Details of the Target

General Information of Target

Target ID LDTP05543
Target Name Forkhead box protein M1 (FOXM1)
Gene Name FOXM1
Gene ID 2305
Synonyms
FKHL16; HFH11; MPP2; WIN; Forkhead box protein M1; Forkhead-related protein FKHL16; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; HNF-3/fork-head homolog 11; M-phase phosphoprotein 2; MPM-2 reactive phosphoprotein 2; Transcription factor Trident; Winged-helix factor from INS-1 cells
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKTSPRRPLILKRRRLPLPVQNAPSETSEEEPKRSPAQQESNQAEASKEVAESNSCKFPA
GIKIINHPTMPNTQVVAIPNNANIHSIITALTAKGKESGSSGPNKFILISCGGAPTQPPG
LRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGALCEQKRETCADGEAAGCTINNS
LSNIQWLRKMSSDGLGSRSIKQEMEEKENCHLEQRQVKVEEPSRPSASWQNSVSERPPYS
YMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVRETS
ANGKVSFWTIHPSANRYLTLDQVFKPLDPGSPQLPEHLESQQKRPNPELRRNMTIKTELP
LGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPLAASLMSSELARHSKRVRIA
PKVLLAEEGIAPLSSAGPGKEEKLLFGEGFSPLLPVQTIKEEEIQPGEEMPHLARPIKVE
SPPLEEWPSPAPSFKEESSHSWEDSSQSPTPRPKKSYSGLRSPTRCVSEMLVIQHRERRE
RSRSRRKQHLLPPCVDEPELLFSEGPSTSRWAAELPFPADSSDPASQLSYSQEVGGPFKT
PIKETLPISSTPSKSVLPRTPESWRLTPPAKVGGLDFSPVQTSQGASDPLPDPLGLMDLS
TTPLQSAPPLESPQRLLSSEPLDLISVPFGNSSPSDIDVPKPGSPEPQVSGLAANRSLTE
GLVLDTMNDSLSKILLDISFPGLDEDPLGPDNINWSQFIPELQ
Target Type
Literature-reported
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2.
TTD ID
T85273
Uniprot ID
Q08050
DrugMap ID
TTD3KOX
Ensemble ID
ENST00000342628.6
HGNC ID
HGNC:3818
ChEMBL ID
CHEMBL4739852

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.P156H DBIA    Probe Info 
CCSW1 SNV: p.D130V .
DEL SNV: p.M530I .
ECC2 SNV: p.T357I DBIA    Probe Info 
HCT15 SNV: p.L724M .
HEC1 SNV: p.I310T DBIA    Probe Info 
HKGZCC Deletion: p.P651_L654del .
LNCaP clone FGC SNV: p.R286H; p.A713G DBIA    Probe Info 
MCC13 SNV: p.R224T
Substitution: p.P618F		 .
RKO Deletion: p.E671NfsTer12 .
TOV21G SNV: p.A431S; p.E461Ter .
U87MG SNV: p.F758L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C210(11.59)  LDD0209  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C111(0.83); C210(1.10); C526(1.04); C160(1.03)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C210(0.99); C526(1.04); C160(0.97)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C210(1.07); C526(0.89); C160(0.97)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C111(1.05); C526(0.91); C160(1.06)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C111(1.15); C210(1.06); C526(0.99); C160(0.97)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C111(1.01); C210(0.96); C526(0.96); C160(0.87)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C111(0.99); C210(1.17); C526(1.03); C160(1.11)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C210(1.08); C526(1.00); C160(1.07)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C210(1.36); C526(1.48); C160(1.29)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C210(0.93); C526(0.97); C160(0.97)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C111(0.84); C526(0.98); C160(1.03)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C210(0.85); C526(1.07); C160(1.01)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C111(0.91); C210(1.08); C526(0.99); C160(1.01)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C111(0.94); C210(0.91); C526(0.99); C160(1.00)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C111(0.81); C210(0.98); C526(0.99); C160(0.98)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C111(1.03); C210(0.95); C526(1.10); C160(1.06)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C210(1.09); C526(1.12); C160(1.02)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C210(1.03); C526(0.86); C160(0.99)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C111(0.93); C526(1.01); C160(1.01)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C210(0.84); C526(1.04); C160(0.96)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C210(1.04); C526(1.17); C160(1.01)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C111(0.96); C210(0.97); C526(0.98); C160(0.97)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C111(1.04); C210(0.97); C526(1.12); C160(0.93)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C111(1.02); C210(1.12); C526(0.90); C160(1.03)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C111(1.07); C210(1.20); C526(0.97); C160(1.10)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C210(0.95); C526(1.02); C160(1.02)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C210(1.15); C526(0.85); C160(1.01)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C111(1.13); C526(0.97); C160(1.08)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C210(0.98); C526(1.06); C160(1.01)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C111(0.96); C210(1.15); C526(1.08); C160(0.92)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C111(0.93); C210(1.00); C526(0.96); C160(0.84)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C111(0.88); C526(0.85); C160(1.05)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C111(0.85); C210(0.98); C526(0.97); C160(1.21)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C111(1.22); C210(1.00); C526(0.90); C160(1.13)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C210(1.04); C526(1.14); C160(1.03)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C210(1.10); C526(0.99); C160(1.01)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C111(1.04); C526(1.01); C160(1.01)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C210(1.06); C526(1.08); C160(1.09)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C111(0.97); C210(0.89); C526(0.97); C160(1.07)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C111(1.15); C210(1.19); C526(1.20); C160(0.87)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C111(0.83); C210(1.02); C526(0.84); C160(1.06)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C111(1.33); C210(0.95); C526(1.06); C160(1.01)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C210(1.10); C526(1.09); C160(1.14)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C210(1.01); C526(1.10); C160(0.97)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C210(1.07); C526(0.98); C160(1.05)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C111(0.93); C526(0.91); C160(1.02)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C210(1.01); C526(0.96); C160(0.98)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C111(0.96); C210(0.97); C526(1.03); C160(1.11)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C111(1.01); C210(1.02); C526(1.04); C160(1.06)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C111(0.96); C210(1.00); C526(0.90); C160(1.09)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C111(1.25); C210(0.93); C526(1.06); C160(1.02)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C210(0.89); C526(1.04); C160(1.08)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C210(1.05); C526(0.80); C160(1.04)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C111(0.98); C210(1.02); C526(0.95); C160(1.02)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C111(1.16); C526(1.01); C160(1.22)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C210(1.02); C526(1.02); C160(0.99)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C111(1.04); C210(1.03); C526(0.98); C160(1.14)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C111(0.92); C210(1.05); C526(1.13); C160(0.94)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C111(0.82); C210(0.99); C526(0.99); C160(1.02)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C111(0.92); C210(1.05); C526(0.98); C160(0.97)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C111(0.78); C210(1.04); C526(0.80); C160(0.91)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C210(0.96); C526(1.04); C160(1.05)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C111(1.04); C210(1.20); C526(1.01); C160(1.13)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C111(0.91); C210(1.14); C526(0.96); C160(0.94)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C111(0.91); C210(1.00); C526(1.07); C160(1.01)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C111(1.08); C210(1.05); C526(0.39); C160(1.02)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C210(0.94); C526(1.05); C160(0.98)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C111(0.90); C210(0.98); C526(0.95); C160(0.96)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C111(1.10); C210(1.00); C526(1.09); C160(0.99)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C111(1.13); C210(1.01); C160(1.00)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C210(0.99); C526(0.93); C160(1.00)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C111(0.90); C210(1.05); C526(0.91); C160(0.93)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C111(1.03); C210(1.02); C526(0.97); C160(0.98)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C111(1.03); C210(0.96); C160(1.05)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C210(0.92); C526(0.96); C160(0.94)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C111(0.91); C210(0.95); C526(0.99); C160(0.93)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C111(1.04); C210(1.00); C526(0.99); C160(1.07)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C111(1.03); C210(1.06); C526(1.02); C160(0.92)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C111(1.14); C210(1.02); C160(1.04)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C210(0.92); C526(0.99); C160(1.00)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C111(0.94); C210(1.03); C526(1.15); C160(1.03)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C111(1.02); C210(0.94); C526(1.11); C160(1.14)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C111(0.95); C210(1.01); C160(1.05)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C210(0.84); C526(1.15); C160(0.98)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C111(0.89); C210(1.04); C526(0.97); C160(1.07)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C111(1.33); C210(1.13); C526(1.10); C160(1.20)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C111(1.14); C210(1.08); C160(1.08)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C111(0.93); C210(1.03); C526(0.97); C160(1.10)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C210(0.93); C526(1.02); C160(1.02)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C111(0.99); C210(1.01); C526(1.00); C160(1.00)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C111(0.98); C210(0.99); C526(1.00); C160(0.93)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C111(1.08); C210(0.88); C160(0.96)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C210(0.85); C526(1.14); C160(1.02)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C111(0.91); C210(0.98); C526(0.95); C160(0.96)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C111(1.11); C210(1.05); C526(1.06); C160(1.10)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C111(1.22); C210(1.02); C160(1.04)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C210(0.95); C526(1.06); C160(1.00)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C111(0.97); C210(1.09); C526(1.32); C160(1.10)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C111(1.10); C210(1.02); C526(0.94); C160(1.00)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C111(1.18); C210(0.95); C160(1.10)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C210(0.98); C526(1.04); C160(1.08)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C111(1.07); C210(0.90); C526(1.11); C160(1.08)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C210(0.94); C526(1.00); C160(1.08)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C210(1.03); C526(0.85); C160(1.05)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C111(1.04); C210(1.09); C526(0.95); C160(1.09)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C111(0.91); C526(1.04); C160(1.16)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C210(0.90); C526(1.12); C160(1.05)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C111(0.94); C210(0.87); C526(1.10); C160(1.19)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C111(0.97); C210(0.99); C526(1.21); C160(1.15)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C111(0.85); C210(1.11); C526(1.10); C160(1.04)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C111(0.90); C210(0.91); C526(1.12); C160(0.97)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C111(1.08); C210(0.98); C526(1.00); C160(0.94)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C111(1.02); C210(1.20); C160(0.96)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C210(0.90); C526(1.00); C160(1.02)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C111(1.18); C210(1.03); C526(1.07); C160(1.04)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C111(1.15); C210(1.08); C160(1.06)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C210(0.91); C526(0.99); C160(1.00)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C210(0.99); C526(1.00); C160(1.00)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C111(0.80); C526(1.01); C160(1.06)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C210(1.12); C526(0.96); C160(1.16)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C111(0.99); C210(0.91); C526(1.13); C160(0.97)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C111(1.12); C210(1.16); C526(0.96); C160(1.01)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C111(0.73); C210(0.99); C526(0.92); C160(1.07)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C111(0.92); C210(0.92); C526(0.83); C160(0.90)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C111(1.01); C210(0.99); C160(1.02)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C210(0.95); C526(1.00); C160(1.03)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C210(1.03); C526(0.96); C160(0.97)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C111(0.94); C210(1.23); C526(1.08); C160(1.01)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C210(0.90); C526(1.05); C160(1.03)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C210(1.05); C526(0.96); C160(1.00)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C111(1.14); C526(0.94); C160(1.09)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C210(1.01); C526(0.97); C160(1.06)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C111(1.01); C210(1.20); C526(0.92); C160(1.01)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C111(0.99); C210(0.94); C526(1.04); C160(0.93)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C111(0.92); C210(0.98); C526(0.93); C160(1.13)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C111(0.97); C210(0.96); C526(0.97); C160(0.91)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C111(1.26); C210(1.19); C526(1.18); C160(1.12)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C111(1.01); C210(1.25); C526(1.08); C160(1.14)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C210(0.98); C526(0.95); C160(1.00)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C111(1.02); C210(1.07); C526(1.05); C160(0.96)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C210(0.84); C526(1.13); C160(0.99)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C210(1.13); C526(0.94); C160(1.06)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C111(1.08); C526(1.00); C160(1.14)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C210(1.02); C526(1.22); C160(1.09)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C111(1.06); C210(1.08); C526(0.94); C160(1.15)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C111(1.10); C210(1.06); C526(1.14); C160(0.93)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C210(0.86); C526(1.20); C160(1.05)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C111(0.81); C210(1.12); C526(1.06); C160(1.30)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C111(0.96); C210(1.02); C526(1.00); C160(0.99)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C111(1.09); C210(1.06); C526(1.08); C160(1.12)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C111(1.06); C210(1.07); C160(1.15)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C210(0.90); C526(0.98); C160(0.95)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C111(1.10); C210(0.96); C526(1.04); C160(1.06)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C210(1.00); C526(1.05); C160(1.06)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C210(1.19); C526(1.01); C160(1.06)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C111(0.95); C526(1.09); C160(1.13)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C210(0.89); C526(1.22); C160(1.00)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C210(1.07); C526(0.97); C160(1.01)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C111(1.05); C210(0.94); C526(0.96); C160(1.00)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C111(1.09); C210(1.14); C526(0.93); C160(1.11)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C111(0.82); C210(1.03); C526(0.94); C160(0.92)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C111(0.92); C210(1.01); C526(0.95); C160(0.94)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C111(1.12); C210(1.08); C526(0.99); C160(1.06)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C210(0.95); C526(1.02); C160(1.00)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C111(0.96); C210(0.99); C526(0.95); C160(1.07)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C210(1.00); C526(1.04); C160(0.99)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C210(1.12); C526(1.08); C160(0.99)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C111(2.16); C526(1.12); C160(1.05)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C111(1.00); C526(1.03); C160(1.03)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C210(0.99); C526(1.06); C160(1.07)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C111(0.91); C210(1.02); C526(1.01); C160(1.06)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C111(0.93); C210(0.97); C526(1.02); C160(0.91)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C111(0.98); C210(1.04); C526(1.02); C160(1.05)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C111(0.91); C210(0.98); C526(0.89); C160(0.90)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C111(1.16); C210(0.96); C526(1.01); C160(1.08)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C111(1.03); C210(1.04); C160(1.11)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C210(0.92); C526(1.05); C160(0.99)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C111(1.01); C210(1.14); C526(0.93); C160(1.02)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C210(0.94); C526(1.04); C160(1.03)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C210(0.88); C526(1.09); C160(0.89)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C210(1.01); C526(0.98); C160(1.03)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C111(0.95); C526(0.88); C160(1.09)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C210(1.01); C526(1.11); C160(1.03)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C111(0.90); C210(0.95); C526(1.05); C160(1.12)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C111(1.38); C210(1.23); C526(1.29); C160(1.06)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C111(0.76); C210(1.16); C526(1.08); C160(0.96)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C111(0.88); C210(0.97); C526(0.96); C160(1.02)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C111(1.01); C210(1.05); C526(1.17); C160(1.24)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C111(1.15); C210(0.90); C160(1.06)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C111(1.12); C210(1.08); C160(1.08)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C111(1.13); C210(0.98); C160(0.99)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C111(1.09); C210(1.05); C526(1.17); C160(1.00)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C210(0.91); C160(1.02); C111(0.85)  LDD1492  [2]
 LDCM0023  KB03 Jurkat C210(11.59)  LDD0209  [1]
 LDCM0024  KB05 UACC257 C210(1.86)  LDD3325  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aspartate--tRNA ligase, cytoplasmic (DARS1) Class-II aminoacyl-tRNA synthetase family P14868
Cyclin-dependent kinase 6 (CDK6) CMGC Ser/Thr protein kinase family Q00534
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Forkhead box protein O3 (FOXO3) . O43524
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
G1/S-specific cyclin-E1 (CCNE1) Cyclin family P24864
Origin recognition complex subunit 2 (ORC2) ORC2 family Q13416
Pescadillo homolog (PES1) Pescadillo family O00541
Transcriptional regulator PINT87aa (LINC-PINT) . A0A455ZAR2
Zinc finger CCCH domain-containing protein 11A (ZC3H11A) . O75152

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(D-arg)(9)-p19(Arf) 26-44 Peptide . D01FSW

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840