 LDCM0436  CL46 HCT 116 C1291(1.24)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C1291(1.40)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C1291(1.24)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C1291(1.59)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C1266(1.07); C464(1.17); C57(1.06)  LDD1644  [7]
 LDCM0441  CL50 HCT 116 C1291(0.97)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C1291(1.16)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C1291(1.23)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C1291(1.12)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C1291(1.15)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C1291(0.98)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C1291(1.02)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C1291(1.06)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C1291(1.24)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C1291(1.02)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C1266(1.07); C525(0.90); C1019(0.88); C464(1.09)  LDD1654  [7]
 LDCM0452  CL60 HCT 116 C1291(1.51)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C1291(1.24)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C1291(1.20)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C1291(1.13)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C1291(1.09)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C1291(1.07)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C1291(1.24)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C1291(0.84)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C1291(1.12)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C1291(1.49)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C1266(0.86); C525(1.06); C336(1.25); C464(0.86)  LDD1665  [7]
 LDCM0463  CL70 HCT 116 C1291(0.97)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C1291(1.03)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C1291(1.00)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C1291(1.61)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C1291(1.35)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C1266(0.92); C525(1.04); C1019(1.04); C464(1.01)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C1266(0.93); C464(1.02); C57(1.90)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C1266(1.00); C525(0.85); C1019(0.92); C464(1.10)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C1266(0.95); C525(1.00); C336(1.08); C464(0.80)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C1266(0.95); C525(0.78); C1019(0.88); C464(0.65)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C1266(1.12); C525(1.04); C1019(1.19); C464(0.73)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C1266(0.97); C336(1.16); C464(0.95); C57(0.91)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C1266(1.11); C1279(0.93); C464(0.92); C57(1.06)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C1266(0.98); C525(1.02); C57(1.00)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C1266(1.06); C525(0.76); C1019(0.94); C464(0.97)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C1266(1.06); C525(0.99); C464(1.14); C57(1.39)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C525(1.08); C464(0.92); C57(1.04)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C1266(0.76); C525(1.07); C464(1.03); C57(1.04)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C1266(1.08); C525(1.23); C1019(1.05); C464(1.05)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C1266(0.94); C464(1.21); C57(1.11)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C1266(0.99); C336(1.14); C464(0.85); C57(1.24)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C1266(1.08); C525(0.77); C1019(0.73); C464(1.11)  LDD1688  [7]
 LDCM0486  CL91 HCT 116 C1291(0.91)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C1291(0.86)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C1291(1.02)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C1291(1.01)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C1291(1.01)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C1291(1.09)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C1291(1.18)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C1291(1.07)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C1291(0.91)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C1266(0.84); C525(0.82); C464(1.09); C57(0.85)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C1291(0.92)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C525(1.15); C464(1.17); C57(0.99)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C525(0.98); C464(1.13); C57(0.72)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C1279(10.23)  LDD0209  [8]
 LDCM0024  KB05 G361 C1291(2.11)  LDD3311  [9]
 LDCM0109  NEM HeLa N.A.  LDD0225  [1]
 LDCM0021  THZ1 HCT 116 C1304(0.94)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane gamma-carboxyglutamic acid protein 4 (PRRG4) Commissureless family Q9BZD6
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-1 adrenergic receptor (ADRB1) G-protein coupled receptor 1 family P08588
Beta-2 adrenergic receptor (ADRB2) G-protein coupled receptor 1 family P07550
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mediator of RNA polymerase II transcription subunit 28 (MED28) Mediator complex subunit 28 family Q9H204

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840