Details of the Target

General Information of Target

Target ID LDTP06895
Target Name Kelch-like protein 12 (KLHL12)
Gene Name KLHL12
Gene ID 59349
Synonyms
C3IP1; Kelch-like protein 12; CUL3-interacting protein 1; DKIR homolog; hDKIR
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCA
MFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQ
ACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVE
KLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEP
FIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVE
KYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWY
SVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAG
LVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG
FDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECY
DPIIDSWEVVTSMGTQRCDAGVCVLREK
Target Bioclass
Other
Subcellular location
Cytoplasmic vesicle, COPII-coated vesicle
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export. As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins.
Uniprot ID
Q53G59
Ensemble ID
ENST00000367261.8
HGNC ID
HGNC:19360

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HGC27 SNV: p.R276C .
LOXIMVI Deletion: p.A110PfsTer6 .
MCC13 SNV: p.S499F .
NCIH1155 SNV: p.R48W .
NCIH358 SNV: p.A492V .
NCIH661 SNV: p.C111S .
SW403 SNV: p.V100M .
WM1552C SNV: p.E187K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C511(10.42)  LDD0209  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C185(0.88); C511(0.92)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C185(1.15)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C185(1.08)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C185(1.20)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C185(1.03)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C185(1.06)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C185(1.00); C511(1.06)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C185(0.95)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C185(0.94)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C185(0.98)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C185(1.08)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C185(1.09)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C185(1.12)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C185(0.97)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C185(1.15)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C185(1.01); C511(1.37)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C185(1.28)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C185(0.99)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C185(1.04)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C185(0.97)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C185(1.09)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C185(0.94)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C185(0.96)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C185(0.94)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C185(0.85); C511(1.23)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C185(1.21)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C185(0.98)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C185(0.96)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C185(1.06)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C185(0.97)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C185(1.10)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C185(1.01)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C185(1.05)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C185(0.95); C511(1.16)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C185(1.10)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C185(1.09)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C185(1.14)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C185(0.99)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C185(1.09)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C185(1.03)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C185(1.17)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C185(0.94); C511(1.31)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C185(1.33)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C185(1.29)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C185(1.07)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C185(1.06)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C185(1.05)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C185(1.07)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C185(1.20)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C185(1.00)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C185(0.91); C511(0.93)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C185(1.11)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C185(1.01)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C185(0.90)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C185(1.02)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C185(1.06)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C185(1.01)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C185(1.02)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C185(1.02)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C185(1.13)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C185(1.01)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C185(1.31)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C185(0.97); C511(1.11)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C185(1.17)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C185(0.99)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C185(1.11)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C185(1.23)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C185(0.95)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C185(1.12)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C185(1.14)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C185(0.91)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C185(0.89)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C185(1.12)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C185(1.16)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C185(0.80)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C185(1.15)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C185(0.94)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C185(1.13)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C185(1.22)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C185(0.82)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C185(0.96)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C185(0.97)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C185(1.15)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C185(1.27)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C185(1.02)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C185(1.22)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C185(1.16)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C185(0.93)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C185(1.10)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C185(0.87)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C185(1.13)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C185(1.18)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C185(1.41)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C185(0.99)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C185(1.02)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C185(0.97)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C185(0.83)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C185(0.88)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C185(1.18)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C185(1.24)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C185(1.35)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C185(0.84); C511(0.92)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C185(1.01)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C185(1.08)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C185(1.04)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C185(1.01)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C185(1.01)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C185(1.20)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C185(1.15)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C185(1.01)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C185(0.91)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C185(1.21)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C185(1.08)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C185(0.99)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C185(0.82); C511(1.15)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C185(1.25)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C185(1.12)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C185(1.00)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C185(1.05)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C185(1.14)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C185(0.86)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C185(1.03)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C185(1.14)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C185(1.20)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C185(0.96)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C185(0.91)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C185(0.85)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C185(0.92); C511(1.31)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C185(1.03)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C185(0.84)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C185(0.88)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C185(1.07)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C185(1.10)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C185(0.94)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C185(1.00)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C185(1.08)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C185(0.84); C511(1.06)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C185(0.97)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C185(0.87)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C185(1.18); C511(1.03)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C185(1.26)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C185(0.90)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C185(1.01)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C185(0.88)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C185(0.93)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C185(0.99)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C185(0.87)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C185(0.96)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C185(0.98)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C185(1.16)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C185(1.09)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C185(0.82)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C185(0.95); C511(1.08)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C185(0.99)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C185(1.10)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C185(1.00)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C185(1.24)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C185(1.05)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C185(1.07)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C185(0.92)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C185(1.08)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C185(0.99)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C185(1.22)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C185(0.95)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C185(0.94); C511(0.92)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C185(1.14)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C185(0.90)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C185(0.65)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C185(1.14)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C185(1.12)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C185(1.03)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C185(0.95)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C185(0.98)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C185(0.94)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C185(0.97)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C185(1.02)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C185(1.09)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C185(1.08); C511(0.85)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C185(0.89)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C185(1.39)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C185(0.96)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C185(0.94)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C185(1.23)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C185(0.78)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C185(0.86)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C185(0.88)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C185(0.71)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C185(1.15)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C185(1.09)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C185(1.19)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C185(1.05)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C185(1.21)  LDD1631  [2]
 LDCM0022  KB02 786-O C549(1.64)  LDD2247  [3]
 LDCM0023  KB03 Jurkat C511(10.42)  LDD0209  [1]
 LDCM0024  KB05 MSTO-211H C549(1.47)  LDD3337  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arrestin domain-containing protein 1 (ARRDC1) Arrestin family Q8N5I2
Indolethylamine N-methyltransferase (INMT) NNMT/PNMT/TEMT family O95050
Cullin-3 (CUL3) Cullin family Q13618
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
DNA polymerase delta catalytic subunit (POLD1) DNA polymerase type-B family P28340
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Ribonuclease P protein subunit p25-like protein (RPP25L) Histone-like Alba family Q8N5L8
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Tau-tubulin kinase 2 (TTBK2) CK1 Ser/Thr protein kinase family Q6IQ55
Platelet-derived growth factor receptor beta (PDGFRB) Tyr protein kinase family P09619
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Sorting nexin-20 (SNX20) Sorting nexin family Q7Z614
Kelch-like protein 2 (KLHL2) . O95198
Kelch-like protein 3 (KLHL3) . Q9UH77
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell lymphoma 6 protein (BCL6) . P41182
Zinc finger and BTB domain-containing protein 4 (ZBTB4) . Q9P1Z0
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Collagen and calcium-binding EGF domain-containing protein 1 (CCBE1) CCBE1 family Q6UXH8
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
55 kDa erythrocyte membrane protein (MPP1) MAGUK family Q00013
Microtubule-associated protein RP/EB family member 1 (MAPRE1) MAPRE family Q15691
Mediator of RNA polymerase II transcription subunit 25 (MED25) Mediator complex subunit 25 family Q71SY5
Nesprin-4 (SYNE4) Nesprin family Q8N205
Vascular endothelial growth factor B (VEGFB) PDGF/VEGF growth factor family P49765
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
Large ribosomal subunit protein uL10m (MRPL10) Universal ribosomal protein uL10 family Q7Z7H8
Carabin (TBC1D10C) . Q8IV04
Complement C1q tumor necrosis factor-related protein 2 (C1QTNF2) . Q9BXJ5
FYVE, RhoGEF and PH domain-containing protein 2 (FGD2) . Q7Z6J4
Kelch-like protein 12 (KLHL12) . Q53G59
Kelch-like protein 24 (KLHL24) . Q6TFL4
Large proline-rich protein BAG6 (BAG6) . P46379
Peflin (PEF1) . Q9UBV8
Proline-rich protein 13 (PRR13) . Q9NZ81
Ral guanine nucleotide dissociation stimulator-like 3 (RGL3) . Q3MIN7

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840