Details of the Target

General Information of Target

Target ID LDTP05555
Target Name Sodium-dependent phosphate transporter 2 (SLC20A2)
Gene Name SLC20A2
Gene ID 6575
Synonyms
GLVR2; PIT2; Sodium-dependent phosphate transporter 2; Gibbon ape leukemia virus receptor 2; GLVR-2; Phosphate transporter 2; PiT-2; Pit2; hPit2; Solute carrier family 20 member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSV
LLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVG
STIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGL
RALPVFYAATIAINVFSIMYTGAPVLGLVLPMWAIALISFGVALLFAFFVWLFVCPWMRR
KITGKLQKEGALSRVSDESLSKVQEAESPVFKELPGAKANDDSTIPLTGAAGETLGTSEG
TSAGSHPRAAYGRALSMTHGSVKSPISNGTFGFDGHTRSDGHVYHTVHKDSGLYKDLLHK
IHIDRGPEEKPAQESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAPEDSEKLVGDT
VSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMKLASELADPDQPREDPAEEEKEEKDA
PEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYG
GVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVG
SVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGILPYV
Target Bioclass
Transporter and channel
Family
Inorganic phosphate transporter (PiT) (TC 2.A.20) family
Subcellular location
Cell membrane
Function
Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion. Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization. Required to maintain normal cerebrospinal fluid phosphate levels. Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs.; (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.
Uniprot ID
Q08357
Ensemble ID
ENST00000342228.7
HGNC ID
HGNC:10947
ChEMBL ID
CHEMBL4295806

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C48(3.82)  LDD3313  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C437(0.99)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C437(1.16)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C437(1.02)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C437(1.00)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C437(0.90)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C437(1.12)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C437(0.88)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C437(1.16)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C437(1.09)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C437(0.87)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C437(0.72)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C437(0.94); C48(0.96)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C437(0.79)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C437(0.97)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C437(1.17)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C437(1.07)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C437(1.16)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C437(0.96)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C437(1.02)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C437(0.99); C48(0.98)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C437(1.03)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C437(0.84)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C437(1.05)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C437(1.06)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C437(1.00)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C437(1.10)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C437(1.01)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C437(0.76)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C437(0.90); C48(1.12)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C437(0.97)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C437(1.03)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C437(0.94)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C437(0.98)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C437(1.20)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C437(1.25)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C437(1.07)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C437(1.05)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C437(0.93); C48(0.98)  LDD1546  [3]
 LDCM0308  AC46 PaTu 8988t C437(1.07)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C437(1.13)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C437(1.75)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C437(1.31)  LDD1190  [4]
 LDCM0312  AC5 HEK-293T C437(0.93); C48(1.00)  LDD1551  [3]
 LDCM0313  AC50 PaTu 8988t C437(1.16)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C437(1.10)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C437(1.44)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C437(1.65)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C437(1.57)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C437(1.66)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C437(1.47)  LDD1198  [4]
 LDCM0320  AC57 HEK-293T C437(1.03)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C437(1.06)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C437(0.92)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C437(0.98)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C437(0.84)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C437(0.91); C48(1.10)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C437(1.00)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C437(1.15)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C437(0.91)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C437(1.07)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C437(1.00)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C437(0.94); C48(0.96)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C437(1.07)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C437(1.00)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C437(0.96)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C437(1.43)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C437(0.96); C48(1.07)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C437(1.11)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C437(1.01); C48(1.09)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C437(0.92)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C437(1.05); C48(0.96)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C437(0.92)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C437(1.03); C48(1.04)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C437(0.82)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C437(1.01); C48(1.08)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C437(0.96)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C437(1.31)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C437(0.94); C48(1.35)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C437(1.10)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C437(0.96); C48(0.93)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C437(1.00)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C437(1.06); C48(1.08)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C437(0.71)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C437(0.99); C48(0.99)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C437(1.05)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C437(1.09); C48(0.86)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C437(0.81)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C437(1.33)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C437(1.02); C48(1.02)  LDD1595  [3]
 LDCM0392  CL121 PaTu 8988t C437(1.33)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C437(1.62)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C437(1.97)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C437(1.23)  LDD1274  [4]
 LDCM0396  CL125 HEK-293T C437(1.28)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C437(1.15); C48(1.22)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C437(1.01)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C437(1.02); C48(1.10)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C437(0.99)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C437(1.10); C48(1.05)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C437(0.84)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C437(0.95); C48(1.10)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C437(0.93)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C437(1.14)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C437(1.03)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C437(1.14); C48(1.05)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C437(0.94)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C437(1.12); C48(1.80)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C437(1.09)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C437(1.45)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C437(1.06)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C437(0.93)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C437(1.01); C48(0.91)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C437(1.02)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C437(0.98); C48(1.10)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C437(1.03)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C437(1.10)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C437(1.06)  LDD1623  [3]
 LDCM0420  CL31 PaTu 8988t C437(1.26)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C437(0.95)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C437(2.08)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C437(1.16)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C437(1.12)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C437(1.46)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C437(1.21)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C437(1.70)  LDD1307  [4]
 LDCM0429  CL4 HEK-293T C437(1.03); C48(1.41)  LDD1633  [3]
 LDCM0430  CL40 PaTu 8988t C437(1.87)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C437(1.19)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C437(1.41)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C437(1.87)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C437(1.31)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C437(1.37)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C437(1.28)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C437(1.23)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C437(1.23)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C437(1.16)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C437(1.09)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C437(1.13); C48(1.13)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C437(0.96); C48(1.01)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C437(1.06)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C437(1.42)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C437(0.96)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C437(1.02)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C437(1.22); C48(1.45)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C437(1.13)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C437(1.46)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C437(1.20)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C437(1.13)  LDD1655  [3]
 LDCM0453  CL61 PaTu 8988t C437(0.78)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C437(0.66)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C437(0.66)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C437(0.99)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C437(0.95)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C437(0.93)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C437(1.14)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C437(1.77)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C437(1.56)  LDD1340  [4]
 LDCM0462  CL7 HEK-293T C437(1.09)  LDD1665  [3]
 LDCM0463  CL70 PaTu 8988t C437(1.08)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C437(0.65)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C437(0.63)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C437(1.19)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C437(0.88)  LDD1346  [4]
 LDCM0469  CL76 PaTu 8988t C437(1.07)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C437(1.14)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C437(1.45)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C437(1.35)  LDD1351  [4]
 LDCM0473  CL8 HEK-293T C437(1.36)  LDD1676  [3]
 LDCM0474  CL80 PaTu 8988t C437(1.40)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C437(1.51)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C437(1.73)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C437(1.56)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C437(1.72)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C437(1.41)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C437(1.16)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C437(1.84)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C437(1.76)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C437(1.41)  LDD1362  [4]
 LDCM0484  CL9 HEK-293T C437(1.16); C48(1.41)  LDD1687  [3]
 LDCM0485  CL90 PaTu 8988t C437(1.72)  LDD1364  [4]
 LDCM0486  CL91 HEK-293T C437(1.01)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C437(0.75)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C437(0.91); C48(1.55)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C437(1.10)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C437(1.15)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C437(1.13)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C437(0.99)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C437(1.06); C48(1.02)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C437(0.94)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C437(1.02)  LDD1698  [3]
 LDCM0468  Fragment33 PaTu 8988t C437(0.80)  LDD1347  [4]
 LDCM0427  Fragment51 PaTu 8988t C437(1.64)  LDD1306  [4]
 LDCM0022  KB02 EFO-21 C48(2.40)  LDD2321  [1]
 LDCM0023  KB03 EFO-21 C48(2.80)  LDD2738  [1]
 LDCM0024  KB05 Hs 936.T C48(3.82)  LDD3313  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.