General Information of Target

Target ID LDTP05970
Target Name Activin receptor type-2B (ACVR2B)
Gene Name ACVR2B
Gene ID 93
Synonyms
Activin receptor type-2B; EC 2.7.11.30; Activin receptor type IIB; ACTR-IIB
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY
ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG
GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP
PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK
HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY
LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG
TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ
HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL
IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Subcellular location
Cell membrane
Function
Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.
TTD ID
T80338
Uniprot ID
Q13705
DrugMap ID
TTLFRKS
Ensemble ID
ENST00000352511.5
HGNC ID
HGNC:174
ChEMBL ID
CHEMBL5466

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.M239T .
JM1 SNV: p.A61P .
NCIH1793 SNV: p.L15P .
NCIH2172 SNV: p.M411L .
NCIH446 SNV: p.C77F .
RL952 Deletion: p.Y167TfsTer21 .
TE4 SNV: p.R383P; p.M389I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C49(0.99); C473(1.01); C288(0.95)  LDD1492  [1]
W1
 Probe Info 
N.A.  LDD0236  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C473(0.90); C288(0.80); C49(0.99); C308(1.25)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C473(0.90); C288(1.02); C492(1.06); C308(0.97)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C473(0.90); C288(0.98); C492(1.14); C49(1.34)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C473(1.06); C288(1.09); C29(0.98)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C473(0.91); C288(0.97); C49(1.18); C308(1.03)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C473(0.96); C288(1.05); C49(1.05); C308(1.03)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C473(0.96); C288(0.94); C49(1.27); C308(1.10)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C473(0.90); C288(0.89); C492(0.90); C308(0.87)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C473(0.98); C288(1.01); C492(0.92); C49(3.58)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C473(0.93); C288(0.97); C492(1.06); C308(0.95)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C473(0.96); C288(0.95); C29(0.92)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C473(0.99); C288(0.97); C492(1.03); C308(1.00)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C473(1.16); C288(0.99); C49(1.02); C308(1.01)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C473(1.03); C288(0.96); C49(1.08); C308(0.95)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C473(0.80); C288(1.09); C308(0.95); C59(1.08)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C473(0.92); C288(0.92); C49(0.90); C308(1.14)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C473(0.99); C288(0.99); C492(0.92); C308(0.96)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C473(0.94); C288(0.99); C492(1.00); C49(1.19)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C473(0.87); C288(1.04); C29(0.93)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C473(1.07); C288(0.98); C492(1.21); C308(1.00)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C473(0.96); C288(0.93); C492(1.14); C49(1.23)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C473(1.09); C288(0.95); C49(1.08); C308(1.11)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C473(0.98); C288(0.95); C49(1.01); C308(1.19)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C473(0.79); C288(1.06); C308(0.92); C59(1.04)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C473(1.02); C288(1.03); C49(1.01); C308(1.19)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C473(0.91); C288(0.92); C492(1.00); C308(1.05)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C473(0.88); C288(1.07); C492(1.27); C49(1.21)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C473(0.99); C288(1.13); C29(0.86)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C473(1.43); C288(1.03); C492(0.86); C308(0.94)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C473(1.13); C288(1.07); C49(1.28); C308(1.06)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C473(1.01); C288(1.02); C49(1.17); C308(0.99)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C473(0.97); C288(0.95); C29(0.91)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C473(1.07); C288(1.01); C308(1.12); C59(1.18)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C473(0.98); C288(1.02); C49(1.22); C308(0.96)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C473(0.94); C288(0.89); C492(0.88); C308(1.05)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C473(1.00); C288(1.04); C492(1.29); C49(1.28)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C473(0.96); C288(0.95); C29(0.99)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C473(1.14); C288(0.92); C492(0.79); C308(1.04)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C473(1.16); C288(1.02); C49(1.11); C308(1.12)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C473(1.03); C288(1.04); C49(1.18); C308(1.02)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C473(0.81); C288(1.00); C308(0.98); C59(1.19)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C473(0.90); C288(1.03); C49(1.42); C308(1.07)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C473(1.03); C288(1.00); C492(0.92); C308(0.95)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C473(0.94); C288(1.17); C492(0.87); C308(0.96)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C473(0.95); C288(1.06); C492(1.13); C49(1.06)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C473(0.96); C288(1.01); C29(1.02)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C473(1.07); C288(1.01); C492(1.06); C308(0.97)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C473(0.96); C288(1.06); C49(1.11); C308(1.08)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C473(1.00); C288(0.98); C49(1.13); C308(0.98)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C473(0.72); C288(0.94); C308(0.98); C59(1.17)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C473(0.94); C288(1.02); C49(1.27); C308(1.15)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C473(0.98); C288(1.11); C492(1.00); C308(0.92)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C473(0.95); C288(1.04); C492(1.05); C49(1.14)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C473(1.05); C288(1.02); C49(0.93); C308(1.04)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C473(0.94); C288(1.12); C29(0.90)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C473(1.29); C288(1.08); C492(0.97); C308(1.00)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C473(1.05); C288(0.96); C49(1.08); C308(1.09)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C473(1.02); C288(1.13); C49(1.02); C308(0.96)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C473(0.69); C288(1.06); C308(0.95); C59(0.98)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C473(1.00); C288(0.94); C49(1.06); C308(0.99)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C473(0.71); C288(0.95); C308(1.00); C59(1.19)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C473(1.03); C288(1.04); C492(1.07); C308(0.96)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C473(0.98); C288(0.98); C49(1.15); C308(1.18)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C473(0.93); C288(0.98); C308(1.04); C59(1.35)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C473(0.85); C288(1.02); C49(0.74)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C473(0.88); C288(1.27); C49(1.10); C308(1.66)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C288(0.86); C308(1.00); C59(1.08)  LDD1573  [1]
 LDCM0370  CL101 HEK-293T C473(0.91); C288(0.96); C49(0.97)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C473(0.91); C288(0.91); C308(1.12)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C473(0.91); C288(1.01)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C288(0.91); C308(0.98); C59(0.97)  LDD1577  [1]
 LDCM0374  CL105 HEK-293T C473(0.80); C288(0.93); C49(0.78)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C473(1.09); C288(0.90); C308(1.08)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C473(0.90); C288(0.96)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C288(0.83); C308(1.01); C59(0.91)  LDD1581  [1]
 LDCM0378  CL109 HEK-293T C473(1.00); C288(0.81); C49(0.77)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C473(1.09); C288(1.12); C49(1.10); C308(1.13)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C473(1.00); C288(0.87); C308(1.13)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C473(0.88); C288(1.02)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C288(0.92); C308(1.02); C59(0.94)  LDD1586  [1]
 LDCM0383  CL113 HEK-293T C473(0.96); C288(1.18); C49(0.91)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C473(0.88); C288(0.91); C308(1.11)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C473(0.94); C288(0.93)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C288(0.99); C308(1.10); C59(0.94)  LDD1590  [1]
 LDCM0387  CL117 HEK-293T C473(0.89); C288(1.02); C49(0.93)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C473(1.01); C288(1.06); C308(1.00)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C473(0.97); C288(0.98)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C473(0.88); C288(1.21); C308(1.15); C59(1.04)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C288(0.89); C308(1.01); C59(0.99)  LDD1595  [1]
 LDCM0392  CL121 HEK-293T C473(1.03); C288(0.99); C49(0.97)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C473(1.00); C288(1.02); C308(1.04)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C473(0.84); C288(1.01)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C288(0.93); C308(1.04); C59(1.04)  LDD1599  [1]
 LDCM0396  CL125 HEK-293T C473(0.95); C288(1.04); C49(0.86)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C473(0.91); C288(1.03); C308(0.99)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C473(0.94); C288(1.04)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C288(0.91); C308(0.99); C59(1.07)  LDD1603  [1]
 LDCM0400  CL13 HEK-293T C473(0.85); C288(0.92); C49(1.20)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C473(0.73); C288(0.91); C308(1.11)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C473(0.82); C288(0.95)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C288(0.93); C308(0.97); C59(0.99)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C473(0.92); C288(1.09); C49(1.06); C308(1.41)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C473(0.93); C288(1.09); C492(1.13); C308(0.90)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C473(0.88); C288(1.07); C492(0.98); C49(1.28)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C473(0.77); C288(0.99); C308(0.95)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C473(1.00); C288(1.22); C29(0.88)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C473(1.07); C288(1.08); C492(0.80); C308(1.25)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C473(1.00); C288(1.23); C49(1.02); C308(1.22)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C473(1.09); C288(1.34); C49(1.18); C308(0.94)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C473(0.83); C288(1.17); C308(1.16); C59(1.14)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C473(0.96); C288(1.08); C49(0.79)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C473(1.00); C288(0.94); C308(1.11)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C473(0.94); C288(0.92)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C288(0.89); C308(1.09); C59(0.99)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C473(1.00); C288(1.00); C49(1.05); C308(1.13)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C473(0.91); C288(1.07)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C473(1.08); C288(0.99); C492(1.02); C308(0.93)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C473(1.10); C288(1.04); C492(1.32); C49(1.21)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C473(1.05); C288(1.01); C29(0.98)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C473(1.25); C288(1.09); C492(1.09); C308(1.27)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C473(1.09); C288(1.24); C49(1.05); C308(1.15)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C473(1.17); C288(1.36); C49(1.11); C308(1.03)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C473(0.95); C288(1.21); C308(0.94); C59(1.16)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C473(0.85); C288(0.93); C49(0.82)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C473(0.88); C288(0.96)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C288(0.99); C308(1.09); C59(0.99)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C288(0.93); C308(1.05); C59(0.95)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C473(0.96); C288(1.10); C49(1.10); C308(1.03)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C473(1.02); C288(0.81); C492(1.03); C308(0.92)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C473(0.98); C288(1.06); C492(0.98); C49(1.07)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C473(1.06); C288(1.09); C29(0.94)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C473(1.13); C288(1.10); C492(1.04); C308(1.18)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C473(0.94); C288(1.10); C49(0.91); C308(1.13)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C473(1.14); C288(1.30); C49(1.08); C308(0.81)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C473(0.97); C288(1.11); C308(0.97); C59(1.21)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C473(0.87); C288(0.89); C49(0.81)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C473(0.96); C288(1.07); C49(1.22); C308(1.09)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C473(1.00); C288(0.99); C308(1.15)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C288(0.99); C308(1.03); C59(1.01)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C473(0.99); C288(1.06); C49(1.14); C308(1.19)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C473(0.89); C288(1.00); C492(1.00); C308(0.96)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C473(0.91); C288(1.05); C492(1.03); C49(1.22)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C473(1.03); C288(1.01); C29(0.97)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C473(1.05); C288(0.98); C492(0.82); C308(1.12)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C473(1.57); C288(1.19); C49(1.40); C308(1.25)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C473(1.10); C288(1.08); C49(1.16); C308(1.01)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C473(0.91); C288(0.95); C492(1.10); C308(1.12)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C473(1.32); C288(1.12); C308(1.20); C59(1.19)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C473(0.89); C288(1.00); C49(0.78)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C473(0.99); C288(1.11); C308(1.10)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C473(0.90); C288(0.88)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C288(1.03); C308(1.11); C59(1.32)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C473(0.96); C288(0.99); C49(0.99); C308(1.12)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C473(0.94); C288(1.06); C492(0.99); C308(0.95)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C473(0.93); C288(1.20); C492(1.16); C49(1.28)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C473(1.06); C288(1.11); C29(1.00)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C473(1.35); C288(1.03); C492(1.24); C308(1.02)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C473(0.98); C288(1.11); C492(1.21); C49(1.07)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C473(1.12); C288(1.13); C49(1.21); C308(1.30)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C473(1.13); C288(1.06); C49(1.15); C308(0.98)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C473(0.90); C288(1.45); C308(1.07); C59(1.19)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C473(0.89); C288(1.02); C49(0.85)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C473(0.85); C288(1.09); C308(1.05)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C288(0.98); C308(1.03); C59(1.15)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C473(0.92); C288(0.93); C49(1.08); C308(1.21)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C473(1.03); C288(1.00); C492(1.16); C308(1.00)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C473(1.02); C288(0.97); C492(1.22); C49(1.32)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C473(1.10); C288(1.20); C29(0.89)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C473(1.09); C288(1.21); C29(0.87)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C473(1.14); C288(1.04); C492(1.06); C308(0.93)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C473(0.86); C288(1.18); C49(1.08); C308(1.13)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C473(1.06); C288(1.18); C49(1.19); C308(0.87)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C473(0.98); C288(1.18); C308(0.97); C59(1.20)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C473(0.92); C288(1.09); C49(0.81)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C473(0.88); C288(1.10); C308(1.05)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C473(0.97); C288(0.94)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C288(0.97); C308(1.08); C59(1.06)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C473(1.00); C288(1.00); C49(1.05); C308(0.95)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C473(1.03); C288(1.04); C492(0.87); C308(1.06)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C473(0.99); C288(0.97); C492(0.96); C308(1.07)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C473(1.05); C288(1.02); C492(1.01); C49(1.14)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C473(0.96); C288(1.05); C29(0.96)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C473(1.23); C288(1.01); C492(0.70); C308(1.11)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C473(1.11); C288(1.10); C49(1.05); C308(1.08)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C473(1.18); C288(1.11); C49(1.04); C308(0.94)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C473(0.92); C288(1.12); C308(1.11); C59(1.15)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C473(0.81); C288(0.97); C49(0.89)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C473(0.94); C288(1.00); C308(1.21)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C473(0.88); C288(0.72)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C473(0.90); C288(0.87)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C473(0.86); C288(1.01)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C473(1.05); C288(0.94); C308(1.20)  LDD1631  [1]
 LDCM0022  KB02 HEK-293T C49(0.99); C473(1.01); C288(0.95)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C49(1.03); C473(1.06); C288(1.06)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C49(0.87); C473(0.91); C288(1.10)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Growth/differentiation factor 8 (MSTN) TGF-beta family O14793

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acvr2b . D0GK9J

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.