Details of the Target

General Information of Target

Target ID LDTP06626
Target Name Hydroxyacylglutathione hydrolase, mitochondrial (HAGH)
Gene Name HAGH
Gene ID 3029
Synonyms
GLO2; HAGH1; Hydroxyacylglutathione hydrolase, mitochondrial; EC 3.1.2.6; Glyoxalase II; Glx II
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVVGRGLLGRRSLAALGAACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDN
YMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESG
LKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFT
GDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAA
IREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREK
DQFKMPRD
Target Bioclass
Enzyme
Family
Metallo-beta-lactamase superfamily, Glyoxalase II family
Subcellular location
Cytoplasm; Mitochondrion matrix
Function Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
Uniprot ID
Q16775
Ensemble ID
ENST00000397353.6
HGNC ID
HGNC:4805
ChEMBL ID
CHEMBL2261

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.T292A .
TCCSUP SNV: p.R216K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y193(20.00)  LDD0260  [1]
STPyne
 Probe Info  		K116(10.00)  LDD0277  [2]
DBIA
 Probe Info  		C219(1.86)  LDD3316  [3]
BTD
 Probe Info  		C219(1.03)  LDD2107  [4]
IPM
 Probe Info  		C20(4.19)  LDD1701  [4]
HHS-465
 Probe Info  		Y193(10.00)  LDD2237  [5]
Acrolein
 Probe Info  		N.A.  LDD0221  [6]
1d-yne
 Probe Info  		N.A.  LDD0358  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C201(0.00); C189(0.00); C219(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		C201(0.00); C219(0.00)  LDD0037  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
TFBX
 Probe Info  		C219(0.00); C201(0.00)  LDD0148  [11]
NAIA_5
 Probe Info  		C201(0.00); C219(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C251
 Probe Info  		30.48  LDD1924  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C219(1.06)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C219(1.00)  LDD2152  [4]
 LDCM0214  AC1 HEK-293T C219(0.97)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C219(0.94)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C219(0.97); C34(1.09)  LDD1509  [14]
 LDCM0259  AC14 HEK-293T C219(1.10)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C189(1.14)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C219(0.95)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C219(0.91)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C219(0.98); C34(1.30)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C219(0.87)  LDD1518  [14]
 LDCM0281  AC21 HEK-293T C219(0.96)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C219(0.92)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C189(0.87)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C219(0.93); C34(1.12); C157(0.99)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C219(1.02)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C219(1.00)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C219(1.01); C34(1.11)  LDD1526  [14]
 LDCM0289  AC29 HEK-293T C219(1.08)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C219(1.05); C34(0.92)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C219(0.98)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C189(1.01)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C219(0.95); C34(1.19); C157(0.96)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C219(0.94)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C219(0.92)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C219(1.07); C34(1.12)  LDD1535  [14]
 LDCM0298  AC37 HEK-293T C219(0.97)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C219(1.13)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C189(1.10)  LDD1539  [14]
 LDCM0302  AC40 HEK-293T C219(0.90); C34(0.98); C157(1.17)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C219(0.97)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C219(0.94)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C219(0.99); C34(1.07)  LDD1544  [14]
 LDCM0307  AC45 HEK-293T C219(0.99)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C219(1.09)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C189(1.03)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C219(0.95); C34(1.12); C157(1.20)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C219(0.87)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C219(1.05)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C219(0.91)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C219(1.05); C34(1.00)  LDD1553  [14]
 LDCM0316  AC53 HEK-293T C219(1.03)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C219(1.12)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C189(1.34)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C219(0.95); C34(1.55); C157(1.05)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C219(0.98)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C219(0.90)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C219(1.02); C34(1.08)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C219(1.09)  LDD1562  [14]
 LDCM0325  AC61 HEK-293T C219(1.05)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C219(1.06)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C189(0.96)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C219(0.91); C34(1.10); C157(1.02)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C189(1.09)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C219(0.91); C34(1.77); C157(1.02)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C219(1.06)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C219(0.97)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C219(0.95); C34(1.27); C157(1.04)  LDD1514  [14]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C219(1.07); C34(1.55)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C219(1.53)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C219(1.15); C34(1.01)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C219(1.04); C34(1.01)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C219(1.09); C34(0.74)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C219(1.00)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C219(1.02); C34(0.92)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C219(1.05); C34(0.96)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C219(1.00); C34(0.93)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C219(0.92)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C219(0.97); C34(0.92)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C219(1.06); C34(0.98)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C189(1.04)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C219(1.22); C34(0.73)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C219(0.98)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C219(1.02); C34(0.93)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C219(1.00); C34(1.35)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C219(1.08); C34(0.96)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C219(1.02)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C219(1.07); C34(0.94)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C219(0.96); C34(1.11)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C219(1.01); C34(1.19)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C219(1.02)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C219(0.96); C34(1.57); C157(1.14)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C219(0.96); C34(1.03)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C219(1.05); C34(0.88)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C219(1.02); C34(0.81)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C219(1.07)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C219(0.99); C34(0.98)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C219(1.00); C34(1.24)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C219(1.00); C34(0.97)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C219(1.17)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C219(1.07); C34(0.95)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C219(1.03); C34(1.06)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C219(1.04); C34(1.01)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C219(0.96)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C219(1.07); C34(0.88)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C219(0.95)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C219(0.84)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C219(1.07); C34(0.81)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C219(1.03); C34(1.11)  LDD1611  [14]
 LDCM0409  CL21 HEK-293T C219(1.02)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C219(1.14)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C189(1.31)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C219(0.88); C34(1.80); C157(1.16)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C219(1.18); C34(0.72)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C219(1.01); C34(0.93)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C219(0.98)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C219(1.05); C34(0.95)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C219(0.97)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C219(1.07)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C219(0.87)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C219(1.12); C34(0.90)  LDD1624  [14]
 LDCM0422  CL33 HEK-293T C219(1.16)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C219(1.12)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C189(1.46)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C219(0.95); C34(0.95); C157(1.22)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C219(1.18); C34(1.21)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C219(1.03)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C219(1.17); C34(0.98)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C219(1.07); C34(1.01)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C219(0.95)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C219(0.97)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C219(1.07); C34(0.85)  LDD1637  [14]
 LDCM0435  CL45 HEK-293T C219(1.11)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C219(0.96)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C189(1.19)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C219(0.95); C34(1.45); C157(1.42)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C219(1.10); C34(0.93)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C219(1.01)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C219(1.10); C34(0.87)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C219(1.09); C34(1.04)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C219(1.01)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C219(1.31)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C219(1.07); C34(0.96)  LDD1649  [14]
 LDCM0448  CL57 HEK-293T C219(1.14)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C219(1.23)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C189(1.08)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C219(1.11)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C219(0.95); C34(1.38); C157(1.26)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C219(1.10); C34(1.21)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C219(0.98); C34(0.95)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C219(1.02)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C219(1.10); C34(1.03)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C219(0.89)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C219(0.83)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C219(0.98); C34(0.90)  LDD1662  [14]
 LDCM0461  CL69 HEK-293T C219(1.03)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C219(1.14); C34(0.95)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C219(1.11)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C189(1.19)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C219(0.91); C34(1.11); C157(1.19)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C219(1.01); C34(1.03)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C219(1.00); C34(0.99)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C219(0.97); C34(0.97)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C219(0.98)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C219(0.94)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C219(1.07); C34(0.84)  LDD1675  [14]
 LDCM0475  CL81 HEK-293T C219(0.92)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C219(1.04)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C189(1.19)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C219(1.00); C34(1.68); C157(1.17)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C219(1.07); C34(0.72)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C219(1.07); C34(0.93)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C219(0.98)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C219(0.93); C34(0.99)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C219(1.02)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C219(1.14)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C219(1.00)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C219(1.11); C34(0.94)  LDD1689  [14]
 LDCM0488  CL93 HEK-293T C219(1.08)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C219(1.12)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C189(1.22)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C219(0.87); C34(1.03); C157(0.97)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C219(1.20); C34(0.75)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C219(1.07); C34(0.87)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C219(1.00)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C219(1.16)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C20(1.38)  LDD1702  [4]
 LDCM0468  Fragment33 HEK-293T C219(1.01)  LDD1671  [14]
 LDCM0427  Fragment51 HEK-293T C219(1.01); C34(0.94)  LDD1631  [14]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C219(0.91); C189(1.03)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C219(1.00); C189(0.97)  LDD1497  [14]
 LDCM0024  KB05 MEL167 C219(1.86)  LDD3316  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C219(1.03)  LDD2107  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C219(1.06)  LDD2119  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C219(1.01)  LDD2125  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C219(1.03)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C219(1.04)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C219(1.06)  LDD2136  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C219(1.48)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C219(1.21)  LDD2146  [4]
 LDCM0131  RA190 MM1.R C219(1.62)  LDD0304  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA dC->dU-editing enzyme APOBEC-3A (APOBEC3A) Cytidine and deoxycytidylate deaminase family P31941
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glutathione Small molecular drug DB00143
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
S-(N-hydroxy-n-bromophenylcarbamoyl)Glutathione . DB03889

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
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