Details of the Target

General Information of Target

Target ID LDTP05205
Target Name Zinc finger BED domain-containing protein 6 (ZBED6)
Gene Name ZBED6
Gene ID 100381270
Synonyms
Zinc finger BED domain-containing protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVCTLSVPVSSLSPGRRCNTFSDSGILGCVPINSNTDEEDVVEEKMVAEGVNKEAKQPA
KKKRKKGLRIKGKRRRKKLILAKKFSKDLGSGRPVADAPALLASNDPEQDEESLFESNIE
KQIYLPSTRAKTSIVWHFFHVDPQYTWRAICNLCEKSVSRGKPGSHLGTSTLQRHLQARH
SPHWTRANKFGVASGEEDFTLDVSLSPSSGSNGSFEYIPTDPLDDNRMGKKHDKSASDAL
RAERGRFLIKSNIVKHALIPGTRAKTSAVWNFFYTDPQHISRAVCNICKRSVSRGRPGSH
LGTSTLQRHLQATHPIHWAVANKDSGAVANGLDEAETERSDLLSDTLHGEKSTGSQDLTA
EDLSDSDSDEPMLEVENRSESPIPVAEQGTLMRAQERETTCCGNPVSSHISQAIIQMIVE
DMHPYNYFSTPAFQRFMQIVAPDYRLPSETYFFTKAVPQLYDCVREKIFLTLENVQSQKI
HLTVDIWTHDPSTDYFIVTVHWVSLETASFLNNGRIPDFRKWAVLCVTGLAKDCLITNIL
QELNDQIGLWLSPNFLIPSFIVSDNSSNVVHAIKDGGFTHVPCFLHCLNMVIQDFFCEHK
SIENMLVAARKTCHHFSHSVKARQILQEFQNDHQLPWKNLKQDETGHWISTFYMLKWLLE
HCYSVHHSLGRASGVVLTSLQWTLMTYVCDILKPFEEATQKVSVKTAGLNQVLPLIHHLL
LSLQKLREDFQVRGITQALNLVDSLSLKLETDTLLSAMLKSKPCILATLLDPCFKNSLED
FFPQGADLETYKQFLAEEVCNYMESSPEICQIPTSEASCPSVTVGADSFTSSLKEGTSSS
GSVDSSAVDNVALGSKSFMFPSAVAVVDEYFKEKYSEFSGGDDPLIYWQRKISIWPALTQ
VAIQYLSCPMCSWQSECIFTKNSHFHPKQIMSLDFDNIEQLMFLKMNLKNVNYDYSTLVL
SWDPEQNEVVQSSEKEILP
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific. Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP. Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females. Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription. Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2. Positively regulates the cell cycle and survival of pancreatic beta cells. Binds to the CDH2 gene and may directly repress CDH2 transcription. Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells. May also play a role in embryonic beta cell differentiation. May play a role in insulin sensitivity and glucose clearance.
Uniprot ID
P86452
Ensemble ID
ENST00000550078.3
HGNC ID
HGNC:33273

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C764(1.05); C773(1.05)  LDD1094  [1]
TFBX
 Probe Info  		N.A.  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C764(1.05); C773(1.05)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C764(1.05); C773(1.05)  LDD1105  [1]
 LDCM0230  AC113 PaTu 8988t C764(1.30); C773(1.30)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C764(1.19); C773(1.19)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C764(0.98); C773(0.98)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C764(1.16); C773(1.16)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C764(1.00); C773(1.00)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C764(1.00); C773(1.00)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C764(1.16); C773(1.16)  LDD1115  [1]
 LDCM0237  AC12 PaTu 8988t C764(1.15); C773(1.15)  LDD1116  [1]
 LDCM0238  AC120 PaTu 8988t C764(1.26); C773(1.26)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C764(1.16); C773(1.16)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C764(1.28); C773(1.28)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C764(1.34); C773(1.34)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C764(1.19); C773(1.19)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C764(0.97); C773(0.97)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C764(1.15); C773(1.15)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C764(1.28); C773(1.28)  LDD1124  [1]
 LDCM0246  AC128 PaTu 8988t C764(1.02); C773(1.02)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C764(0.78); C773(0.78)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C764(0.91); C773(0.91)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C764(1.15); C773(1.15)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C764(0.93); C773(0.93)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C764(0.89); C773(0.89)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C764(0.87); C773(0.87)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C764(0.77); C773(0.77)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C764(0.74); C773(0.74)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C764(0.90); C773(0.90)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C764(0.71); C773(0.71)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C764(1.00); C773(1.00)  LDD1137  [1]
 LDCM0259  AC14 PaTu 8988t C764(0.99); C773(0.99)  LDD1138  [1]
 LDCM0260  AC140 PaTu 8988t C764(0.74); C773(0.74)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C764(0.89); C773(0.89)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C764(0.79); C773(0.79)  LDD1141  [1]
 LDCM0263  AC143 PaTu 8988t C764(1.02); C773(1.02)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C764(0.91); C773(0.91)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C764(0.91); C773(0.91)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C764(0.83); C773(0.83)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C764(0.96); C773(0.96)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C764(1.09); C773(1.09)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C764(1.30); C773(1.30)  LDD1148  [1]
 LDCM0270  AC15 PaTu 8988t C764(1.03); C773(1.03)  LDD1149  [1]
 LDCM0271  AC150 PaTu 8988t C764(1.08); C773(1.08)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C764(1.06); C773(1.06)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C764(1.10); C773(1.10)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C764(1.23); C773(1.23)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C764(1.11); C773(1.11)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C764(0.92); C773(0.92)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C764(1.02); C773(1.02)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C764(1.07); C773(1.07)  LDD2169  [1]
 LDCM0278  AC19 HEK-293T C288(0.97)  LDD1517  [3]
 LDCM0280  AC20 HEK-293T C285(0.93); C288(0.93)  LDD1519  [3]
 LDCM0287  AC27 HEK-293T C288(1.09)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C285(0.85); C288(0.85)  LDD1527  [3]
 LDCM0290  AC3 HEK-293T C288(0.87)  LDD1529  [3]
 LDCM0296  AC35 PaTu 8988t C764(0.74); C773(0.74)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C764(0.72); C773(0.72)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C764(0.80); C773(0.80)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C764(0.78); C773(0.78)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C764(0.78); C773(0.78)  LDD1179  [1]
 LDCM0301  AC4 HEK-293T C285(0.80); C288(0.80)  LDD1540  [3]
 LDCM0302  AC40 PaTu 8988t C764(0.66); C773(0.66)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C764(1.06); C773(1.06)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C764(0.96); C773(0.96)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C764(0.88); C773(0.88)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C764(0.94); C773(0.94)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C764(0.88); C773(0.88)  LDD1186  [1]
 LDCM0314  AC51 HEK-293T C288(0.96)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C285(0.85); C288(0.85)  LDD1554  [3]
 LDCM0322  AC59 HEK-293T C288(0.91)  LDD1561  [3]
 LDCM0323  AC6 PaTu 8988t C764(0.93); C773(0.93)  LDD1202  [1]
 LDCM0324  AC60 HEK-293T C285(0.89); C288(0.89)  LDD1563  [3]
 LDCM0334  AC7 PaTu 8988t C764(0.98); C773(0.98)  LDD1213  [1]
 LDCM0345  AC8 PaTu 8988t C764(0.92); C773(0.92)  LDD1224  [1]
 LDCM0349  AC83 PaTu 8988t C764(1.11); C773(1.11)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C764(1.09); C773(1.09)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C764(1.07); C773(1.07)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C764(1.12); C773(1.12)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C764(1.01); C773(1.01)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C764(1.05); C773(1.05)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C764(1.09); C773(1.09)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C764(1.07); C773(1.07)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C764(1.00); C773(1.00)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C764(1.04); C773(1.04)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C764(1.23); C773(1.23)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C764(1.13); C773(1.13)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C764(1.02); C773(1.02)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C764(1.03); C773(1.03)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C764(1.03); C773(1.03)  LDD1243  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C764(1.05); C773(1.05)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C764(0.85); C773(0.85)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C764(0.81); C773(0.81)  LDD1154  [1]
 LDCM0367  CL1 PaTu 8988t C764(0.92); C773(0.92)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C764(0.94); C773(0.94)  LDD1247  [1]
 LDCM0370  CL101 PaTu 8988t C764(0.96); C773(0.96)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C764(0.90); C773(0.90)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C764(1.17); C773(1.17)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C764(0.93); C773(0.93)  LDD1252  [1]
 LDCM0379  CL11 PaTu 8988t C764(0.84); C773(0.84)  LDD1258  [1]
 LDCM0387  CL117 PaTu 8988t C764(0.93); C773(0.93)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C764(0.87); C773(0.87)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C764(0.95); C773(0.95)  LDD1268  [1]
 LDCM0390  CL12 PaTu 8988t C764(1.19); C773(1.19)  LDD1269  [1]
 LDCM0391  CL120 PaTu 8988t C764(1.01); C773(1.01)  LDD1270  [1]
 LDCM0400  CL13 PaTu 8988t C764(1.34); C773(1.34)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C764(1.43); C773(1.43)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C764(1.04); C773(1.04)  LDD1281  [1]
 LDCM0406  CL19 HEK-293T C288(1.79)  LDD1610  [3]
 LDCM0407  CL2 PaTu 8988t C764(0.93); C773(0.93)  LDD1286  [1]
 LDCM0408  CL20 HEK-293T C285(0.90); C288(0.90)  LDD1612  [3]
 LDCM0418  CL3 PaTu 8988t C764(0.74); C773(0.74)  LDD1297  [1]
 LDCM0420  CL31 HEK-293T C288(2.05)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C285(0.83); C288(0.83)  LDD1625  [3]
 LDCM0429  CL4 PaTu 8988t C764(0.85); C773(0.85)  LDD1308  [1]
 LDCM0433  CL43 HEK-293T C288(1.75)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C285(0.86); C288(0.86)  LDD1638  [3]
 LDCM0436  CL46 PaTu 8988t C764(1.09); C773(1.09)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C764(0.75); C773(0.75)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C764(0.80); C773(0.80)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C764(1.01); C773(1.01)  LDD1318  [1]
 LDCM0440  CL5 PaTu 8988t C764(1.09); C773(1.09)  LDD1319  [1]
 LDCM0441  CL50 PaTu 8988t C764(0.85); C773(0.85)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C764(0.73); C773(0.73)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C764(0.76); C773(0.76)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C764(0.72); C773(0.72)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C764(0.81); C773(0.81)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C764(0.72); C773(0.72)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C764(0.18); C773(0.18)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C764(0.96); C773(0.96)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C764(0.81); C773(0.81)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C764(1.00); C773(1.00)  LDD1329  [1]
 LDCM0451  CL6 PaTu 8988t C764(0.92); C773(0.92)  LDD1330  [1]
 LDCM0452  CL60 PaTu 8988t C764(0.87); C773(0.87)  LDD1331  [1]
 LDCM0459  CL67 HEK-293T C288(1.61)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C285(0.80); C288(0.80)  LDD1663  [3]
 LDCM0462  CL7 PaTu 8988t C764(1.02); C773(1.02)  LDD1341  [1]
 LDCM0469  CL76 PaTu 8988t C764(0.97); C773(0.97)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C764(0.94); C773(0.94)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C764(0.93); C773(0.93)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C764(1.16); C773(1.16)  LDD1351  [1]
 LDCM0473  CL8 PaTu 8988t C764(0.89); C773(0.89)  LDD1352  [1]
 LDCM0474  CL80 PaTu 8988t C764(0.82); C773(0.82)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C764(1.04); C773(1.04)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C764(1.02); C773(1.02)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C764(0.97); C773(0.97)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C764(0.98); C773(0.98)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C764(0.88); C773(0.88)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C764(0.90); C773(0.90)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C764(1.07); C773(1.07)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C764(0.99); C773(0.99)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C764(1.12); C773(1.12)  LDD1362  [1]
 LDCM0484  CL9 PaTu 8988t C764(1.06); C773(1.06)  LDD1363  [1]
 LDCM0485  CL90 PaTu 8988t C764(1.06); C773(1.06)  LDD1364  [1]
 LDCM0486  CL91 HEK-293T C288(1.23)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C285(0.80); C288(0.80)  LDD1690  [3]
 LDCM0022  KB02 HEK-293T C288(0.91)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C288(0.92)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C288(0.85)  LDD1502  [3]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402