Details of the Target

General Information of Target

Target ID LDTP06327
Target Name Cyclin-dependent kinase 10 (CDK10)
Gene Name CDK10
Gene ID 8558
Synonyms
Cyclin-dependent kinase 10; EC 2.7.11.22; Cell division protein kinase 10; Serine/threonine-protein kinase PISSLRE
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEPDLECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQ
TDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYC
EQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTA
DFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLP
GTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLL
HFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Subcellular location
Cytoplasm, cytoskeleton, cilium basal body
Function
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.
Uniprot ID
Q15131
Ensemble ID
ENST00000353379.12
HGNC ID
HGNC:1770
ChEMBL ID
CHEMBL1795191

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.R357L .
HT SNV: p.H341R .
MFE296 SNV: p.G183S DBIA    Probe Info 
NCIH23 SNV: p.I52F .
SKMEL28 SNV: p.S293A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C71(0.92)  LDD3316  [2]
IPM
 Probe Info  		C142(3.83)  LDD1701  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
NAIA_5
 Probe Info  		N.A.  LDD2225  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C142(0.88)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C142(0.96)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C142(0.95)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C142(0.99)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C142(0.91)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C142(1.05)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C142(1.04)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C142(0.92)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C142(0.93)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C142(1.11)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C142(1.25)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C142(0.95)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C142(0.88)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C142(1.04)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C142(0.94)  LDD1523  [6]
 LDCM0285  AC25 PaTu 8988t C142(1.42)  LDD1164  [7]
 LDCM0286  AC26 PaTu 8988t C142(1.01)  LDD1165  [7]
 LDCM0287  AC27 PaTu 8988t C142(1.47)  LDD1166  [7]
 LDCM0288  AC28 PaTu 8988t C142(1.21)  LDD1167  [7]
 LDCM0289  AC29 PaTu 8988t C142(1.21)  LDD1168  [7]
 LDCM0290  AC3 HEK-293T C142(0.96)  LDD1529  [6]
 LDCM0291  AC30 PaTu 8988t C142(1.42)  LDD1170  [7]
 LDCM0292  AC31 PaTu 8988t C142(1.20)  LDD1171  [7]
 LDCM0293  AC32 PaTu 8988t C142(1.00)  LDD1172  [7]
 LDCM0294  AC33 PaTu 8988t C142(1.15)  LDD1173  [7]
 LDCM0295  AC34 PaTu 8988t C142(1.20)  LDD1174  [7]
 LDCM0296  AC35 PaTu 8988t C142(1.06)  LDD1175  [7]
 LDCM0297  AC36 PaTu 8988t C142(0.99)  LDD1176  [7]
 LDCM0298  AC37 PaTu 8988t C142(1.34)  LDD1177  [7]
 LDCM0299  AC38 PaTu 8988t C142(1.14)  LDD1178  [7]
 LDCM0300  AC39 PaTu 8988t C142(1.12)  LDD1179  [7]
 LDCM0301  AC4 HEK-293T C142(1.08)  LDD1540  [6]
 LDCM0302  AC40 PaTu 8988t C142(1.15)  LDD1181  [7]
 LDCM0303  AC41 PaTu 8988t C142(0.92)  LDD1182  [7]
 LDCM0304  AC42 PaTu 8988t C142(1.39)  LDD1183  [7]
 LDCM0305  AC43 PaTu 8988t C142(1.43)  LDD1184  [7]
 LDCM0306  AC44 PaTu 8988t C142(1.32)  LDD1185  [7]
 LDCM0307  AC45 PaTu 8988t C142(1.04)  LDD1186  [7]
 LDCM0308  AC46 PaTu 8988t C142(0.90)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C142(0.84)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C142(1.08)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C142(1.18)  LDD1190  [7]
 LDCM0312  AC5 HEK-293T C142(0.94)  LDD1551  [6]
 LDCM0313  AC50 PaTu 8988t C142(0.99)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C142(0.90)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C142(1.08)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C142(1.05)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C142(1.25)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C142(1.00)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C142(0.86)  LDD1198  [7]
 LDCM0320  AC57 HEK-293T C142(1.00)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C142(1.09)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C142(1.04)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C142(0.77)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C142(1.06)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C142(1.07)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C142(0.93)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C142(1.20)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C142(0.89)  LDD1567  [6]
 LDCM0332  AC68 PaTu 8988t C142(0.86)  LDD1211  [7]
 LDCM0333  AC69 PaTu 8988t C142(1.36)  LDD1212  [7]
 LDCM0334  AC7 HEK-293T C142(1.07)  LDD1568  [6]
 LDCM0335  AC70 PaTu 8988t C142(0.92)  LDD1214  [7]
 LDCM0336  AC71 PaTu 8988t C142(0.79)  LDD1215  [7]
 LDCM0337  AC72 PaTu 8988t C142(1.33)  LDD1216  [7]
 LDCM0338  AC73 PaTu 8988t C142(1.24)  LDD1217  [7]
 LDCM0339  AC74 PaTu 8988t C142(1.14)  LDD1218  [7]
 LDCM0340  AC75 PaTu 8988t C142(1.12)  LDD1219  [7]
 LDCM0341  AC76 PaTu 8988t C142(0.99)  LDD1220  [7]
 LDCM0342  AC77 PaTu 8988t C142(0.89)  LDD1221  [7]
 LDCM0343  AC78 PaTu 8988t C142(1.07)  LDD1222  [7]
 LDCM0344  AC79 PaTu 8988t C142(1.16)  LDD1223  [7]
 LDCM0345  AC8 HEK-293T C142(0.79)  LDD1569  [6]
 LDCM0346  AC80 PaTu 8988t C142(1.20)  LDD1225  [7]
 LDCM0347  AC81 PaTu 8988t C142(1.31)  LDD1226  [7]
 LDCM0348  AC82 PaTu 8988t C142(1.33)  LDD1227  [7]
 LDCM0248  AKOS034007472 HEK-293T C142(1.06)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C142(1.01)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C142(0.89)  LDD1514  [6]
 LDCM0632  CL-Sc Hep-G2 C8(20.00)  LDD2227  [5]
 LDCM0367  CL1 PaTu 8988t C142(1.15)  LDD1246  [7]
 LDCM0368  CL10 PaTu 8988t C142(1.74)  LDD1247  [7]
 LDCM0369  CL100 HEK-293T C142(1.22)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C142(1.01)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C142(1.04)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C142(1.03)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C142(0.97)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C142(1.02)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C142(1.07)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C142(1.00)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C142(0.91)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C142(1.07)  LDD1582  [6]
 LDCM0379  CL11 PaTu 8988t C142(1.17)  LDD1258  [7]
 LDCM0380  CL110 HEK-293T C142(1.20)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C142(1.05)  LDD1585  [6]
 LDCM0382  CL112 PaTu 8988t C142(1.37)  LDD1261  [7]
 LDCM0383  CL113 PaTu 8988t C142(1.06)  LDD1262  [7]
 LDCM0384  CL114 PaTu 8988t C142(1.21)  LDD1263  [7]
 LDCM0385  CL115 PaTu 8988t C142(1.49)  LDD1264  [7]
 LDCM0386  CL116 PaTu 8988t C142(1.10)  LDD1265  [7]
 LDCM0387  CL117 PaTu 8988t C142(0.96)  LDD1266  [7]
 LDCM0388  CL118 PaTu 8988t C142(1.35)  LDD1267  [7]
 LDCM0389  CL119 PaTu 8988t C142(0.85)  LDD1268  [7]
 LDCM0390  CL12 PaTu 8988t C142(1.10)  LDD1269  [7]
 LDCM0391  CL120 PaTu 8988t C142(1.21)  LDD1270  [7]
 LDCM0392  CL121 PaTu 8988t C142(1.33)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C142(1.00)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C142(1.18)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C142(1.11)  LDD1274  [7]
 LDCM0396  CL125 HEK-293T C142(1.00)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C142(1.07)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C142(1.15)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C142(0.94)  LDD1603  [6]
 LDCM0400  CL13 PaTu 8988t C142(1.55)  LDD1279  [7]
 LDCM0401  CL14 PaTu 8988t C142(1.05)  LDD1280  [7]
 LDCM0402  CL15 PaTu 8988t C142(1.46)  LDD1281  [7]
 LDCM0403  CL16 HEK-293T C142(0.92)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C142(1.27)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C142(0.91)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C142(1.18)  LDD1610  [6]
 LDCM0407  CL2 PaTu 8988t C142(0.91)  LDD1286  [7]
 LDCM0408  CL20 HEK-293T C142(1.26)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C142(0.94)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C142(1.05)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C142(1.05)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C142(0.98)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C142(1.06)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C142(1.07)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C142(1.02)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C142(0.99)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C142(0.93)  LDD1621  [6]
 LDCM0418  CL3 PaTu 8988t C142(1.06)  LDD1297  [7]
 LDCM0419  CL30 HEK-293T C142(0.92)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C142(1.00)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C142(1.02)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C142(0.87)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C142(0.95)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C142(1.29)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C142(1.04)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C142(1.20)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C142(1.08)  LDD1632  [6]
 LDCM0429  CL4 PaTu 8988t C142(1.11)  LDD1308  [7]
 LDCM0430  CL40 HEK-293T C142(0.92)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C142(1.05)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C142(0.98)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C142(1.22)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C142(1.08)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C142(1.04)  LDD1639  [6]
 LDCM0436  CL46 PaTu 8988t C142(1.10)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C142(1.05)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C142(1.20)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C142(1.62)  LDD1318  [7]
 LDCM0440  CL5 PaTu 8988t C142(1.04)  LDD1319  [7]
 LDCM0441  CL50 PaTu 8988t C142(1.25)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C142(1.35)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C142(1.37)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C142(1.39)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C142(1.23)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C142(1.13)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C142(0.72)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C142(1.80)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C142(1.45)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C142(1.82)  LDD1329  [7]
 LDCM0451  CL6 PaTu 8988t C142(1.12)  LDD1330  [7]
 LDCM0452  CL60 PaTu 8988t C142(1.59)  LDD1331  [7]
 LDCM0453  CL61 HEK-293T C142(0.92)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C142(1.13)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C142(1.05)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C142(1.04)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C142(0.99)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C142(0.92)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C142(1.01)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C142(1.10)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C142(1.10)  LDD1664  [6]
 LDCM0462  CL7 PaTu 8988t C142(1.03)  LDD1341  [7]
 LDCM0463  CL70 HEK-293T C142(0.98)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C142(1.29)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C142(0.90)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C142(1.05)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C142(0.99)  LDD1670  [6]
 LDCM0469  CL76 PaTu 8988t C142(1.01)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C142(1.03)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C142(1.17)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C142(1.56)  LDD1351  [7]
 LDCM0473  CL8 PaTu 8988t C142(1.27)  LDD1352  [7]
 LDCM0474  CL80 PaTu 8988t C142(1.41)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C142(1.50)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C142(1.41)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C142(1.55)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C142(1.58)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C142(1.16)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C142(1.44)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C142(1.51)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C142(1.18)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C142(1.22)  LDD1362  [7]
 LDCM0484  CL9 PaTu 8988t C142(0.92)  LDD1363  [7]
 LDCM0485  CL90 PaTu 8988t C142(1.69)  LDD1364  [7]
 LDCM0486  CL91 HEK-293T C142(1.03)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C142(0.84)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C142(1.03)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C142(0.96)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C142(1.20)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C142(1.02)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C142(1.12)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C142(1.10)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C142(0.97)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C142(0.90)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C142(0.96)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C142(1.05)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C142(0.93)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C142(0.94)  LDD1497  [6]
 LDCM0024  KB05 MEL167 C71(0.92)  LDD3316  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein C-ets-2 (ETS2) ETS family P15036
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-Q (CCNQ) Cyclin family Q8N1B3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD044402
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