Details of the Target

General Information of Target

Target ID LDTP05952
Target Name Apoptosis-stimulating of p53 protein 2 (TP53BP2)
Gene Name TP53BP2
Gene ID 7159
Synonyms
ASPP2; BBP; Apoptosis-stimulating of p53 protein 2; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; 53BP2; p53-binding protein 2; p53BP2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMPMFLTVYLSNNEQHFTEVPVTPETICRDVVDLCKEPGESDCHLAEVWCGSERPVADNE
RMFDVLQRFGSQRNEVRFFLRHERPPGRDIVSGPRSQDPSLKRNGVKVPGEYRRKENGVN
SPRMDLTLAELQEMASRQQQQIEAQQQLLATKEQRLKFLKQQDQRQQQQVAEQEKLKRLK
EIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNNLFQQKQRELVLAVSKVEELTR
QLEMLKNGRIDSHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAV
MDKRVNELRDRLWKKKAALQQKENLPVSSDGNLPQQAASAPSRVAAVGPYIQSSTMPRMP
SRPELLVKPALPDGSLVIQASEGPMKIQTLPNMRSGAASQTKGSKIHPVGPDWSPSNADL
FPSQGSASVPQSTGNALDQVDDGEVPLREKEKKVRPFSMFDAVDQSNAPPSFGTLRKNQS
SEDILRDAQVANKNVAKVPPPVPTKPKQINLPYFGQTNQPPSDIKPDGSSQQLSTVVPSM
GTKPKPAGQQPRVLLSPSIPSVGQDQTLSPGSKQESPPAAAVRPFTPQPSKDTLLPPFRK
PQTVAASSIYSMYTQQQAPGKNFQQAVQSALTKTHTRGPHFSSVYGKPVIAAAQNQQQHP
ENIYSNSQGKPGSPEPETEPVSSVQENHENERIPRPLSPTKLLPFLSNPYRNQSDADLEA
LRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPSYPSKSASVTAS
SESPVEIQNPYLHVEPEKEVVSLVPESLSPEDVGNASTENSDMPAPSPGLDYEPEGVPDN
SPNLQNNPEEPNPEAPHVLDVYLEEYPPYPPPPYPSGEPEGPGEDSVSMRPPEITGQVSL
PPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGI
TALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFA
MTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYEPQNDDELPMKE
GDCMTIIHREDEDEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA
Target Bioclass
Other
Family
ASPP family
Subcellular location
Cytoplasm, perinuclear region
Function
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
Uniprot ID
Q13625
Ensemble ID
ENST00000343537.12
HGNC ID
HGNC:12000

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.75  LDD0402  [1]
STPyne
 Probe Info  		K203(2.27); K633(2.56)  LDD0277  [2]
DBIA
 Probe Info  		C960(1.55)  LDD3467  [3]
BTD
 Probe Info  		C290(0.71)  LDD2096  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
AOyne
 Probe Info  		8.10  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1083(0.99); C50(0.88)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C1083(0.93)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C1083(1.03); C50(0.93)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C1083(0.94)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C1083(0.83); C50(0.87)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C1083(1.10); C50(1.00)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C1083(0.80); C50(1.14)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C1083(0.96)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C1083(1.02); C50(1.01)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C1083(1.20)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C1083(0.91)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C1083(0.99); C50(1.07)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C1083(0.87); C50(1.00)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C1083(0.90); C50(0.96)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C1083(0.87); C50(0.92)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C1083(0.94); C50(0.96)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C1083(1.09)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C1083(0.83); C50(0.99)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C1083(0.91)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C1083(1.04); C50(1.15)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C1083(1.08); C50(0.82)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C1083(1.15); C50(0.82)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C1083(0.93); C50(1.14)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C1083(1.01); C50(1.18)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C1083(0.82); C50(0.98)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C1083(0.95)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C1083(1.11); C50(1.04)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C1083(0.97)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C1083(1.07); C50(1.05)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C1083(1.17); C50(1.02)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C1083(1.17); C50(1.15)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C1083(1.00)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C1083(1.12); C50(0.98)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C1083(1.01); C50(0.96)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C1083(0.90)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C1083(1.23); C50(0.89)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C1083(0.91)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C1083(1.15); C50(0.94)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C1083(0.78); C50(0.87)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C1083(0.98); C50(1.07)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C1083(1.06); C50(0.80)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C1083(1.02); C50(1.07)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C1083(0.95); C50(1.03)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C1083(0.95)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C1083(0.93); C50(0.80)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C1083(1.08)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C1083(1.03); C50(1.05)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C1083(0.97); C50(0.99)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C1083(1.00); C50(1.03)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C1083(0.84); C50(0.88)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C1083(0.99); C50(1.08)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C1083(0.87)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C1083(0.98); C50(0.89)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C1083(0.96); C50(1.01)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C1083(0.91)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C1083(1.16); C50(0.99)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C1083(0.94); C50(0.87)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C1083(0.98); C50(1.01)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C1083(1.08); C50(0.96)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C1083(1.01); C50(0.87)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C1083(1.13); C50(0.89)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C1083(1.15); C50(1.04)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C1083(1.01); C50(1.12)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C1083(0.73); C50(0.84)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C1083(0.91); C50(1.20)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C1083(0.68); C50(0.93)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C1083(0.78); C50(0.92)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C1083(0.94); C50(1.02)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C50(1.09)  LDD1575  [7]
 LDCM0373  CL104 HEK-293T C1083(1.04); C50(1.05)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C1083(0.90); C50(1.07)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C50(0.86)  LDD1579  [7]
 LDCM0377  CL108 HEK-293T C1083(0.77); C50(1.16)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C1083(0.86); C50(1.14)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C1083(0.69); C50(0.98)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C50(1.16)  LDD1584  [7]
 LDCM0382  CL112 HEK-293T C1083(1.12); C50(0.98)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C1083(0.96); C50(1.07)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C50(1.01)  LDD1588  [7]
 LDCM0386  CL116 HEK-293T C1083(1.18); C50(1.31)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C1083(1.01); C50(1.02)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C50(1.13)  LDD1592  [7]
 LDCM0390  CL12 HEK-293T C1083(0.84); C50(0.92)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C1083(0.86); C50(0.96)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C1083(0.89); C50(0.97)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C50(0.95)  LDD1597  [7]
 LDCM0395  CL124 HEK-293T C1083(1.07); C50(1.01)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C1083(1.06); C50(0.99)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C50(0.97)  LDD1601  [7]
 LDCM0399  CL128 HEK-293T C1083(1.18); C50(1.14)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C1083(0.99); C50(1.12)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C50(1.22)  LDD1605  [7]
 LDCM0403  CL16 HEK-293T C1083(0.88); C50(1.08)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C1083(0.82); C50(0.96)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C1083(1.15)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C1083(0.89); C50(0.91)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C50(1.31)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C1083(0.85)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C1083(0.82); C50(1.05)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C1083(0.83); C50(0.95)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C1083(0.99); C50(1.13)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C1083(1.12); C50(0.89)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C1083(0.83); C50(0.90)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C50(1.16)  LDD1618  [7]
 LDCM0416  CL28 HEK-293T C1083(0.83); C50(0.96)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C1083(0.91); C50(1.04)  LDD1621  [7]
 LDCM0419  CL30 HEK-293T C1083(0.97)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C1083(0.93); C50(0.97)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C1083(0.85)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C1083(0.87); C50(0.88)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C1083(0.92); C50(0.96)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C1083(0.85); C50(1.16)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C1083(1.00); C50(0.96)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C1083(1.03); C50(1.00)  LDD1630  [7]
 LDCM0429  CL4 HEK-293T C1083(0.82); C50(1.04)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C1083(1.20); C50(1.29)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C1083(0.96); C50(0.89)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C1083(0.98)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C1083(1.02); C50(0.99)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C1083(0.85)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C1083(0.86); C50(0.83)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C1083(0.85); C50(0.91)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C1083(0.86); C50(1.12)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C1083(0.93); C50(0.84)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C1083(1.20); C50(0.90)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C1083(1.05); C50(0.98)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C50(1.02)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C1083(0.98); C50(1.15)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C1083(0.94); C50(0.91)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C1083(0.79)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C1083(0.91); C50(0.99)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C1083(0.88)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C1083(0.83); C50(1.18)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C1083(0.87); C50(0.93)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C1083(0.88); C50(1.09)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C1083(0.72)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C1083(1.13); C50(0.85)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C1083(1.04); C50(1.00)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C50(1.03)  LDD1657  [7]
 LDCM0456  CL64 HEK-293T C1083(0.62); C50(1.09)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C1083(1.00); C50(1.09)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C1083(1.09)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C1083(1.13); C50(0.89)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C1083(0.90)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C1083(0.94); C50(1.01)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C1083(1.03); C50(0.82)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C1083(0.82); C50(0.92)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C1083(0.84); C50(1.08)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C1083(0.70); C50(0.83)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C1083(1.24); C50(1.07)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C50(1.07)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C1083(0.68); C50(1.03)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C1083(0.72); C50(1.02)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C1083(1.03)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C1083(0.88); C50(1.04)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C1083(0.66)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C1083(0.94)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C1083(0.90); C50(0.93)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C1083(0.74); C50(0.90)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C1083(1.03); C50(1.01)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C1083(0.94); C50(0.97)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C1083(0.95); C50(0.98)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C50(0.92)  LDD1683  [7]
 LDCM0482  CL88 HEK-293T C1083(1.13); C50(1.13)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C1083(0.94); C50(0.94)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C1083(0.90); C50(0.98)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C1083(0.70)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C1083(1.03); C50(0.85)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C1083(0.94)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C1083(0.98); C50(0.95)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C1083(1.05); C50(1.05)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C1083(0.80); C50(1.10)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C1083(0.89); C50(0.75)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C1083(0.86); C50(1.02)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C50(0.84)  LDD1696  [7]
 LDCM0427  Fragment51 HEK-293T C50(0.94)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C50(1.04)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C50(1.04)  LDD1497  [7]
 LDCM0024  KB05 TE-10 C960(1.55)  LDD3467  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C290(0.43)  LDD2121  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C290(0.71)  LDD2096  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C290(2.62)  LDD2105  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C290(1.08)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C290(0.79)  LDD2122  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C290(0.66)  LDD2124  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C290(0.86)  LDD2128  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C290(0.71)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C290(0.28)  LDD2150  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L) Archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family P62875
Ubiquitin thioesterase OTUB2 (OTUB2) Peptidase C65 family Q96DC9
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) PPP phosphatase family P62140
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC) PPP phosphatase family P36873
Myotubularin-related protein 14 (MTMR14) Protein-tyrosine phosphatase family Q8NCE2
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
GTP-binding nuclear protein Ran (RAN) Ran family P62826
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
DCN1-like protein 1 (DCUN1D1) . Q96GG9
E3 ubiquitin-protein ligase Itchy homolog (ITCH) . Q96J02
Histone acetyltransferase p300 (EP300) . Q09472
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Amyloid-beta precursor protein (APP) APP family P05067
Apoptosis regulator Bcl-2 (BCL2) Bcl-2 family P10415
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 26 (ZNF26) Krueppel C2H2-type zinc-finger protein family P17031
Tumor protein 63 (TP63) P53 family Q9H3D4
Tumor protein p73 (TP73) P53 family O15350
Transcription factor p65 (RELA) . Q04206
Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) . Q8N5A5
Other
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenomatous polyposis coli protein 2 (APC2) Adenomatous polyposis coli (APC) family O95996
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Apoptosis-stimulating of p53 protein 2 (TP53BP2) ASPP family Q13625
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Histone H2B type 1-C/E/F/G/I (H2BC4; H2BC6; H2BC7; H2BC8; H2BC10) Histone H2B family P62807
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
NUT family member 1 (NUTM1) NUT family Q86Y26
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Alpha-taxilin (TXLNA) Taxilin family P40222
T-cell leukemia/lymphoma protein 1A (TCL1A) TCL1 family P56279
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) . Q9UQB8
Coiled-coil domain-containing protein 92 (CCDC92) . Q53HC0
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) . Q9BUJ2
LIM domain transcription factor LMO4 (LMO4) . P61968
Pleckstrin homology domain-containing family N member 1 (PLEKHN1) . Q494U1
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
TRAF family member-associated NF-kappa-B activator (TANK) . Q92844
Ubiquitin-associated and SH3 domain-containing protein A (UBASH3A) . P57075

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402