Details of the Target

General Information of Target

Target ID LDTP06474
Target Name Nuclear receptor coactivator 1 (NCOA1)
Gene Name NCOA1
Gene ID 8648
Synonyms
BHLHE74; SRC1; Nuclear receptor coactivator 1; NCoA-1; EC 2.3.1.48; Class E basic helix-loop-helix protein 74; bHLHe74; Protein Hin-2; RIP160; Renal carcinoma antigen NY-REN-52; Steroid receptor coactivator 1; SRC-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL
SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL
DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG
VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ
SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF
QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG
IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR
QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG
ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS
LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN
SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC
TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS
VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ
MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV
TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN
QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL
VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT
MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF
AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF
GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN
RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI
PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS
MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE
ADGTQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLT
E
Target Bioclass
Enzyme
Family
SRC/p160 nuclear receptor coactivator family
Subcellular location
Nucleus
Function
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
Uniprot ID
Q15788
Ensemble ID
ENST00000288599.9
HGNC ID
HGNC:7668
ChEMBL ID
CHEMBL1615387

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.D952Y .
CALU6 SNV: p.E905K .
EOL1 SNV: p.S1422L DBIA    Probe Info 
FTC133 SNV: p.S192G .
HCC1806 Substitution: p.R402P .
HCT116 SNV: p.T979M .
HDQP1 SNV: p.D914H .
KASUMI2 SNV: p.R189Ter .
LN229 SNV: p.M1209V .
MEWO SNV: p.S1275F .
NCIH1944 SNV: p.S682L .
RKO SNV: p.E822G; p.D837Y .
SKOV3 SNV: p.E1242K .
TE10 SNV: p.I481T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
HHS-465
 Probe Info  		Y626(3.29)  LDD2237  [2]
DBIA
 Probe Info  		C215(1.19)  LDD0080  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
IPM
 Probe Info  		C24(0.00); C831(0.00); C654(0.00); C1368(0.00)  LDD2156  [5]
VSF
 Probe Info  		N.A.  LDD0007  [6]
AOyne
 Probe Info  		10.20  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C831(0.85); C1368(1.23)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C831(1.08)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C831(1.03)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C215(0.89); C831(0.95); C1368(0.94)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C831(0.93)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C831(1.02); C1368(1.25)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C831(0.96); C1368(1.15)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C831(1.07)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C831(1.15)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C831(1.05)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C215(1.22); C831(1.13); C1368(1.04)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C215(1.37); C831(0.97)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C831(1.02)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C831(1.09); C1368(1.18)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C215(1.36); C831(1.06)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C831(1.05); C1368(1.22)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C831(0.94)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C831(0.97)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C215(0.87); C831(0.99); C1368(1.01)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C215(1.12); C831(0.98)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C831(0.92)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C831(0.90)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C831(0.97); C1368(1.08)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C215(1.10); C831(1.06)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C831(0.81); C1368(1.41)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C831(1.14)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C831(1.00)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C215(0.98); C831(0.99); C1368(0.98)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C215(1.14); C831(0.97)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C831(1.02)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C831(1.14); C1368(1.35)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C215(1.20); C831(0.87); C1368(0.95)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C215(1.00); C831(1.03)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C831(0.90); C1368(1.12)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C831(1.06)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C831(1.01)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C215(0.89); C831(0.92); C1368(1.23)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C215(1.05); C831(1.05)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C831(0.93)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C831(1.14); C1368(1.15)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C215(1.06); C831(1.04)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C831(0.94); C1368(1.20)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C215(1.02); C831(0.86)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C831(1.08)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C831(1.05)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C215(1.21); C831(0.89); C1368(0.95)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C215(1.37); C831(0.92)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C831(0.99)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C831(1.02); C1368(1.14)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C215(0.91); C831(1.03)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C831(1.01); C1368(1.35)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C831(1.04)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C831(0.98)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C831(0.92)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C215(1.11); C831(0.98); C1368(1.01)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C215(0.92); C831(0.89)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C831(0.88)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C831(1.05); C1368(1.27)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C215(0.81); C831(1.04)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C831(1.12); C1368(1.04)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C215(1.21); C831(1.02)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C215(1.37); C831(0.92)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C831(0.90); C1368(1.31)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C215(1.13); C831(0.97)  LDD1514  [8]
 LDCM0156  Aniline NCI-H1299 10.22  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C215(1.03); C831(1.05)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C831(0.95)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C215(0.76); C831(1.22)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C215(1.02); C831(1.01)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C831(0.92)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C831(1.10); C1368(1.39)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C215(0.82); C831(1.04)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C215(1.06); C831(1.19)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C831(1.16)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C831(1.22); C1368(1.33)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C215(1.16); C831(0.90)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C215(0.98); C831(1.05)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C831(1.19); C1368(1.12)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C831(1.07)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C831(1.12); C1368(1.38)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C215(1.08); C831(1.06)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C215(1.17); C831(1.17)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C831(1.07)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C831(1.06); C1368(1.28)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C215(1.22); C831(1.22)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C215(0.96); C831(1.05)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C831(1.25)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C831(1.05); C1368(1.14)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C215(1.06); C831(1.04)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C215(0.72); C831(1.41)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C215(1.05); C831(1.04)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C831(1.14)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C831(1.07); C1368(1.07)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C215(0.91); C831(1.15)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C215(1.10); C831(0.94)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C831(1.16)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C831(1.12); C1368(1.19)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C215(1.16); C831(1.29)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C215(1.03); C831(1.11)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C831(0.67)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C831(0.98); C1368(1.18)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C215(0.81); C831(1.12)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C831(1.16); C1368(1.22)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C831(1.02)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C831(1.12)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C831(1.61)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C215(0.93); C831(0.98); C1368(1.03)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C215(1.37); C831(0.93)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C831(1.19)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C831(1.08); C1368(1.07)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C215(1.04); C831(1.34)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C215(0.94); C831(0.97)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C831(1.01)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C831(1.05); C1368(0.81)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C215(0.79); C831(1.04)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C831(1.00); C1368(0.99)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C831(0.97); C1368(1.34)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C831(1.06)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C831(1.05)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C215(0.93); C831(0.94); C1368(1.13)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C215(1.30); C831(0.90)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C831(0.98)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C831(1.04); C1368(1.08)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C215(0.87); C831(0.99)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C215(1.04); C831(1.02)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C831(1.07); C1368(1.46)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C215(1.12); C831(1.13)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C215(0.93); C831(1.46)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C831(1.08); C1368(1.33)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C831(1.06)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C831(1.09)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C215(1.20); C831(1.11); C1368(0.96)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C215(0.81); C831(0.99)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C831(1.02)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C831(1.12); C1368(1.04)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C215(1.36); C831(1.12)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C215(1.05); C831(0.92)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C831(1.10); C1368(1.22)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C831(1.04)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C215(0.77); C831(1.13)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C831(1.00); C1368(1.43)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C831(1.01)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C831(1.00)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C215(1.22); C831(1.07); C1368(0.87)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C215(1.20); C831(1.04)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C831(1.26)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C831(1.09); C1368(1.08)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C831(0.97)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C215(1.24); C831(1.06)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C215(1.03); C831(1.03)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C831(0.98)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C831(1.17); C1368(1.21)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C215(1.06); C831(1.08)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C831(0.84); C1368(1.27)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C831(1.04)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C831(1.07)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C215(0.96); C831(1.13); C1368(0.98)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C215(1.01); C831(1.01)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C831(1.04)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C831(0.99)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C831(1.12); C1368(1.10)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C215(0.90); C831(1.10)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C215(0.97); C831(1.17)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C831(1.10)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C215(1.04); C831(1.12)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C831(1.01); C1368(1.03)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C831(1.09)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C831(1.06)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C215(0.79); C831(0.86); C1368(1.06)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C215(0.87); C831(1.00); C1368(0.98)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C215(1.43); C831(0.90)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C831(0.98)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C831(1.13); C1368(1.01)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C215(1.04); C831(1.08)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C215(1.02); C831(1.15)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C831(1.24)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C831(1.05); C1368(1.57)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C215(1.28); C831(0.95)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C831(0.94); C1368(1.15)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C215(1.06); C831(0.91)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C831(0.96)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C831(1.08)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C215(0.98); C831(0.95); C1368(1.03)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C215(1.17); C831(0.94)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C831(1.05)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C831(1.08); C1368(1.69)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C215(1.27); C831(1.03)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C215(1.01); C831(0.97)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C831(1.33)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C831(1.02); C1368(1.21)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C831(1.13); C1368(1.05)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C831(1.12); C1368(1.09)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C831(1.13)  LDD1631  [8]
 LDCM0022  KB02 HCT 116 C215(1.19)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C215(1.23)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C215(1.14)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit beta type-9 (PSMB9) Peptidase T1B family P28065
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
G/T mismatch-specific thymine DNA glycosylase (TDG) TDG/mug family Q13569
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear receptor subfamily 1 group I member 2 (NR1I2) Nuclear hormone receptor family O75469
Oxysterols receptor LXR-alpha (NR1H3) Nuclear hormone receptor family Q13133
Vitamin D3 receptor (VDR) Nuclear hormone receptor family P11473
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bile acid receptor (NR1H4) Nuclear hormone receptor family Q96RI1
Nuclear receptor ROR-gamma (RORC) Nuclear hormone receptor family P51449
Retinoic acid receptor alpha (RARA) Nuclear hormone receptor family P10276
Retinoic acid receptor RXR-alpha (RXRA) Nuclear hormone receptor family P19793
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
PAXIP1-associated glutamate-rich protein 1 (PAGR1) . Q9BTK6

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 21 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-chloro-6-(4-hydroxyphenyl)-2-naphthol Small molecular drug DB07119
320-pregnanedione Small molecular drug DB07557
4-(4-hydroxyphenyl)-1-naphthaldehyde Oxime Small molecular drug DB07150
Aleglitazar Small molecular drug DB08915
Corticosterone Small molecular drug DB04652
Genistein Small molecular drug DB01645
Indeglitazar Small molecular drug DB07724
Myristic Acid Small molecular drug DB08231
To-901317 Small molecular drug DB07080
(1r3r)-5-[(2e)-3-{(1s3r)-223-trimethyl-3-[666-trifluoro-5-hydroxy-5-(Trifluoromethyl)Hex-3-yn-1-yl]Cyclopentyl}Prop-2-en-1-ylidene]Cyclohexane-13-diol . DB07530
(2s)-3-(1-{[2-(2-chlorophenyl)-5-methyl-13-oxazol-4-yl]Methyl}-1h-indol-5-yl)-2-ethoxypropanoic Acid . DB06908
(8alpha10alpha13alpha17beta)-17-[(4-hydroxyphenyl)Carbonyl]Androsta-35-diene-3-carboxylic Acid . DB08220
13-cyclohexanediol 4-methylene-5-[(2e)-[(1s3as7as)-octahydro-1-(5-hydroxy-5-methyl-13-hexadiynyl)-7a-methyl-4h-inden-4-ylidene]Ethylidene]- (1r3s5z) . DB08742
2-(5-hydroxy-naphthalen-1-yl)-13-benzooxazol-6-ol . DB07009
3-(6-hydroxy-naphthalen-2-yl)-benzo[D]Isooxazol-6-ol . DB07236
3-bromo-6-hydroxy-2-(4-hydroxyphenyl)-1h-inden-1-one . DB07230
5-hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-carbonitrile . DB07198
Erb-196 . DB06875
Gw-590735 . DB07215
Prinaberel . DB06832
[5-hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-yl]Acetonitrile . DB06927

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402