Details of the Target

General Information of Target

Target ID LDTP05132
Target Name Protein jagged-1 (JAG1)
Gene Name JAG1
Gene ID 182
Synonyms
JAGL1; Protein jagged-1; Jagged1; hJ1; CD antigen CD339
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARN
PGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRI
VLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFE
YQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSP
KHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYC
GTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFEC
ECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP
CVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYA
GDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQC
YNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCG
PHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWE
GAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTC
YDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICA
QNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEIN
GYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPR
PCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCAN
ITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAED
IRDDGNPIKEITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVA
WICCLVTAFYWCLRKRRKPGSHTHSASEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYE
NKNSKMSKIRTHNSEVEEDDMDKHQQKARFAKQPAYTLVDREEKPPNGTPTKHPNWTNKQ
DNRDLESAQSLNRMEYIV
Target Bioclass
Other
Subcellular location
Membrane
Function
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Uniprot ID
P78504
Ensemble ID
ENST00000254958.10
HGNC ID
HGNC:6188
ChEMBL ID
CHEMBL3217396

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.W280Ter .
CCLP1 Deletion: p.N115HfsTer24 .
COLO678 SNV: p.S584F .
HEC1B SNV: p.A581D .
IM95 SNV: p.R683H .
JURKAT SNV: p.T370I .
OVCAR4 SNV: p.R843P .
PF382 SNV: p.E1127K .
RKO Deletion: p.G387AfsTer25
SNV: p.T570A		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C844(0.96); C846(0.96)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C187(1.04); C196(1.04)  LDD0531  [1]
 LDCM0246  AC128 HCT 116 C187(0.89); C196(0.89)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C187(1.19); C196(1.19)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C187(0.75); C196(0.75)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C187(1.06); C196(1.06)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C187(1.07); C196(1.07)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C187(0.93); C196(0.93)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C187(0.84); C196(0.84)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C187(0.78); C196(0.78)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C187(1.01); C196(1.01)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C187(1.00); C196(1.00)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C187(0.82); C196(0.82)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C187(0.69); C196(0.69)  LDD0575  [1]
 LDCM0260  AC140 HCT 116 C187(0.69); C196(0.69)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C187(0.79); C196(0.79)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C187(0.90); C196(0.90)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C187(1.11); C196(1.11)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C187(0.64); C196(0.64)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C187(0.94); C196(0.94)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C187(0.66); C196(0.66)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C187(0.61); C196(0.61)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C187(0.52); C196(0.52)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C187(0.52); C196(0.52)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C187(0.89); C196(0.89)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C187(0.95); C196(0.95)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C187(0.69); C196(0.69)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C187(0.57); C196(0.57)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C187(0.71); C196(0.71)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C187(0.84); C196(0.84)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C187(2.63); C196(2.63)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C187(1.32); C196(1.32)  LDD2161  [1]
 LDCM0279  AC2 HCT 116 C187(0.88); C196(0.88)  LDD0596  [1]
 LDCM0290  AC3 HCT 116 C187(0.94); C196(0.94)  LDD0607  [1]
 LDCM0301  AC4 HCT 116 C187(0.80); C196(0.80)  LDD0618  [1]
 LDCM0312  AC5 HCT 116 C187(0.77); C196(0.77)  LDD0629  [1]
 LDCM0349  AC83 HCT 116 C187(0.69); C196(0.69)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C187(0.77); C196(0.77)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C187(1.07); C196(1.07)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C187(0.70); C196(0.70)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C187(0.90); C196(0.90)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C187(0.68); C196(0.68)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C187(0.77); C196(0.77)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C187(1.44); C196(1.44)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C187(0.63); C196(0.63)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C187(0.54); C196(0.54)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C187(0.84); C196(0.84)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C187(1.08); C196(1.08)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C187(0.99); C196(0.99)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C187(0.82); C196(0.82)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C187(0.65); C196(0.65)  LDD0681  [1]
 LDCM0020  ARS-1620 HCC44 C844(0.96); C846(0.96)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C187(1.94); C196(1.94)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C187(0.88); C196(0.88)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C187(0.76); C196(0.76)  LDD0686  [1]
 LDCM0379  CL11 HCT 116 C187(0.67); C196(0.67)  LDD0696  [1]
 LDCM0390  CL12 HCT 116 C187(0.97); C196(0.97)  LDD0707  [1]
 LDCM0400  CL13 HCT 116 C187(0.89); C196(0.89)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C187(1.04); C196(1.04)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C187(1.29); C196(1.29)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C187(0.71); C196(0.71)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C187(0.93); C196(0.93)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C187(0.84); C196(0.84)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C187(0.83); C196(0.83)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C187(0.80); C196(0.80)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C187(0.62); C196(0.62)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C187(0.63); C196(0.63)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C187(0.67); C196(0.67)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C187(0.64); C196(0.64)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C187(0.57); C196(0.57)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C187(0.49); C196(0.49)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C187(0.64); C196(0.64)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C187(0.87); C196(0.87)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C187(0.89); C196(0.89)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C187(0.61); C196(0.61)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C187(0.65); C196(0.65)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C187(0.71); C196(0.71)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C187(1.09); C196(1.09)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C187(1.54); C196(1.54)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C187(1.33); C196(1.33)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C187(0.86); C196(0.86)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C187(1.08); C196(1.08)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C187(0.84); C196(0.84)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C187(0.75); C196(0.75)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C187(0.78); C196(0.78)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C187(1.11); C196(1.11)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C187(0.96); C196(0.96)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C187(0.94); C196(0.94)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C187(0.65); C196(0.65)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C187(0.73); C196(0.73)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C187(0.71); C196(0.71)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C187(0.77); C196(0.77)  LDD0752  [1]
 LDCM0440  CL5 HCT 116 C187(0.86); C196(0.86)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C187(1.64); C196(1.64)  LDD0768  [1]
 LDCM0462  CL7 HCT 116 C187(0.76); C196(0.76)  LDD0779  [1]
 LDCM0473  CL8 HCT 116 C187(0.66); C196(0.66)  LDD0790  [1]
 LDCM0484  CL9 HCT 116 C187(0.69); C196(0.69)  LDD0801  [1]
 LDCM0486  CL91 HCT 116 C187(1.14); C196(1.14)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C187(1.14); C196(1.14)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C187(0.93); C196(0.93)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C187(0.92); C196(0.92)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C187(1.01); C196(1.01)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C187(1.07); C196(1.07)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C187(0.91); C196(0.91)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C187(0.68); C196(0.68)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C187(0.78); C196(0.78)  LDD0811  [1]
 LDCM0427  Fragment51 HCT 116 C187(0.85); C196(0.85)  LDD0744  [1]
 LDCM0022  KB02 A2058 C92(1.95)  LDD2253  [2]
 LDCM0023  KB03 A2780 C551(1.89); C79(1.26)  LDD2671  [2]
 LDCM0024  KB05 NCI-H1975 C79(2.08)  LDD3352  [2]
 LDCM0021  THZ1 HCT 116 C475(1.05); C484(1.05)  LDD2173  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840