Details of the Target

General Information of Target

Target ID LDTP06859
Target Name Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1)
Gene Name SVEP1
Gene ID 79987
Synonyms
C9orf13; CCP22; SELOB; Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; CCP module-containing protein 22; Polydom; Selectin-like osteoblast-derived protein; SEL-OB; Serologically defined breast cancer antigen NY-BR-38
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWPRLAFCCWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSR
VERLGQAFRRRVRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTAT
RVAIVTFSSKNYVVPRVDYISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQIL
LHARENSTKVVFLITDGYSNGGDPRPIAASLRDSGVEIFTFGIWQGNIRELNDMASTPKE
EHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHT
GHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDC
VCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILC
LPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC
QGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKE
MLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEK
VSVHVHPAFTPPYLFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQ
VSEKVHAASWDEPQFSDNSGAELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHI
VIKGSPCEIPFTPVNGDFICTPDNTGVNCTLTCLEGYDFTEGSTDKYYCAYEDGVWKPTY
TTEWPDCAKKRFANHGFKSFEMFYKAARCDDTDLMKKFSEAFETTLGKMVPSFCSDAEDI
DCRLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSYDDFLDTVQETATSIGNAKS
SRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKLKRTLNKD
PMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRI
GSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPK
FGSRSCLSCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFC
LACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFN
PCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSG
YTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNA
VCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHC
ELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVM
LDGMLPSLHALTCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGREKIT
NCPSVNDGRWHHIAITWTSANGIWKVYIDGKLSDGGAGLSVGLPIPGGGALVLGQEQDKK
GEGFSPAESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVK
IDSKSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQ
PLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVS
PSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHS
SGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEE
LAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSG
LTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFT
FRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFG
DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKA
KFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGS
NYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTG
RIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENF
EVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTT
EVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHF
GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLS
TALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTV
TYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIY
SCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDM
MEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQ
EDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN
RKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKN
WDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWS
GATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAE
IPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSP
SCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCE
HTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPL
SCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKK
CPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVS
CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCE
TPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVP
FVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPA
HVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGG
ICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPC
LNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF
Target Bioclass
Other
Subcellular location
Secreted
Function
Required for morphological development, cell alignment and migration of lymphatic endothelial cells during embryonic development, potentially via modulation of ANGPT2-TIE1 signaling and subsequent activation of FOXC2 transcription. Required for embryonic lymphatic vascular development, via mediating the correct formation of the first lymphovenous contact site and tight association of the lymphatic endothelium with the venous endothelium. Represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells, via its interaction with integrins, thereby inhibiting vasocontraction. Promotes platelet activation, via its interaction with PEAR1 and subsequent activation of AKT/mTOR signaling. Plays a role in epidermal development and keratinocyte differentiation, independent of cell-cell adhesion. May play a role in initial cell attachment of stromal osteogenic cells. May promote myoblast cell adhesion when in the presence of integrin ITGA9:ITGB1.
Uniprot ID
Q4LDE5
Ensemble ID
ENST00000374461.1
HGNC ID
HGNC:15985

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.D1765H; p.W2310Ter .
A375 SNV: p.K1281E .
A3KAW SNV: p.E1562K .
AN3CA SNV: p.N1494S; p.K2209N .
C4II SNV: p.T3403M .
CCK81 SNV: p.A123V .
CCSW1 SNV: p.G1538S .
COLO792 SNV: p.E217Q; p.G3528R .
CORL23 SNV: p.K149M .
DANG SNV: p.C636F .
DU145 SNV: p.E801Q .
G415 SNV: p.E761Ter .
HCT15 SNV: p.Q371H .
HEC1 SNV: p.P1639H; p.M1728V .
HSC4 SNV: p.E2224D .
HT SNV: p.C569W .
HT115 SNV: p.F1329L; p.Y2677C .
IGR1 SNV: p.G2265E .
IGROV1 Deletion: p.S2372FfsTer5 .
Ishikawa (Heraklio) 02 ER SNV: p.G2842D .
KMS11 SNV: p.N1733Y .
KPL1 SNV: p.A1142S .
KU1919 SNV: p.N875S .
KYSE30 SNV: p.P2433S .
KYSE410 SNV: p.N748H .
LOXIMVI SNV: p.P591S .
LS123 SNV: p.I3103V .
MCC13 SNV: p.E2642K; p.G2877E .
MCC26 SNV: p.Y2741C .
MCF7 SNV: p.A1142S .
MELJUSO SNV: p.V106A; p.C3207W; p.G3343E .
MEWO SNV: p.F738I; p.L1579F .
MFE319 SNV: p.D758G .
MOLT4 SNV: p.P1544S .
NCIH1048 SNV: p.H1203R .
NCIH1155 SNV: p.C1202Y .
NCIH146 SNV: p.V3422L .
OVCAR8 SNV: p.E1016G .
RD SNV: p.N596K .
SKMEL2 SNV: p.G1561R .
SW403 SNV: p.T3162N .
SW756 SNV: p.V552I .
TE4 SNV: p.W2544R .
TOV21G SNV: p.K576N .
WM2664 Insertion: p.D2299EfsTer14 .
YSCCC SNV: p.E3228K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C2770(0.92); C2775(0.92)  LDD1507  [1]
CY4
 Probe Info  		N.A.  LDD0247  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C2770(0.92); C2775(0.92)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C1409(0.98); C2770(0.83); C2775(0.83)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C1409(1.10); C2770(0.99); C2775(0.99)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C1409(1.13); C2770(0.95); C2775(0.95)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C1409(1.32); C2770(1.07); C2775(1.07)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C2770(1.11); C2775(1.11)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C2770(1.03); C2775(1.03)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C1409(0.91); C2770(0.87); C2775(0.87)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C1409(0.92); C2770(1.01); C2775(1.01)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C1409(0.89); C2770(0.80); C2775(0.80)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C1409(1.01); C2770(0.93); C2775(0.93)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C1409(1.17); C2770(1.08); C2775(1.08)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C1409(1.13); C2770(1.08); C2775(1.08)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C2770(1.02); C2775(1.02)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C2770(0.94); C2775(0.94)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C2770(0.97); C2775(0.97)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C1409(0.95); C2770(0.87); C2775(0.87)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C1409(1.05); C2770(0.92); C2775(0.92)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C1409(0.96); C2770(0.90); C2775(0.90)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C1409(1.10); C2770(1.10); C2775(1.10)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C1409(0.93); C2770(0.98); C2775(0.98)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C1409(1.01); C2770(1.02); C2775(1.02)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C2770(0.94); C2775(0.94)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C2770(0.77); C2775(0.77)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C2770(0.96); C2775(0.96)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C1409(1.06); C2770(0.84); C2775(0.84)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C1409(1.11); C2770(0.97); C2775(0.97)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C1409(1.06); C2770(0.98); C2775(0.98)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C1409(0.95); C2770(1.02); C2775(1.02)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C1409(1.24); C2770(1.00); C2775(1.00)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C2770(1.06); C2775(1.06)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C1409(0.87); C2770(1.03); C2775(1.03)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C2770(1.03); C2775(1.03)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C2770(0.93); C2775(0.93)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C1409(0.87); C2770(0.92); C2775(0.92)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C1409(1.14); C2770(0.92); C2775(0.92)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C1409(1.01); C2770(1.10); C2775(1.10)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C1409(1.04); C2770(1.07); C2775(1.07)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C1409(1.11); C2770(1.03); C2775(1.03)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C2770(0.95); C2775(0.95)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C2770(0.80); C2775(0.80)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C2770(0.89); C2775(0.89)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C1409(0.93); C2770(0.94); C2775(0.94)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C1409(0.91); C2770(0.78); C2775(0.78)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C1409(1.11); C2770(0.93); C2775(0.93)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C1409(1.03); C2770(0.98); C2775(0.98)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C1409(1.11); C2770(0.94); C2775(0.94)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C1409(1.25); C2770(0.95); C2775(0.95)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C2770(1.04); C2775(1.04)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C2770(0.87); C2775(0.87)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C2770(0.98); C2775(0.98)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C1409(0.88); C2770(0.85); C2775(0.85)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C1409(0.89); C2770(0.82); C2775(0.82)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C1409(1.00); C2770(0.97); C2775(0.97)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C1409(0.86); C2770(0.89); C2775(0.89)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C1409(0.93); C2770(0.97); C2775(0.97)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C1409(0.95); C2770(0.91); C2775(0.91)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C2770(1.05); C2775(1.05)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C2770(0.76); C2775(0.76)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C2770(1.03); C2775(1.03)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C2770(0.93); C2775(0.93)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C1409(1.15); C2770(1.01); C2775(1.01)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C2770(0.93); C2775(0.93)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C2770(0.89); C2775(0.89)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C2770(1.12); C2775(1.12)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C1409(4.13); C2770(2.11); C2775(2.11)  LDD1572  [1]
 LDCM0370  CL101 HEK-293T C2770(0.98); C2775(0.98)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C2770(1.10); C2775(1.10)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C1409(1.06); C2770(1.16); C2775(1.16)  LDD1576  [1]
 LDCM0374  CL105 HEK-293T C2770(0.99); C2775(0.99)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C2770(1.03); C2775(1.03)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C1409(1.00); C2770(1.06); C2775(1.06)  LDD1580  [1]
 LDCM0378  CL109 HEK-293T C2770(0.95); C2775(0.95)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C2770(2.21); C2775(2.21)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C2770(1.10); C2775(1.10)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C1409(0.99); C2770(1.11); C2775(1.11)  LDD1585  [1]
 LDCM0383  CL113 HEK-293T C2770(0.93); C2775(0.93)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C2770(0.91); C2775(0.91)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C1409(1.04); C2770(1.14); C2775(1.14)  LDD1589  [1]
 LDCM0387  CL117 HEK-293T C2770(1.04); C2775(1.04)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C2770(1.11); C2775(1.11)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C1409(0.98); C2770(1.07); C2775(1.07)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C2770(1.75); C2775(1.75)  LDD1594  [1]
 LDCM0392  CL121 HEK-293T C2770(0.90); C2775(0.90)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C2770(0.96); C2775(0.96)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C1409(1.13); C2770(1.04); C2775(1.04)  LDD1598  [1]
 LDCM0396  CL125 HEK-293T C2770(0.89); C2775(0.89)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C2770(0.96); C2775(0.96)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C1409(0.79); C2770(0.94); C2775(0.94)  LDD1602  [1]
 LDCM0400  CL13 HEK-293T C2770(1.02); C2775(1.02)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C2770(1.03); C2775(1.03)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C1409(1.26); C2770(1.24); C2775(1.24)  LDD1606  [1]
 LDCM0404  CL17 HEK-293T C2770(1.22); C2775(1.22)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C1409(1.86); C2770(1.09); C2775(1.09)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C1409(2.48); C2770(1.25); C2775(1.25)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C2770(1.23); C2775(1.23)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C1409(2.64); C2770(2.00); C2775(2.00)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C1409(6.27); C2770(2.47); C2775(2.47)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C1409(4.45); C2770(1.90); C2775(1.90)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C2770(2.61); C2775(2.61)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C2770(1.50); C2775(1.50)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C2770(1.02); C2775(1.02)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C2770(1.28); C2775(1.28)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C1409(1.07); C2770(1.22); C2775(1.22)  LDD1619  [1]
 LDCM0417  CL29 HEK-293T C2770(1.23); C2775(1.23)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C1409(1.10); C2770(1.36); C2775(1.36)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C1409(1.45); C2770(1.25); C2775(1.25)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C1409(2.17); C2770(1.79); C2775(1.79)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C1409(3.11); C2770(1.56); C2775(1.56)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C1409(2.78); C2770(2.36); C2775(2.36)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C1409(3.58); C2770(2.14); C2775(2.14)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C2770(2.16); C2775(2.16)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C2770(1.52); C2775(1.52)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C2770(0.92); C2775(0.92)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C1409(1.41); C2770(1.23); C2775(1.23)  LDD1632  [1]
 LDCM0431  CL41 HEK-293T C2770(1.19); C2775(1.19)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C1409(1.36); C2770(1.00); C2775(1.00)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C1409(1.84); C2770(1.26); C2775(1.26)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C1409(2.35); C2770(1.64); C2775(1.64)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C1409(2.63); C2770(2.14); C2775(2.14)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C1409(3.62); C2770(2.00); C2775(2.00)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C2770(1.62); C2775(1.62)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C2770(1.32); C2775(1.32)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C2770(1.00); C2775(1.00)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C2770(1.07); C2775(1.07)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C2770(1.16); C2775(1.16)  LDD1645  [1]
 LDCM0444  CL53 HEK-293T C2770(1.18); C2775(1.18)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C1409(1.40); C2770(1.07); C2775(1.07)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C1409(1.98); C2770(1.36); C2775(1.36)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C1409(3.39); C2770(1.89); C2775(1.89)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C1409(2.39); C2770(2.61); C2775(2.61)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C1409(3.84); C2770(2.08); C2775(2.08)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C2770(1.89); C2775(1.89)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C1409(1.29); C2770(1.15); C2775(1.15)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C2770(1.60); C2775(1.60)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C2770(0.91); C2775(0.91)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C2770(0.89); C2775(0.89)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C1409(1.03); C2770(1.09); C2775(1.09)  LDD1658  [1]
 LDCM0457  CL65 HEK-293T C2770(0.86); C2775(0.86)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C1409(1.52); C2770(0.96); C2775(0.96)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C1409(1.74); C2770(1.17); C2775(1.17)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C1409(2.17); C2770(1.64); C2775(1.64)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C1409(2.55); C2770(1.75); C2775(1.75)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C1409(1.71); C2770(1.37); C2775(1.37)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C1409(2.76); C2770(1.96); C2775(1.96)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C2770(2.01); C2775(2.01)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C2770(1.87); C2775(1.87)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C2770(0.93); C2775(0.93)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C2770(0.98); C2775(0.98)  LDD1670  [1]
 LDCM0470  CL77 HEK-293T C2770(0.97); C2775(0.97)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C1409(1.37); C2770(1.03); C2775(1.03)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C1409(1.72); C2770(1.26); C2775(1.26)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C1409(1.72); C2770(1.77); C2775(1.77)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C1409(1.90); C2770(1.53); C2775(1.53)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C1409(2.45); C2770(1.65); C2775(1.65)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C1409(2.70); C2770(1.61); C2775(1.61)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C2770(1.72); C2775(1.72)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C2770(1.42); C2775(1.42)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C2770(0.88); C2775(0.88)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C2770(0.94); C2775(0.94)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C1409(0.77); C2770(1.08); C2775(1.08)  LDD1684  [1]
 LDCM0483  CL89 HEK-293T C2770(0.90); C2775(0.90)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C1409(2.82); C2770(2.23); C2775(2.23)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C1409(0.98); C2770(1.03); C2775(1.03)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C1409(2.05); C2770(1.24); C2775(1.24)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C1409(1.49); C2770(1.29); C2775(1.29)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C1409(1.89); C2770(1.91); C2775(1.91)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C1409(2.39); C2770(1.59); C2775(1.59)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C2770(1.43); C2775(1.43)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C2770(1.28); C2775(1.28)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C2770(1.08); C2775(1.08)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C2770(1.00); C2775(1.00)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C1409(0.94); C2770(0.95); C2775(0.95)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C1409(1.14); C2770(1.13); C2775(1.13)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C1409(1.08); C2770(1.06); C2775(1.06)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C2770(1.02); C2775(1.02)  LDD1631  [1]
 LDCM0022  KB02 Hs 839.T C716(2.34)  LDD2361  [4]
 LDCM0023  KB03 Hs 839.T C716(3.61)  LDD2778  [4]
 LDCM0024  KB05 Hs 839.T C716(4.26)  LDD3195  [4]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840