Details of the Target

General Information of Target

Target ID LDTP05775
Target Name Mitogen-activated protein kinase 7 (MAPK7)
Gene Name MAPK7
Gene ID 5598
Synonyms
BMK1; ERK5; PRKM7; Mitogen-activated protein kinase 7; MAP kinase 7; MAPK 7; EC 2.7.11.24; Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIET
IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI
LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH
RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT
QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS
LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA
PPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMP
SPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALK
AALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERER
KERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPV
QPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATS
TSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKS
QVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLAD
WLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
Subcellular location
Cytoplasm
Function
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
TTD ID
T70851
Uniprot ID
Q13164
DrugMap ID
TTU6FSC
Ensemble ID
ENST00000299612.11
HGNC ID
HGNC:6880
ChEMBL ID
CHEMBL5332

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.L583I .
AN3CA Deletion: p.P673LfsTer41 .
DAOY SNV: p.I792T .
DU145 SNV: p.S718F .
HCT15 SNV: p.P728H .
IGROV1 Deletion: p.L726CfsTer26 .
IM95 SNV: p.E723K .
IPC298 SNV: p.S585F .
KNS81FD SNV: p.E519Q .
NALM6 SNV: p.R543Q .
NCIH1993 SNV: p.A621T .
SKNSH SNV: p.P613H .
SUPT1 SNV: p.G78S .
SW1271 SNV: p.W781C .
TE4 SNV: p.E461Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.65  LDD0402  [1]
STPyne
 Probe Info  		K41(10.00); K480(6.57)  LDD0277  [2]
DBIA
 Probe Info  		C69(2.14)  LDD3404  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C194(0.00); C208(0.00); C359(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C208(0.00); C194(0.00)  LDD0037  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C208(0.95); C359(1.14)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C208(0.99); C359(1.14)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C208(0.68); C194(1.44); C359(0.99)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C208(0.92); C194(0.88); C359(1.04)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C208(1.00); C194(1.36); C359(1.07)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C208(0.82); C359(1.04)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C208(0.90); C359(1.10)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C208(0.97); C359(1.34)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C208(0.80); C194(1.23); C359(1.06)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C208(0.92); C359(1.15)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C208(0.89); C194(0.87); C359(0.91)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C208(0.95); C359(1.00)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C208(0.96); C194(0.85); C359(0.97)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C208(0.87); C359(1.10)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C208(1.04); C194(1.13); C359(1.04)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C208(1.12); C359(1.11)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C208(0.82); C359(1.02)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C208(1.11); C194(1.24); C359(1.06)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C208(0.92); C194(0.81); C359(1.01)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C208(0.95); C359(1.02)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C208(1.03); C194(1.26); C359(0.97)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C208(0.85); C194(0.90); C359(1.02)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C208(0.90); C359(1.09)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C208(1.00); C194(1.09); C359(1.05)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C208(0.89); C359(1.06)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C208(0.93); C359(1.15)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C208(1.47); C194(1.43); C359(1.08)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C208(0.92); C194(1.03); C359(0.97)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C208(0.96); C359(1.06)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C208(1.02); C194(1.25); C359(1.15)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C208(0.83); C359(1.01)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C208(1.04); C194(0.90); C359(0.86)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C208(0.99); C194(1.12); C359(1.07)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C208(0.87); C359(1.13)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C208(0.94); C359(1.08)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C208(0.95); C194(2.39); C359(1.03)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C208(0.88); C194(1.17); C359(0.93)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C208(0.94); C359(1.05)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C208(0.97); C194(1.00); C359(1.01)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C208(0.97); C359(1.08)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C208(1.00); C194(1.12); C359(1.08)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C208(0.93); C359(1.10)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C208(0.97); C359(1.10)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C208(0.97); C359(1.17)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C208(1.34); C194(1.05); C359(1.10)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C208(0.96); C194(0.94); C359(1.01)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C208(1.06); C359(0.98)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C208(0.88); C194(1.05); C359(1.08)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C208(0.83); C359(1.09)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C208(0.96); C194(1.21); C359(1.12)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C208(0.99); C359(1.13)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C208(1.00); C359(1.25)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C208(0.93); C194(1.26); C359(1.09)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C208(0.93); C194(0.99); C359(0.90)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C208(1.01); C194(0.85); C359(1.08)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C208(0.90); C359(1.09)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C208(0.90); C194(0.96); C359(1.05)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C208(0.84); C359(1.10)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C208(0.94); C194(1.14); C359(1.11)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C208(0.86); C359(0.99)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C208(1.06); C194(1.05); C359(1.13)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C208(0.98); C359(1.10)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C208(0.88); C359(1.19)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C208(1.04); C194(1.11); C359(1.09)  LDD1514  [6]
 LDCM0156  Aniline NCI-H1299 11.91  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C208(1.17); C194(1.24); C359(1.21)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C208(1.04); C194(1.05); C359(0.99)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C208(0.86); C194(1.01); C359(1.06)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C208(0.97); C194(1.06); C359(1.02)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C208(0.92); C194(0.96); C359(1.39)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C208(1.19); C194(1.06); C359(1.01)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C208(0.85); C194(1.04); C359(1.07)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C208(1.01); C194(0.96); C359(0.91)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C208(0.99); C194(1.03); C359(1.64)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C208(0.95); C194(1.15); C359(0.90)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C208(0.85); C194(0.97); C359(0.98)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C208(1.11); C194(0.99); C359(1.15)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C208(0.90); C359(1.13)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C208(0.91); C194(0.91); C359(1.74)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C208(0.80); C194(0.96); C359(1.01)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C208(1.13); C194(0.98); C359(1.14)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C208(0.99); C194(1.08); C359(1.17)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C208(0.98); C194(0.95); C359(1.77)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C208(0.98); C194(1.04); C359(1.03)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C208(0.93); C194(1.01); C359(1.03)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C208(0.98); C194(0.98); C359(1.09)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C208(0.89); C194(1.21); C359(0.96)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C208(1.12); C194(1.02); C359(0.94)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C208(1.13); C194(1.26); C359(1.31)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C208(1.13); C194(1.00); C359(1.09)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C208(0.95); C194(1.04); C359(1.12)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C208(0.95); C194(1.00); C359(1.08)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C208(0.94); C194(0.95); C359(0.99)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C208(0.87); C194(1.17); C359(1.13)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C208(0.85); C194(1.03); C359(1.11)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C208(1.01); C194(0.95); C359(0.99)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C208(0.95); C194(1.03); C359(1.14)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C208(0.81); C194(0.98); C359(1.05)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C208(1.03); C194(1.19); C359(1.18)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C208(0.99); C194(1.28); C359(1.08)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C208(0.82); C194(1.07); C359(0.95)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C208(0.82); C194(1.28); C359(1.25)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C208(0.88); C359(1.69)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C208(0.83); C359(1.35)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C208(0.85); C194(1.65); C359(1.13)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C208(1.07); C194(1.10); C359(1.18)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C208(0.98); C194(1.41); C359(1.16)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C208(0.98); C359(1.01)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C208(0.86); C194(1.16); C359(1.13)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C208(0.84); C359(1.20)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C208(0.96); C194(1.38); C359(1.11)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C208(0.78); C194(1.01); C359(1.07)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C208(0.89); C194(0.96); C359(1.01)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C208(1.05); C194(1.06); C359(1.01)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C208(0.82); C194(1.01); C359(1.03)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C208(0.80); C359(1.29)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C208(0.96); C194(1.08); C359(1.04)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C208(0.82); C359(0.91)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C208(1.03); C194(1.46); C359(1.03)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C208(0.78); C194(1.24); C359(1.22)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C208(0.77); C359(1.28)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C208(0.91); C194(1.50); C359(1.17)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C208(0.77); C359(1.10)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C208(0.96); C194(1.23); C359(1.09)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C208(0.94); C194(1.00); C359(1.09)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C208(1.08); C194(0.99); C359(1.10)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C208(0.86); C194(1.13); C359(1.12)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C208(0.80); C194(1.07); C359(1.07)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C208(0.91); C359(1.74)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C208(0.81); C359(1.39)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C208(0.78); C194(1.79); C359(1.11)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C208(0.90); C194(1.13); C359(0.93)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C208(0.94); C359(0.93)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C208(0.91); C194(1.24); C359(0.91)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C208(0.82); C359(1.11)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C208(0.94); C194(1.20); C359(1.14)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C208(0.81); C194(1.04); C359(1.18)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C208(0.95); C359(1.21)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C208(0.86); C194(1.00); C359(1.27)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C208(0.93); C194(1.03); C359(1.14)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C208(0.94); C359(1.36)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C208(0.79); C359(1.13)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C208(0.84); C194(1.82); C359(1.09)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C208(0.92); C194(1.37); C359(1.14)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C208(0.87); C359(1.21)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C208(0.80); C194(1.82); C359(1.00)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C208(0.74); C359(1.02)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C208(0.75); C359(2.05)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C208(0.94); C194(1.26); C359(1.18)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C208(1.02); C194(1.23); C359(1.14)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C208(0.92); C194(1.13); C359(1.13)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C208(0.85); C194(1.16); C359(1.01)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C208(0.72); C194(0.96); C359(1.15)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C208(0.95); C359(1.04)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C208(0.83); C359(1.29)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C208(1.33); C194(1.26); C359(1.20)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C208(0.81); C194(1.11); C359(1.08)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C208(0.88); C359(1.12)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C208(0.79); C194(1.17); C359(1.10)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C208(0.85); C194(1.19); C359(1.06)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C208(0.74); C359(1.30)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C208(0.92); C194(1.08); C359(1.08)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C208(0.90); C194(1.06); C359(1.16)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C208(0.88); C194(0.96); C359(1.13)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C208(1.04); C194(1.00); C359(1.10)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C208(0.95); C359(1.66)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C208(0.77); C359(1.09)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C208(0.83); C194(1.21); C359(1.04)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C208(0.80); C194(1.18); C359(1.07)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C208(0.77); C194(0.99); C359(1.16)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C208(0.84); C359(1.12)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C208(0.75); C194(1.27); C359(1.01)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C208(0.77); C359(1.11)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C208(0.83); C194(1.21); C359(1.17)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C208(1.00); C194(1.11); C359(0.96)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C208(0.97); C194(0.99); C359(1.72)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C208(0.97); C194(1.20); C359(1.07)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C208(0.99); C194(1.13); C359(1.19)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C208(0.94); C359(1.12)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C208(1.02); C359(1.13)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C208(0.76); C359(1.22)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C208(0.75); C194(1.56); C359(1.13)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C208(0.92); C194(1.32); C359(1.03)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C208(0.79); C359(1.14)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C208(0.90); C194(1.79); C359(1.22)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C208(0.77); C359(1.07)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C208(0.90); C194(1.07); C359(1.17)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C208(1.01); C194(1.04); C359(1.15)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C208(0.98); C194(0.96); C359(1.20)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C208(1.17); C194(0.92); C359(1.05)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C208(0.98); C194(0.92); C359(1.05)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C208(1.09); C194(1.16); C359(0.97)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C208(0.82); C194(0.94); C359(0.92)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C208(1.10); C359(0.87)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C208(1.03); C359(1.13)  LDD1497  [6]
 LDCM0024  KB05 SJRH30 C69(2.14)  LDD3404  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) STE Ser/Thr protein kinase family Q13163
Ubiquitin-conjugating enzyme E2 C (UBE2C) Ubiquitin-conjugating enzyme family O00762
Protein PML (PML) . P29590
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein with KRAB and SCAN domains 1 (ZKSCAN1) Krueppel C2H2-type zinc-finger protein family P17029
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BAG family molecular chaperone regulator 2 (BAG2) . O95816
Coiled-coil domain-containing protein 6 (CCDC6) . Q16204

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acetylsalicylic Acid Small molecular drug DB00945
Fostamatinib Small molecular drug DB12010
Minocycline Small molecular drug DB01017
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Colforsin Small molecular drug DB02587
Xmd8-92 Small molecular drug D0M0QQ
Patented
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid26924192-compound-30 Small molecular drug D0L7SK
Pmid26924192-compound-32 Small molecular drug D0SB3H
Pmid26924192-compound-33 Small molecular drug D0VB3P

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402