Details of the Target

General Information of Target

Target ID LDTP07127
Target Name Adhesion G-protein coupled receptor F1 (ADGRF1)
Gene Name ADGRF1
Gene ID 266977
Synonyms
GPR110; PGR19; Adhesion G-protein coupled receptor F1; G protein-coupled receptor 110; G protein-coupled receptor KPG_012; G protein-coupled receptor PGR19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKVGVLWLISFFTFTDGHGGFLGKNDGIKTKKELIVNKKKHLGPVEEYQLLLQVTYRDSK
EKRDLRNFLKLLKPPLLWSHGLIRIIRAKATTDCNSLNGVLQCTCEDSYTWFPPSCLDPQ
NCYLHTAGALPSCECHLNNLSQSVNFCERTKIWGTFKINERFTNDLLNSSSAIYSKYANG
IEIQLKKAYERIQGFESVQVTQFRNGSIVAGYEVVGSSSASELLSAIEHVAEKAKTALHK
LFPLEDGSFRVFGKAQCNDIVFGFGSKDDEYTLPCSSGYRGNITAKCESSGWQVIRETCV
LSLLEELNKNFSMIVGNATEAAVSSFVQNLSVIIRQNPSTTVGNLASVVSILSNISSLSL
ASHFRVSNSTMEDVISIADNILNSASVTNWTVLLREEKYASSRLLETLENISTLVPPTAL
PLNFSRKFIDWKGIPVNKSQLKRGYSYQIKMCPQNTSIPIRGRVLIGSDQFQRSLPETII
SMASLTLGNILPVSKNGNAQVNGPVISTVIQNYSINEVFLFFSKIESNLSQPHCVFWDFS
HLQWNDAGCHLVNETQDIVTCQCTHLTSFSILMSPFVPSTIFPVVKWITYVGLGISIGSL
ILCLIIEALFWKQIKKSQTSHTRRICMVNIALSLLIADVWFIVGATVDTTVNPSGVCTAA
VFFTHFFYLSLFFWMLMLGILLAYRIILVFHHMAQHLMMAVGFCLGYGCPLIISVITIAV
TQPSNTYKRKDVCWLNWSNGSKPLLAFVVPALAIVAVNFVVVLLVLTKLWRPTVGERLSR
DDKATIIRVGKSLLILTPLLGLTWGFGIGTIVDSQNLAWHVIFALLNAFQGFFILCFGIL
LDSKLRQLLFNKLSALSSWKQTEKQNSSDLSAKPKFSKPFNPLQNKGHYAFSHTGDSSDN
IMLTQFVSNE
Target Bioclass
GPCR
Family
G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
Subcellular location
Secreted; Cell membrane
Function Orphan receptor.
Uniprot ID
Q5T601
Ensemble ID
ENST00000371243.2
HGNC ID
HGNC:18990
ChEMBL ID
CHEMBL4523872

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 Deletion: p.I601FfsTer4 .
BICR22 SNV: p.S741R .
CORL23 SNV: p.P578L .
HCC1395 SNV: p.G895R .
HT115 SNV: p.L244V .
LNCaP clone FGC SNV: p.A818V .
MFE319 Deletion: p.S523PfsTer3 .
MONOMAC6 SNV: p.T564I .
NB1 SNV: p.L117P .
NCIH1793 Deletion: p.A719CfsTer5 .
OAW42 SNV: p.Q142K .
SCC25 SNV: p.K39R .
SISO Deletion: p.D896LfsTer13 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C287(1.30)  LDD0580  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0263  AC143 HCT 116 C287(1.30)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C287(0.91)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C287(0.86)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C287(1.16)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C287(1.11)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C287(0.79)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C287(0.97)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C287(0.92)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C287(1.17)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C287(1.08)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C287(0.74)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C287(1.04)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C287(0.79)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C287(1.13)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C287(1.14)  LDD2161  [1]
 LDCM0296  AC35 HCT 116 C287(0.78)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C287(0.83)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C287(0.73)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C287(0.76)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C287(1.05)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C287(1.29)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C287(1.14)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C287(0.92)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C287(0.73)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C287(0.84)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C287(0.87)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C287(1.51)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C287(1.31)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C287(1.23)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C287(1.08)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C287(0.86)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C287(1.18)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C287(1.10)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C287(1.01)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C287(0.78)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C287(0.87)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C287(0.78)  LDD0636  [1]
 LDCM0387  CL117 HCT 116 C287(0.57)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C287(0.96)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C287(1.04)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C287(0.79)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C287(0.82)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C287(1.24)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C287(1.76)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C287(1.13)  LDD0712  [1]
 LDCM0403  CL16 HCT 116 C287(0.76)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C287(1.42)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C287(1.18)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C287(1.51)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C287(1.16)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C287(1.04)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C287(1.49)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C287(1.30)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C287(2.16)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C287(1.47)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C287(0.92)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C287(1.62)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C287(1.39)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C287(1.88)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C287(1.44)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C287(0.80)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C287(1.26)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C287(1.11)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C287(0.81)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C287(1.36)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C287(1.20)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C287(1.07)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C287(1.00)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C287(1.07)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C287(0.77)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C287(1.00)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C287(0.96)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C287(0.97)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C287(0.85)  LDD0752  [1]
 LDCM0427  Fragment51 HCT 116 C287(0.80)  LDD0744  [1]
 LDCM0022  KB02 COR-L88 C299(0.97)  LDD2311  [2]
 LDCM0023  KB03 ECC2 C299(3.40)  LDD2737  [2]
 LDCM0024  KB05 HMCB C299(1.63)  LDD3312  [2]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840